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1 factor is associated with risk of a specific chromosomal translocation.
2 multiple myeloma due to a recurrent t(4;14) chromosomal translocation.
3 ffects in ALL with the t(12;21)/(ETV6-RUNX1) chromosomal translocation.
4 (PML)/RARalpha, which is generated in APL by chromosomal translocation.
5 f PAX5 in cells with and without the t(8;21) chromosomal translocation.
6 s formed as the result of a disease-specific chromosomal translocation.
7 me expansion, chromosomal rearrangement, and chromosomal translocation.
8 R1- (EWS) fusion genes that are derived from chromosomal translocation.
9 ociated with a balanced t(1;11)(q42.1;q14.3) chromosomal translocation.
10 cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation.
11 dily detected circulating disease or canonic chromosomal translocations.
12 d with mutations, altered gene expression or chromosomal translocations.
13 rrangement and the role of ATM in preventing chromosomal translocations.
14 ed due to involvement in leukemia-associated chromosomal translocations.
15 ollicular lymphoma is one of the most common chromosomal translocations.
16 mplicated in joining DSBs found in oncogenic chromosomal translocations.
17 repair activity, but at the cost of frequent chromosomal translocations.
18 from GC B cells and frequently involves MYC chromosomal translocations.
19 quence identity that can potentially mediate chromosomal translocations.
20 tion of signal ends as potentially oncogenic chromosomal translocations.
21 reater potential than SIT, but depended upon chromosomal translocations.
22 yndrome (DS-ALL) patients, lacking recurring chromosomal translocations.
23 e NHEJ, an error-prone pathway implicated in chromosomal translocations.
24 s that can serve as substrates for oncogenic chromosomal translocations.
25 type marginal zone (MZ) lymphomas because of chromosomal translocations.
26 s, rather than breakpoints in trans, forming chromosomal translocations.
27 and is a frequent target of leukemia-related chromosomal translocations.
28 d by gene expression profiling and recurrent chromosomal translocations.
29 ation in B lymphocytes, but it also promotes chromosomal translocations.
30 icated in cancer-associated gene fusions and chromosomal translocations.
31 hub of RAG-mediated V(D)J recombination and chromosomal translocations.
32 arranged in a number of different cancers by chromosomal translocations.
33 nst DNA damage, and reduces the frequency of chromosomal translocations.
34 ements, including deletions, inversions, and chromosomal translocations.
35 for the formation of AID-dependent Igh-cMyc chromosomal translocations.
36 stic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression
37 ia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scot
40 riants in NR2F2 including a de novo balanced chromosomal translocation, a de novo substitution disrup
41 a snoRNA overexpressed as a consequence of a chromosomal translocation, a potent driving force of the
44 dly develop thymic lymphomas bearing complex chromosomal translocations, amplifications and deletions
45 M-dependent DNA damage responses, leading to chromosomal translocation and defective G(2)/M checkpoin
46 ful platform for understanding the effect of chromosomal translocation and for the development of new
47 iple myeloma (MM) as a result of the t(4;14) chromosomal translocation and in a broad variety of othe
48 Two of these driving loci are linked by a chromosomal translocation and thus constitute a novel ty
49 in originally identified as the product of a chromosomal translocation and which associates with both
50 ll lymphomas sustain BCL6 expression through chromosomal translocations and activating mutations.
52 Ls that respond poorly to current therapies, chromosomal translocations and amplification lead to con
53 re involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cel
54 ps with an alternative breakpoint region for chromosomal translocations and contains a GC-specific no
56 promotes lymphocyte malignancies by causing chromosomal translocations and DNA deletions at cancer g
58 ressive pro-B cell lymphomas bearing complex chromosomal translocations and gene amplifications invol
60 neage leukemia (MLL) fusion genes arise from chromosomal translocations and induce acute myeloid leuk
61 ia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, an
62 ic development and its dysregulation through chromosomal translocations and loss-of-function mutation
63 genomic instability by initiating oncogenic chromosomal translocations and mutations involved in the
65 pathologically coexpressed, because of BCL2 chromosomal translocations and other mechanisms, includi
66 data define PARP1 as a critical mediator of chromosomal translocations and raise the possibility tha
67 homologous end joining, which contributes to chromosomal translocations and telomere fusions, but the
70 int mutations, amplifications/deletions, and chromosomal translocations, and how these aberrant event
82 t(8;21)(q22;q22), which is a common form of chromosomal translocation associated with development of
84 ) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemi
85 g it suitable for discovering and cataloging chromosomal translocations associated with specific grou
86 ndicated that T-DNA insertion lines can have chromosomal translocations associated with the T-DNA ins
89 ), is the premier model of cancer-associated chromosomal translocations because it is the only transl
90 ressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, g
91 EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12,
92 identification of the genes associated with chromosomal translocation breakpoints has fundamentally
93 We examine a set of clinically important chromosomal translocation breakpoints that occur at long
94 was not seen in conjunction with established chromosomal translocations but 6 (12%) cases had high hy
95 only for the repair of pathologic DSBs as in chromosomal translocations, but also for the repair of p
96 first recognized by gene activation through chromosomal translocations, but it is also responsible f
97 t of ESC-based cellular and animal models of chromosomal translocation by CRISPR/Cas9 provides a powe
98 nd frequency of DNA damage in the genesis of chromosomal translocations by measuring these parameters
102 210(BCR-ABL), the fusion product of a (9;22) chromosomal translocation causative for chronic myeloid
105 ription factor c-Myc, e.g. caused by t(8;14) chromosomal translocation commonly found in Burkitt lymp
107 osa, we determined that dosage variation and chromosomal translocations consistent with homoeologous
108 leotide substitutions, insertions/deletions, chromosomal translocations, copy number abnormalities, a
109 Over 80% of aRMSs are characterized by a chromosomal translocation-derived fusion transcription f
110 d as part of a protein fusion derived from a chromosomal translocation detected in the majority of an
111 tly driven by genetic abnormalities, such as chromosomal translocations directly involving the MYC lo
113 netic-epigenetic interplay at breakpoints of chromosomal translocations disrupting CG-rich loci, we q
115 by a single amino acid substitution or by a chromosomal translocation [e.g., t(8;21)], is linked to
117 Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding tumor-specific mutan
118 DNA sequencing data, we developed Fusion And Chromosomal Translocation Enumeration and Recovery Algor
121 hese domains would be lost or disrupted by a chromosomal translocation event after amino acid 597, wh
122 nalysis identified a pattern of paired intra-chromosomal translocations flanking focal amplifications
123 vement of interchromosomal LCRs in recurrent chromosomal translocation formation, we performed comput
125 AID and increased somatic hypermutation and chromosomal translocation frequency to the Igh locus and
126 OZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p
127 essive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-S
128 show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs
131 two defined loci can produce stable balanced chromosomal translocations, however, a single engineered
132 The lack of cellular and animal models for chromosomal translocations, however, has hampered our ab
134 contribute to oncogenic activation, when in chromosomal translocations Ig enhancer elements and onco
135 PARP1 protein expression strongly repressed chromosomal translocations, implying that PARP1 is essen
136 transcriptionally as a result of the t(4;14) chromosomal translocation in a subset of patients with M
137 s a fusion oncoprotein generated by the 2;13 chromosomal translocation in alveolar rhabdomyosarcoma (
138 ression, suggesting that its deregulation by chromosomal translocation in BL leads to miR-28 suppress
139 ncogenic fusion gene EWS-WT1 is the defining chromosomal translocation in desmoplastic small round-ce
140 ic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early
142 s created by the recurrent t(11;18)(q21;q21) chromosomal translocation in mucosa-associated lymphoid
143 as a proto-oncogene resulting from a t(6;14) chromosomal translocation in multiple myeloma and its ex
145 asked whether PARP1 inhibition could prevent chromosomal translocations in 3 translocation reporter s
146 disposes to thymic lymphomas associated with chromosomal translocations in a p53 mutant background, a
147 anscription factor, is overexpressed through chromosomal translocations in a subset of B cell lymphom
148 rand breaks, inverted duplications and intra-chromosomal translocations in a wide spectrum of organis
150 ation genes (MTGs), originally identified as chromosomal translocations in acute myelogenous leukemia
151 MTG16 (CBFA2T3) are identified as targets of chromosomal translocations in acute myeloid leukemia (AM
157 advances toward understanding the origin of chromosomal translocations in incipient lymphoid cancers
159 t for the formation of the most common human chromosomal translocations in lymphoid malignancies, yet
160 ome non-consensus RSS, frequently present at chromosomal translocations in lymphoid neoplasms, may pr
165 wn as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloi
169 ther V(D)J recombination or CSR can initiate chromosomal translocations, including oncogenic IgH locu
170 genomic instability has been associated with chromosomal translocations, including the recurrent t(11
171 o an oncoantigen resulting from an oncogenic chromosomal translocation inhibits lymphoma disseminatio
172 A variety of genetic lesions, including chromosomal translocations, internal tandem duplications
173 cells express oncogenic ALK resulting from a chromosomal translocation involved in lymphomagenesis.
175 ymphoid malignancies characterized by clonal chromosomal translocations involving antigen receptor ge
179 alterations of GNA13, CREBBP, and EZH2, and chromosomal translocations involving IgH and either BCL2
180 ator of normal hematopoietic development and chromosomal translocations involving MLL are one of the
181 xpression in leukemic cells, suggesting that chromosomal translocations involving MLL could lead to t
182 in their absence aberrant recombination and chromosomal translocations involving S regions occur.
191 subset of acute myeloid leukemias (AML) with chromosomal translocations involving the MLL gene have a
193 y harbored RAG-dependent reciprocal t(14:15) chromosomal translocations involving the T cell receptor
196 ytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT
199 al organization of the genome contributes to chromosomal translocations is an important question in c
200 rors in CSR can lead to dangerous, oncogenic chromosomal translocations it is important to identify t
206 are frequently altered in leukaemia through chromosomal translocation, mutation or aberrant expressi
208 In this regard, major RAG off-targets in chromosomal translocations occur as convergent RSS pairs
210 dominant-negative truncation that models the chromosomal translocation of human DISC1 in schizophreni
211 rying both a deletion of FcgammaRIIB and the chromosomal translocation of Y-linked autoimmune acceler
212 ) is frequently associated with mutations or chromosomal translocations of genes encoding transcripti
213 g of cells that have acquired cancer-causing chromosomal translocations of great relevance for humans
217 ns and targeted somatic engineering of inter-chromosomal translocations, offering multifaceted opport
218 etically altered by mutation, amplification, chromosomal translocation or inversion, has been shown t
220 ia (MLL) gene is also frequently involved in chromosomal translocations or partial tandem duplication
222 ally as a consequence of gene amplification, chromosomal translocations, or posttranslational mechani
223 actors are commonly deregulated in cancer by chromosomal translocation, overexpression or post-transl
225 hronic phase, this sole genetic abnormality (chromosomal translocation Ph(+): t(9;22)(q34;q11)) at th
226 cluding castration resistance and subsequent chromosomal translocations, play key roles in prostate c
227 expression, transcriptional activity, or by chromosomal translocation plays a critical role in carci
228 actor complex that is frequently involved in chromosomal translocations, point mutations, or deletion
232 or protein tyrosine kinase, is involved in a chromosomal translocation resulting in expression of a B
234 In prostate and lung cancers, recurrent chromosomal translocations resulting in tumorigenic fusi
235 MLL1 gene is a frequent target for recurrent chromosomal translocations, resulting in transformation
236 several recent reports, we demonstrate that chromosomal translocation risk is causally unrelated to
237 e location of genes involved in carcinogenic chromosomal translocations, suggesting their role in can
240 AML2 fusion oncogene, encoded by a recurring chromosomal translocation t(11;19)(q14-21;p12-13), is a
241 FLI1 is a fusion gene product generated by a chromosomal translocation t(11;22)(q24;q12) found in Ewi
242 ietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the for
243 E2A-PBX1 fusion oncogene, which results from chromosomal translocation t(1;19) and is present in 5% t
245 e fusion protein NUP98-HOXD13 (NHD13) of the chromosomal translocation t(2;11)(q31;p15) is expressed
246 th acute myeloid leukemia characterized by a chromosomal translocation t(7;12)-HLXB9/TEL and concomit
247 skin tumor associated with a characteristic chromosomal translocation (t[17;22][q22;q13]) resulting
248 ients, 2 of which were associated with known chromosomal translocations (t(1;19)(TCF3-PBX1) or MLL),
250 y identified at the breakpoint of a balanced chromosomal translocation, t(1;11) (q42.1;14.3), in a fa
251 illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co
254 are 100- to 1,000-fold more prone to undergo chromosomal translocation than the adjacent regions.
255 (PML) was originally identified as part of a chromosomal translocation that contributes to the develo
256 is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic
257 hypotonia that harbored a de novo, balanced chromosomal translocation that disrupts the CAPZB gene.
258 Ewing's sarcoma contain the (11;22)(q24;q12) chromosomal translocation that encodes the EWS/FLI oncop
259 s frequently harbored a CSR-based reciprocal chromosomal translocation that fused IgH to c-myc, as we
260 hyroid carcinomas contains a t(2;3)(q13;p25) chromosomal translocation that fuses paired box gene 8 (
261 3 gene cause Waardenburg syndrome, whereas a chromosomal translocation that generates a PAX3-FOXO1 fu
262 oft tissue malignancy initiated by a t(X;18) chromosomal translocation that generates an SS18-SSX fus
263 ), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene
264 ALL) harbor a fusion oncogene results from a chromosomal translocation that juxtaposes the mixed-line
266 cells, BCR expression is retained despite a chromosomal translocation that links the antiapoptotic g
267 osarcoma is characterized by a pathognomonic chromosomal translocation that results in an oncogenic f
271 EJ) in the generation of large deletions and chromosomal translocations that are frequently observed
272 xpressed at the transcriptional level due to chromosomal translocations that bring the MYC gene under
273 but improper regulation of DSBs can lead to chromosomal translocations that can result in B cell lym
274 he MLL gene is involved in a large number of chromosomal translocations that create chimeric proteins
275 K expression in nonneural cells results from chromosomal translocations that create novel fusion prot
277 ; 3 of 97 tumors examined) harbors oncogenic chromosomal translocations that fuse in-frame the tyrosi
278 promyelocytic leukemia is causally linked to chromosomal translocations that generate chimeric retino
282 l carcinomas (TFE-fusion RCCs) are caused by chromosomal translocations that lead to overexpression o
283 Ewing sarcoma family tumors (ESFTs) exhibit chromosomal translocations that lead to the creation of
284 vere forms of DNA damage and responsible for chromosomal translocations that may lead to gene fusions
286 acterized by simple karyotypes and recurrent chromosomal translocations, the mechanisms driving cytog
287 this approach in three patients with complex chromosomal translocations: The first had craniofacial a
292 eover, a BCAM-AKT2 fusion gene generated via chromosomal translocation using the CRISPR/Cas9 system l
293 e putative effects of the disease-associated chromosomal translocation we demonstrate that impaired D
294 AML1 function and its direct involvement in chromosomal translocation, we demonstrate that both the
298 ces the risk for aberrant recombinations and chromosomal translocations when exposed to DNA damage, i
299 kemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of th
300 promyelocytic leukemia (APL) is driven by a chromosomal translocation whose product, the PML/retinoi
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