ライフサイエンスコーパス: chromosomal loci

1 ences in the dynamic properties of different chromosomal loci.

2 es and epigenetic gene silencing at specific chromosomal loci.

3 annotated gene expression levels to specific chromosomal loci.

4 coordinately controlled by several unlinked chromosomal loci.

5 he known fluctuating and elastic dynamics of chromosomal loci.

6 tion of tRNA gene position effects at native chromosomal loci.

7 probes that hybridize to the 14q32 and 11q13 chromosomal loci.

8 m myositis and anti-Mi-2 autoantibodies at 4 chromosomal loci.

9 es may be most effective at highly expressed chromosomal loci.

10 omain is not primarily used to direct SCM to chromosomal loci.

11 structural functions by binding to specific chromosomal loci.

12 ns (ctn) contain copies of CTRT1 at multiple chromosomal loci.

13 c recombination and targeted modification of chromosomal loci.

14 cessibility and remodeling within endogenous chromosomal loci.

15 with the discrete positioning of particular chromosomal loci.

16 between introduced DNA and the corresponding chromosomal loci.

17 etween asthma-associated traits and specific chromosomal loci.

18 in each of these ethnic groups differ at two chromosomal loci.

19 causative gene in any of the NCLs at defined chromosomal loci.

20 ine retinal disease, others because of their chromosomal loci.

21 h the invasive carcinoma at some but not all chromosomal loci.

22 fragility of four, and apparently only four, chromosomal loci.

23 expression site (ES) promoters, into various chromosomal loci.

24 parison of an approximately random sample of chromosomal loci.

25 at 43 polymorphic autosomal loci and seven X chromosomal loci.

26 to distinguish genetic groups at plasmid and chromosomal loci.

27 cases, the multiple forms arise from single chromosomal loci.

28 mly repeated in plant genomes at one or more chromosomal loci.

29 pendent on genes located in several adjacent chromosomal loci.

30 rvation of spatiotemporal aspects of damaged chromosomal loci.

31 nsport of plasmids, protein machineries, and chromosomal loci.

32 oorganisms may arise by mutations at certain chromosomal loci.

33 ision impact recombinants formed at multiple chromosomal loci.

34 and insertion/deletion polymorphisms at five chromosomal loci.

35 ry genomic map of Rpd3L- and Rpd3S-regulated chromosomal loci.

36 introducing double-strand breaks at selected chromosomal loci.

37 reaks (DSBs) to be introduced into specified chromosomal loci.

38 ells and to target modifications of specific chromosomal loci.

39 leukin-6 (IL-6) STAT3-dependent promoters on chromosomal loci.

40 g, parSI stretches far away from neighboring chromosomal loci.

41 are also clustered on six cancer-associated chromosomal loci.

42 uage phenotypes was established at two novel chromosomal loci, 15q23-26 and 16p12.

43 of 18 UC specimens with instability at other chromosomal loci (17%) showed TGF-beta 1RII poly A tract

44 rs associated with tumor suppressor genes at chromosomal loci 1p, 3p, 5q, 9p, 10q, 17p, 17q, 18q, 21q

45 e have identified three vitamin D-responsive chromosomal loci (1p36, 19q13, and 6p25) and show the in

46 These translocation breakpoints involve six chromosomal loci: 4p16.3 (two lines and the one tumor);

47 ive of but not limited to genes localized to chromosomal loci 8p, 9p, 11q, and 13q.

48 Chromosomal loci adjacent to the integrated vector were

49 assess the overall genomic instability, and chromosomal loci affected by genomic alterations were de

50 ery that despite the disparate nature of the chromosomal loci affected by senescence in fibroblasts a

51 t shock and translocates from nucleoplasm to chromosomal loci after heat shock.

52 c complementation studies suggested that two chromosomal loci, agr and sar, are involved in the upreg

53 covered one novel human PTP gene and defined chromosomal loci and exon structure of the additional 37

54 Chromosomal loci and many protein complexes are position

55 nts, which are encoded by plasmid as well as chromosomal loci and mediate plasmid and genomic island

56 cription factors is discussed in relation to chromosomal loci and other nuclear domains.

57 ly our analysis to experimental data sets of chromosomal loci and RNA-protein particles in Escherichi

58 merase-II activity is concentrated at single chromosomal loci and that cleavage sites extend over app

59 ne strain is genetically heterogeneous at 46 chromosomal loci and that heterogeneity was maintained u

60 chromosomal abnormalities, including several chromosomal loci and the genes coding for p53, p57, and

61 has a strong impact on interactions between chromosomal loci, and appears to explain the tendency of

62 es affected with TAA have identified several chromosomal loci, and further mapping of familial TAA ge

63 ing loss of heterozygosity (LOH) at multiple chromosomal loci, and these aberrations are strongly ass

64 h H3K27Me2 and Ago2-2 concurrently enrich at chromosomal loci; and an established silencing phase in

65 Moreover, chromosomal loci are redirected toward the nucleolus and

66 3 (miR-133), which are clustered on the same chromosomal loci, are transcribed together in a tissue-s

67 Chromosomal loci associated with 49 DCPs were confirmed

68 been made in the identification of genes and chromosomal loci associated with several types of motor

69 interacts with adenine and thymine (AT)-rich chromosomal loci, associates with the promoter regions o

70 d which places the replication machinery and chromosomal loci at defined locations that change during

71 es to partition and place many, if not most, chromosomal loci at defined subcellular sites.

72 Tracking the motion of chromosomal loci at short timescales provides informatio

73 Centromeres are the chromosomal loci at which spindle microtubules attach to

74 the same gene expression state at individual chromosomal loci before and after DNA replication.

75 early activation of late origins at internal chromosomal loci but did not alter the initiation timing

76 as powerful tools to alter genomes and mark chromosomal loci, but an inexpensive method for generati

77 roducing the target gene into pre-determined chromosomal loci, but recombination between the availabl

78 DNA was analyzed in duplicate for LOH at 10 chromosomal loci by PCR and polyacrylamide gel electroph

79 ication in metazoans initiates from multiple chromosomal loci called origins.

80 Functional silencing of chromosomal loci can be induced by transgenes (cosuppres

81 dered to function by targeting regulators to chromosomal loci carrying specific histone modifications

82 bes the relative probabilities that pairs of chromosomal loci collide with one another in living cell

83 was twice that of the X rDNA array with both chromosomal loci containing regions where the rate of el

84 rosophila ovarian follicle cells amplify the chromosomal loci containing the chorion gene clusters up

85 To map chromosomal loci contributing to DAT susceptibility, we

86 As a first step toward identification of chromosomal loci contributing to genetic predisposition

87 To identify chromosomal loci contributing to vulnerability, we have

88 phila Rabs with YFP(MYC) at their endogenous chromosomal loci, determined their expression and subcel

89 s hybridization of transcripts to homologous chromosomal loci distinct from their site of synthesis.

90 y, we use single-particle tracking of tagged chromosomal loci during interphase in live yeast cells t

91 -tagged proteins expressed from their native chromosomal loci, examining cytosolic dynamics and inter

92 of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics.

93 To ascertain whether distinct chromosomal loci existed that were linked to severe obes

94 When integrated at either of two chromosomal loci, expansion rates were 1 x 10(-5) to 4 x

95 llin genes that are uniquely arranged in two chromosomal loci, flaABCDE and flaF.

96 V. cholerae flagellin genes, arranged in two chromosomal loci, flaAC and flaEDB; all five genes have

97 Our linkage data suggest specific chromosomal loci for future fine-mapping genetic analysi

98 ow Rnf20 is recruited to its specific target chromosomal loci for the establishment of H2Bub1.

99 smokers and nonsmokers that were located at chromosomal loci frequently altered in non-small cell lu

100 nactivation of several of the genes at their chromosomal loci had no effect on the intracellular grow

101 Linkage to several chromosomal loci has been established for other forms of

102 gments containing the ade6-M26 gene to other chromosomal loci has previously demonstrated that the he

103 The direct visualization of specific chromosomal loci has revealed that bacteria condense, mo

104 er in up to 19% of patients, and a number of chromosomal loci have been identified for the condition.

105 Different chromosomal loci have been linked with three autosomal d

106 However, conflicting chromosomal loci have been reported in human genomic dat

107 Early reports of linkage to chromosomal loci have fallen into doubt; however they ha

108 The 15 reproducible chromosomal loci identified here are good candidates to

109 g(2+), forms feedforward loops that regulate chromosomal loci identified through a motif search over

110 sk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological process

111 complex rearrangements occur at one or a few chromosomal loci in a single catastrophic event.

112 hypothesized that subcellular positioning of chromosomal loci in bacteria may be influenced by gene f

113 0.1-10 s) dynamics of fluorescently labelled chromosomal loci in Escherichia coli at different growth

114 e protein expression affects the position of chromosomal loci in Escherichia coli.

115 omplex, as it is associated with hundreds of chromosomal loci in euchromatin of salivary gland polyte

116 genomes supported the involvement of various chromosomal loci in glycan metabolism.

117 emonstrate simultaneous imaging of up to six chromosomal loci in individual live cells and document l

118 Our approach first labels and tracks chromosomal loci in live cells with the CRISPR-Cas9 syst

119 do not suppress the aberrant positioning of chromosomal loci in mukB cells, despite suppressing the

120 ntified the mobility of a pair of homologous chromosomal loci in the interphase nuclei of Caenorhabdi

121 romosome segregation by visualizing specific chromosomal loci in the presence and absence of the Tus

122 We examined the arrangement of chromosomal loci in the very large, highly polyploid, un

123 Whether instability was present at other chromosomal loci in these lesions was determined.

124 By tracking fluorescently labeled chromosomal loci in thousands of cells throughout the en

125 ) are widely used to monitor the behavior of chromosomal loci in various systems.

126 track and analyze the movements of specific chromosomal loci in vivo using four-dimensional microsco

127 We identified several chromosomal loci in which many (sometimes more than 20)

128 IgH) translocations that involve 5 recurrent chromosomal loci, including 11q13 (cyclin D1), 6p21 (cyc

129 re U snRNPs but also associate with specific chromosomal loci, including gene clusters that encode U

130 shown to play diverse functions at multiple chromosomal loci, including telomeres.

131 antibody stained coiled bodies and specific chromosomal loci, including terminal granules, axial gra

132 dividual residuals, grouped or aggregated by chromosomal loci, indicate problematic samples and poten

133 Chromosomal loci involved in the recombination were foun

134 Loss of heterozygosity (LOH) at several chromosomal loci is a common feature of the malignant pr

135 eems likely that the cellular positioning of chromosomal loci is the outcome of the formation of two

136 Chromosomal loci jiggle in place between segregation eve

137 has been recognized previously and highlight chromosomal loci likely to contain oncogenes or tumor su

138 rential expression of six genes localized to chromosomal loci linked to forms of human hereditary myo

139 tem, which allows inducible amplification of chromosomal loci linked to the SV40 origin.

140 The first model is a dissection of chromosomal loci linked to the variance in airway respon

141 rays in vivo and brings spatial proximity of chromosomal loci marked with those arrays back to the wi

142 on of the R and C subunit genes to different chromosomal loci, mechanisms exist that coordinately reg

143 nduce H3K27Me2 deposits at both episomal and chromosomal loci, mediating gene silencing.

144 stance to quinolones was assigned to several chromosomal loci, mostly encoding transport systems that

145 H locus and a diverse but nonrandom array of chromosomal loci occur in most multiple myeloma (MM) tum

146 Sequence variation was determined in 10 chromosomal loci of 231 strains that predominantly origi

147 The chromosomal loci of both proviruses were determined in t

148 gy, similar genomic structure, and identical chromosomal loci of hKID, MIP, and AQP-2 suggest a MIP f

149 ociation of genotypes at plasmid-encoded and chromosomal loci of native Rhizobium, the nitrogen-fixin

150 As test cases, the chromosomal loci of the C. glabrata genes encoding amino

151 transgenic mouse lines, irrespective of the chromosomal loci of the insertion sites.

152 the genome or is concentrated at just a few chromosomal loci or on plasmids.

153 (with the exception of some autosomal and X-chromosomal loci) or for the time of separation between

154 chromatid cohesion and localize to the same chromosomal loci over the same cell cycle window.

155 apping deletions are only available at a few chromosomal loci, partly due to drawbacks of existing me

156 recombination intermediates at interstitial chromosomal loci, perhaps through the noncrossover branc

157 achomatis, glgA and other plasmid-responsive chromosomal loci (PRCLs) were transcriptionally responsi

158 Nucleotide sequence analysis of chromosomal loci previously identified through insertion

159 Common fragile sites are chromosomal loci prone to breakage and rearrangement, hy

160 ontaneous, loss-of-function mutations at two chromosomal loci (pyrF and pyrE) enabled the first molec

161 Several chromosomal loci reflect potential adaptation to the inf

162 The present study identified the possible chromosomal loci regulating fear conditioning in BXD rec

163 y which this complex is targeted to specific chromosomal loci remains unknown.

164 Centromeres are chromosomal loci required for accurate segregation of si

165 Although 6 chromosomal loci responsible for autosomal dominant FDCM

166 evious studies of intraspecific variation at chromosomal loci, revealing that lacY has unusually low

167 rvation in the context of the defined murine chromosomal loci ROSA26 and TIGRE.

168 n frequencies and rates were measured at two chromosomal loci, rpoB and gyrA, and base substitution a

169 Four chromosomal loci showed suggestive evidence of linkage:

170 none of the ARD QTLs was homologous to human chromosomal loci so far implicated in age-related macula

171 Of thousands of chromosomal loci studied, the same locus had the stronge

172 Two distinct chromosomal loci, termed major (chromosome 3) and minor

173 ikely to undergo homologous recombination at chromosomal loci than parental cells.

174 Chromosomal loci that are enriched sources of microDNA i

175 s frequently contain fragments from multiple chromosomal loci that are fused to form new open reading

176 essed the stability of common fragile sites, chromosomal loci that are prone to breakage in cells und

177 Two S. flexneri chromosomal loci that are required for these processes w

178 kage studies have attempted only to identify chromosomal loci that cause or increase the risk of deve

179 Centromeres are chromosomal loci that direct segregation of the genome d

180 We screened chromosomal loci that encode known and predicted Tat-dep

181 eneral screen for tetracycline (Tet)-induced chromosomal loci that exhibited Tet-activated or Tet-rep

182 Centromeres are the chromosomal loci that facilitate segregation, and, in mo

183 9 genetic variants in 128 candidate genes or chromosomal loci that had at least three data sources.

184 nction and found mutations in three separate chromosomal loci that had this phenotype.

185 the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this

186 Cytogenetic studies have targeted candidate chromosomal loci that may be perturbed during cardiac li

187 covered one significant and three suggestive chromosomal loci that modulate tau phosphorylation.

188 We also identified several chromosomal loci that possess pagC-type genes without th

189 Centromeres are unique chromosomal loci that promote the assembly of kinetochor

190 We first identified chromosomal loci that were strongly associated with coro

191 DNA sequences of four chromosomal loci (the 16S rRNA gene, flaB, gyrB, and glp

192 microarrays identified a conserved group of chromosomal loci, the expression of which was similarly

193 r positional identity, are clustered in four chromosomal loci; the Hox genes are expressed in nested

194 introducing double-strand breaks at specific chromosomal loci, thereby increasing the recombination f

195 otobleaching show a rapid exchange of HSF at chromosomal loci under non-heat-shock conditions but a v

196 of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility.

197 fragments specific for three M. tuberculosis chromosomal loci used for the identification of W-Beijin

198 RSS or the insertion of signal circles into chromosomal loci via a V(D)J recombination-like mechanis

199 Amplification bias among eight chromosomal loci was less than 3-fold in contrast to 4-6

200 To identify chromosomal loci, we performed a genome scan on 939 F(2)

201 Individual chromosomal loci were detected by expression of a protei

202 0 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion.

203 A copy of bacteriophage HP1 and 46 further chromosomal loci were identified in the BPF but not in t

204 Multiple chromosomal loci were identified, including an insertion

205 The cellular positions of other chromosomal loci were in the wild-type order relative to

206 eous patterns of allelic loss at one or more chromosomal loci were observed in adjacent DCIS foci.

207 Nucleolus organizer regions (NORs) are chromosomal loci where hundreds of rRNA genes are cluste

208 ellite analysis for allelic loss at 10 major chromosomal loci which have been defined previously.

209 lative probabilities that different pairs of chromosomal loci will collide with one another in vegeta

210 GFP provides an improved system for studying chromosomal loci with a low pairing background.

211 transgene can be inserted into predetermined chromosomal loci with high efficiency (up to 40%), and f

212 nt types of mutations can be introduced into chromosomal loci with high fidelity and without genotoxi

213 can be efficiently mobilized from a range of chromosomal loci with high inducibility and low backgrou

214 This analysis revealed 3 chromosomal loci with multiple markers demonstrating evi

215 f AN and BMI loci revealed variants at three chromosomal loci with potential joint impact.