ライフサイエンスコーパス: chromatin organization

1 ociating Domains (TADs) that represent a sub-chromatin organization.

2 hlight fundamental principles of single-cell chromatin organization.

3 silencing and maintenance of siRNA-dependent chromatin organization.

4 lates with reduced RNA synthesis and altered chromatin organization.

5 onal links between transcriptome control and chromatin organization.

6 ification regulating nucleosome dynamics and chromatin organization.

7 (tRNA) genes, which have been implicated in chromatin organization.

8 ual roles in nucleocytoplasmic transport and chromatin organization.

9 regulation, chromatin state and higher order chromatin organization.

10 , impact on gene expression, and the role of chromatin organization.

11 enetically inheritable nature of centromeric chromatin organization.

12 ge-specific regulators as well as changes in chromatin organization.

13 role of Nup157, and its paralogue Nup170, in chromatin organization.

14 les in the regulation of gene expression and chromatin organization.

15 ts into an additional layer of complexity in chromatin organization.

16 this process dramatically changed interphase chromatin organization.

17 genome-wide, three-dimensional (3D) view of chromatin organization.

18 To understand this mistargeting, we examined chromatin organization.

19 ding replication, repair, transcription, and chromatin organization.

20 studies on the influence of DNA sequence on chromatin organization.

21 ucible, and functionally coherent changes in chromatin organization.

22 nomics can help discover new determinants of chromatin organization.

23 Condensins play a central role in global chromatin organization.

24 nscription factor-binding sites, and maps of chromatin organization.

25 echanisms by which torsional stresses impact chromatin organization.

26 ating a surprising plasticity of large-scale chromatin organization.

27 stent with their ascribed role in regulating chromatin organization.

28 importance of lamins in nuclear assembly and chromatin organization.

29 ites involved in complex gene regulation and chromatin organization.

30 ation in meiosis requires dynamic changes in chromatin organization.

31 e trajectories are used to explore the local chromatin organization.

32 FRDA cells consistent with a more repressive chromatin organization.

33 ed in yeast chromosomes, have a noncanonical chromatin organization.

34 vivo and establish the basis of their novel chromatin organization.

35 is a major component of gene regulation and chromatin organization.

36 n nuclear-envelope function and the other in chromatin organization.

37 ispensable for the formation of higher order chromatin organization.

38 rter genes was at least in part repressed by chromatin organization.

39 e result in heritable, epigenetic changes in chromatin organization.

40 elated in part to its effects on large-scale chromatin organization.

41 f histone tails modulate gene expression via chromatin organization.

42 gene activity is mediated by alterations in chromatin organization.

43 es global repressive mechanisms that involve chromatin organization.

44 H3, demonstrating flexibility of centromeric chromatin organization.

45 ave a role in transcriptional regulation and chromatin organization.

46 g modifications in promoter architecture and chromatin organization.

47 enable kinetochore assembly and centromeric chromatin organization.

48 es, respectively, does not alter genome-wide chromatin organization.

49 in interface influence both NE structure and chromatin organization.

50 nking transcription regulatory potential and chromatin organization.

51 ur mutations in enzymes that are involved in chromatin organization.

52 identifying SMARCA4 as a novel component of chromatin organization.

53 suggesting an inherent structural memory in chromatin organization.

54 bodies while retaining the role of MeCP2 in chromatin organization.

55 lating to transcription, DNA replication and chromatin organization.

56 In eukaryotes, gene expression depends on chromatin organization.

57 DNA binding, cell cycle, differentiation and chromatin organization.

58 ally related to biological processes such as chromatin organization.

59 egation (PEV), suggesting that it influences chromatin organization.

60 e nuclear lamina regulates proliferation and chromatin organization.

61 rovide a useful guide for the exploration of chromatin organization.

62 leted of maternal PIWI proteins also exhibit chromatin organization abnormalities.

63 group being characterized by deregulation of chromatin organization, actin filament, and microfilamen

64 s to the repair machinery and to restore the chromatin organization after repair remain elusive.

65 cetylation and methylation, and higher order chromatin organization allow the maintenance of gene exp

66 irus insertional mutagenesis whereby spatial chromatin organization allows distally located provirus,

67 inding protein that plays important roles in chromatin organization, although the mechanism by which

68 sion by establishing higher-order domains of chromatin organization, although the specific mechanisms

69 important insight into our understanding of chromatin organization among different cells of a living

70 previously unidentified type of centromeric chromatin organization among eukaryotes.

71 patterns reveals many conserved features of chromatin organization among the three organisms.

72 eins are important for nuclear structure and chromatin organization and also have been implicated in

73 points including initiation, elongation and chromatin organization and are the first studies to show

74 To systematically investigate chromatin organization and associated gene regulation ac

75 metes; proteins involved in DNA replication, chromatin organization and axoneme formation.

76 Here, we compared chromatin organization and binding dynamics for twelve M

77 mina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that th

78 EL) and two significantly enriched pathways (chromatin organization and cellular stress response) sug

79 d we will discuss how epigenetic regulation, chromatin organization and circuit dynamics may contribu

80 cal roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syn

81 trotransposon families play a direct role in chromatin organization and developmental progression.

82 Plants share many features of chromatin organization and DNA repair with fungi and ani

83 DNA arrays, Hu et al. gain new insights into chromatin organization and dynamics, and into the associ

84 To gain insight into chromatin organization and dynamics, we developed transg

85 ariety of signaling processes, which control chromatin organization and dynamics.

86 nection between the pluripotency network and chromatin organization and emphasize that maintaining an

87 Thus, different layers of chromatin organization and epigenetic control mechanisms

88 linked to long-range changes in higher-order chromatin organization and epigenetic dysregulation in c

89 ing RNAs (ncRNAs) play major roles in proper chromatin organization and function.

90 iption and contributes to cell-type-specific chromatin organization and function.

91 ulatory systems but highlights regulation of chromatin organization and gene expression as major syst

92 rphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal

93 mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote th

94 of SMARCA4-dependent changes in higher-order chromatin organization and gene expression, identifying

95 re DNA binding factors with central roles in chromatin organization and gene expression.

96 ruciform structures that also have a role in chromatin organization and gene expression.

97 ng protein that is thought to play a role in chromatin organization and gene expression.

98 atb2 is a DNA-binding protein that regulates chromatin organization and gene expression.

99 NA-binding protein thought to play a role in chromatin organization and gene expression.

100 mphocyte involves rapid and major changes in chromatin organization and gene expression; however, the

101 protein CTCF, which functions in genome-wide chromatin organization and gene regulation, is recruited

102 To study the relation between chromatin organization and gene regulation, we introduce

103 nding factor (CTCF) functions in genome-wide chromatin organization and gene regulation.

104 TCF and cohesin contribute differentially to chromatin organization and gene regulation.

105 omes into nuclesomes plays critical roles in chromatin organization and gene regulation.

106 ethyltransferase complexes are essential for chromatin organization and gene regulation.

107 Chromatin organization and gene-gene interactions are cr

108 messenger RNA stability, protein synthesis, chromatin organization and genome structure.

109 ne and non-histone protein complexes defines chromatin organization and hence regulates numerous nucl

110 Our studies reveal that Snf2h controls chromatin organization and histone H1 dynamics for the e

111 ear basket nucleoporins (Tpr and Nup153) and chromatin organization and how altering the host environ

112 role of combinatorial readout in maintaining chromatin organization and in enforcing the transcriptio

113 After introducing chromatin organization and its impact on gene regulation

114 s allows the investigation of spatiotemporal chromatin organization and its role in gene regulation a

115 nvolved in cis-based mechanisms of telomeric chromatin organization and maintenance.

116 To investigate the relationship between chromatin organization and meiotic processes, we used fo

117 e, high-resolution molecular data reflecting chromatin organization and methylation, such relationshi

118 hought to be important for processes such as chromatin organization and modulation of gene expression

119 PCs and that it plays a role in subtelomeric chromatin organization and NE tethering.

120 ic tensile loading (DL) regulates changes in chromatin organization and nuclear mechanics in MSCs.

121 epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is par

122 These structures are important for chromatin organization and our data suggest a role for U

123 The mutual dependencies between chromatin organization and patterns of epigenetic marks,

124 ing those driving transcription of essential chromatin organization and protein synthesis genes.

125 Understanding the role of chromatin organization and regulation in HSC homeostasis

126 cyte differentiation with distinct levels of chromatin organization and remodeling.

127 ins which are thought to play a role in both chromatin organization and RNA metabolism.

128 ding cells had abnormal nuclear envelope and chromatin organization and severe defects in postembryon

129 ohesin binding is critical for developmental chromatin organization and the gene activation function

130 To understand the relationship between chromatin organization and the genomic structure of huma

131 elements that are thought to play a role in chromatin organization and the regulation of gene expres

132 e of fundamental importance for higher-order chromatin organization and the regulation of gene expres

133 SATB1 reprogrammes chromatin organization and the transcription profiles of

134 tes PRDM15 depletion, both in terms of local chromatin organization and the transcriptional modulatio

135 Here, we identified alterations in chromatin organization and transcript profiles associate

136 ST/EiJ and C57BL/6J mice have very different chromatin organization and transcription profiles in the

137 some assembly pathway, leading to changes in chromatin organization and transcription, remains unknow

138 it has emerged as an important regulator of chromatin organization and transcription.

139 -DNA and protein-protein interactions during chromatin organization and transcription.

140 of nuclear protein hyperacetylation on both chromatin organization and transcriptional activation of

141 Our findings demonstrate that chromatin organization and transcriptional programs are

142 The relationship between chromatin organization and transcriptional regulation is

143 ciples that capture the relationship between chromatin organization and transcriptional regulation.

144 To investigate the relationship between chromatin organization and tumor phenotype, we used an e

145 modelin" that improved nuclear architecture, chromatin organization, and fitness of both human lamin

146 s that control nuclear structure, signaling, chromatin organization, and gene silencing.

147 n of mRNA stability, productive translation, chromatin organization, and genome structure.

148 mportant role for NE81 in nuclear integrity, chromatin organization, and mechanical stability of cell

149 DNA binding protein involved in higher-order chromatin organization, and mutations in the human CTCF

150 TA factor exchange reconfigures higher-order chromatin organization, and suggests that de novo chroma

151 opment that controls stem cell self-renewal, chromatin organization, and the DNA damage response, act

152 ntenance of transcription factor activation, chromatin organization, and tissue-specific gene express

153 ng, homo- and heterodimerization, high-order chromatin organization, and transcriptional activation.

154 and demonstrate that architecture and global chromatin organization are coupled and highly plastic.

155 Changes in chromatin organization are emerging as key regulators in

156 uring meiosis, the basic features of genomic chromatin organization are essentially a fixed property

157 Differences in chromatin organization are key to the multiplicity of ce

158 Imprinting, non-coding RNA and chromatin organization are modes of epigenetic regulatio

159 Both cellular nutrient metabolism and chromatin organization are remodeled in cancer cells, an

160 that play a structural role in higher order chromatin organization are the heterochromatin protein 1

161 Analysis of chromatin organization around Nkx2.2-, Nkx6.1- and Olig2

162 epidermal tissue that alternative states of chromatin organization around the GL2 locus are required

163 Here we discuss higher-order chromatin organization as a unifying mechanism for diver

164 The plasticity of chromatin organization as chromosomes undergo a full com

165 ces of loss of these factors on higher-order chromatin organization, as well as the transcriptome.

166 n A and C cause misshapen nuclei and altered chromatin organization associated with cancer and lamino

167 Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory elements, but t

168 olution, and uncovered general principles of chromatin organization at different types of genomic fea

169 We found a stereotyped chromatin organization at Pol II promoters consisting of

170 ily and represses transcription by modifying chromatin organization at specific promoters.

171 s of the partitioning system, as well as the chromatin organization at STB, are important for cohesin

172 e N-terminal tail, which results in a unique chromatin organization at the primary constriction, the

173 hanges result in establishment of a specific chromatin organization at the RSS that facilitates acces

174 re, and recent data have characterized their chromatin organization at very different scales, from su

175 a polymer model, that accounts for the local chromatin organization before and after a double-strande

176 ing domains (TADs) as a conserved feature of chromatin organization, but how TADs are spatially organ

177 have been implicated in maintaining an open chromatin organization, but how these processes are conn

178 and enable the NPC to play an active role in chromatin organization by facilitating the transition of

179 ker histone H1 is believed to be involved in chromatin organization by stabilizing higher-order chrom

180 omain proteins influence gene expression and chromatin organization by way of histone demethylation,

181 ible changes in gene activity and long-range chromatin organization can be induced experimentally.

182 hylation channels and show that higher-order chromatin organization can be predicted from their infor

183 Chromatin organization can be probed by Chromosomal Capt

184 and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromoso

185 To assess whether 3D chromatin organization changes during this transition, w

186 eq data to predict two important features of chromatin organization: chromatin interaction hubs and t

187 ved from multiple tissues, consistent with a chromatin organization common to epithelial cell lines.

188 ome arrays, highlighting a key difference in chromatin organization compared to model organisms.

189 es other functions, such as having a role in chromatin organization, connecting the nucleus to the cy

190 Chromatin organization contributes to regional variation

191 Higher-order chromatin organization controls transcriptional programs

192 In the latter, pore clustering resulted in chromatin organization defects and led to a significant

193 r data uncover how IBPs dynamically regulate chromatin organization depending on distinct cofactors.

194 ins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription,

195 ) approach, we examined the reprogramming of chromatin organization during early development in mice.

196 ltiplexed 4C-seq to study dynamic changes in chromatin organization during early G1.

197 nation plays an important role in regulating chromatin organization during gene transcription.

198 east cancer tissues, changes in higher-order chromatin organization during tumorigenesis have not bee

199 clin loci, indicating a disruption to normal chromatin organization essential to life-cycle progressi

200 These data suggest that a unique level of chromatin organization exists within gene-rich recombina

201 dels, this dynamic plasticity of large-scale chromatin organization explains how localized changes in

202 rces to the nucleus, resulting in changes to chromatin organization, followed by nuclear deformation.

203 germline may permit rapid reconstitution of chromatin organization following fertilization.

204 even genes predicted to encode regulators of chromatin organization for RNAi-induced enhancement of m

205 comb-repressed states, and observed distinct chromatin organizations for each state.

206 maintenance, DNA replication initiation, and chromatin organization functions.

207 ncRNAs and the roles played by these RNAs in chromatin organization, gene expression, and disease eti

208 uild the nuclear lamina and are required for chromatin organization, gene expression, cell cycle prog

209 skeletal organization, mechanical stability, chromatin organization, gene regulation, genome stabilit

210 ortant roles in post-replication DNA repair, chromatin organization, gene silencing and meiosis.

211 However, whether piRNAs primarily control chromatin organization, gene transcription, RNA stabilit

212 Chromatin organization has a fundamental impact on the w

213 nship between transcriptional activators and chromatin organization has focused largely on lower leve

214 underlying mechanisms that determine in vivo chromatin organization have diverged and that comparativ

215 find that the naturally occurring changes in chromatin organization impart a regulation on the spatia

216 ng that cross-linking captured a specialized chromatin organization imposed by Sir proteins.

217 nsidered to be of fundamental importance for chromatin organization in all eukaryotic cells.

218 les including NE reassembly, cell cycle, and chromatin organization in cells, and subtly alters its n

219 esolution imaging approach for investigating chromatin organization in complex tissues.

220 Spt16 has a broad role in regulating chromatin organization in gene bodies, including those n

221 critical roles of nucleosome positioning and chromatin organization in gene regulation during reprogr

222 into the function of histone methylation and chromatin organization in genome function.

223 ding the powerful role played by large-scale chromatin organization in normal and aberrant lineage-sp

224 In contrast, much less is known about chromatin organization in plants.

225 ritical to initiate preRC assembly in G1 and chromatin organization in post-G1 cells.

226 To study three-dimensional chromatin organization in rare cell types, we developed

227 ates the development of methods that measure chromatin organization in single cells.

228 in the NPC is crucial to control large-scale chromatin organization in the nucleus.

229 Chromatin organization in the stem cell state is known t

230 which dynamic tensile loading (DL) regulates chromatin organization in this cell type.

231 and methods for evaluating three-dimensional chromatin organization in vivo have resulted in importan

232 so function in mitochondrial respiration and chromatin organization in ways that may not involve tran

233 provide the first evidence that higher-order chromatin organization influences the enhancer-blocking

234 either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the transcriptional act

235 on via a nanos-regulated, germ cell-specific chromatin organization is a conserved feature of germlin

236 An open and decondensed chromatin organization is a defining property of pluripo

237 nexpectedly, the subsequent establishment of chromatin organization is a prolonged process that exten

238 Genome-wide mapping of three dimensional chromatin organization is an important yet technically c

239 This revealed that human chromatin organization is dominated by large (100-500 kb

240 Three-dimensional (3D) chromatin organization is important for proper gene regu

241 nclusions with regard to the extent to which chromatin organization is inherited from mother to daugh

242 ed when the replication fork passes, but how chromatin organization is re-established following repli

243 ed quantitative framework describing spatial chromatin organization is still lacking.

244 is known in molecular detail of centromeric chromatin organization, its propagation through cell div

245 In addition, chromatin organization may be governed in part by intera

246 This shift to a repressive chromatin organization may be important to inhibit local

247 rds a more comprehensive model of how global chromatin organization may coordinate gene expression ov

248 n in vivo study of how genetic variation and chromatin organization may dictate susceptibility to DNA

249 This ability to remodel chromatin organization may provide the basis for the pla

250 as an input to an energy landscape model for chromatin organization [Minimal Chromatin Model (MiChroM

251 We conclude that cell-type-specific chromatin organization occurs at the submegabase scale a

252 To determine the chromatin organization of activated or extinguished serp

253 We have analyzed the 3D chromatin organization of Hox clusters during their earl

254 role in insulator function and higher-order chromatin organization of mammalian genomes.

255 is therefore well-suited to characterize the chromatin organization of single cells in heterogeneous

256 ssion, conceivably by mediating higher-order chromatin organization of subtelomeres and Tf2 elements,

257 The distinct chromatin organization of the CCA response elements appe

258 spatiotemporally integrate to the functional chromatin organization of the cell nucleus.

259 transcription by TSA does not depend on the chromatin organization of the promoter because a transie

260 icant insight into Xist binding patterns and chromatin organization of the Xi.

261 We recently reported the chromatin organization of this approximately 130 kb regi

262 rticosteroid-binding globulin (CBG), and the chromatin organization of this approximately 130-kb regi

263 Our results demonstrate that the global chromatin organization of zygote nuclei is fundamentally

264 However, the impact of this spatial chromatin organization on gene expression and its degree

265 To investigate the impact of chromatin organization on gene regulation, we performed

266 Chromatin organization plays a key role in the regulatio

267 nar cells indicates that changes in NuMA and chromatin organization precede loss of acinar differenti

268 ecently, the influence of telomere length on chromatin organization prior to senescence has revealed

269 should shed light on the relationships among chromatin organization, protein-DNA interactions, and ge

270 The dynamics of chromatin organization regulates DNA accessibility to eu

271 on upon nucleosome binding and its impact on chromatin organization remain unknown.

272 y, dynamics, and relation to other layers of chromatin organization remained elusive.

273 fectors include regulators of transcription, chromatin organization, RNA processing, and translation,

274 altering the expression of genes involved in chromatin organization, signaling, adhesion, motility, d

275 ever, most of published genome-wide unbiased chromatin organization studies have used cultured cell l

276 ikely involving local or regional changes in chromatin organization that determine whether a gene esc

277 he unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease

278 gions of DNA, thereby mediating higher order chromatin organization that is critical for sister chrom

279 s share a deeply evolutionarily conserved 3D chromatin organization that predates the Cambrian explos

280 pears to be involved in the establishment of chromatin organization through its ability to mediate th

281 d positioning of gene loci and regulation of chromatin organization through protein complexes and non

282 r self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization t

283 The relationships of higher order chromatin organization to mammalian gene expression rema

284 e contribution of human subtelomeric DNA and chromatin organization to telomere integrity and chromos

285 volved in many nuclear activities, including chromatin organization, transcription and replication.

286 ds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macro

287 ending the nuclear envelope and required for chromatin organization, transcriptional regulation and m

288 at ancestral TBT exposure induces changes in chromatin organization transmissible through meiosis and

289 In mammals, chromatin organization undergoes drastic reprogramming a

290 ors investigate changes to transcription and chromatin organization upon stress and find that activat

291 believed to be a crucial player in bacterial chromatin organization via its DNA-bridging activity.

292 A quantitative model of large-scale chromatin organization was applied to nuclei of fission

293 undary function depends on a higher order of chromatin organization, we examined the function of seve

294 To investigate the role of Chz1p in chromatin organization, we performed genome-wide express

295 revisiae promoters have a highly stereotyped chromatin organization, where nucleosome-free regions (N

296 hain locus V(D)J recombination requires a 3D chromatin organization which permits widely distributed

297 By associating variation in chromatin organization with mutations in SETD2, which en

298 d electron microscopy, little is known about chromatin organization with respect to the chromosome ax

299 ation of the nucleus and its relationship to chromatin organization within various cell types of a si

300 t structural and functional components of 3D chromatin organization, yet the relationship between the