ライフサイエンスコーパス: chromosomal region

1 DOCK4 as a pathogenic gene located on the 7q chromosomal region.

2 deficiency complementation analysis on this chromosomal region.

3 es and it maps the mutated gene to a defined chromosomal region.

4 and horn length is attributable to the same chromosomal region.

5 the cell, a position characteristic of that chromosomal region.

6 aternally expressed gene(s) in the 15q11-q13 chromosomal region.

7 esence of a tumor suppressor gene(s) in this chromosomal region.

8 ytokines that have genes located in the same chromosomal region.

9 s flanking genes, diverged from a duplicated chromosomal region.

10 nce of tumor suppressor genes (TSGs) in this chromosomal region.

11 rther suppresses DSBs within the surrounding chromosomal region.

12 ession of genes located in amplified/deleted chromosomal regions.

13 tes frequently involves interactions between chromosomal regions.

14 which recruits more MRN to the DSB-flanking chromosomal regions.

15 ting regulatory interactions across discrete chromosomal regions.

16 ogaster heterochromatic sequence to specific chromosomal regions.

17 were preferentially targeted to transcribed chromosomal regions.

18 syndromes and with common variants from 3-5 chromosomal regions.

19 significant evidence of linkage to specific chromosomal regions.

20 ogenes and tumor suppressors) found in those chromosomal regions.

21 ential loss of methylated TEs from gene-rich chromosomal regions.

22 will help to penetrate the core of apomixis chromosomal regions.

23 hin the silent-mating-type loci and telomere chromosomal regions.

24 elevations is also a feature of subtelomeric chromosomal regions.

25 as, including three common major polymorphic chromosomal regions.

26 genomic stability tunes plasticity of these chromosomal regions.

27 ial genomes to allow cotransfer of disparate chromosomal regions.

28 e proximity to NUP-1, the NPCs and telomeric chromosomal regions.

29 telomeric sequence insertion (TSI) at intra-chromosomal regions.

30 partition system highly correlate with dense chromosomal regions.

31 ervation of gene arrangement (synteny) along chromosomal regions.

32 r the maintenance of mating-type determining chromosomal regions.

33 nt loci met this threshold in eight distinct chromosomal regions.

34 ng seven independent glioma risk loci in six chromosomal regions.

35 stances on randomly selected non-centromeric chromosomal regions.

36 transcribed parents and reside in gene-rich chromosomal regions.

37 ptional "hot spots" that represent activated chromosomal regions.

38 ortionately fewer copies of late-replicating chromosomal regions.

39 Chromosomal region 1-1/1-1-3 was found to influence the

40 n higher eukaryotes commonly encompass broad chromosomal regions (100 kb and more) and are littered w

41 Linkage to chromosomal regions 10q22 and 6q23 with maximum logarith

42 Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have bee

43 nding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified

44 fied two susceptibility loci: for lobar ICH, chromosomal region 12q21.1 (rs11179580, odds ratio [OR]

45 factor with typical ZNF and KRAB domains, in chromosomal region 13q12.11 (beta = 0.14 SD, P = 3.5 x 1

46 Deletion of chromosomal region 13q14 represents the most common gene

47 A common variant on chromosomal region 15q24-25.1, marked by rs1051730, was

48 Recurrent deletions and duplications at chromosomal region 16p11.2 are a major genetic contribut

49 Copy number variations of human chromosomal region 16p11.2 are genetically linked to 1%

50 Deletion of the recurrent ~600 kb BP4-BP5 chromosomal region 16p11.2 has been associated with a wi

51 cleotide polymorphisms (SNPs) located in the chromosomal region 16p13.13 have been previously associa

52 c hearing impairment (ARNSHI), was mapped to chromosomal region 16q21-q23.2 in three unrelated, consa

53 Sequence analysis of six chromosomal regions (16S rRNA, gltA, groEL, ftsZ, rpoB,

54 c Acid Induced 1 gene (RAI1), located in the chromosomal region 17p11.2.

55 The chromosomal region 17q23 containing the RPS6KB1 gene is

56 CYGB is assigned to chromosomal region 17q25, which is frequently lost in mu

57 TOC locus to a small genomic interval within chromosomal region 17q25.

58 PSORS2 (psoriasis susceptibility locus 2) to chromosomal region 17q25.3-qter after a genome-wide link

59 tors encoded in the immune response locus in chromosomal region 1p36.

60 56, p = 7.0 x 10(-8)); and for nonlobar ICH, chromosomal region 1q22 (rs2984613, OR = 1.44, p = 1.6 x

61 Bone morphogenetic protein 2 (BMP2) in chromosomal region 20p12 belongs to a gene superfamily e

62 CK1; gene, PCK1 orthologous/homologous human chromosomal region 20q13.31) at 0.9 gestation (G).

63 inct constitutional microdeletions involving chromosomal region 21q22.12.

64 ll as new mutator candidates PPP2R2A and the chromosomal region 22q13.33.

65 ovel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22, 15q24 and 19p13).

66 e a large cohort with genetic alterations of chromosomal region 2q23.1 and acquired 65 subjects with

67 Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-

68 are risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another

69 ied a recurrent focal amplification on mouse chromosomal region 2qB, which contains the LIM-homeodoma

70 Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homo

71 order to a approximately 16.8 cM interval in chromosomal region 3q22-24, and by sequencing candidate

72 s are identified (these include deletions in chromosomal regions 3q27, 3p13, and 3p26 and duplication

73 tic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent associat

74 Amplification of chromosomal region 5q31-5q35.3 has been used to predict

75 tors expressed by myeloid cells 2 (TREM2) in chromosomal region 6p21 (p = 10(-10)).

76 ophila hindgut development; (b) it lies in a chromosomal region (6p22.1) amplified in colorectal canc

77 7q11.23) and deletion (Williams syndrome) of chromosomal region 7q11.23 cause neurodevelopmental diso

78 cant associations for several markers in the chromosomal region 7q21.12 harbouring both the ABCB1 and

79 C1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15.

80 Mtss1 is located within chromosomal region 8q23-24, which is one of the three mo

81 at the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C

82 the DMS-MFH tumor-suppressing-gene locus to chromosomal region 9p21-22 but failed to identify mutati

83 The chromosomal regions across the human orthologous were in

84 Genovese and colleagues examined large chromosomal regions adjacent to MYH9 using genome-wide a

85 ed expression levels were located within the chromosomal regions affected by the segmental aneuploidy

86 A total of 22 chromosomal regions, all containing putative TP0092-bind

87 ules, including the identification of shared chromosomal regions among affected family members, prior

88 Mendelian inheritance or identifying shared chromosomal regions among affected family members.

89 istic coevolution between two tightly linked chromosomal regions: an inducer region that initiates re

90 in the bulk of association between the 10q26 chromosomal region and AMD.

91 methylated promoters tend to cluster by both chromosomal region and gene function.

92 s in multiple cancer samples across the same chromosomal region and has greater implication in tumori

93 We mapped the disease to the 2q34-q36.1 chromosomal region and identified a homozygous splice mu

94 report refined mapping of Idd4.1 to a 1.1-Mb chromosomal region and provide genomic sequence analysis

95 uperfamily (IgSF) genes in the human 1q21-23 chromosomal region and revealed significant diversity fo

96 markers to estimate genetic ancestry in each chromosomal region and then tested the association betwe

97 are encoded in a single contiguous gene-rich chromosomal region and VCBP3 is encoded in a separate lo

98 DnaA also binds to other chromosomal regions and functions as a transcription fac

99 al profiling identified several dysregulated chromosomal regions and genes representing an enriched s

100 t findings that demonstrate the movements of chromosomal regions and genomic loci in association with

101 sion, as well as for fluorescence tagging of chromosomal regions and individual mRNAs to track their

102 s (TSF) are variable, being dependent on the chromosomal regions and potential competition with endog

103 rent papillomaviruses interact with distinct chromosomal regions and targets.

104 We demonstrate that pairing involves larger chromosomal regions and that the two chromosome territor

105 Web-based system to find and align syntenic chromosomal regions and visualize the output in an intui

106 ch confine centromere activity to a discrete chromosomal region, and holocentric organisms, which dis

107 a sequence-based physical map for a complex chromosomal region, and we raise the possibility of poly

108 mes in order to identify putative homologous chromosomal regions, and align these regions using genes

109 calize SlmA DNA sites near membrane-tethered chromosomal regions, and cellular studies show that SlmA

110 are found in both intergenic and intragenic chromosomal regions, and contain an array of diverse mot

111 Three chromosomal regions are associated with a significant di

112 but it is not the only actor and particular chromosomal regions are known to facilitate the meiotic

113 ting that the mechanisms of how heterologous chromosomal regions are silenced involves, at some stage

114 n genes, which lie in a relatively gene-poor chromosomal region, are not bound by this complex in non

115 ted in cis tend to be located in polymorphic chromosomal regions, are preferentially associated with

116 We recently identified Mpdz within this chromosomal region as a gene that influences alcohol and

117 The gene maps to the same chromosomal region as the maximum peak we observed in a

118 tortions are present at multiple scales, and chromosomal regions as broad as 5 Mb show a significant

119 Here, we used excision of chromosomal regions as circular "loop outs" to convert s

120 lly expressed Magel2 gene, which maps to the chromosomal region associated with Prader-Willi Syndrome

121 European population have identified multiple chromosomal regions associated with blood pressure, and

122 Genome-wide studies can determine chromosomal regions associated with IBK susceptibility.

123 The present study was conducted to identify chromosomal regions associated with thylakoid membrane d

124 recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase

125 tive trait loci (QTL) into a 2.0-cM (2.2 Mb) chromosomal region between genetic marker D11Mit70 and t

126 es reveal that TAF3 localizes to a subset of chromosomal regions bound by CTCF/cohesin that are selec

127 ve helicase, are associated with many of the chromosomal regions bound by DnaA in Bacillus subtilis.

128 aD associates with DnaA at oriC and at other chromosomal regions bound by DnaA.

129 The silencing of large chromosomal regions by epigenetic mechanisms has been re

130 ked locus, alr1, has been mapped to the same chromosomal region, called the allorecognition complex (

131 been impeded by a low efficiency (0.5-2%) of chromosomal region capture during yeast transformants wh

132 DNA and to tailor nucleosome composition in chromosomal regions, cells have evolved a set of special

133 MiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 delet

134 a large-scale rearrangement that shifts many chromosomal regions closer to the nuclear envelope.

135 PX-RICS is located in the chromosomal region commonly deleted in JBS patients with

136 We performed MDiGS capture for three chromosomal regions consisting of approximately 550 kb o

137 We found that genes located on contiguous chromosomal regions contain similar motifs in the promot

138 eport expression and epigenetic changes in a chromosomal region containing the MIR172b locus in the a

139 In contrast the chromosomal region containing TRM is not well conserved

140 eres are positioned within specific megabase chromosomal regions containing alpha-satellite DNA repea

141 Increasing evidence suggests that chromosomal regions containing microRNAs are functionall

142 too short reads to unambiguously reconstruct chromosomal regions containing repetitive DNA sequences.

143 This chromosomal region contains HYPERMETHYLATED IN CANCER 1

144 Remarkably, a single chromosomal region contains the highest effect size QTL

145 This chromosomal region contains the modifier of tubby hearin

146 ies support the hypothesis that the 15q13-14 chromosomal region contributes to the etiology of schizo

147 We show that MvaT and MvaU bind the same chromosomal regions, coregulating the expression of appr

148 r panel, genotyped in families to search for chromosomal regions correlated with acrophobia.

149 g to generate mice harboring deletion of the chromosomal region corresponding to 16p11.2, as well as

150 Six putative chromosomal regions critical for clonal expansion of int

151 In vivo Aire interactions with chromosomal regions depleted of H3K4me3 were dependent o

152 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defe

153 me segregation, but associate with different chromosomal regions during mitosis and meiosis.

154 established at different times for different chromosomal regions during speciation as recombination a

155 The two linked chromosomal regions each harbor functional candidate gen

156 Twenty-nine distinct loci mapping to three chromosomal regions encode receptor-type structures poss

157 this recombination event, which replaces the chromosomal region encoding secreted NADase and streptol

158 ition by horizontal gene transfer of a large chromosomal region encoding secreted toxins NAD(+)-glyco

159 The chromosomal region encoding the nuclear NAD(+) synthesis

160 uted along chromosomes and are suppressed in chromosomal regions encompassing compact, hypermethylate

161 e on both broad and fine scales and that few chromosomal regions escape selection-induced distortions

162 ur focal genes, At1g67140 and At3g03700, all chromosomal regions exhibited extreme variation in the p

163 screened to obtain a clone with the desired chromosomal region, extensive experience with yeast is n

164 The method isolates haploid chromosomal regions flanking targeted SNPs by hybridizin

165 the differential segregation of polymorphic chromosomal regions following the backcross and single-s

166 leprosy per se, we investigated the TNFSF15 chromosomal region for a possible contribution to suscep

167 oducible, it is unclear what distinguishes a chromosomal region for cohesin association.

168 In this study, we compare orthologous chromosomal regions for which the human locus establishe

169 or suppressor gene that localizes to 6p23, a chromosomal region frequently associated with loss of he

170 5), a protein encoded by a gene located on a chromosomal region frequently deleted during breast and

171 tations/nucleotide/generation for the same Y-chromosomal region from published human-chimpanzee compa

172 congenic strain approach to determine which chromosomal regions from 129Sl/SvImJ provide protection

173 In particular, the data suggest that chromosomal regions from chicken chromosomes (GGA) Z and

174 lence of interactions between pairs of short chromosomal regions from one species (Solanum habrochait

175 mbiotic mesorhizobia received three separate chromosomal regions from the donor Mesorhizobium ciceri

176 nces) shotgun sequencing to assemble the six chromosomal regions from the Non-Stiff Stalk maize inbre

177 ion about the genetic context of SNPs (gene, chromosomal region, functional location, haplotypes tags

178 Amplification of large chromosomal regions (gene amplification) is a common som

179 Thus, these chromosomal regions harbor genes implicated in cell cycl

180 We sought to identify chromosomal regions harboring quantitative trait loci th

181 entified four transcriptional "hot spots" at chromosomal regions harboring statistically increased nu

182 Gain' of supernumerary copies of the 8q24.21 chromosomal region has been shown to be common in many h

183 r or within the COL5A1 gene, at 9q34.2-q34.3 chromosomal region have been reported in association wit

184 Some chromosomal regions have a significant excess of eQTL ov

185 ver six loci spanning between 30- and 500-kb chromosomal regions have been described in two Iowa Stif

186 Several genes and chromosomal regions have been implicated in the genetic

187 tion to select only gene-centric SNPs from a chromosomal region in an automated fashion.

188 ciation between genetic variants in the 9p21 chromosomal region in humans and the presence of cardiov

189 We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjec

190 Estimates of the ancestry of specific chromosomal regions in admixed individuals are useful fo

191 Somatic homozygous deletions of chromosomal regions in cancer, while not necessarily onc

192 lular transport of various cargos, including chromosomal regions in Caulobacter crescentus.

193 plicon, one of the most frequently amplified chromosomal regions in human cancer, but its functional

194 or two of the three most strongly associated chromosomal regions in the Ferreira study, CACNA1C (rs10

195 n changes are preferentially associated with chromosomal regions in which histone H3 lysine residues

196 ultiple, noncontiguous genes encoded in this chromosomal region, in concert with modulatory impacts o

197 tect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk l

198 stical evidence of recent selection in three chromosomal regions, including the human leukocyte antig

199 t there may be within-locus heterogeneity in chromosomal regions involved in both AD and psoriasis.

200 tiveness of selection between chromosomes or chromosomal regions involving a number of genes.

201 Amplification of the 8p11-12 chromosomal region is a common genetic event in many epi

202 re is a defined temporal order by which each chromosomal region is duplicated.

203 10 Idd9 congenic mice, in which the NOD Idd9 chromosomal region is replaced by the Idd9 from T1D-resi

204 resulted in loss of heterozygosity, where a chromosomal region is represented by the genotype of onl

205 One example of an affected chromosomal region is the gene coding for Nup214, a nucl

206 contrast to previous studies of a different chromosomal region, IS1236 was involved in 86% of these

207 8 known pneumococcal capsule types, are in a chromosomal region known as the cps locus.

208 revious finding of BFB as well as identify a chromosomal region likely rearranged by BFB cycles, demo

209 ed out a genomewide linkage scan to identify chromosomal regions likely to contain genes that contrib

210 Chromosomal region maintenance 1 (CRM1) is a nuclear exp

211 Chromosomal region maintenance 1 (CRM1) mediates p53 nuc

212 tion modulated the interaction of ErbB4 with chromosomal region maintenance 1 (CRM1), the major nucle

213 r export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1).

214 tural attribute of the murine version of the chromosomal region maintenance 1 (mCRM1) nuclear export

215 regulatory elements and to a transcript-poor chromosomal region, markedly decreasing expression.

216 spatial distributions of highly-transcribed chromosomal regions matching recent experimental measure

217 Chromosomal regions meeting genome-wide suggestive crite

218 We found that the chromosomal region most tightly linked to this locus con

219 ntation was assessed in situ by labeling two chromosomal regions, no specific pattern was detected.

220 ng aberrant Pkhd1, but lacking the c3 and c4 chromosomal regions (NOD.Abd3), reproduces the immunopat

221 refZ and RBM mutants capture chromosomal regions normally excluded from the forespore

222 Additionally, we identify chromosomal regions not previously associated with lupus

223 nd secondary AML tended to affect particular chromosomal regions, occurred more frequently in Alu-poo

224 Consequently, meiotic progression in distal chromosomal regions occurs in coordination with the chro

225 estigate multiple markers covering a gene or chromosomal region of interest.

226 rs the allocation of cytosine methylation in chromosomal regions of 50 kb to 2 Mb and, in addition, l

227 Overall, our results suggest that sex chromosomal regions of birds and mammals were recruited

228 We conducted high-resolution scans for chromosomal regions of extreme divergence between these

229 Chromosomal regions of identical or nearly identical DNA

230 h-quality sequence assemblies of orthologous chromosomal regions of interest from multiple species.

231 ear to be eQTL hotspots many of these are in chromosomal regions of low recombination, such as geneti

232 SNP array analysis has also identified chromosomal regions of somatic uniparental disomy (UPD)

233 l a genome shaped by recombination involving chromosomal regions of tens to hundreds of kilobases lon

234 Alignment of respective chromosomal regions of these species via conserved genes

235 ber variations (deletion or duplication of a chromosomal region) of synaptic genes have been recently

236 The H19 gene, which localizes within a chromosomal region on human chromosome 11p15 that is com

237 owing to either microdeletion of the entire chromosomal region or ELN point mutations.

238 t of variation in the number of chromosomes, chromosomal regions, or gene copies, and the importance

239 SNPs in five chromosomal regions plus a family history of prostate ca

240 discrete genes, but it can also affect large chromosomal regions, potentially leading to LRES.

241 l aggregation, and suggestive linkage to two chromosomal regions previously implicated in major menta

242 Centromeres are the chromosomal regions promoting kinetochore assembly for c

243 Defined this way, 15 chromosomal regions (QTLR) affecting MDV resistance, dis

244 s, which can be identified by the absence of chromosomal region RD1(mic).

245 Two chromosomal regions reached genome-wide significance lev

246 syndromic forms of CDH, a detailed review of chromosomal regions recurrently altered in CDH, a descri

247 To evaluate candidate genes present within chromosomal regions recurrently deleted in human cancers

248 as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigeneti

249 al sequence is centrally located at the 1q42 chromosomal region relative to microsatellites previousl

250 gators targeting 129/Sv genes mapping within chromosomal regions reported herein or elsewhere in the

251 Centromeres are essential chromosomal regions required for kinetochore assembly an

252 entified were subsequently overlaid with the chromosomal regions shared among 5 affected family membe

253 everal higher eukaryotes where the outermost chromosomal regions show increased crossing over.

254 s of the joint effects of changes in the six chromosomal regions showed that six signatures, includin

255 nome-wide association study, we identified 3 chromosomal regions significantly associated with serum

256 his study was to determine whether there are chromosomal regions specifically linked to compulsive ho

257 Chromosomal regions such as subtelomeres that show defec

258 The chromosomal region surrounding attB varied among the iso

259 family are proteins that associate with the chromosomal region surrounding the centromere (the peric

260 of nucleotide polymorphism and divergence in chromosomal regions surrounding four low-diversity loci.

261 resents a recombination hot spot at the 1q42 chromosomal region that influences the development and d

262 The goal of our study was to identify chromosomal regions that are likely to harbor genetic de

263 study focused on amplification events in two chromosomal regions that are near one of six copies of t

264 Centromeres, chromosomal regions that become physically linked to the

265 in situ hybridization (FISH), we identified chromosomal regions that colocalize frequently with the

266 ent study is to delineate additional non-MHC chromosomal regions that control susceptibility to EAU,

267 Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA

268 a genome-wide linkage analysis to search for chromosomal regions that harbor genetic variants conferr

269 zebrafish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.

270 re numerous candidate genes and QTL in these chromosomal regions that may indicate shared genetic reg

271 he sites of sister chromatid cohesion to the chromosomal regions that mediate spindle attachment (the

272 ngle-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each at 17q12

273 ively mapped long-range associations between chromosomal regions throughout the fission yeast genome

274 ocal cross, and sex interacted with numerous chromosomal regions to affect growth traits.

275 enome and exome sequencing and mapped shared chromosomal regions to identify genetic predisposition i

276 -immunoFISH, we demonstrate repositioning of chromosomal regions to the nuclear lamina that is depend

277 ntromeric determinants localized to a single chromosomal region) to holocentricity (centromeric deter

278 Of the six newly identified chromosomal regions, two were associated with LDL choles

279 has been a powerful tool for localizing the chromosomal regions underlying complex traits, systemati

280 actor (protein) or small RNA molecule to the chromosomal region upstream of a regulated gene.

281 PML NBs coordinate chromosomal regions via modification of nuclear proteins

282 omolog-directed interactions at interstitial chromosomal regions was ambiguous, perhaps as a conseque

283 Results for changes in six chromosomal regions were analyzed using univariate and m

284 assively parallel sequencing (ChIP-seq), 312 chromosomal regions were highly enriched by coimmunoprec

285 -wide association study, 4 SNPs mapping to 3 chromosomal regions were independently associated with c

286 on cohort), 7 independent associations, in 5 chromosomal regions, were associated with IL-18 levels (

287 symbiosis ICEs that exist as three separate chromosomal regions when integrated in their hosts, but

288 common feature of eukaryote genomes is large chromosomal regions where recombination is absent or str

289 In this study, we evaluated the 16q24.1 chromosomal region, which has been identified by multipl

290 o known as MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to approxim

291 the position of this event determines which chromosomal regions will undergo cohesion release at ana

292 e different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (

293 Both intriguing and perplexing is a distal chromosomal region with the greatest DNA similarity betw

294 3 M genotyped and imputed SNPs resulted in 3 chromosomal regions with association P approximately 10(

295 In this way, large chromosomal regions with atypical features are identifie

296 oping and using a novel approach to identify chromosomal regions with consistent introgression signal

297 Chromosomal regions with newly acquired cenH3 are coloni

298 In chromosomal regions with suppressed recombination, delet

299 eplication study, we selected 10 SNPs in six chromosomal regions with the strongest association (sing

300 out the genome without bias for a particular chromosomal region, with the exception of a small region