ライフサイエンスコーパス: chromosomal gene

1 tRNA position effect can operate on a native chromosomal gene.

2 change of an internal miaA fragment into the chromosomal gene.

3 expressed from an autosomal homolog of the X chromosomal gene.

4 mutations in either a targeted plasmid or a chromosomal gene.

5 is encoded by a single exon of a single-copy chromosomal gene.

6 ocytosis patients, we cloned the human ANK-1 chromosomal gene.

7 lso be used to control the expression of any chromosomal gene.

8 LCR elements in cis, as is the case for the chromosomal gene.

9 general adaptive mutability available to any chromosomal gene.

10 n subunit (HcpA) that is encoded by the hcpA chromosomal gene.

11 ese proteins in the regulation of the native chromosomal gene.

12 quinolone resistance arises by mutations in chromosomal genes.

13 onstructs similar to those effective against chromosomal genes.

14 te elevated mutation on plasmids relative to chromosomal genes.

15 ucibly undergoing immunoglobulin SR on their chromosomal genes.

16 roducts, we made 13 different disruptions of chromosomal genes.

17 orescent protein (GFP)-FtsQ from single-copy chromosomal genes.

18 osed to account for the acquisition of these chromosomal genes.

19 ably higher frequency than that observed for chromosomal genes.

20 alteration of the transcriptional profile of chromosomal genes.

21 y of phosphatases is encoded by at least six chromosomal genes.

22 tly altering the transcription of 18% of all chromosomal genes.

23 ) that are the products of tandemly arranged chromosomal genes.

24 cation-binding proteins, are only known from chromosomal genes.

25 sion from three promoters in a linked set of chromosomal genes.

26 LENs to target specific loci in native yeast chromosomal genes.

27 ce through its effects on plasmid-responsive chromosomal genes.

28 smid's ability to regulate the expression of chromosomal genes.

29 eading frames of pCF10 and a set of selected chromosomal genes.

30 n or repression in vivo of a large number of chromosomal genes.

31 somal DNA can cause silencing of homologous, chromosomal genes.

32 isomes can modulate the expression of active chromosomal genes.

33 rA showed altered expression of more than 60 chromosomal genes: 76% showed increased expression and 2

34 ence matches (99%) than those seen in normal chromosomal genes (88 to 98%) or in other IS elements (9

35 ome sequencing microarrays and analyzed 1199 chromosomal genes (a total of 1,167,948 bp) and 92,721 b

36 fibroblasts was used to knock out alleles of chromosomal genes adjacent to promoter inserts, generati

37 Upregulation of CTn4-bt genes and other chromosomal genes affected by CTnDOT was controlled by t

38 MarA protein controls expression of multiple chromosomal genes affecting resistance to antibiotics an

39 revealed the presence of a mutation in the X chromosomal gene ALAS2, which encodes 5'-aminolevulinate

40 rray, we confirmed the general similarity of chromosomal genes among this group of close relatives.

41 e introduced the Trp306Phe mutation into the chromosomal gene and tested the non-photoreducible W306F

42 The expression of 66 chromosomal genes and 32 plasmid-encoded genes was incre

43 the latter organism has at least 81% of the chromosomal genes and 43% of the plasmid genes of B. bur

44 Eighty-six chromosomal genes and 80 plasmid-encoded genes were expr

45 ate translational fusions between Salmonella chromosomal genes and a fragment of the calmodulin-depen

46 We discovered 906 SNPs in 523 chromosomal genes and observed a high level of DNA polym

47 In contrast, Ca2+ had little effect on chromosomal genes and ORFs, of which 235 were thermally

48 dentical to those obtained from endosymbiont chromosomal genes and the plasmid-borne trpEG.

49 iants, and compelling work suggests that sex chromosomal genes and/or sex hormones, especially testos

50 lacement of just the open reading frame of a chromosomal gene, and the presence of naturally occurrin

51 ncoded genes were more highly regulated than chromosomal genes, and both positive and negative effect

52 e efficient homologous modification of human chromosomal genes, and for subsequent phenotypic analyse

53 rrelia burgdorferi, four results emerge: (1) chromosomal genes are clonal; (2) there is little or no

54 , incomplete in humans: up to one-third of X-chromosomal genes are expressed from both the active and

55 eletions in the plasmid gene virG and in the chromosomal gene aroA.

56 ns of Drosophila robusta are polymorphic for chromosomal gene arrangements in most of its range, the

57 (directly or indirectly) of 12 to 41% of all chromosomal genes, as assessed by growth in Todd-Hewitt

58 We also find that condensin-dependent intra-chromosomal gene associations and chromosome territories

59 s study suggests that condensin-driven intra-chromosomal gene associations contribute to the organiza

60 coincident mutations at lac (on the F') and chromosomal genes behave as independent events, whereas

61 curs in vivo that results in many more small chromosomal genes being expressed during growth in the i

62 -programmed to knock down mRNA of a selected chromosomal gene (beta-galactosidase) using an artificia

63 hylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is

64 Regulation of chromosomal genes by atxA is particularly intriguing, gi

65 he positive and negative regulations of some chromosomal genes by pGP4 and pGP5, respectively, may al

66 Sixteen chromosomal genes (cap5A through cap5P) are involved in

67 a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia c

68 enomic techniques, we identified a conserved chromosomal gene cluster in Shewanella oneidensis MR-1 (

69 tabolic enzymes encoded in the TM0412-TM0416 chromosomal gene cluster.

70 of DNA-methylation patterns, as small inter-chromosomal gene clusters activated in concert in a prop

71 'pathway-specific' regulators located within chromosomal gene clusters encoding biosynthesis of indiv

72 gulatory locus not located within any of the chromosomal gene clusters it targets, and further demons

73 Pathogenicity islands are chromosomal gene clusters, often located adjacent to tRN

74 ous and orthologous sequences, and conserved chromosomal gene clusters.

75 asculinization or demasculinization of the X-chromosomal gene content.

76 f DNA damage and improved gene targeting and chromosomal gene conversion with either double-stranded

77 ecombination, by trans-splicing, or by trans-chromosomal gene conversion, we generated and analyzed e

78 ession (ASE) - unequal expression of the two chromosomal gene copies.

79 e the entire isolation procedure of a single chromosomal gene could be accomplished in approximately

80 Thus, the chromosomal gene could only be replaced with a disrupted

81 sing a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia c

82 They contain the essential chromosomal gene, dapD, under the control of the lac ope

83 Mutations in the X-chromosomal gene DCX, encoding doublecortin, is the main

84 copper-dependent expression of at least one chromosomal gene, designated cusC (ylcB), which is allel

85 describes the cloning of the murine stomatin chromosomal gene, determination of its genomic structure

86 d by creating a yeast strain carrying an L25 chromosomal gene disruption and a plasmid-encoded FLAG-t

87 p II introns can be used for highly specific chromosomal gene disruption in Escherichia coli and othe

88 ults in complementation of the corresponding chromosomal gene disruption.

89 The chromosomal gene dsbA, which encodes a periplasmic disul

90 The unique chromosomal genes encode proteins involved in capsule an

91 in type III secretion and identified ttsA, a chromosomal gene encoding a polytopic membrane protein.

92 DNA library contain an adherence-conferring chromosomal gene encoding a protein similar to iron-regu

93 ed by a mutation in OLE1, an essential yeast chromosomal gene encoding delta9 fatty acid desaturase,

94 The chromosomal gene encoding RNA ligase in E. coli was disr

95 occus aureus strains possessing mutations in chromosomal genes encoding 23S rRNA or ribosomal protein

96 were expressed in a yeast strain lacking the chromosomal genes encoding Kex2 and prepro-alpha-factor.

97 h two X chromosomes) achieve expression of X-chromosomal genes equivalent to that of males (one X and

98 f the low rates of recombination, "ordinary" chromosomal gene evolution in bacteria is different from

99 erize and determine the function of Yersinia chromosomal genes expressed in lymphoid tissue after int

100 d antisense RNA can effectively downregulate chromosomal gene expression both in vitro and in vivo.

101 r the investigation of complex regulation of chromosomal gene expression in this bacteria.

102 ation, induction of apoptosis, activation of chromosomal gene expression, and direct binding to chrom

103 ases we find relatively little effect upon X chromosomal gene expression.

104 The second group, consisting of Y-chromosomal gene families expressed specifically in test

105 ions, encoded by the bmp genes of paralogous chromosomal gene family 36.

106 CDY is a human Y-chromosomal gene family expressed exclusively in the tes

107 both wild-type cells and cells expressing a chromosomal gene for a functional epitope-tagged form of

108 with the subdomain sequence deleted from the chromosomal gene for IMPDH.

109 rey parrot (Psittacus erithacus) lacks the W-chromosomal gene for the alpha subunit of mitochondrial

110 onstruction of a strain of E. coli where the chromosomal gene for the essential molecular chaperone G

111 ease in the transcript levels of a subset of chromosomal genes for strain L2(25667R).

112 An intra-chromosomal gene fusion involving the estrogen receptor

113 targeted gene inactivation and generation of chromosomal gene fusions in Pasteurella haemolytica has

114 sed by analysis of transcripts and by use of chromosomal gene fusions.

115 class of regulatory frameshifting of stable chromosomal genes governs cellular polyamine levels from

116 very limited number of readthrough cases in chromosomal genes had been reported.

117 f c-Myb; however, regulation of the resident chromosomal gene has not yet been demonstrated.

118 al and pathogenesis, but the contribution of chromosomal genes has been largely unexplored.

119 n between plasmid resistances and those from chromosomal genes has blurred, because for some metals (

120 In addition, 43 of the 383 fully annotated chromosomal genes have ZDRs within 2 nucleosomes upstrea

121 erse transcription-PCR demonstrated that the chromosomal genes (hpt, purA, and purB) were transcribed

122 transfer and the interbacterial transfer of chromosomal genes (i.e., chromosome-mobilizing ability [

123 hat incomplete XCI affects at least 23% of X-chromosomal genes, identify seven genes that escape XCI

124 latter controls expression of multiple other chromosomal genes implicated in cell physiology, multipl

125 This site-directed modification of a native chromosomal gene in intact human cells under conditions

126 that mediate site-specific mutagenesis of a chromosomal gene in living cells.

127 sequence tags (ESTs) to randomly inactivate chromosomal genes in a bovine kidney cell line (LF-BK) t

128 suggest that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic e

129 pproximately 40,000 human ESTs to inactivate chromosomal genes in a human cell population, and we iso

130 rR and VirS to regulate the transcription of chromosomal genes in a process that ultimately promoted

131 enes influence the expression of a number of chromosomal genes in addition to the LEE.

132 We inactivated several plasmid and chromosomal genes in B31 MI and determined that clones c

133 njugative transposon CTnDOT on expression of chromosomal genes in Bacteroides thetaiotaomicron 5482 (

134 imple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR prime

135 ce tags (ESTs), we randomly inactivated host chromosomal genes in HeLa cells and isolated clones that

136 Multicopy Y-chromosomal genes in human and mouse have been postulate

137 his study, we identified several plasmid and chromosomal genes in the pathogenic enteroaggregative E.

138 To identify the ancestral chromosomal genes in V. cholerae regulated by AphA, we c

139 To identify the ancestral chromosomal genes in V. cholerae regulated by AphB, we c

140 rect the alteration of single nucleotides in chromosomal genes in yeast.

141 of deletions through the use of the one-step chromosomal gene inactivation technique to identify SXT

142 ulness of antisense EST libraries for global chromosomal gene inactivation, establish the practicalit

143 t time that AggR activates the expression of chromosomal genes, including 25 contiguous genes (aaiA-Y

144 uences transcription of 15% (n = 271) of all chromosomal genes, including many that encode surface an

145 gulator of plasmid-encoded pgp3 and multiple chromosomal genes, including the glycogen synthase gene

146 thin an ancestral TET2 gene that underwent a chromosomal gene inversion during evolution, thus separa

147 Fourteen chromosomal genes involved in energy metabolism, substra

148 ants, we have identified mutants affected in chromosomal genes involved in synthesis of the sideropho

149 a coli (EcDmlA) naturally expressed from its chromosomal gene is capable of complementing leucine aux

150 on-replicating plasmid that has received the chromosomal gene is recovered, rather than being allowed

151 We show that XCI at 683 X-chromosomal genes is generally uniform across human tiss

152 ld-type copy of the enzyme, derived from the chromosomal gene, is separated from the mutant form of t

153 strain containing a conditionally essential chromosomal gene (kan) under the control of the lac oper

154 e high sequence identity and the overlapping chromosomal gene loci suggest that both proteases evolve

155 introducing the epitope tag into the native chromosomal gene locus in vertebrate cells, embryonic st

156 Chromosomal genes modulate Ty retrotransposon movement i

157 ng male-related genes, then the out-of-the-X chromosomal gene movement should not be limited to retro

158 female heterogamety have found any nonrandom chromosomal gene movement.

159 more commonly affected protein, either by X-chromosomal gene mutations or in autoimmune-mediated acq

160 ed iteratively and also enables searches for chromosomal gene neighbors and Rosetta Stone linkages.

161 th probes complementary to S. hyodysenteriae chromosomal genes nox and flaA1.

162 Hypermutation of chromosomal genes occurs in association with adaptive La

163 tabilizing mutations into folA--an essential chromosomal gene of Escherichia coli encoding dihydrofol

164 alanine substitution mutations into the vacA chromosomal gene of H. pylori and analyzed the propertie

165 Low rates of replication errors in chromosomal genes of Sulfolobus spp. demonstrate that th

166 some of them might affect the expression of chromosomal genes of the new host.

167 e origin of the plasmid-borne trpEG from the chromosomal genes of the same lineage and the absence of

168 cant similarity to proteases in a screen for chromosomal genes of Y. enterocolitica that were exclusi

169 RNA encoding ExsB' was not detectable from chromosomal genes or complementation constructs, indicat

170 Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms.

171 Although a single mutation event in the X-chromosomal gene PIGA is known to cause GPI-anchored pro

172 er with other odd features of the island's Y-chromosomal gene pool, is best explained as the genetic

173 erica subspecies I to identify the conserved chromosomal gene pool.

174 w here that a fraction of the B. burgdorferi chromosomal gene product BB0337, annotated as enolase or

175 port of in vitro transcription of M. xanthus chromosomal genes, providing a foundation for further bi

176 PCR analysis of the chromosomal gene recA in cultured B. burgdorferi was con

177 ere inactivated through successive cycles of chromosomal gene replacement mutagenesis.

178 tion mutant of ibeA (ZD1) was constructed by chromosomal gene replacement with a suicide plasmid pCVD

179 Interruption of the chromosomal gene resulted in loss of expression of an ap

180 Disruption of these two chromosomal genes results in adenine auxotrophy, whereas

181 Cloning of the Kcnk8 chromosomal gene revealed that it is composed of three e

182 Cloning of the corresponding chromosomal gene revealed that the ankyrin 1 muscle tran

183 The chromosomal gene rfaL (waaL) was recently identified as

184 rmatogenesis and consequent sterility; the Y chromosomal gene(s) with this essential early role in sp

185 re not required for efficient recognition of chromosomal gene segments by V(D)J recombinase.

186 function and cripples V(D)J recombination of chromosomal gene segments.

187 mutant strain harbors Tn5 integrated into a chromosomal gene sharing high sequence identity with a t

188 examined was lacking a third cluster of five chromosomal genes (STM1555 to -1559).

189 ve mutations show hypermutation of unrelated chromosomal genes, suggesting that chromosomal sites als

190 we found that C. muridarum with mutations in chromosomal genes tc0237 and/or tc0668 was defective in

191 ants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH)

192 A region of the bovine X-chromosomal gene that has inhibitory activity when assay

193 h strain carries roughly 300 strain-specific chromosomal genes that account for differences in their

194 ith their host's chromosome, and may acquire chromosomal genes that could then spread through the pop

195 me isolates by mecR1 and mecI, cotranscribed chromosomal genes that encode a putative signal transduc

196 These copies gave rise to nuclear chromosomal genes that encode cytosolic proteins and pre

197 e is a divalent metal-activated repressor of chromosomal genes that encode proteins responsible for s

198 One of the chromosomal genes that is highly correlated with virulen

199 es from around the world reveal 32 Y. pestis chromosomal genes that, together with the two Y. pestis-

200 rovar were essentially identical for all LT2 chromosomal genes, the isolates differed in their simila

201 hereby allowing formerly recombining X and Y chromosomal genes to diverge independently.

202 o a circular form, we isolated a S. lividans chromosomal gene (tpgL) that we found specifies a protei

203 throughout the tra gene affected plasmid and chromosomal gene transfer, insertions in a 200-amino-aci

204 These strains also express from single-copy chromosomal genes vanRa, vanRb, or vanRSb behind their r

205 Within core chromosomal genes we find that one SNP per every 985 bas

206 ed (79%), while the differentially expressed chromosomal genes were almost entirely up-regulated (93%

207 e absent from the pig, and 38 pig-specific X-chromosomal genes were annotated, 22 of which were olfac

208 ry low level, while the corresponding native chromosomal genes were expressed at approximately normal

209 It is widely believed that most or all Y-chromosomal genes were once shared with the X chromosome

210 In total, 745 X-chromosomal genes were screened.

211 sed antisense RNA strategy that can identify chromosomal genes whose functional disablement leads to

212 be used to correct a variety of mutations in chromosomal genes with high fidelity and specificity.

213 NA synthesis and capping defects, we deleted chromosomal gene XRN1, encoding the major exonuclease th

214 the library repeatedly identified a 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein