ライフサイエンスコーパス: chromatid

1 ssary for homologous pairing with the sister chromatid.

2 SYCP3 to link distant sites along the sister chromatid.

3 chanisms comprise complete sets of nonsister chromatids.

4 ng mitosis depend on cohesion between sister chromatids.

5 r global recombination repair between sister chromatids.

6 plication and faithful segregation of sister chromatids.

7 cription take place in the context of sister chromatids.

8 tic information between sister or homologous chromatids.

9 c recombination occurs solely between sister chromatids.

10 rate mechanical forces that segregate sister chromatids.

11 a single cohesin complex entraps both sister chromatids.

12 tromeres) to mediate cohesion between sister chromatids.

13 ing spindle physically segregates the sister chromatids.

14 is crucial to achieve segregation of sister chromatids.

15 iant on the transcriptionally silent mitotic chromatids.

16 l core, which may physically separate sister chromatids.

17 required to promote bi-orientation of sister chromatids.

18 ring mitosis to capture and segregate sister chromatids.

19 information between two homologous nonsister chromatids.

20 mes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisiae depen

21 ment of proteinaceous bridges between sister chromatids, a function provided by a ring-shaped complex

22 DSBs, at least in barley, involve the sister chromatid and occur during S or G2 phase of the cell cyc

23 clin B, leading to the dissolution of sister chromatids and anaphase onset [1].

24 The mechanism by which chromatids and chromosomes are segregated during mitosis

25 in complex that regulates cohesion of sister chromatids and gene transcription.

26 o S phase of the cell cycle to repair broken chromatids and prevent iHR.

27 that each SC layer may connect two nonsister chromatids, and present a 3D model of the Drosophila SC

28 ome-microtubule attachments even when sister chromatids are correctly bioriented.

29 Sister chromatids are held together by cohesin, a tripartite ri

30 arase-mediated cleavage ensuring that sister chromatids are kept together until their separation in m

31 , Pebble nuclear sequestration when trailing chromatids are present at the midzone.Chromatid segregat

32 ination during cell cycle phases when sister chromatids are present.

33 While sister chromatids are segregated from one another in mitosis an

34 Sister chromatids are tethered together by the cohesin complex

35 ir rereplication-associated DSBs, and sister chromatids are used as templates for such HR-mediated DS

36 he centromere as cohesion is released on the chromatid arms when the homologs segregate at anaphase I

37 ation of cohesins along the length of sister chromatid arms.

38 in undamaged cells causes diminished sister chromatid association at centromeric sequences.

39 in which both homologs separate their sister chromatids at meiosis I; detect selection for higher rec

40 ion at meiosis I but also the fate of sister chromatids at meiosis II.

41 rt chromosomal drive against non-recombinant chromatids at meiosis II.

42 Human sister chromatids at metaphase are primarily linked by centrome

43 , which ensures proper segregation of sister chromatids at mitosis by mediating the interaction betwe

44 H3T3ph signals occur between cohered sister chromatids at prometaphase.

45 rast to G2/M, Top2 removes SCIs from cohesed chromatids at the anaphase onset.

46 During mitosis, duplicated sister chromatids attach to microtubules emanating from opposin

47 Sister chromatid attachment during meiosis II (MII) is maintain

48 phosphorylated at S/T18 decorated the inter-chromatid axial DNA on mitotic chromosomes.

49 s requires the physical separation of sister chromatids before nuclear envelope reassembly (NER).

50 se embryonic fibroblasts displayed increased chromatid breaks and persistence of gammaH2AX foci follo

51 i, micronuclei, and chromosomal aberrations (chromatid breaks and radials) relative to Rev3L(+/-) cel

52 ulted in remarkably increased chromosome and chromatid breaks in Mcph1(-/-)p53(-/-) lymphomas and MEF

53 DNA break repair and induced chromosome and chromatid breaks independent of p53, leading to genome i

54 reased levels of spontaneous and MMC-induced chromatid breaks.

55 ity to ensure accurate segregation of sister chromatids, but, as in centromere localization, they do

56 lation locks cohesin rings around the sister chromatids by counteracting an activity associated with

57 n implicated in the alignment of four sister chromatids by forming parallel guanine quadruplexes duri

58 late switches between homologs versus sister chromatids by using microhomology to prime DNA replicati

59 or multinucleate, and the replicated sister chromatids can remain attached and aligned, producing po

60 rodimeric ATPase, the kleisin subunit sister chromatid cohesion 1 (Scc1) that links the two ATPase he

61 The sister chromatid cohesion 2 and 4 (Scc2-Scc4) complex loads coh

62 esin and condensin, are important for sister chromatid cohesion and condensation, respectively; howev

63 s are inviable and defective for both sister chromatid cohesion and condensation.

64 ial roles in chromosome condensation, sister chromatid cohesion and DNA repair.

65 h DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis and segr

66 ut the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.

67 spliceosome components contribute to sister chromatid cohesion and mitotic chromosome segregation th

68 ong-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosome struc

69 mplex was discovered for its roles in sister chromatid cohesion and segregation, and the Polycomb gro

70 d defects in chromosomal congression, sister chromatid cohesion and spindle positioning, thereby resu

71 any chromosomal activities, including sister chromatid cohesion and transcriptional regulation.

72 , but their relative contributions to sister chromatid cohesion are unknown.

73 nd live-cell imaging, that persistent sister chromatid cohesion at telomeres triggers a prolonged ana

74 he centromere region until release of sister-chromatid cohesion at the metaphase II/anaphase II trans

75 for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activit

76 Sister chromatid cohesion conferred by entrapment of sister DNA

77 al multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of ch

78 lly interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mitotic arr

79 Initiation of sister chromatid cohesion depends on a separate complex, Scc2(N

80 Cohesins establish sister chromatid cohesion during S phase and are removed when c

81 y cohesin's Smc3 subunit to establish sister chromatid cohesion during S phase, but differ in their N

82 In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin co

83 ates replication fork progression and sister chromatid cohesion establishment.

84 Inactivation of known Fanconi anemia and chromatid cohesion genes does explain CIN in the minorit

85 Timely resolution of sister chromatid cohesion in G2/M is essential for genome integ

86 plicing factors that are required for sister chromatid cohesion in human cells.

87 eviously been shown to play a role in sister-chromatid cohesion in metazoans.

88 t notably those encoding p.Ser24Phe, disrupt chromatid cohesion in normal cells, occur in SCC precurs

89 dify different effectors and regulate sister-chromatid cohesion in opposing ways.

90 Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type

91 Sister chromatid cohesion is essential for tension-sensing mech

92 Sister-chromatid cohesion is established by Eco1-mediated acety

93 Sister chromatid cohesion is established during replication by

94 L-induced chromosomal breakage and defective chromatid cohesion is frequently observed in HNSCC.

95 ase in securin that ultimately causes sister chromatid cohesion loss.

96 Sister chromatid cohesion mediated by the cohesin complex is es

97 Sister chromatid cohesion mediated by the cohesin complex is es

98 The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex

99 ng the recruitment of kinetochore and sister-chromatid cohesion proteins, both required for correct c

100 During the cell cycle, sister-chromatid cohesion tethers sister chromatids together fr

101 establishment and two-step release of sister chromatid cohesion that underlies the production of hapl

102 se is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome segrega

103 Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell survival.

104 In addition, defective sister chromatid cohesion was observed in five HNSCC cell lines

105 es DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping)

106 ure to repair DNA damage or defective sister chromatid cohesion, a process essential for correct chro

107 recombination, DNA repair, DNA replication, chromatid cohesion, and chromosome segregation.

108 Mitotic chromosome condensation, sister chromatid cohesion, and higher order folding of interpha

109 onserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA damage

110 osome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair,

111 romosome structure, thereby promoting sister chromatid cohesion, chromosome condensation, DNA repair,

112 tin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regul

113 subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repai

114 In addition to its role in sister chromatid cohesion, genome stability and integrity, the

115 rophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and chromos

116 s SOLO, SUNN, and ORD is required for sister-chromatid cohesion, localizes to the centromeres and is

117 s, aberrations of the centrosome, and failed chromatid cohesion, mirroring findings from cancer biolo

118 rmation, kinetochore-microtubule attachment, chromatid cohesion, mitotic checkpoint monitoring or cyt

119 leted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role for CON

120 -like protein and ORD is required for sister-chromatid cohesion, we tested the hypothesis that these

121 Sister chromatid cohesion, which is mediated by the cohesin com

122 point activation and establishment of sister chromatid cohesion.

123 on as antagonists to regulate meiotic sister chromatid cohesion.

124 tinct sites on chromosomes to mediate sister chromatid cohesion.

125 ivity, is required for Chl1's role in sister chromatid cohesion.

126 y, assembly, and the establishment of sister chromatid cohesion.

127 a stable complex may be required for sister-chromatid cohesion.

128 icase involved in DNA replication and sister chromatid cohesion.

129 to promote chromosome compaction and sister-chromatid cohesion.

130 PDS5A or STAG2 resulted in inadequate sister chromatid cohesion.

131 ation of cohesin establishes enduring sister chromatid cohesion.

132 DDX11, a DNA helicase that is essential for chromatid cohesion.

133 some positioning, gene expression and sister chromatid cohesion.

134 to form tripartite rings that mediate sister chromatid cohesion.

135 of cohesin distinct from its role in sister chromatid cohesion.

136 e cohesin ring, which ensures correct sister chromatid cohesion.

137 ng homologous recombination linked to sister-chromatid cohesion.

138 istry may occur before dissolution of sister chromatid cohesion.

139 eiosis I division in which replicated sister chromatids comigrate, rather than separate as in mitosis

140 ochores during meiosis I may underlie sister chromatid comigration in diverse organisms, but direct e

141 Thus, kinetochore fusion directs sister chromatid comigration, a conserved feature of meiosis th

142 DNA, fully replicated and intertwined sister chromatids--commonly referred to as DNA catenation--and

143 equence, making recombination between sister chromatids difficult to detect.

144 re they are the consequence of failed sister chromatid disentanglement during chromosome compaction.

145 nsure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic ch

146 RA SPINDLE POLES, ESP) plays a major role in chromatid disjunction and cell expansion in Arabidopsis

147 This liberates separase triggering sister chromatid disjunction and inactivates cyclin-dependent k

148 cyclin B1 proteolysis at the time of sister chromatid disjunction destabilizes kinetochore-microtubu

149 rases are large proteins that mediate sister chromatid disjunction in all eukaryotes.

150 ssembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes are att

151 M by Top2-dependent concatenation of cohesed chromatids due to their physical proximity.

152 Accurate and efficient separation of sister chromatids during anaphase is critical for faithful cell

153 in the dissolution of cohesion among sister chromatids during chromosome segregation.

154 1D2 alleles prevent the segregation of the Y chromatids during meiosis II, causing female-biased sex

155 it SMC3 to regulate the separation of sister chromatids during mitosis and meiosis.

156 ) ensures the accurate segregation of sister chromatids during mitosis.

157 regulates the proper biorientation of sister chromatids during mitosis.

158 essential for faithful segregation of sister chromatids during mitosis.

159 etric tethering of plasmid sisters to sister chromatids embodies the replication-dependent component.

160 demonstrate that H3T3P distinguishes sister chromatids enriched with distinct pools of H3 in order t

161 d Strand-seq, that can be used to map sister chromatid exchange (SCE) events genome-wide in single ce

162 multaneous high-resolution mapping of sister chromatid exchange (SCE), facilitating the study of this

163 -induced G1/S checkpoint response and sister chromatid exchange (SCE).

164 (C62A/C65A) cells exhibited increased sister-chromatid exchange and chromosome abnormalities.

165 eric CO-FISH patterns consistent with sister chromatid exchange at the frequency of 5% in primary tis

166 ic but causes DNA breaks and elevates sister chromatid exchange in mammalian cells.

167 interhomolog recombination and intra/sister chromatid exchange in the CUP1 locus.

168 lomeric circle formation and telomere sister chromatid exchange, both arising out of nucleolytic proc

169 be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations, 53BP1

170 ccur by replication slippage, unequal sister chromatid exchange, homologous recombination, and aberra

171 ic recombination, a high frequency of sister chromatid exchanges and double strand DNA breaks, indica

172 ere shortening, elevation of telomere sister-chromatid exchanges and increased aphidicolin-induced te

173 RECQ5 is significant in suppressing sister chromatid exchanges during homologous recombination but

174 Positional coincidence of >81% of sister chromatid exchanges with target loci is unprecedented fo

175 Sister chromatid exchanges, a surrogate measure of iHR, was sig

176 n its absence cells display increased sister chromatid exchanges, replication origin firing and chrom

177 correlated with the accumulation of aberrant chromatid exchanges.

178 n) mutants during meiosis II when the sister chromatids exhibit random distribution.

179 removes catenanes persisting between sister chromatids following DNA replication.

180 ation and reciprocal exchange of DNA between chromatids, forming Holliday junctions.

181 o collapse of stalled replication forks into chromatid fragments that require resolution through the

182 tation and subsequent reassembly of a single chromatid from a micronucleus.

183 adly applicable strategy for the analysis of chromatids from a single meiosis at two recombination ho

184 The ability to examine all chromatids from a single meiosis in yeast tetrads has be

185 Cohesin stably holds together the sister chromatids from S phase until mitosis.

186 Here we report that cells clear trailing chromatids from the cleavage site by undergoing two phas

187 e the authors show that cells clear trailing chromatids from the cleavage site in a two-step cell elo

188 Along these chromatids, heterozygosity is maximal at the centromeres

189 ange with the homolog rather than the sister chromatid (homolog bias).

190 he reproducibility of banding between sister chromatids, homologue pairs and from one metaphase sprea

191 luding homologous recombination (HR), sister chromatid HR, resolution of branched HR intermediates, p

192 re thought to bind by encircling both sister chromatids in a topological embrace.

193 ssential for efficient segregation of sister chromatids in eukaryotes [1-4].

194 rovide crucial links between pairs of sister chromatids in eukaryotic meiosis.

195 e resection needed for repair between sister chromatids in G-2 arrested cells of random, radiation-in

196 hat monitor bipolar attachment of replicated chromatids in metaphase.

197 ndensin complexes compact and resolve sister chromatids in mitosis and by which cohesin generates top

198 stem prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of c

199 stem prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of c

200 espite a loss in centromere cohesion, sister chromatids in STAG2 mutant tumor cells maintain cohesion

201 me fails to condense and resolve into sister chromatids in synchrony with the maternal genome.

202 Trailing chromatids induce a delay in nuclear envelope reassembly

203 his may reflect that cohesin-mediated sister chromatid interactions are sufficient for double-strand

204 Negative crossover interference and weak chromatid interference are observed at the population le

205 poisomerase II (topo II) must resolve sister chromatid intertwines (SCI) formed during deoxynucleic a

206 These mitotic sister chromatid intertwines (SCIs) can be found as; short regi

207 Sister chromatid intertwines (SCIs), or catenanes, are topologi

208 ns as circular "loop outs" to convert sister chromatid intertwines into catenated circles.

209 d by drastic changes in the degree of sister chromatid intertwines.

210 ansition and ensures accurate segregation of chromatids into daughter cells.

211 iated with reciprocal exchange, the unbroken chromatid is not altered in noncrossover gene conversion

212 The establishment of tension between sister chromatids is essential for quenching a checkpoint kinas

213 Homologous recombination involving sister chromatids is the most accurate, and thus most frequentl

214 ct." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attache

215 coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with activ

216 referred to as DNA catenation--and as sister chromatid linkages generated by homologous recombination

217 This requires that sister chromatids maintain cohesion at the centromere as cohesi

218 Cohesion between sister chromatids, mediated by the chromosomal cohesin complex,

219 During mitosis, sister chromatids must be faithfully segregated to ensure that

220 F-193-treated PICH(-/-) cells undergo sister chromatid non-disjunction in anaphase, and frequently ab

221 Furthermore, whilst Pa ESP can rescue the chromatid nondisjunction phenotype of Arabidopsis ESP mu

222 phosphomimetic Yen1 mutant increased sister chromatid nondisjunction.

223 a chromothripsis event involving both sister chromatids of the Robertsonian chromosome, a novel mecha

224 ng hermaphrodite spermatogenesis, the sister chromatids of the X chromosomes separate during meiosis

225 ted the triplication occurred between sister chromatids on the duplication-bearing chromosome and cou

226 by homologous recombination using the sister chromatid or the homologous chromosome (homolog) as a te

227 mation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently link

228 junctions (HJs) that physically link sister chromatids or homologous chromosomes are formed as inter

229 Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subun

230 specific cohesin member, required for sister chromatid pairing and for preventing telomere shortening

231 delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while the SA

232 mosomes once each cell cycle produces sister chromatid pairs, which separate accurately at anaphase.

233 The cohesion of replicated sister chromatids promotes chromosome biorientation, gene regul

234 replication forks may be processed by sister chromatid recombination (SCR), generating error-free or

235 the extended repair synthesis during sister chromatid recombination (SCR).

236 The rate of intra/sister chromatid recombination exceeded the rate of interhomolo

237 n rate of both interhomolog and intra/sister chromatid recombination in the CUP1 array; recombination

238 Despite its importance, sister chromatid recombination is not easily studied because it

239 tromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pericentr

240 Sister chromatid resolution during mitosis required the evictio

241 Tetrad analysis, which examines the four chromatids resulting from a single meiosis, is an ideal

242 segregate to opposite poles; and (3) sister chromatids segregate to opposite poles.

243 separate during meiosis I, and homologous X chromatids segregate to the functional sperm to create d

244 Chromatid segregation must be coordinated with cytokines

245 ailing chromatids are present at the midzone.Chromatid segregation must be coordinated with cytokines

246 ng complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and the establishment

247 APC/C, controlling sister chromatid segregation, cytokinesis, and the establishmen

248 response mechanism ensuring accurate sister chromatid segregation.

249 se mechanisms is necessary to achieve proper chromatid segregation.

250 H2AThr133ph on maize lines containing sister chromatids separate precociously in anaphase I revealed

251 er kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant separas

252 microtubules and prevents precocious sister-chromatid separation and aneuploidy.

253 emonstrate that the roles of ESP in daughter chromatid separation and cell expansion are conserved be

254 ed bone marrow aplasia with premature sister chromatid separation and revealed an absolute requiremen

255 Hos1 depletion significantly delayed sister chromatid separation and segregation.

256 n through its prevention of premature sister-chromatid separation and the formation of DNA loops.

257 art of the cellular response triggered by a "chromatid separation checkpoint" that delays nuclear env

258 Removal of cohesin is necessary for sister chromatid separation during anaphase, and this is regula

259 Precise control of sister chromatid separation during mitosis is pivotal to mainta

260 s) is critically important for proper sister chromatid separation during mitosis.

261 Crucially, sister chromatid separation must be delayed until all the chrom

262 sures genomic stability by preventing sister chromatid separation until all chromosomes are attached

263 Coupling sister chromatid separation with subsequent exit from mitosis b

264 segregation depends on the precise timing of chromatid separation, which is enforced by checkpoint si

265 uring and following S-phase, aided by sister chromatid separation.

266 e induces chromosomal aberrations, including chromatid telomere loss and telomere associations, disti

267 ed both for the tethering together of sister chromatids (termed cohesion) and subsequent condensation

268 hotspots form more frequently between sister chromatids than between homologs, but a novel species, p

269 Sister chromatids that arrested with a lateral attachment to on

270 es, are topological links between replicated chromatids that interfere with chromosome segregation.

271 ributed relatively uniformly across the four chromatids that make up each chromosome pair is poorly u

272 g that it controls the segregation of sister chromatids through heterochromatin modification.

273 out PRC2, H3K27me is transmitted to daughter chromatids through several rounds of cell division.

274 The cohesin complex embraces sister chromatids throughout interphase, but during mitosis mos

275 egation requires centromeres on every sister chromatid to correctly form and attach the microtubule s

276 in the cell cycle when the lack of a sister chromatid to serve as a homologous template prevents com

277 a ring-shaped structure that embraces sister chromatids to promote their cohesion.

278 ep removal of cohesin is required for sister chromatids to separate.

279 that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called kineto

280 anaphase until correct bipolar attachment of chromatids to the mitotic spindle is achieved.

281 ng almost the entire poleward surface of the chromatids, to which spindle fibers attach.

282 e latter then cleaves cohesin holding sister chromatids together [2].

283 The ability of cohesin to tether sister chromatids together depends on acetylation of its Smc3 s

284 le, sister-chromatid cohesion tethers sister chromatids together from S phase to the metaphase-anapha

285 Cohesin complexes holding chromatids together in vivo do indeed have the configura

286 e cohesin ring holds newly replicated sister chromatids together until their separation at anaphase.

287 diated cleavage, in order to maintain sister chromatids together until their separation in meiosis II

288 cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and th

289 ied through its major role in holding sister chromatids together.

290 ent of high levels of cohesin to link sister chromatids together.

291 Chromosome and chromatid translocations are manifestations of erroneous

292 bly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mit

293 merization, but recombination between sister chromatids was largely unaffected.

294 Finally, an abnormal separation of sister chromatids was observed upon INO80 downregulation in CH1

295 s requires the physical separation of sister chromatids which depends on correct position of mitotic

296 npaired X precociously separates into sister chromatids, which co-segregate with the autosome set to

297 sin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segr

298 c fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph and cen

299 ngle chromosomes, arriving at individualized chromatids with morphology observed in vivo.

300 onsistent with cohesin embracing both sister chromatids within silent chromatin domains.