ライフサイエンスコーパス: chromatin structure

1 endent changes in the composition of nascent chromatin structure.

2 pha3 helix play organismal roles in defining chromatin structure.

3 using Shannon's entropy, associating it with chromatin structure.

4 tral role in gene regulation by manipulating chromatin structure.

5 g sister chromatid cohesion and higher-order chromatin structure.

6 during development through modifications in chromatin structure.

7 that metabolic events in podocytes regulate chromatin structure.

8 rstand the cellular mechanisms that regulate chromatin structure.

9 -strand break (DSB) repair in the context of chromatin structure.

10 histone acetylation and links metabolism and chromatin structure.

11 tribution of histone marks and disruption of chromatin structure.

12 on each gene may result in a highly dynamic chromatin structure.

13 tional relationships that perhaps arise from chromatin structure.

14 location on the nucleosome and higher-order chromatin structure.

15 n important regulator of gene expression and chromatin structure.

16 with sequence context, replication timing or chromatin structure.

17 egulation of genes involved in apoptosis and chromatin structure.

18 II pausing in mammalian gene regulation and chromatin structure.

19 e these data with high-resolution maps of 3D chromatin structure.

20 n (H3K9me3) and the decondensation of global chromatin structure.

21 bly through epigenetic factors that regulate chromatin structure.

22 ses to the Foxp3 locus to produce a 'closed' chromatin structure.

23 ccessibility, consistent with a more compact chromatin structure.

24 chromosomes to regulate gene expression and chromatin structure.

25 throughout development, mostly by regulating chromatin structure.

26 he molecular mechanisms whereby HMGNs affect chromatin structure.

27 s mammalian genomes and navigates eukaryotic chromatin structure.

28 length discretization caused by higher-order chromatin structure.

29 lexes in mobilizing nucleosomes and altering chromatin structure.

30 er interactions and topology of higher-order chromatin structure.

31 at regulates gene expression by modifying 3D chromatin structure.

32 tion that necessitates epigenomic changes in chromatin structure.

33 bly, dissociating prior to the maturation of chromatin structure.

34 operative manner to form a stable repressive chromatin structure.

35 er-relationships between DNA methylation and chromatin structure.

36 t the promoter, suggesting they might affect chromatin structure.

37 esult, activates gene expression by altering chromatin structure.

38 lication and is facilitated by a decondensed chromatin structure.

39 lex patterns of viral gene transcription and chromatin structure.

40 ked to a corresponding shift in higher-order chromatin structures.

41 mammalian genomes is organized in precise 3D chromatin structures.

42 ion is paralleled by changes in higher-order chromatin structures.

43 ation of nucleosome arrays into higher-order chromatin structures.

44 ich is critical for stabilizing higher-order chromatin structures.

45 which are the key components of higher-order chromatin structures.

46 Higher order chromatin structures across the genome are maintained in

47 Chromatin structure affects DNA replication patterns, bu

48 ompanied by visible unfolding of large-scale chromatin structure and a repositioning of the region wi

49 cleosome composition actively contributes to chromatin structure and accessibility.

50 by numerous mechanisms, including modifying chromatin structure and altering the function of chromat

51 oject to investigate the association between chromatin structure and alternative splicing.

52 rated to explore the role of this protein in chromatin structure and cardiac phenotype.

53 to hematological phenotype, gene expression, chromatin structure and chromosome conformation, without

54 's chromatin association, thereby modulating chromatin structure and coordinating gene expression in

55 hesized that reduced cohesin function alters chromatin structure and disrupts cis-regulatory architec

56 h regulate gene expression via modulation of chromatin structure and DNA accessibility.

57 Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromat

58 er communication (EPC); however, the role of chromatin structure and dynamics in this process remains

59 self-assembly is important for understanding chromatin structure and dynamics.

60 ategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics.

61 the most outstanding scientists studying how chromatin structure and epigenetic mechanisms regulate g

62 Bub), a modification that broadly influences chromatin structure and eukaryotic transcription.

63 oteins, which bind to nucleosomes and affect chromatin structure and function, co-localize with, and

64 mutations in genes that encode regulators of chromatin structure and function, highlighting the centr

65 bind specifically to nucleosomes and affect chromatin structure and function, including transcriptio

66 ations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to

67 al modifications (PTMs) of histones regulate chromatin structure and function.

68 has been instrumental to our current view of chromatin structure and function.

69 accumulating data to facilitate studying 3D chromatin structure and function.

70 slational modifications (PTMs) that modulate chromatin structure and function.

71 how its properties may influence studies of chromatin structure and function.

72 tions (PTMs) that cooperatively modulate the chromatin structure and function.

73 alized histone variants promotes altering of chromatin structure and function.

74 ngly being associated with the regulation of chromatin structure and gene activity via histone citrul

75 r protein with important roles in regulating chromatin structure and gene expression, and mutations i

76 een Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression.

77 ested to play key roles in the regulation of chromatin structure and gene expression.

78 Histones are essential elements of chromatin structure and gene regulation in eukaryotes.

79 factor (CTCF) is a key regulator of nuclear chromatin structure and gene regulation.

80 e sequential or combinatorial action affects chromatin structure and genome function.

81 results show an intimate link between local chromatin structure and higher-order chromosome architec

82 siae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct

83 a dose dependency for cohesin in regulating chromatin structure and HSC function.

84 is essential to the maintenance of telomere chromatin structure and integrity.

85 vates gene transcription by influencing both chromatin structure and interplay with nonhistone protei

86 nd reported here extend our understanding of chromatin structure and its potential roles in gene regu

87 Both chromatin structure and local sequence composition near

88 monstrate a direct link between higher-order chromatin structure and mitochondrial membrane potential

89 st-translational modification that regulates chromatin structure and plays an important role in gene

90 ecognize nucleosomes or function to maintain chromatin structure and prevent cryptic transcriptional

91 hat exhibit mitotically heritable changes in chromatin structure and promoter recruitment of poised R

92 lational modification (PTM) for manipulating chromatin structure and regulating gene expression, and

93 Chromatin structure and regulation provide a substrate t

94 obligatory interaction with TBX3 to regulate chromatin structure and repress transcription of CDKN2A-

95 proteins with functions related to nucleolar chromatin structure and RNA polymerase I transcription r

96 Small RNAs modify chromatin structure and silence transcription by guiding

97 D1) family of histone demethylases regulates chromatin structure and the transcriptional potential of

98 he mechanisms underlying context-specific 3D chromatin structure and transcription during cellular di

99 ations lead to a partial opening of the D4Z4 chromatin structure and transcription of D4Z4-encoded po

100 ) complex is a highly conserved regulator of chromatin structure and transcription.

101 otein (H1K34hcit), pivotal in altering local chromatin structure and transcriptional activation.

102 ail of histone H3 (H3K18Ac), thus modulating chromatin structure and transcriptional competency.

103 control of alternative pre-mRNA splicing by chromatin structure and transcriptional elongation.

104 residues on histones, leading to changes in chromatin structure and transcriptional regulation.

105 ytes daily, involves dramatic changes in the chromatin structure and transcriptome of erythroblasts,

106 these enzymes likely lead to differences in chromatin structure and, thereby, transcriptional contro

107 uman erythroblasts and found that, globally, chromatin structures and compartments A/B are highly sim

108 lex involved in gene repression and telomere chromatin structure, and a DAXX-SETDB1-KAP1-HDAC1 comple

109 interactions in DNA repair, gene expression, chromatin structure, and cell fate determination.

110 R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cel

111 tail modifications, noncoding RNA control of chromatin structure, and nucleosome remodeling.

112 Nucleolar morphology is controlled by chromatin structure, and the high levels of euchromatic

113 at the crossroads of metabolism, signaling, chromatin structure, and transcription.

114 as predominantly near genes, and its overall chromatin structure appeared more similar to euchromatin

115 in time resolution how heritable patterns of chromatin structure are initially established and mainta

116 to recent in situ Hi-C data, we found the 3D chromatin structures are highly conserved across various

117 required to sustain these complex interphase chromatin structures are unknown.

118 ongly correlate (R(2) = 0.98) with the sperm chromatin structure assay.

119 tly with CBP, eRNAs contribute to the unique chromatin structure at active enhancers, which, in turn,

120 OCT4 alters the higher-order chromatin structure at both Sox-2 and Sox-17 loci.

121 , CAF-1 suppression led to a more accessible chromatin structure at enhancer elements early during re

122 remodeling response and produced a "closed" chromatin structure at interleukin-17 (IL-17) locus to i

123 Chromatin structure at NSRs and NDRs was well maintained

124 extensively studied, less is known about the chromatin structure at pol III promoters in human cells.

125 y analyzes multiple contact maps to infer 3D chromatin structure at the genome scale.

126 Chromatin structure at the length scale encompassing loc

127 uppression and do not establish a repressive chromatin structure at the transgenic locus.

128 by the fusion remodeler recapitulates closed chromatin structure at Ume6-sensitive genes analogous to

129 ness are required for induction of signature chromatin structures at CGIs.

130 ression timing was largely due to changes of chromatin structures at poised genes, particularly those

131 protocols for brain and compare higher-order chromatin structures at the chromosome 6p22.2-22.1 schiz

132 the Bayesian model and infer an ensemble of chromatin structures based on interaction frequency data

133 To probe the differences in higher-order chromatin structure between mammary epithelial and breas

134 els, with little known about the dynamics of chromatin structure between these scales due to a lack o

135 ent stabilization of higher order 'tertiary' chromatin structures but do not alter the intrinsic abil

136 methods to recover the underlying 3D spatial chromatin structure, but challenges abound.

137 mplexes play an essential role in regulating chromatin structure, but information about their assembl

138 mes to promote the formation of higher-order chromatin structure, but the underlying molecular detail

139 is organized into complex three-dimensional chromatin structures, but how this spatial organization

140 pendent on reorganization of the surrounding chromatin structure by chromatin remodeling complexes.

141 The SWI/SNF-family remodelers regulate chromatin structure by coupling the free energy from ATP

142 e a routine task to map epigenetic marks and chromatin structure by deep sequencing methods.

143 atment regimen can lead to remodeling of the chromatin structure by histone modifications and recruit

144 alters local histone H3 methylation as well chromatin structure by inducing DNA-chromatin loops conn

145 epressor that orchestrates reorganization of chromatin structure by punctuating chromosomes with foci

146 over, we find a genome-wide co-regulation of chromatin structure by Set1 and Jhd2 at different groups

147 affects gene expression at the level of the chromatin structure by triggering heterochromatinization

148 he NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nu

149 Chromatin structure can also influence alternative splic

150 For proper information output, higher-order chromatin structures can be regulated dynamically.

151 amage response and repair, transcription and chromatin structure, cell cycle and cell death, as well

152 tionships between regulatory factor binding, chromatin structure, cis-regulatory elements and RNA-reg

153 , similar rates of ICL/R, and more condensed chromatin structure compared with nonresponders.

154 The nuclear chromatin structure confines the movement of large macro

155 it is known that an epigenetic remodeling of chromatin structure controls developmental plasticity in

156 Analysis of higher-order chromatin structure data and RNA polymerase II ChIA-PET

157 ated with genomic landmarks and higher order chromatin structure datasets to identify potential roles

158 Chromatin structure determines DNA accessibility.

159 These alterations in chromatin structure directly resulted in up-regulated ge

160 ole-genome microarray analysis and evaluated chromatin structure, DNA lesion load, glutathione conten

161 We characterize the changes in chromatin structure, DNA methylation and transcription d

162 regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and

163 e is evidence that injury-induced changes in chromatin structure drive stable changes in gene express

164 we use live-cell PWS to study the change in chromatin structure due to DNA damage and expand on the

165 on that warrants inheritance of a repressive chromatin structure during cell division, thereby assuri

166 hip between transcription factor binding and chromatin structure during cell fate reprogramming.

167 ATP-dependent chromatin remodelers regulate chromatin structure during multiple stages of transcript

168 ling and might be crucial for transitions in chromatin structure during reprogramming.

169 In addition, global changes in chromatin structure during senescence were analyzed via

170 We propose that H3 T118ph alters the chromatin structure during specific phases of mitosis to

171 of nucleosome-free DNA regions can modulate chromatin structure/dynamics and, in turn, affect the ra

172 h gradient-seq provides a genome-wide map of chromatin structure, elucidating subtypes of repressed d

173 uclei can impair nuclear integrity and alter chromatin structure, especially in fragile cells such as

174 factors but also dependent on the underlying chromatin structure, especially on covalent histone modi

175 Higher order chromatin structure establishes domains that organize th

176 or global reprogramming of transcriptome and chromatin structure for quiescence driven by a highly co

177 s represent an important class of regulatory chromatin structures for the spatiotemporal control of t

178 tilization triggers assembly of higher-order chromatin structure from a condensed maternal and a naiv

179 that differentiates the special centromeric chromatin structures from bulk nucleosomes.

180 ylation (DNAm) has been linked to changes in chromatin structure, gene expression and disease.

181 e interrogated, including genetic variation, chromatin structure, gene expression patterns, small RNA

182 ld has expanded to include the regulation of chromatin structure, gene expression, and RNA processing

183 regulation that is strongly correlated with chromatin structure, gene expression, DNA repair, and ge

184 ion to regulate gene expression by affecting chromatin structure, gene transcription, pre-mRNA proces

185 DNA sequence, despite the huge disruption to chromatin structure generated by unwinding the parental

186 he newly identified principles of endogenous chromatin structure have key implications for epigenetic

187 s affecting cell type- and regional-specific chromatin structures have also been shown to contribute

188 Although dynamic chromatin structures have been identified in the genome,

189 findings have profound implications linking chromatin structure, histone modification and splicing r

190 Additional factors, such as chromatin structure, histone, or DNA modifications, also

191 synthesis, light signaling and DNA synthesis/chromatin structure; however, the genes related to antho

192 DNA replication, indicative of a decondensed chromatin structure in all regions of the replicating ge

193 pigenetic regulators, and the part played by chromatin structure in cellular plasticity in both devel

194 VAD modulates chromatin structure in cis and activates gene expression

195 ese tools in complex genomes and the role of chromatin structure in determining DNA binding are not w

196 l for investigating the role of higher-order chromatin structure in gene regulation.

197 -Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet nume

198 t CNVs may repress recombination by altering chromatin structure in meiosis.

199 To understand the role of chromatin structure in mitotic memory, we performed the

200 vide a model system for studying the role of chromatin structure in modulating alternative splicing d

201 ds within histone H3 make to cell growth and chromatin structure in Saccharomyces cerevisiae.

202 G9a activity not only reorganises the chromatin structure in T-cells, but also affects the sti

203 ich reinforces a notion of a central role of chromatin structure in the regulation of cellular DDR re

204 We have recently shown that altered chromatin structure in yeast induces respiration by a me

205 its RGG domain to regulate human interphase chromatin structures in a transcription-dependent manner

206 Our knowledge of the role of higher-order chromatin structures in transcription of microRNA genes

207 ), which links DNA methylation to repressive chromatin structure, in regulating expression of a range

208 ased studies have indicated higher levels of chromatin structures including compartments and topologi

209 nd melanoma through a vast reorganization of chromatin structure, inducing both repression and activa

210 Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes a

211 The modulation of chromatin structure is a key step in transcription regul

212 rmentation to respiration induced by altered chromatin structure is associated with the induction of

213 Moreover, the regulation of chromatin structure is critical as thymocytes transition

214 Regulation of chromatin structure is critical for brain development an

215 Higher-order chromatin structure is emerging as an important regulato

216 Remodeling of the local chromatin structure is essential for the regulation of g

217 The analysis of chromatin structure is essential for the understanding o

218 tent cells, suggesting that lineage-specific chromatin structure is established in tissue progenitor

219 Open chromatin structure is important for DNA damage response

220 The role for other effects on chromatin structure is less understood.

221 genitalia, the limb-associated bimodal HoxD chromatin structure is maintained at the snake locus.

222 Higher-order chromatin structure is often perturbed in cancer and oth

223 Chromatin structure is tightly intertwined with transcri

224 These changes in viral chromatin structure lead to the generation of a repressi

225 On the molecular level, abnormal chromatin structure leads to a dramatic decrease in the

226 rol module governed by a renal cell-specific chromatin structure located distal to Cyp27b1 that media

227 d polycombs-mediated changes in higher-order chromatin structure mediate instruction of early cell fa

228 itis elegans, but the molecular basis of how chromatin structure modulates longevity is not well unde

229 To carry epigenetic information, the chromatin structure must be accurately rebuilt after its

230 cations have been associated with changes in chromatin structure necessary for transcription, replica

231 Interestingly, the H3K4me3/H3K27me3 bivalent chromatin structure observed in progenitors persists at

232 The chromatin structure of a CHE-1 target locus is less comp

233 likely that the silencing mechanisms and the chromatin structure of a genome have been shaped by thes

234 The chromatin structure of DNA determines genome compaction

235 lular microenvironment, gene expression, and chromatin structure of Ku70-deficient mouse embryonic fi

236 nly beginning to understand the higher-order chromatin structure of pluripotent stem cells and its re

237 analysis to show substantial differences in chromatin structure of pol II and pol III promoters, and

238 RPS6 and AtHD2B brings about a change in the chromatin structure of rDNA and thus plays an important

239 determined changes in the transcriptome and chromatin structure of S. cerevisiae upon quiescence ent

240 D) complex subunits to repressively regulate chromatin structure of the cardiac genes by switching op

241 een these genomic regions and determines the chromatin structure of the proximal promoter to allow ge

242 SLBP increased promoter engagement with the chromatin structures of the host gene high mobility grou

243 However, the effect of chromatin structure on BER protein recruitment to DNA da

244 igenetic features associated with high-order chromatin structure, opening new directions in the study

245 SSB1-TERT interaction relies upon a specific chromatin structure or context.

246 Maintenance of a regular chromatin structure over the coding regions of genes occ

247 Quantitative characterization of the chromatin structure, particularly at submicron length sc

248 ne proteins are central to the regulation of chromatin structure, playing vital roles in regulating t

249 Chromatin structure plays a pivotal role in facilitating

250 ing proteins and can also involve changes in chromatin structure, potentially through nongenetic mech

251 expression that is the product of a relaxed chromatin structure present in 1-cell embryos.

252 lights novel strategies that use genome-wide chromatin structure profiling to identify the deregulate

253 st that Pol III transcription is involved in chromatin structure re-organization during the onset of

254 ctions in transcription complex assembly and chromatin structure regulation.

255 romatin remodelling complex, are critical in chromatin structure regulation.

256 Additionally, we found that the long-range chromatin-structure regulator CTCF plays a pivotal role

257 Together, our data indicate that altered chromatin structure relieves glucose repression of mitoc

258 lian gene expression and its relationship to chromatin structure remain poorly understood.

259 er and known to regulate oncogenesis through chromatin structure remodeling and controlling protein a

260 In the absence of H2Bub1, incomplete chromatin structures resulted in several replication def

261 lack of continuous H3.3/H4 deposition alters chromatin structure, resulting in increased DNase I sens

262 nd allows a detailed analysis of alternative chromatin structure states.

263 us be due, at least in part, to noncanonical chromatin structures such as labile nucleosome-like part

264 od of fetal development and the processes of chromatin structure, synaptic function, and neuron-glial

265 odifying complexes to create the appropriate chromatin structure that allows ORC binding and subseque

266 gy pathway and eventually leading to an open chromatin structure that facilitates efficient HR DSB re

267 progenitor cells displayed global changes in chromatin structure that likely hindered effective dista

268 q enables the identification of noncanonical chromatin structures that are likely to be important for

269 uisites for further assembly of higher-order chromatin structures that are refractory to transcriptio

270 Telomeres are specialized chromatin structures that protect chromosome ends from d

271 e organized into bipartite three-dimensional chromatin structures that separate long-range regulatory

272 With this altered chromatin structure, the RNAPII elongation rate increase

273 , which regulates histone H3 acetylation and chromatin structure, thereby promoting efficient DNA rep

274 hondrial stress causes widespread changes in chromatin structure through histone H3K9 di-methylation

275 pendent chromatin remodeling complexes alter chromatin structure through interactions with chromatin

276 The SWI/SNF multisubunit complex modulates chromatin structure through the activity of two mutually

277 e that pre-mRNA splicing may be regulated by chromatin structure through the modulation of the RNAPII

278 This binding remodels the chromatin structure to allow interaction with other tran

279 a comprehensive, high-resolution analysis of chromatin structure to compare the landscapes of HCT116

280 ur data support a model where Bcd influences chromatin structure to gain access to concentration-sens

281 terest is to systematically map variation in chromatin structure to gene-expression regulation across

282 n factors that initiate changes in the local chromatin structure to increase promoter accessibility a

283 lecular function in establishing appropriate chromatin structure to regulate crucial NC stem-cell sig

284 demethylases, and result in modification of chromatin structure to repress or activate transcription

285 However, the contribution of non-covalent chromatin structure to the poised state is not well unde

286 litate the switch from protamine-based sperm chromatin structures to the somatic nucleosomal chromati

287 s modulation of plant hormone levels, and of chromatin structure, transcription, and translation.

288 We have further confirmed the inferred chromatin structures using the known genetic interaction

289 levels were analysed by GC-MS and the local chromatin structure was investigated by chromatin immuno

290 mutational burden is known to be coupled to chromatin structure, we examine how somatic mutations ar

291 As transcription influences chromatin structure, we took a genome-wide approach to a

292 R), double-strand breaks repair (DSB/R), and chromatin structure were evaluated in multiple myeloma (

293 tone H1 and HMGD1 in creating a higher-order chromatin structure, which is susceptible to chromatin r

294 These reconstituted chromatin structures, which we call "oligomers", are glo

295 SAF-A oligomerization decompacts large-scale chromatin structure while SAF-A loss or monomerization p

296 orward means for the genome-wide analysis of chromatin structure with minimal DNA sequence bias.

297 leosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outco

298 with the disruption and re-establishment of chromatin structure within a cell cycle remains largely

299 endent loop extrusion generates higher-order chromatin structures within the one-cell embryo.

300 nm, thus primarily probing the higher-order chromatin structure, without resolving the actual struct