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1 nt fusion partner in leukemia patients (8p11 chromosomal rearrangements).
2 relationships and/or extremely low rates of chromosomal rearrangement.
3 4 mRNA is not exclusive to cases harboring a chromosomal rearrangement.
4 in the clinical interpretation of non-coding chromosomal rearrangements.
5 o promote tumorigenesis by causing oncogenic chromosomal rearrangements.
6 rtions or deletions, copy number changes and chromosomal rearrangements.
7 chromosomes, followed by numerous additional chromosomal rearrangements.
8 from the zygotic nucleus through a series of chromosomal rearrangements.
9 sruption of RAD51 activity and generation of chromosomal rearrangements.
10 mosomal fragile sites that can trigger gross chromosomal rearrangements.
11 lso shed light on the origin of endemic-like chromosomal rearrangements.
12 lternative RNA splicing events and oncogenic chromosomal rearrangements.
13 ave an intrinsic predisposition for frequent chromosomal rearrangements.
14 ve DNA elements, repair of which can lead to chromosomal rearrangements.
15 and trex2(null) cells exhibited spontaneous chromosomal rearrangements.
16 ontaneous broken chromosomes and spontaneous chromosomal rearrangements.
17 ent-related leukemias characterized by 11q23 chromosomal rearrangements.
18 ns and deletions, copy number variation, and chromosomal rearrangements.
19 ecular defects, tumor spectrum and oncogenic chromosomal rearrangements.
20 slocation is a universal mechanism producing chromosomal rearrangements.
21 end-joining, neither of which leads to gross chromosomal rearrangements.
22 ongly correlated with the formation of gross chromosomal rearrangements.
23 logous recombination, thus avoiding possible chromosomal rearrangements.
24 inational repair of a DSB and enhances gross chromosomal rearrangements.
25 by triggering double-strand breaks and gross chromosomal rearrangements.
26 raction, possibly >50%, of mosaic diagnostic chromosomal rearrangements.
27 diated DNA damage response, DNA lesions, and chromosomal rearrangements.
28 f DNA replication in the initiation of these chromosomal rearrangements.
29 1 gene encoding cyclin D1, and other complex chromosomal rearrangements.
30 loss of gene expression in studies involving chromosomal rearrangements.
31 alled/collapsed forks by processes involving chromosomal rearrangements.
32 y oncogenic chimeric proteins resulting from chromosomal rearrangements.
33 hat Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements.
34 erve as fragile sites that generate DSBs and chromosomal rearrangements.
35 deed, RNase H-deficient cells have increased chromosomal rearrangements.
36 ) continuously arise and cause mutations and chromosomal rearrangements.
37 they were thought to be generated solely by chromosomal rearrangements.
38 of DNA replication errors and attenuation of chromosomal rearrangements.
39 c.131G>A variant-expressing uteri developed chromosomal rearrangements.
40 als compared with perennials, due in part to chromosomal rearrangements.
41 wth defect with sgs1Delta and elevated gross chromosomal rearrangements.
42 termine the origin and mechanisms of complex chromosomal rearrangements.
43 solution of recombination intermediates into chromosomal rearrangements.
44 ter remnants became reunited via large-scale chromosomal rearrangements.
45 fission induces the formation of large-scale chromosomal rearrangements.
46 n downregulation, in particular TRF2, favors chromosomal rearrangements.
47 h sgs1Delta and exo1Delta and elevated gross chromosomal rearrangements.
49 of 152, mostly de novo, apparently balanced chromosomal rearrangement (ABCR) breakpoints in 76 indiv
52 to be effective, NIPT must be able to detect chromosomal rearrangements across the whole genome for a
54 a unique opportunity to analyze genome-scale chromosomal rearrangements among a group of closely rela
55 y number alterations, translocations, and/or chromosomal rearrangements--an be leveraged, in principl
56 particularly susceptible to the formation of chromosomal rearrangements analogous to those observed i
58 l variation includes many different types of chromosomal rearrangement and encompasses millions of ba
59 display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the p
60 of transposable elements, small RNA content, chromosomal rearrangement and segregation distortion.
61 , describe the diverse mutational origins of chromosomal rearrangements and argue that their complexi
62 with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancest
63 und a highly significant association of both chromosomal rearrangements and CNVs with elevated recomb
64 in whole genome sequencing, detect balanced chromosomal rearrangements and compute enrichment of mes
65 enomic region is particularly susceptible to chromosomal rearrangements and contains many genes cruci
66 These adducts have been suggested to cause chromosomal rearrangements and contribute to cytotoxicit
67 ncer transcriptome and genome has identified chromosomal rearrangements and copy number gains and los
69 Here we developed a novel strategy using chromosomal rearrangements and embryonic phenotypes to p
70 DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heteroz
71 ) was recently proposed to explain clustered chromosomal rearrangements and genomic amplifications in
72 ation has long been associated with specific chromosomal rearrangements and genomic disorders, but it
73 efficacy of the method for genotyping large chromosomal rearrangements and haplotyping SNPs over lon
74 In addition, we observed a higher number of chromosomal rearrangements and higher frequency of reten
75 ver outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
77 n only detect the majority of larger (>6 Mb) chromosomal rearrangements and requires knowledge of fet
78 dure for the modeling or correction of large chromosomal rearrangements and short nucleotide repeat e
79 hat the molecular mechanisms responsible for chromosomal rearrangements and some duplicated genes hav
80 eld of existing microarray testing for large chromosomal rearrangements and targeted CNV detection.
83 utionary processes such as genome expansion, chromosomal rearrangement, and chromosomal translocation
84 efine new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis.
85 rrant telomere maintenance, premature aging, chromosomal rearrangements, and predisposition to malign
86 is that there is an association between CNV, chromosomal rearrangements, and recombination by correla
87 sized B. napus involved aneuploidy and gross chromosomal rearrangements, and that dosage balance mech
88 osome translocation, trans-splicing, complex chromosomal rearrangements, and transcriptional read thr
89 titution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantiall
90 -nuclear and nuclear-cytoplasmic factors and chromosomal rearrangements appear to contribute to intri
91 cell lymphomas in humans are associated with chromosomal rearrangements ( approximately 40%) and/or m
101 icarte-Filho and colleagues demonstrate that chromosomal rearrangements are the oncogenic "drivers" i
102 ies are modestly reduced in these cells, and chromosomal rearrangements arise at elevated rates in re
103 vestigated both loss of genetic material and chromosomal rearrangement as possible causes of LMNB1 ov
104 ic factors accumulate, fostering large-scale chromosomal rearrangements as functional reduction proce
105 l features that may point to the presence of chromosomal rearrangements as the primary disease cause.
106 etween levels of genetic differentiation and chromosomal rearrangements (as reported in a prior publi
108 mechanistic insight into the way a balanced chromosomal rearrangement associated with a neurodevelop
109 n a head-to-tail configuration and joined by chromosomal rearrangement at the amphibian-to-reptile ev
110 We defined the genetic landscape of balanced chromosomal rearrangements at nucleotide resolution by s
113 xt-generation DNA sequencing, we developed a chromosomal rearrangement-based approach to differentiat
115 c damage through insertional mutagenesis and chromosomal rearrangements between non-allelic SINEs at
117 cies, hybrid sterility is probably caused by chromosomal rearrangements, but for all the other specie
118 ted in the mapping of 77 breakpoints from 40 chromosomal rearrangements by FISH with BACs and fosmids
119 ts on genome integrity could be critical, as chromosomal rearrangements can lead to reproductive isol
120 In approximately 50% of prostate cancers, chromosomal rearrangements cause the fusion of the promo
122 vation results in hyper-recombination, gross chromosomal rearrangements, chromosome segregation defec
123 ormalities in newborns with de novo balanced chromosomal rearrangements, comprehensive interpretation
124 by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to ac
125 acterized their recurrent somatic mutations, chromosomal rearrangements, copy number alterations (CNA
127 mosomal polymorphisms largely resulting from chromosomal rearrangements (CRs) are widely documented i
128 sulted via several other mechanisms, such as chromosomal rearrangements, deletion/insertion, transpos
131 g a cryptic heptamer implicated in oncogenic chromosomal rearrangements, destabilize the PCC, allowin
132 ying the evolutionary forces responsible for chromosomal rearrangements, determining how often prezyg
133 imary 53BP1(-/-) B cells revealed that their chromosomal rearrangements differ from those found in wi
135 challenge the claim that the accumulation of chromosomal rearrangements drive complete reproductive i
137 n easy screen for studying the mechanisms of chromosomal rearrangements during the propagation of a s
140 t an oxidative stress is responsible for the chromosomal rearrangements found in radio-induced papill
141 SGS1 results in a 110-fold increase in gross chromosomal rearrangement frequency during aging of nond
142 (TFG) promotes tumorigenesis when present in chromosomal rearrangements from various human-cancer typ
144 creens for mutations causing increased gross chromosomal rearrangement (GCR) rates in Saccharomyces c
146 to DNA replication are known to induce gross chromosomal rearrangements (GCRs) and copy-number variat
149 s, small DNA insertions/deletions, and gross chromosomal rearrangements (GCRs) in sch9Delta mutants i
151 ommon processes such as suppression of gross chromosomal rearrangements (GCRs), DNA repair, modificat
153 c28 activity results in suppression of gross chromosomal rearrangements (GCRs), indicating that Cdc28
157 own to have a major role in preventing gross chromosomal rearrangements (GCRs); however, relatively l
159 re Sequencing (TC-Seq), a method to document chromosomal rearrangements genome-wide, in primary cells
160 l variations and genetic elements, including chromosomal rearrangements, genomic macrosynteny, gene f
161 This seems one of the few cases where a chromosomal rearrangement has been functionally demonstr
162 of genes affected by disease-associated rare chromosomal rearrangements has led to the cloning of sev
168 int mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tum
169 anges, ranging from point mutations to large chromosomal rearrangements, have been identified in pati
170 gy to successfully generate several types of chromosomal rearrangements implicated as driver events i
171 1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exc
172 presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells.
173 mia 1 (TCL1) oncoprotein is overexpressed by chromosomal rearrangement in the majority of cases of T-
174 tly increased the rate of accumulating gross-chromosomal rearrangements in a dosage-dependent manner
176 Examination of the coordinates of various chromosomal rearrangements in conjunction with the genom
178 f over 1700 breakpoints from the most common chromosomal rearrangements in human leukemias and lympho
180 riants of uncertain significance, especially chromosomal rearrangements in non-coding regions of the
181 type and the high rate of formation of gross chromosomal rearrangements in pif1Delta mutants, suggest
182 or detection of both balanced and unbalanced chromosomal rearrangements in primary human tumour sampl
183 -generation sequencing techniques to examine chromosomal rearrangements in primary murine B cells and
184 However, somatic alterations predisposing to chromosomal rearrangements in prostate cancer remain lar
187 bors a direct repeat, and are prone to gross chromosomal rearrangements in response to replication st
188 and evaluate sequencing results of balanced chromosomal rearrangements in ten prenatal subjects with
189 hould be considered as alternatives to gross chromosomal rearrangements in the interpretation of whol
190 cribe an efficient method to induce specific chromosomal rearrangements in vivo using viral-mediated
191 y fuse inverted repeats to generate unstable chromosomal rearrangements in wild-type mouse embryonic
192 dem duplications, and clinically significant chromosomal rearrangements including MLL translocations
193 ells exhibit reduced proliferation and gross chromosomal rearrangements including Robertsonian transl
195 ng-range haplotyping and characterization of chromosomal rearrangements, including copy number variat
197 ells containing inverted dimers led to gross chromosomal rearrangements, including translocations, tr
198 -Myc/DNMT3B7 mediastinal lymphomas have more chromosomal rearrangements, increased global DNA methyla
200 ethanesulfonate-derived mutant shows unusual chromosomal rearrangement instead of a point mutation.
203 g approximate boundaries of intra- and extra-chromosomal rearrangements involving gene orthologs, whi
204 noma, is defined by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4-N
208 standardized characterization of structural chromosomal rearrangements is essential both for researc
209 also identify multiple cases of catastrophic chromosomal rearrangements known as chromoanagenesis, in
211 icronuclei levels, the number of large-scale chromosomal rearrangements (LST), and the status of seve
212 ansposable element system can generate major chromosomal rearrangements (MCRs), but the underlying me
213 occus species provide evidence that multiple chromosomal rearrangements mediated by intercentromeric
217 : Mature B-cell lymphomas bearing concurrent chromosomal rearrangement of MYC/8q24 and BCL2/18q21 are
218 resulted in genome plasticity manifested as chromosomal rearrangement of syntenic blocks and DNA ins
219 etected several expected events, including a chromosomal rearrangement of the nonessential arm of chr
224 The genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage leukemia
226 expression signature predominantly driven by chromosomal rearrangements of the ZNF384 gene with histo
227 FET proteins are of medical interest because chromosomal rearrangements of their genes promote variou
231 can be generated either through insertional chromosomal rearrangement or by intrachromosomal deletio
232 ted recombination in hybrids, such as within chromosomal rearrangements or areas adjacent to centrome
233 nongradual, saltatory leaps, driven through chromosomal rearrangements or genome doubling, may be pa
234 s (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple misc
235 crotransposition, we have analyzed heritable chromosomal rearrangements produced by a chromosome-brea
236 palindromic duplications, the major class of chromosomal rearrangements recovered from yeast cells la
237 e B. napus cultivar Stellar, we detected one chromosomal rearrangement relative to the parental karyo
238 ke effector genes and has at least ten major chromosomal rearrangements relative to KACC10331 and MAF
241 ents between LCRs during meiosis can lead to chromosomal rearrangements responsible for many genomic
243 proportion of human prostate cancers carry a chromosomal rearrangement resulting in the overexpressio
245 peats on chromosome 22q11.2 (LCR22s) mediate chromosomal rearrangements resulting in deletions, dupli
246 re can affect the whole cell and may lead to chromosomal rearrangements resulting in genomic instabil
247 te cancers have been shown to have recurrent chromosomal rearrangements resulting in the fusion of th
248 ly, while others are recurrently involved in chromosomal rearrangement, resulting in breakpoint reuse
249 ed to include DNA gene knock-out, deletions, chromosomal rearrangements, RNA editing and genome-wide
253 reads can also be used to delineate complex chromosomal rearrangements, such as those that occur in
254 t the potato and tomato genomes contain more chromosomal rearrangements than those reported previousl
255 ously published E. coli construct revealed a chromosomal rearrangement that alleviates replication-tr
257 ation of Robertsonian (Rb) fusions, a common chromosomal rearrangement that joins two telocentric chr
258 en exhibit genomic instability, resulting in chromosomal rearrangements that affect the structure and
260 l proximity within the nucleus can result in chromosomal rearrangements that are important in the pat
261 are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating
262 tation was disrupted only in the presence of chromosomal rearrangements that break<or=650 kbp from ye
263 arising during DNA replication and prevents chromosomal rearrangements that can occur from the misre
265 unexpected CNV complexities, including inter-chromosomal rearrangements that cannot be resolved by aC
266 mors from these mice might exhibit oncogenic chromosomal rearrangements that cooperate with activated
268 dinated epigenetic effects of constitutional chromosomal rearrangements that disrupt genes associated
269 g data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancer
272 x interplay between duplicated sequences and chromosomal rearrangements that rapidly alter the cytoge
273 gous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregat
274 low copy repeats (LCRs) mediate many of the chromosomal rearrangements that underlie these disorders
276 tabilize the genome by causing mutations and chromosomal rearrangements, the driving forces for carci
277 D loci onto the same chromosome, and further chromosomal rearrangements then resulted in the 2 MAT lo
279 tgroup comparisons allowed directionality of chromosomal rearrangements to be established, enabling p
282 by Ed Lewis, we generated and characterized chromosomal rearrangements to define a region in cis to
283 thyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leuke
284 c1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of mali
285 ated by sensitivity to sex steroids, and the chromosomal rearrangement underlying the polymorphism ha
286 We developed bioinformatic tools to identify chromosomal rearrangements using genome-wide, next-gener
289 s from C. arabica and C. canephora, numerous chromosomal rearrangements were detected, including inve
292 distribution of heterochromatins, as well as chromosomal rearrangements, were uncovered between the t
293 er is able to accurately reconstruct complex chromosomal rearrangements when compared to well-charact
294 nents, originating from the A complement via chromosomal rearrangements, which follow their own evolu
295 ission, all MRE populations showed extensive chromosomal rearrangements, which we attributed to genet
296 erval, was deleted in a patient with an 8q23 chromosomal rearrangement, while its expression was sign
297 novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential re
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