ライフサイエンスコーパス: chromosomal instability

1 repair pathway that protects the genome from chromosomal instability.

2 mis-segregate whole chromosomes and display chromosomal instability.

3 oplastic tissue, is attributed to continuous chromosomal instability.

4 bipolar spindle assembly and a high rate of chromosomal instability.

5 r and promotes tumor growth, metastasis, and chromosomal instability.

6 atumor heterogeneity, genetic diversity, and chromosomal instability.

7 ploidy single-handedly triggered cancer-like chromosomal instability.

8 onical Hh signaling through the induction of chromosomal instability.

9 cellular cholesterol homeostasis also causes chromosomal instability.

10 he development of HGSOC, and associated with chromosomal instability.

11 nes associated with cancer proliferation and chromosomal instability.

12 Human cells lacking RECQL5 display chromosomal instability.

13 cterized by progressive fatal BM failure and chromosomal instability.

14 nt human tumors and strongly correlates with chromosomal instability.

15 kinase A (AURKA) drives tumor aneuploidy and chromosomal instability.

16 em cells, uncoupling cell cycle defects from chromosomal instability.

17 essive disorders characterized by cancer and chromosomal instability.

18 nd processing, HR-type DSB repair, and overt chromosomal instability.

19 and led to concomitant telomerase-dependent chromosomal instability.

20 No evidence was found of G-CSF-induced chromosomal instability.

21 umor development to drive the acquisition of chromosomal instability.

22 ted MEK1-tubulin in spindle organization and chromosomal instability.

23 s chromosome content, two characteristics of chromosomal instability.

24 repton reduced liver overgrowth and signs of chromosomal instability.

25 tic event associated with gene silencing and chromosomal instability.

26 evoid of RECQL1 and RECQL5 display increased chromosomal instability.

27 resence of extra centrosomes correlates with chromosomal instability.

28 histomorphologic parameters associated with chromosomal instability.

29 intraepithelial lesions, yet did not exhibit chromosomal instability.

30 sease characterized at the cellular level by chromosomal instability.

31 ve double-strand break repair, and increased chromosomal instability.

32 llular superoxide, to the acute induction of chromosomal instability.

33 ochastic model, driven by the observation of chromosomal instability.

34 arities involving anaphase bridges and gross chromosomal instability.

35 y of p53 lesions, and display high levels of chromosomal instability.

36 a gene expression signature associated with chromosomal instability.

37 to mitomycin C and exhibited high levels of chromosomal instability.

38 ersensitivity to DNA crosslinking agents and chromosomal instability.

39 susceptibility to apoptosis, and by inducing chromosomal instability.

40 ssential for the promotion of c-Myc-mediated chromosomal instability.

41 E7 in FA-deficient cells led to accelerated chromosomal instability.

42 A1 transcriptional repression and subsequent chromosomal instability.

43 er associated with cancer predisposition and chromosomal instability.

44 checkpoint activity and the potentiation of chromosomal instability.

45 A1 leading to abnormal centrosome number and chromosomal instability.

46 Pot1a deletion also results in chromosomal instability.

47 severely compromised DSB repair resulting in chromosomal instability.

48 , but was a potent inducer of aneuploidy and chromosomal instability.

49 eukemia (AML) is frequently characterized by chromosomal instability.

50 centromeres are altered in cancer cells with chromosomal instability.

51 evelopmental impairment, embryonic death and chromosomal instability.

52 s, hypersensitivity to genotoxic agents, and chromosomal instability.

53 evaluation of tumors revealed characteristic chromosomal instability.

54 levels and promoted checkpoint weakness and chromosomal instability.

55 ng of telomeres, seems to be associated with chromosomal instability.

56 VHL with increased miR-28-5p expression and chromosomal instability.

57 athway to propagate structural and numerical chromosomal instabilities.

58 ts in sensitivity to DNA-damaging agents and chromosomal instabilities.

59 -positive ALT cells were found to have gross chromosomal instabilities.

60 ulation of Bub1 mediated by LANA resulted in chromosomal instability, a hallmark of cancer.

61 hindered in p27-deficient cells, leading to chromosomal instability, a hallmark of cancers with poor

62 y defects have recently been associated with chromosomal instability, a hallmark of human cancer.

63 These diseases are associated with chromosomal instability, a hallmark of human cancer.

64 auses polyploidy, which in turn can generate chromosomal instability, a hallmark of many cancers.

65 essing tissues with age, consistent with the chromosomal instability accompanying a polzeta defect.

66 data implicate MAK in both AR activation and chromosomal instability, acting in both early and late p

67 hormone-induced tumors display considerable chromosomal instability and aneuploidy, despite the pres

68 meres are associated with the development of chromosomal instability and aneuploidy, the latter being

69 he top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy.

70 are implicated in hereditary human disease, chromosomal instability and cancer, and underlie the cli

71 disrupted by BRCA2 mutations, which lead to chromosomal instability and cancer.

72 rly or late stages of tumorigenesis promotes chromosomal instability and carcinogenesis in telomerase

73 down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects i

74 been implicated as an important mediator of chromosomal instability and colon cancer triggered by En

75 Acquired chromosomal instability and copy number alterations are

76 pt management of small melanoma might reduce chromosomal instability and could improve overall patien

77 ly, loss of TRAIP function leads to enhanced chromosomal instability and decreased cell survival afte

78 of FA including DNA crosslinker sensitivity, chromosomal instability and defective FA pathway activat

79 ks whose unfaithful repair may contribute to chromosomal instability and disease progression to blast

80 The aneuploid cells display increased chromosomal instability and DNA damage, a mutator phenot

81 ons disturb mitosis and cytokinesis, causing chromosomal instability and greatly increased susceptibi

82 UBE2C is an important marker of chromosomal instability and has been associated with mal

83 ) is a rare genetic disease characterized by chromosomal instability and impaired DNA damage repair.

84 -deficient B cells also exhibited pronounced chromosomal instability and impaired proliferation capac

85 t CDK inhibitors may have use in suppressing chromosomal instability and in synthetic lethal drug com

86 iferation, while prolonged expression caused chromosomal instability and in vivo tumor suppression.

87 eat shock protein Hsp72 was shown to promote chromosomal instability and increase radiation sensitivi

88 es provide valuable information for studying chromosomal instability and its consequences in cancer.

89 esulting from these interactions may promote chromosomal instability and leave the hepatocyte unable

90 th endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasi

91 Chromosomal instability and mitotic errors may contribut

92 , they demonstrate that MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum

93 Coexpression of Tax and PTTG enhanced chromosomal instability and neoplastic changes to levels

94 bishield emergency program drives evasion of chromosomal instability and phagocytosis checkpoints by

95 gests a possible causal relationship between chromosomal instability and premature aging.

96 n, immune deficiency, cancer predisposition, chromosomal instability and radiation sensitivity.

97 All hybrids exhibited the same pattern of chromosomal instability and remodeling specifically with

98 ct as posttranscriptional safeguards against chromosomal instability and replication stress by integr

99 , tumors overexpressing Shh exhibited marked chromosomal instability and Smoothened-independent upreg

100 r that plays a key role in the prevention of chromosomal instability and suppresses the acquisition o

101 ntribute to tumor formation by both inducing chromosomal instability and suppressing the DDR pathway.

102 n gene expression signatures for RB loss and chromosomal instability and the ability of genes up-regu

103 e report that LANA promoted the induction of chromosomal instability and the formation of micronuclei

104 Chromosomal instability and the subsequent genetic mutat

105 Chromosomal instability and the subsequent genetic mutat

106 shorter telomeres have been associated with chromosomal instability and tumor progression.

107 DNA replication stress can cause chromosomal instability and tumor progression.

108 ction as a result of Tpp1 depletion promotes chromosomal instability and tumorigenesis in the absence

109 not been linked to carcinogenesis, can cause chromosomal instability and, consequently, cancer by fus

110 is coincident with centrosome amplification, chromosomal instability, and aneuploidy, and represent a

111 of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing

112 nificant differences in mutational patterns, chromosomal instability, and gene expression that correl

113 Intriguingly, silencing of NIAM accelerated chromosomal instability, and microarray analyses showed

114 phases of cellular transformation, exhibited chromosomal instability, and promoted increase in nuclea

115 ted hypersensitivity to DNA damage reagents, chromosomal instability, and reduced ATM-dependent phosp

116 aberrant Bub1 expression is associated with chromosomal instability, aneuploidy, and human cancer.

117 Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive t

118 Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells.

119 how that the loss of APC immediately induces chromosomal instability as a result of a combination of

120 These results underscore the role of chromosomal instability as a result of mitotic checkpoin

121 VirD5 promotes chromosomal instability as seen by the high-frequency lo

122 syndrome, respectively, and associated with chromosomal instability as well as premature aging.

123 uggest that KIF5B is critical in suppressing chromosomal instability at the early stages of female me

124 ongly associated with tumor stage, a mitotic chromosomal instability attractor strongly associated wi

125 a striking association between the degree of chromosomal instability, both numerical and structural,

126 bute to tumor formation not only by inducing chromosomal instability but also by suppressing the func

127 n increases tumor initiation by induction of chromosomal instability, but that initiated tumors need

128 erwise harmless virus rapidly causes massive chromosomal instability by fusing cells whose cell cycle

129 the absence of NORAD, PUMILIO proteins drive chromosomal instability by hyperactively repressing mito

130 l human cancers where they can contribute to chromosomal instability by promoting mitotic spindle abn

131 that LMW-E expression primes cells to accrue chromosomal instability by shortening the length of mito

132 tastrophe and apoptosis; and 4) induction of chromosomal instability by telomere aggregate formation.

133 Chromosomal instability can result from defective contro

134 mouse Mcm4(Chaos3) mutation associated with chromosomal instability, cancer, and decreased intersubu

135 ity in mouse thymi and small intestines, the chromosomal instability caused by Atf3 deficiency was la

136 rt that Spartan insufficiency in mice causes chromosomal instability, cellular senescence and early o

137 tellite stable but most are characterized by chromosomal instability (CIN pathway).

138 omes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2].

139 and anaphase bridges, which are hallmarks of chromosomal instability (CIN) and Bub1 insufficiency.

140 rives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness.

141 air (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis.

142 The mechanisms that safeguard cells against chromosomal instability (CIN) are of great interest, as

143 Myc upregulation and increasing chromosomal instability (CIN) characterized the evolutio

144 Chromosomal instability (CIN) contributes to cancer evol

145 d that the rate of chromosome missegregation/chromosomal instability (CIN) determines the effect of a

146 oup related to drug resistance that contains chromosomal instability (CIN) genes.

147 be related to events in tumor cells causing chromosomal instability (CIN) in human disease.

148 uces extracellular superoxide, could promote chromosomal instability (CIN) in mammalian cells.

149 Chromosomal instability (CIN) in tumors is characterized

150 ness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoieti

151 euploidy, Separase overexpression results in chromosomal instability (CIN) including premature chroma

152 Chromosomal instability (CIN) is a hallmark of cancer th

153 Chromosomal instability (CIN) is a hallmark of human neo

154 Chromosomal instability (CIN) is a hallmark of many tumo

155 Chromosomal instability (CIN) is a major driving force o

156 Chromosomal instability (CIN) is associated with poor ou

157 Chromosomal instability (CIN) is widely considered a hal

158 ers of the panel, and several lines produced chromosomal instability (CIN) manifested by high numbers

159 Cancer chromosomal instability (CIN) results in an increased ra

160 egregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the

161 Chromosomal instability (CIN) underlies malignant proper

162 ve increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects r

163 Whole chromosomal instability (CIN), manifested as unequal chr

164 hways in colorectal cancer pathogenesis: the chromosomal instability (CIN), microsatellite instabilit

165 Chromosomal instability (CIN), the persistent inability

166 ations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-c

167 chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of ma

168 Polyploid cancer cells exhibit chromosomal instability (CIN), which is associated with

169 loss of BRCA1 in human cancer cells leads to chromosomal instability (CIN), which is defined as a per

170 Segregation errors lead to chromosomal instability (CIN), with deleterious conseque

171 the other is subclonal aneuploidy caused by chromosomal instability (CIN).

172 mosome missegregation in a phenomenon called chromosomal instability (CIN).

173 d-disease phenotypes, notably metastasis and chromosomal instability (CIN).

174 mosomes at high rates in a phenomenon called chromosomal instability (CIN).

175 o evidence to support that [PSI (+)] induces chromosomal instability (CIN).

176 mosomes at high rates in a phenomenon called chromosomal instability (CIN).

177 hromosome missegregation in a process called chromosomal instability (CIN).

178 ate whole chromosomes in a phenomenon called chromosomal instability (CIN).

179 genes are overexpressed in tumors exhibiting chromosomal instability (CIN).

180 scale genomic rearrangements, referred to as chromosomal instability (CIN).

181 mosome missegregation in a phenomenon called chromosomal instability (CIN).

182 t Bax promotes tumor formation by increasing chromosomal instability (CIN).

183 g cell division are strongly associated with chromosomal instability (CIN).

184 es at high rates, a phenotype referred to as chromosomal instability (CIN).

185 s having microsatellite instability (MSI) or chromosomal instability (CIN); herein termed microsatell

186 o search for gene signatures associated with chromosomal instability (CIN); we investigated associati

187 ouble knockout splenocytes displayed reduced chromosomal instability compared with Atm null mice.

188 that macroevolutionary shifts (the onset of chromosomal instability) contribute to the evolution of

189 nd disruption of these complexes can lead to chromosomal instability culminating in cell death or mal

190 Fanconi anaemia is a chromosomal instability disorder associated with cancer

191 Fanconi anemia (FA) is an inherited chromosomal instability disorder characterized by childh

192 FA is a chromosomal instability disorder characterized by multip

193 Fanconi anemia (FA) is a chromosomal instability disorder in which DNA-damage pro

194 uster DNA helicase genetically linked to the chromosomal instability disorder Warsaw breakage syndrom

195 Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a varie

196 nd Bloom's syndrome (BS) are rare hereditary chromosomal instability disorders.

197 tically stable epithelial cells can initiate chromosomal instability, DNA damage, cell transformation

198 summary, we propose that Hus1 loss leads to chromosomal instability during DNA replication, triggeri

199 imply that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution an

200 e to genotoxic agents rather than a state of chromosomal instability during the carcinogenic process.

201 Since chromosomal instability emerges when BRCA1 HR function i

202 Chromosomal instability enables tumor development, enabl

203 aling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensi

204 during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the

205 f; that is, whether aneuploidy per se causes chromosomal instability, for example, in patients with i

206 We identified a signature of chromosomal instability from specific genes whose expres

207 Together, these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIalpha

208 as been no systematic exploration of whether chromosomal instability generated as a result of deregul

209 ACH1, designated FANCJ) is implicated in the chromosomal instability genetic disorder Fanconi anemia

210 of the mouse checkpoint gene Hus1 results in chromosomal instability, genotoxin hypersensitivity, and

211 The overall consequences of this chromosomal instability have been largely unexplored in

212 New models of aneuploidy and chromosomal instability have shed light on the diverse e

213 hypersensitivity to DNA cross-linker-induced chromosomal instability in association with developmenta

214 e repair, that may explain in part the whole-chromosomal instability in BRCA2-deficient tumors.

215 What specific defects can cause chromosomal instability in cancer cells?

216 hila epithelial cells to address the role of chromosomal instability in cancer development as they ha

217 dy identifies p120 loss as a driver event of chromosomal instability in cancer.

218 progress has been made to identify causes of chromosomal instability in colorectal cells and to deter

219 of repair of DNA interstrand cross-links and chromosomal instability in FA cells.

220 and provides a novel molecular mechanism for chromosomal instability in HL.

221 increases chromosome missegregation to cause chromosomal instability in human tumors.

222 eveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because

223 chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting from reduced l

224 We tested our hypothesis that targeting chromosomal instability in MM would improve response to

225 how that overexpression of Cyclin B1 induces chromosomal instability in mouse embryonic fibroblasts l

226 mirus provide a second example of prolonged chromosomal instability in natural neoallopolyploid popu

227 omal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells.

228 The role of chromosomal instability in the progression to inflammato

229 eres produce apoptosis, cell senescence, and chromosomal instability in tissue culture and animal mod

230 romosome mis-segregation, a leading cause of chromosomal instability in tumors.

231 e constitutional MdnCNV phenomenon resembles chromosomal instability in various cancers.

232 By identifying a potential mediator of chromosomal instability in VHL-associated cancers, our w

233 cancer cells with a growth advantage, caused chromosomal instability in vitro, and promoted tumor dev

234 Despite considerable chromosomal instability, in most cases the evolution fro

235 evel of somatic mosaicism, a proxy marker of chromosomal instability, in patients with constitutional

236 rylation leads to multiple manifestations of chromosomal instability including increased levels of DN

237 sed replication forks, as well as in various chromosomal instabilities, including loss of heterozygos

238 ot only reduced but the cells also exhibited chromosomal instability, including binucleation and aneu

239 ing from primary causes that do not generate chromosomal instability, including loss of the INK4a tum

240 Cell proliferation and chromosomal instability increased in colon crypt cells o

241 Chromosomal instability index as measured by changes in

242 ation of nucleoplasmic bridges and increased chromosomal instability, indicating that inaccurate endo

243 from undergoing programmed cell death (PCD), chromosomal instability induces neoplasic overgrowth.

244 Underlying the chromosomal instability is a failure to up-regulate the

245 Chromosomal instability is a hallmark of cancer, but mit

246 Chromosomal instability is a hallmark of many tumor type

247 Acquisition of chromosomal instability is an early event in these tumor

248 er hybrid cells displaying radiation-induced chromosomal instability is toxic to unirradiated parenta

249 Interestingly, p53 loss induced chromosomal instability leading to features of transform

250 We first show that chromosomal instability leads to an apoptotic response.

251 rs harboring Rsf-1 amplification, can induce chromosomal instability likely through DDR.

252 pericentric heterochromatin, with consequent chromosomal instability manifested by increased micronuc

253 Thus, early chromosomal instability may be responsible for tumour re

254 cies suggests that substantial and prolonged chromosomal instability might be common in natural popul

255 ) or their localization to sites of frequent chromosomal instability (miR-143, miR-145, miR-26a-1, an

256 The chromosomal instability model proposed here suggests a c

257 ecimens and 37 tumor cell lines derived from chromosomal instability neoplasia and microsatellite ins

258 revealed no evidence of aneuploidy or gross chromosomal instability (no difference to adenomas from

259 mb features, and backbone demethylation with chromosomal instability, NSD1 and TP53 mutations, 5q and

260 It corrected the DNA repair defect and the chromosomal instability observed after exposure to a DNA

261 cancer mouse models with persistent mitotic chromosomal instability, observing a decrease in prolife

262 ncer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought t

263 alteration of FAM190A may contribute to the chromosomal instability of cancer.

264 ncy did not modify the checkpoint defects or chromosomal instability of Mre11 complex mutants; howeve

265 s are found in many tumors, and the enhanced chromosomal instability of polyploid cells in culture su

266 cer cells, was significantly associated with chromosomal instability on 13q and 15q.

267 th in CAFs was significantly associated with chromosomal instability on 4q and 13q and lymphocyte tel

268 bsequent cell divisions, resulting in either chromosomal instabilities or cell cycle arrest.

269 r DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases.

270 early-stage tumors induced by oncoproteins, chromosomal instability, or DNA damage is associated wit

271 ession is a hallmark of cancer cells showing chromosomal instability, particularly in certain breast

272 High module scores of chromosomal instability, phosphatase and tensin homolog

273 attenuated p53 function and telomere-induced chromosomal instability play critical and cooperative ro

274 This hereditary disease is associated with chromosomal instability, premature aging and cancer pred

275 e precise mechanism underlying LANA-mediated chromosomal instability remains uncharted.

276 ndensation defects that underlie the ongoing chromosomal instability seen in aneuploid hPSCs.

277 e same patient samples suggesting a field of chromosomal instability surrounding the tumor.

278 Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone m

279 Fanconi anemia (FA) is an inherited chromosomal instability syndrome that is characterized b

280 The chromosomal instability syndromes Nijmegen breakage synd

281 The DCIS had a lower degree of chromosomal instability than the IDC.

282 ency program and the accumulation of genomic/chromosomal instability that leads to tumorigenesis.

283 Telomere shortening induces chromosomal instability that, in the absence of function

284 e the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways

285 sing disease progression in MPDs by inducing chromosomal instability through the production of DSBs a

286 Overexpression of Mad1 causes aneuploidy and chromosomal instability through weakening mitotic checkp

287 LANA also induces chromosomal instability, thus promoting oncogenesis.

288 Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mous

289 Previous studies showed that chromosomal instability was common in esophageal squamou

290 s overexpressing the oncogene c-Myc, but the chromosomal instability was not further enhanced when Md

291 Chromosomal instability was prevalent in nonhypermutated

292 fork stalling in FAN1-deficient cells causes chromosomal instability, we reasoned that the key functi

293 To address the question of chromosomal instability, we used FISH to evaluate the pe

294 To test how caspase-2 protects against chromosomal instability, we utilized an ex vivo system f

295 Genome doubling and ongoing dynamic chromosomal instability were associated with intratumor

296 osable elements (TEs) generate mutations and chromosomal instability when active.

297 ing during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor ce

298 Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inabilit

299 es mitophagy and results in the promotion of chromosomal instability, which enables tumor cells to ef

300 he reported Fanconi anemia (FA) mouse model, chromosomal instability with radial changes can be detec