ライフサイエンスコーパス: chromosomal abnormality

1 myelodysplastic syndrome (MDS), with the 5q- chromosomal abnormality.

2 ssion bias often indicates the presence of a chromosomal abnormality.

3 to an infant with Down's syndrome or another chromosomal abnormality.

4 tion of HPCs that were JAK2V617F(+) or had a chromosomal abnormality.

5 ypes in 17 subjects with apparently balanced chromosomal abnormalities.

6 ng patients with either normal karyotypes or chromosomal abnormalities.

7 lls manage to divide in the context of gross chromosomal abnormalities.

8 expressed oncomirs not previously linked to chromosomal abnormalities.

9 often acquire large structural and numerical chromosomal abnormalities.

10 s a signature for CLL patients with specific chromosomal abnormalities.

11 haracterized by an increase in the number of chromosomal abnormalities.

12 an arise from single-gene defects as well as chromosomal abnormalities.

13 results in defective spindles that generate chromosomal abnormalities.

14 evels of basal and mitomycin C (MMC)-induced chromosomal abnormalities.

15 to IR-induced apoptosis and several types of chromosomal abnormalities.

16 defined factors does not induce, or require, chromosomal abnormalities.

17 enetically heterogeneous, displaying diverse chromosomal abnormalities.

18 21 were compared to test for potential fetal chromosomal abnormalities.

19 s, predisposing to TCRalpha locus-associated chromosomal abnormalities.

20 and increased frequencies of thymocytes with chromosomal abnormalities.

21 ial aggregation, and association of CDH with chromosomal abnormalities.

22 reported to be associated with one of these chromosomal abnormalities.

23 tive checkpoint responses and high levels of chromosomal abnormalities.

24 samples that harbor one of several selected chromosomal abnormalities.

25 of meiotic metaphase in the face of massive chromosomal abnormalities.

26 transmission of dysfunctional telomeres and chromosomal abnormalities.

27 id cytogenetics; the others had a variety of chromosomal abnormalities.

28 n and continued to proliferate, accumulating chromosomal abnormalities.

29 ients and seldom showed consistent nonrandom chromosomal abnormalities.

30 crosatellite instability nor multiple, major chromosomal abnormalities.

31 as atm mutant seeds germinate with extensive chromosomal abnormalities.

32 gonadotropin is measured to screen for fetal chromosomal abnormalities.

33 ses an increase in endogenous DNA damage and chromosomal abnormalities.

34 ocious resumption of meiosis and spindle and chromosomal abnormalities.

35 f of RAP80 has been linked to an increase in chromosomal abnormalities.

36 or detecting genomic structural variants and chromosomal abnormalities.

37 er and induce double-strand breaks (DSB) and chromosomal abnormalities.

38 ult of its strong association with number of chromosomal abnormalities.

39 lap between IGH@-t, CRLF2-d, and established chromosomal abnormalities.

40 eading to centrosome amplification and gross chromosomal abnormalities.

41 with phenotypes observed in individuals with chromosomal abnormalities.

42 The chromosomal abnormalities 1q21, 5p15/5q35, 9q34, 13q14.3

43 of 45 Htx copy number variations were large chromosomal abnormalities, 38 smaller copy number variat

44 nd B-other ALL, that is, lacking established chromosomal abnormalities (5.6%; 43 of 772 B-other cases

45 patients who had cytogenetically documented chromosomal abnormalities (5q-, 7-, +8, 17-, or 20-).

46 Clonal cytogenetic evolution with additional chromosomal abnormalities (ACAs) in chronic myelogenous

47 Additional chromosomal abnormalities (ACAs) in Philadelphia-positiv

48 with CCA/Ph(-) and those without additional chromosomal abnormalities (ACAs).

49 Chromosomal abnormalities account for the most commonly

50 wever, the molecular mechanism through which chromosomal abnormalities affect the pathogenesis and ou

51 tability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression

52 a significantly increased frequency of gross chromosomal abnormalities and an S-phase-specific accumu

53 Cells with reduced levels of BAP1 exhibit chromosomal abnormalities and decreased DNA repair by ho

54 eletion of mouse Hus1 results in spontaneous chromosomal abnormalities and embryonic lethality.

55 enomic instability in human cells, including chromosomal abnormalities and hyperrecombination.

56 overlapping phenotypes including spontaneous chromosomal abnormalities and increased cancer predispos

57 We and others have demonstrated chromosomal abnormalities and increased DNA damage in PA

58 It is widely accepted that both large-scale chromosomal abnormalities and mutation of specific genes

59 The combination of nonrandom chromosomal abnormalities and other types of genetic alt

60 c abnormalities in leukemia cells (including chromosomal abnormalities and patterns of gene expressio

61 SNP-A analysis allows enhanced detection of chromosomal abnormalities and provides important prognos

62 h of noscapine exposure at 20 muM elucidated chromosomal abnormalities and the inability of chromosom

63 ostic algorithm including gene mutations and chromosomal abnormalities and their changes during clona

64 sis allowed assessment of both the number of chromosomal abnormalities and their heterogeneity throug

65 ata describing the age-specific incidence of chromosomal abnormalities and their prognostic relevance

66 tients display extensive and varied forms of chromosomal abnormalities and this genomic instability i

67 val, and overall survival associated with 21 chromosomal abnormalities and three cytogenetic risk gro

68 ive ductal lesions to accumulate progressive chromosomal abnormalities and to develop toward the stag

69 embryonic fibroblasts exhibited spontaneous chromosomal abnormalities and underwent premature senesc

70 en patients (9%) did not have any detectable chromosomal abnormality and 6 (4%) could not be classifi

71 ession in AML+8 patients with +8 as the sole chromosomal abnormality and AML-CN patients.

72 mal translocation is the most common form of chromosomal abnormality and is often associated with con

73 way; this is sufficient to inhibit oncogenic chromosomal abnormality and suppress tumorigenesis.

74 mester findings of ultrasonographic markers, chromosomal abnormalities, and clinical outcomes for a w

75 ential regions of linkage and two associated chromosomal abnormalities, and evidence is accumulating

76 is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmissio

77 f congenital malformations, deformities, and chromosomal abnormalities, and mental and behavioural di

78 s can expand clonally, accumulate additional chromosomal abnormalities, and progress to cancer.

79 ential regions of linkage and two associated chromosomal abnormalities, and the evidence is accumulat

80 r kg, P < 0.001), year of birth (P < 0.001), chromosomal abnormalities (aOR: 3.83, P < 0.01), longer

81 remarkable for the extent to which the same chromosomal abnormalities are detected in individual tum

82 Using metaphase cytogenetics (MC), chromosomal abnormalities are found in only a proportion

83 Our data demonstrate that widespread chromosomal abnormalities are frequent in lung adenocarc

84 Chromosomal abnormalities are frequent in myeloid malign

85 Chromosomal abnormalities are frequently caused by probl

86 Chromosomal abnormalities are important for the classifi

87 ase spreads, and wider applications to other chromosomal abnormalities are in development.

88 Chromosomal abnormalities are increasingly used to risk

89 tgrowth of cellular variants with additional chromosomal abnormalities are major causes of disease pr

90 s been mapped to chromosome band 3p25, where chromosomal abnormalities are observed in a variety of h

91 However, massive chromosomal abnormalities are only observed when a p53-/

92 ly screening T-DNA lines for the presence of chromosomal abnormalities are presented and discussed.

93 nical associations for more than 20 specific chromosomal abnormalities are presented.

94 Although it is known that gross chromosomal abnormalities are remarkably common in early

95 At least 12 structural chromosomal abnormalities are shared between T24, TSU-Pr

96 Individual chromosomal abnormalities are strong independent indicat

97 a heritable developmental disorder in which chromosomal abnormalities are thought to play a role.

98 Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple mye

99 typically distinct, share the same oncogenic chromosomal abnormalities as well as immunoglobulin heav

100 eby resulting in the genomic alterations and chromosomal abnormalities as well as in altered expressi

101 of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia

102 The t(8;21) is one of the most frequent chromosomal abnormalities associated with acute myeloid

103 However, because of the extensive chromosomal abnormalities associated with CIN, its cause

104 Chromosomal abnormalities associated with hypomethylatio

105 that there are mitotic as well as nonmitotic chromosomal abnormalities associated with loss of conden

106 row and peripheral blood of 25 patients with chromosomal abnormalities associated with MDS (monosomy

107 rom the identification of the first specific chromosomal abnormality associated with cancer to the de

108 of chromosome 20 represents the most common chromosomal abnormality associated with the myeloprolife

109 Aneuploidy, the most common chromosomal abnormality at birth and the main ascertaine

110 Balanced chromosomal abnormalities (BCAs) represent a relatively

111 as copy-number variants (CNVs), but balanced chromosomal abnormalities (BCAs) still require karyotypi

112 espite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization

113 that edited bacterial cells did not harbour chromosomal abnormalities but demonstrated elevated glob

114 n Rag2(-/-) Atm(-/-) mice contained multiple chromosomal abnormalities, but none of these involved th

115 Detection of specific chromosomal abnormalities by FISH and metaphase cytogene

116 We, therefore, examined chromosomal abnormalities by high-resolution single nucl

117 nce that ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11/Rad50/Nbs1

118 the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fl

119 is poorly understood, there is evidence that chromosomal abnormalities can arise through an alteratio

120 The development of chromosomal abnormalities (CAs) in the Philadelphia chro

121 G depletion causes DNA double-strand breaks, chromosomal abnormalities, cell-cycle delays, defective

122 tin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationsh

123 h the disease but having a variety of nearby chromosomal abnormalities, collectively described as cis

124 No patient presented with chromosomal abnormalities commonly seen in secondary leu

125 sease, neuromuscular disease, liver disease, chromosomal abnormalities, congenital immunodeficiencies

126 ma-IR), and cells from these animals exhibit chromosomal abnormalities consistent with defects in DNA

127 Chromosomal abnormalities contribute substantially to re

128 ns, p53 mutation, or the presence of various chromosomal abnormalities corresponds to variability of

129 A number of specific chromosomal abnormalities define the subgroups of multip

130 Chromosomal abnormalities detected by FISH at study entr

131 rrow plasma cell infiltration, with t(11;14) chromosomal abnormality detected by fluorescence in situ

132 mmediately before karyotyping for a possible chromosomal abnormality detected by maternal age and fet

133 n monosomy 7 cells to determine whether this chromosomal abnormality developed de novo or arose as a

134 The presence or absence of other concurrent chromosomal abnormalities did not affect survival in the

135 Most notably, the severe chromosomal abnormality did not cause cell death owing t

136 Telomere dysfunction may result in chromosomal abnormalities, DNA damage responses, and eve

137 e functionally important for accumulation of chromosomal abnormalities during disease progression in

138 rs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with

139 these carried copy number variations and/or chromosomal abnormalities, emphasizing the importance of

140 ds, genetic syndromes, familial aggregation, chromosomal abnormalities, environmental exposures, and

141 Chromosomal abnormalities, especially t(4;14) and del(17

142 Genetically unmodified MSCs can undergo chromosomal abnormalities even at early passages and for

143 f the regions coincided with areas of common chromosomal abnormalities frequently observed in CLL.

144 This chromosomal abnormality fuses part of the AML1/RUNX1 gen

145 opoietic stem cells (HSC) is associated with chromosomal abnormalities, genomic instability, and HSC

146 Use of free fetal DNA to diagnose fetal chromosomal abnormalities has been hindered by the inabi

147 Several nonrandom chromosomal abnormalities have been associated with neur

148 e past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reporte

149 ion whole-genome sequencing, many consistent chromosomal abnormalities have been described together w

150 ges in telomere functions and the associated chromosomal abnormalities have been implicated in human

151 Chromosomal abnormalities have long been proposed to pla

152 has been an increasing number of reports of chromosomal abnormalities identified by subtelomeric flu

153 ty to either known tumor suppressor genes or chromosomal abnormalities identified in previous cytogen

154 Chromosomal abnormalities, immunoglobulin heavy chain va

155 An analysis of chromosomal abnormalities in 10 head and neck cancer cel

156 tudy, we analyzed the prognostic value of 12 chromosomal abnormalities in a series of 354 MM patients

157 -wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA o

158 One of the most common chromosomal abnormalities in acute leukemia is a recipro

159 outcomes associated with distinct high-risk chromosomal abnormalities in acute myeloid leukemia (AML

160 elogenous leukemia (CML), the development of chromosomal abnormalities in addition to the Philadelphi

161 compared the genome-wide distribution of the chromosomal abnormalities in both sexes.

162 one of the mechanisms by which 53BP1 causes chromosomal abnormalities in Brca1-deficient cells.

163 Chromosomal abnormalities in childhood acute lymphoblast

164 Compared with other chromosomal abnormalities in CML, patients with 3q26.2 r

165 Events causing chromosomal abnormalities in ESCs may be related to even

166 These changes included de novo chromosomal abnormalities in five of the 26 patients (19

167 Common recurrent chromosomal abnormalities in FL included gains of 2, 5,

168 rognostic implications of the most recurrent chromosomal abnormalities in human B-cell chronic lympho

169 V6 on band 12p13 are amongst the most common chromosomal abnormalities in human leukemia.

170 In addition, its removal by chromosomal abnormalities in humans could cause split ha

171 in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas deca

172 Two additional perineurioma cases had large chromosomal abnormalities in multiple chromosomes, inclu

173 e the prognostic implications of overlapping chromosomal abnormalities in multiple myeloma (MM), demo

174 nuclear oncoprotein deregulated by recurring chromosomal abnormalities in myelodysplastic syndrome (M

175 lerated or blastic phase or developed clonal chromosomal abnormalities in Ph+ cells or BCR-ABL mutati

176 for CML who were subsequently found to have chromosomal abnormalities in Ph-negative cells.

177 with chronic myeloid leukemia (CML) develop chromosomal abnormalities in Philadelphia chromosome (Ph

178 Clonal chromosomal abnormalities in Philadelphia chromosome-neg

179 ith radioimmunotherapy may identify existing chromosomal abnormalities in previously treated patients

180 enerate DNA strand breakage as we have found chromosomal abnormalities in Rad1-depleted cells.

181 her investigated the role of larger CNVs and chromosomal abnormalities in RDD and performed associati

182 had previously been shown to be the site of chromosomal abnormalities in several other malignancies

183 nical doses of etoposide on the induction of chromosomal abnormalities in spermatocytes and their tra

184 the basis of both the frequent occurrence of chromosomal abnormalities in that region and numerous su

185 The accumulation of chromosomal abnormalities in the absence of proper telom

186 The genetic dissection of hot spots for chromosomal abnormalities in the age of the sequenced hu

187 The long latency (234-299 days) and clonal chromosomal abnormalities in the AMLs suggest that addit

188 s profound DNA damage, resulting in striking chromosomal abnormalities in the form of chromatid or ch

189 y that could not be accounted for by visible chromosomal abnormalities in the karyotype.

190 review the current literature on diagnosing chromosomal abnormalities in the pre-implantation embryo

191 e true prognostic significance of individual chromosomal abnormalities in this age group remains uncl

192 the development of autoimmunity as they age: Chromosomal abnormalities in top3beta(-/-) mice might le

193 duction in the number of HPCs that contained chromosomal abnormalities in two JAK2V617F-negative IM p

194 ultiple genomic regions) is a major cause of chromosomal abnormalities in uterine leiomyomas; we prop

195 A recurrent chromosomal abnormality in acute myeloid leukemia is the

196 The most common chromosomal abnormality in human cancer is the reciproca

197 RUNX1) fusion product and is the most common chromosomal abnormality in pediatric leukemia.

198 1)(p13;q22) translocation is the most common chromosomal abnormality in pediatric leukemia.

199 Importantly, the father possesses the same chromosomal abnormality in the absence of ASD, indicatin

200 tal heart disease even in the absence of any chromosomal abnormality in the newborn.

201 TIC), to identify significant ciliochoroidal chromosomal abnormalities including chromosome-arm-sized

202 Chromosomal abnormalities including the GLI3 locus were

203 ble-stranded DNA breaks (DSBs) can result in chromosomal abnormalities, including deletions, transloc

204 Chromosomal abnormalities, including homozygous deletion

205 Genetic and chromosomal abnormalities, including several chromosomal

206 Human myeloid leukemias are characterized by chromosomal abnormalities, including translocations, del

207 These data support the proposal that chromosomal abnormalities, including translocations, wit

208 t the Bcl-xl/Myc tumors contain a variety of chromosomal abnormalities, including trisomies, transloc

209 ntegrity and cause the accumulation of gross chromosomal abnormalities-including rearrangements, dele

210 ICUS patients carried a somatic mutation or chromosomal abnormality indicative of clonal hematopoies

211 isorder (ASD) in association with a balanced chromosomal abnormality involving 2p16.3.

212 Accumulation of DNA damage, mutations, and chromosomal abnormalities is associated with aging in ma

213 which includes both numerical and structural chromosomal abnormalities, is a hallmark of cancer.

214 Among singleton pregnancies without chromosomal abnormalities lasting >/=20 weeks in Denmark

215 One such patient had a complex chromosomal abnormality, leading to the identification o

216 Chromosomal abnormalities may arise during germ cell and

217 and inflammatory lesions (lichen sclerosus), chromosomal abnormalities may be a driving force in the

218 ultiple myeloma (MM), risk stratification by chromosomal abnormalities may enable a more rational sel

219 Chromosomal abnormalities (namely 13q, 17p, and 11q dele

220 t(8;21) is one of the most frequent chromosomal abnormalities observed in acute myeloid leuk

221 rome is one of the most common and penetrant chromosomal abnormalities observed in individuals with a

222 reased both the numerical and the structural chromosomal abnormalities observed.

223 hromosome 1 (1p) is the second most frequent chromosomal abnormality observed in these tumors.

224 ysis of these tumors indicated that multiple chromosomal abnormalities occurred in each tumor, but th

225 fragile site stability, because spontaneous chromosomal abnormalities occurred preferentially at com

226 To determine whether these chromosomal abnormalities occurred randomly or at specif

227 Subtle chromosomal abnormalities occurred with a frequency of 7

228 The chromosomal abnormalities of 14q32 are often associated

229 Chromosomal abnormalities of 280 patients (58.6%) were c

230 Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of t

231 Heterogeneity of chromosomal abnormalities of chromosomes 1, 3, 6, and 8

232 MBL cells bear the same chromosomal abnormalities of chronic lymphocytic leukemi

233 o increase the likelihood of gaining certain chromosomal abnormalities of the kind thought to lead to

234 had major extracardiac malformations and/or chromosomal abnormalities of which one died in utero wit

235 The most common chromosomal abnormality of infant acute lymphoblastic le

236 sible for this observation and the impact of chromosomal abnormalities on aging.

237 ffymetrix 10K array, we identified a somatic chromosomal abnormality on chromosome 7p in one HH tissu

238 d patterns of gene expression correlate with chromosomal abnormalities or assess expression of genes

239 s (class I mutations) acting in concert with chromosomal abnormalities or gene mutations that block d

240 subtypes that are characterized by specific chromosomal abnormalities or gene mutations.

241 ogical conditions, typically associated with chromosomal abnormalities or mutations in a single gene.

242 in by fluorescence in situ hybridization for chromosomal abnormalities or Western blotting for the in

243 mortality included noncardiac structural or chromosomal abnormalities (OR, 3.2; 95% CI, 1.3-7.9), us

244 14)(q24.1;q32), complex karyotype (5 or more chromosomal abnormalities), or low hypodiploidy/near tri

245 ns, CD38 and ZAP-70 expression, or any other chromosomal abnormality other than 17p deletion, in whic

246 ata revealed that, in addition to leading to chromosomal abnormalities, RAD51D-deficiency resulted in

247 Chromosomal abnormalities resulting in tumor suppressor

248 NA MMR loss may ultimately lead to the gross chromosomal abnormalities seen in t-AML.

249 lomere-based crisis to generate the types of chromosomal abnormalities seen in the earliest lesions o

250 s included 159 congenital malformations, six chromosomal abnormalities, seven stillbirths, and nine n

251 As a variety of diseases are linked to such chromosomal abnormalities, SNP chips promise new insight

252 tumor genetic heterogeneity in neuroblastoma.Chromosomal abnormalities such as 11q deletion are assoc

253 Patients having chromosomal abnormalities such as 11q deletion, trisomy

254 transformed cells often contain a variety of chromosomal abnormalities such as euploidy, translocatio

255 In BS cells, chromosomal abnormalities such as sister chromatid excha

256 Chromosomal abnormalities, such as deletions and duplica

257 tain lymphoid malignancies exhibit recurrent chromosomal abnormalities, such as translocations and de

258 1-null embryos contain increased spontaneous chromosomal abnormalities, suggesting that loss of Hus1

259 Many human chromosomal abnormality syndromes include specific cogni

260 prior cardiothoracic operation, prematurity, chromosomal abnormalities, syndromes, noncardiac congeni

261 es were studied together, we found that each chromosomal abnormality (TEL/AML1, BCR/ABL, or MLL abnor

262 ncer exhibits significantly higher levels of chromosomal abnormalities than sporadic breast cancers.

263 of sarcomas seem to be defined by consistent chromosomal abnormalities that can be detected using a v

264 Our findings suggest that chromosomal abnormalities that disrupt the function of t

265 polymorphism array to identify the secondary chromosomal abnormalities that drive the development of

266 yo, as well as fetal alcohol syndrome (FAS), chromosomal abnormalities that include trisomies 18 and

267 Chromosomal abnormalities that likely arise from recombi

268 In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially lead to infer

269 characterization of single-gene disorders or chromosomal abnormalities that result in a cognitive abn

270 marrow failure, AML, MDS and complex random chromosomal abnormalities that the single-mutant mice do

271 er nearly 40 years of the recognition of the chromosomal abnormality that defines CML, specific thera

272 The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the de

273 Transmitted de novo structural chromosomal abnormalities, the majority of which are pat

274 BRCA2 exhibit radiation hypersensitivity and chromosomal abnormalities, thus revealing a potential ro

275 leted genes, subordinately, with established chromosomal abnormalities to derive a 2-tier genetic cla

276 emia (CML) since the recognition of a common chromosomal abnormality to the introduction of ever more

277 emature chromatid separation (PCS) and gross chromosomal abnormalities typical of genomic instability

278 The incidence of most chromosomal abnormalities varied significantly with age.

279 e intelligence quotient of survivors without chromosomal abnormalities was 79.7 (16.6) with 25% below

280 screen for loss of heterozygosity (LOH) and chromosomal abnormalities was performed with parallel an

281 These chromosomal abnormalities were acquired somatic mutation

282 Two chromosomal abnormalities were associated with a signifi

283 ines were studied alone, we found that these chromosomal abnormalities were associated with the predo

284 onged hypoglycemia, congenital anomalies, or chromosomal abnormalities were excluded from the study.

285 No chromosomal abnormalities were found.

286 cancer and while the number and size of the chromosomal abnormalities were greatly reduced in cells

287 Chromosomal abnormalities were identified by comparative

288 Transient chromosomal abnormalities were infrequent.

289 Cells from 19 AML patients with a variety of chromosomal abnormalities were studied for their ability

290 BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomi

291 These cryptic chromosomal abnormalities, which seem to be nonrandom, h

292 AML), isolated trisomy 13 (AML+13) is a rare chromosomal abnormality whose prognostic relevance is po

293 latform for interrogating the interaction of chromosomal abnormalities with mutations.

294 tion (inv dup) markers, the largest group of chromosomal abnormalities with neocentromere formation,

295 correlated genomic lesion load and specific chromosomal abnormalities with patient survival.

296 cute myeloid leukemia (N = 20) for recurrent chromosomal abnormalities with the use of routine cytoge

297 Overall, 83% of cases have chromosomal abnormalities, with a median of three abnorm

298 , we discovered that arsenic exposure causes chromosomal abnormalities, with a preponderance of end-t

299 ata provide evidence that the development of chromosomal abnormalities within GLI3 is associated with

300 sion of HRAS(V12) increases the frequency of chromosomal abnormalities within one or two cell cycles,