ライフサイエンスコーパス: chromosomal breakage

1 ch NHEJ events can be selected after precise chromosomal breakage.

2 e telomeric bridges to form, with subsequent chromosomal breakage.

3 ays that facilitate cell survival and reduce chromosomal breakage.

4 rradiation and enhanced radiosensitivity and chromosomal breakage.

5 week hepatocytes were aneuploid, and 32% had chromosomal breakage.

6 -DNA plays a role in the generation of these chromosomal breakages.

7 ivity and the S-phase checkpoint and reduced chromosomal breakage after irradiation in AT cells.

8 GGT+ population had a 28 +/- 5% incidence of chromosomal breakage and a 17 +/- 5% incidence of chromo

9 demonstrate that CIN in terms of ICL-induced chromosomal breakage and defective chromatid cohesion is

10 In plants and animals, chromosomal breakage and fusion events based on conserve

11 a modest but noticeable decrease in induced chromosomal breakage and interchange frequencies, sugges

12 l cycle-regulated nuclease, markedly limited chromosomal breakage and led to further accumulation of

13 d2(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the

14 Common fragile sites (CFSs) are hot spots of chromosomal breakage, and CFS breakage models involve pe

15 icient mice revealed aneuploidy, spontaneous chromosomal breakage, and frequent translocation events.

16 dren show signs of growth failure, increased chromosomal breakage, and NK cell deficiency.

17 autosomal recessive disease associated with chromosomal breakage as well as pancytopenia, skin pigme

18 In chromosomal breakage assays, all control cells were mito

19 Common fragile sites predispose to specific chromosomal breakage associated with deletion, amplifica

20 te, acetaldehyde, associated with widespread chromosomal breakage at a concentration not producing br

21 supraphysiological RNR activity and reduced chromosomal breakage at fragile sites.

22 DNA cross-links is the main cause of DSB and chromosomal breakage at low and moderate Cr(VI) doses.

23 nd are indicative of replication pausing and chromosomal breakage at the accompanying fragile sites.

24 chromosome 16p13.1-p13.3, suggesting that a chromosomal breakage between Nubp2 and Nubp1 probably oc

25 Spontaneous chromosomal breakages frequently occur at genomic hot sp

26 the ends of chromosomes that protect against chromosomal breakage-fusion-bridge cycles in dividing ce

27 transposon ends, which initiate McClintock's chromosomal breakage-fusion-bridge cycles in maize.

28 nd this can result in fusions which initiate chromosomal breakage-fusion-bridge cycles, causing genom

29 hese rearrangements required a minimum of 20 chromosomal breakages/fusions.

30 We observed ICL-induced chromosomal breakage in 9 of 17 (53%) HNSCC cell lines d

31 RAD52 promotes stalled fork degradation and chromosomal breakage in BRCA2-defective cells.

32 to potential mechanisms for the induction of chromosomal breakage in cancer cells.

33 We here investigated fork progression and chromosomal breakage in human cells in response to a pan

34 Inactivation of FANCM was responsible for chromosomal breakage in one cell line, whereas in two ot

35 croM doses of Cr(VI) caused 10-15 times more chromosomal breakage in primary human bronchial epitheli

36 r FA consists of cytogenetic quantitation of chromosomal breakage in response to diepoxybutane (DEB)

37 malize cell growth, cell-cycle kinetics, and chromosomal breakage in the presence of MMC.

38 Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcription

39 These results favor the model in which the chromosomal breakage leading to MLL translocations in DN

40 points, together with the region of frequent chromosomal breakage mapped by FISH analysis, further co

41 notypes, per se, are neither associated with chromosomal breakage nor with significant DDR activation

42 study to demonstrate that specific sites of chromosomal breakage observed during a period of chromos

43 Analysis of the chromosomal breakage regions suggests a sequence-indepen

44 ss-linking agents is a frequent finding, and chromosomal breakage responses to MMC may be a sensitive

45 Chromosomal breakage resulting from stabilization of DNA

46 so induced unrestrained fork progression and chromosomal breakage, suggesting fork remodeling as a gl

47 C and FANCG disruption increased spontaneous chromosomal breakage, supporting the role of these genes

48 Recently, it was demonstrated that this chromosomal breakage syndrome is caused by mutations in

49 other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction

50 l in other bone marrow failure syndromes and chromosomal breakage syndromes.

51 Depletion of Plx1 leads to accumulation of chromosomal breakage that is prevented by the addition o

52 sal prevents fork degradation, but increases chromosomal breakage, uncoupling fork protection, and ch

53 which are regions of the genome that exhibit chromosomal breakage under conditions of mild replicatio

54 the mutant mice showed hypersensitivity and chromosomal breakage when treated with mitomycin C, a DN