ライフサイエンスコーパス: chromosome

1 phasing accuracy ( approximately 98% across chromosomes).

2 o our knowledge, the first analysis of the X chromosome.

3 he type I IFN locus on the sex-determining Z chromosome.

4 produce contigs, each representing one whole chromosome.

5 eral bias in GapR binding activity along the chromosome.

6 ip/flop mechanism that inverted a section of chromosome.

7 te into DNA breaks induced on a heterologous chromosome.

8 bound by CTCF and cohesin-lying on the same chromosome.

9 d declining radii of gyration for neutrophil chromosomes.

10 osomal positions (vermicelli), and condenses chromosomes.

11 esses transcription from the hermaphrodite X chromosomes.

12 e present on only a very small percentage of chromosomes.

13 otic arrest and impaired inactivation of sex chromosomes.

14 te repeat-containing centromeres of 23 human chromosomes.

15 systems to initiate replication of secondary chromosomes.

16 l and dosage effects of genes encoded on sex chromosomes.

17 xual dimorphism and genomic expansion of sex chromosomes.

18 es that fold onto themselves to form hairpin chromosomes.

19 dynamically coupled distal regions along the chromosomes.

20 replication and condensation of entire human chromosomes.

21 ies with conspicuous heteromorphic ZW/ZZ sex chromosomes.

22 organizational features of meiotic-prophase chromosomes.

23 responsible for the faithful segregation of chromosomes.

24 ed in Copia, LINE, and MuDR dispersed across chromosomes.

25 or more DNA regions on the same or different chromosomes.

26 nce in bottle gourd, to a 317.8-kb region on chromosome 1.

27 resenting increased nucleotide diversity, on chromosomes 1 and 2 in cultivated G. hirsutum as compare

28 nd phosphatase and tensin homolog deleted on chromosome 10 (PTEN) induces activation of the phospho-5

29 nd PTEN (phosphatase and tensin homologue on chromosome 10) activities.

30 The rs1619661 variant is on chromosome 10, 132 kilobase (kb) downstream from <em>CXC

31 tein 24 (ARHGAP24), angiopoietin 4 (ANGPT4), chromosome 11 open reading frame (C11orf30/EMSY), and ex

32 uster of maternally expressed genes on human chromosome 11p15.5.

33 ntified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previo

34 Cs, 52% were located in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt gene and defin

35 uding regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 x 10(-7)) and 14 (p = 4.

36 order, caused by submicroscopic deletions on chromosome 15q.

37 Human chromosome 16p11.2 microdeletion is among the most commo

38 The other (chromosome 17, rs1531554, OR = 0.68, P = 2.9 x 10(-8)) w

39 ghly significant CAD loci were identified on chromosome 17q21.2 (NPL score of 6.20) and 7p22.2 (NPL s

40 ree Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3.

41 A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock pro

42 Three genes on chromosome 19p13.2 were found to be associated with schi

43 out combined loss of heterozygosity (LOH) at chromosomes 1p and 16q treated in the Children's Oncolog

44 An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are

45 ree novel genome-wide significant signals on chromosomes 2, 11, and 16.

46 a chromosomal duplication syntenic to human chromosome 21q.

47 Chromosome 22q11.2 deletion syndrome (22q11.2DS) is asso

48 The CAPN14 gene is localized at chromosome 2p23.1-p21 and is most homologous to CAPN13 (

49 r(2)>0.9) located in an intergenic region on chromosome 3q26 were associated with fast beta EEG power

50 ide significant signal (p=1.12 x 10(-10)) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR

51 ajor quantitative trait locus (QTL) on wheat chromosome 5A associated with grain weight.

52 two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13).

53 PR98 (G-protein-coupled receptor V1) gene on chromosome 5q14.3.

54 Mapped to chromosome 5q31-q33, the genetic cause of FE is unknown,

55 cting replication-dependent histone genes on chromosome 6, potentially representing the chromatin arc

56 These SNPs reside in a region on chromosome 6q13 comprising the genes small ARF GAP1 (SMA

57 The TTK protein kinase gene (TTK) on chromosome 6q14.1 was the most significant (heterogeneit

58 disorder has been linked to two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13).

59 during post-harvest storage and two loci on chromosomes 7D and 7H(ch) are important for esterificati

60 rotenoids in vivo and the enzymes encoded by chromosomes 7H(ch) and 7D are complementary.

61 For chromosome 8p loss, the OR was highest for ciliary body

62 us localization of the taiep mutation to rat chromosome 9, we tested whether the mutation resided wit

63 e loss strategy to individually delete mouse chromosomes 9, 10, 12, or 14 in tetraploid immortalized

64 Focal deletions of the RanBP6 locus on chromosome 9p were found in a subset of glioblastoma (GB

65 ion: near-uniform copy number alterations of chromosome 9p24.1 and the associated PD-1 ligand loci, C

66 omere sequences typically occurring once per chromosome, a finding that helps to resolve nuclear geno

67 ction of transcribed genes on the inactive X chromosome, a mode of PRC2 function that may apply broad

68 cells from inheriting an abnormal number of chromosomes, a condition that occurs frequently in cance

69 ntify human-specific mechanisms regulating X chromosome activity in early embryonic development.

70 in genes that regulate chromatin remodeling, chromosome alignment, and stability.

71 Because female cells carry two X chromosomes, an emerging treatment strategy has been to

72 osomal as well as mtDNA, X chromosome, and Y chromosome ancestries.

73 use embryonic stem cells with an extra human chromosome and human induced pluripotent stem cells with

74 iffered between males and females; however Y chromosome and mitochondrial DNA haplogroups were not as

75 contained abundant mCH similar to the male X chromosome and the autosomes.

76 arrangements have resulted in nearly hundred chromosomes and a systematic dispersal of gene fragments

77 Telomeres are found at the end of chromosomes and are important for chromosome stability.

78 y subsequently randomly integrate into plant chromosomes and permanently express encoded transgenes,

79 nents at the centromere and leads to lagging chromosomes and spindle pole defects.

80 long-range signal transduction along meiotic chromosomes and underlie the rapid evolution of SC prote

81 otype/genotype (B cell, T cell, Philadelphia chromosome), and EFS and OS.

82 e cell (in contrast to two copies of nuclear chromosomes), and mtDNA deletions may be present on only

83 composition of autosomal as well as mtDNA, X chromosome, and Y chromosome ancestries.

84 defects in karyokinesis, loss of individual chromosomes, and gross defects in spindle assembly or st

85 complex interactions among sex hormones, sex chromosomes, and immune response genes.

86 ela genome sequence has not been resolved to chromosomes, and important genome characteristics have n

87 y characterized by in situ co-examination of chromosome aneuploidy by FISH and immunostaining of mult

88 H-NS from gamma-proteobacteria that affects chromosome architecture and of Lsr2 from Mycobacteria, b

89 ides, to our knowledge, a new perspective on chromosome architecture.

90 c scan, we show that gene transfers to the Y chromosome are much more common than previously suspecte

91 Y-chromosomes are characterized by abundant gene-loss and

92 In conclusion, marker chromosomes are indicative of chromothripsis and associa

93 l regulation afforded by radial confinement, chromosomes are more randomly oriented in Epulopiscium t

94 ein like 1 (IL1RAPL1) gene, located on the X chromosome, are associated with intellectual disability

95 within species, suggesting that nascent sex chromosomes arise frequently over the course of evolutio

96 t the kinetochore, not at damage sites along chromosome arms, such that the APC is fully inhibited wi

97 cruitment and activity of Aurora B kinase on chromosome arms.

98 separase and thereby destroys cohesion along chromosome arms.

99 the hypothesis that the second Vibrionaceae chromosome arose from an ancestral plasmid, and that Rct

100 the genome assembly reveals that the unitary chromosome arose through fusion of six ancestral chromos

101 find that E6 expression results in multiple chromosomes associated with one or both spindle poles, c

102 ivision relies on multiple processes such as chromosome attachment and correct spindle positioning.

103 e previously reported a bacterial artificial chromosome (BAC)-based lymphatic reporter mouse, where E

104 sformation by the B95-8 bacterial artificial chromosome (BAC).IMPORTANCE Epstein-Barr virus (EBV) inf

105 is genomic sequences in bacterial artificial chromosomes (BAC) to analyze the genomic region surround

106 In budding yeast meiosis, homologous chromosomes become linked by chiasmata and then move bac

107 Here we explore the X chromosome behavior in female and hermaphrodite meioses.

108 e important for the faithful distribution of chromosomes between daughter cells during mitosis as wel

109 uces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by

110 ight on how eukaryotes utilize RNA to repair chromosome breaks.

111 Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams around the w

112 is required for the faithful segregation of chromosomes, but the majority of DSBs are processed towa

113 he quantification of telomeres in individual chromosomes, but the use of these methods is dependent o

114 Second, the chromosome can be present at thousands of copies in a si

115 Our exhaustive staining of paddlefish chromosomes combined with cytogenetic mapping of ribosom

116 pendent on SUMOylation, Mer2 mediates global chromosome compaction and post-recombination chiasma dev

117 significantly reduced, although no change in chromosome compaction is observed.

118 eferential local chromatin interactions, and chromosome compartments, defined as higher-order interac

119 accompany interwoven variations in sex, sex chromosome complement, and brain size.SIGNIFICANCE STATE

120 ny processes, including the DNA replication, chromosome condensation and precisely regulated partitio

121 ltisubunit protein complex, is essential for chromosome condensation during cell division and functio

122 resumption of meiosis from prophase arrest, chromosome condensation, and kinetochore-microtubule att

123 Chromosome conformation capture (3C) methods are central

124 we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in pr

125 ed to interact with the 7p14.3 locus by Hi-C chromosome conformation capture data.

126 of genetically complex disorders followed by chromosome conformation studies in relevant tissues can

127 contact pattern and more precisely tractable chromosome conformations, and the large-scale genomic or

128 wever, its non-random distribution along the chromosomes constrains the landscape of potential geneti

129 ia are remarkably large and contain multiple chromosome copies.

130 umulation occurs primarily in early G1 after chromosomes decondense.

131 Os), due to partial redundancy with UTY, a Y-chromosome demethylase-dead homolog.

132 hat reactivation of gene expression on the X chromosome depends on gene chromosomal position.

133 gnificance of this regulation in response to chromosome detachment has not been fully investigated.

134 f the non-recombining region and increased Y chromosome divergence.

135 tween (sister chromatid cohesion) and within chromosomes (DNA looping).

136 variant, is a key epigenetic determinant of chromosome domains known as centromeres.

137 se 8 (KAT8), an important component of the X chromosome dosage compensation system in Drosophila, reg

138 d haploid individuals, which derive from the chromosome-doubled cells of the haploid gametophyte.

139 ween replication and transcription challenge chromosome duplication.

140 Faithful segregation of chromosomes during cell division relies on multiple proc

141 ng analysis of the structure and function of chromosomes during metaphase of 2,572 dividing cells, an

142 romotes proper compaction and segregation of chromosomes during mitosis remains poorly understood.

143 prevents the paternal chromatin from forming chromosomes during the first embryonic mitosis, leading

144 In bacteria, chromosome dynamics and gene expression are modulated by

145 onal segregation can contribute to oncogenic chromosome dynamics and that the embryonal theory for ca

146 ne the coordination of growth, division, and chromosome dynamics at a single-cell level in Mycobacter

147 TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telome

148 nucleotides of (T2AG3)n lost from replicated chromosome ends as a single elongation event.

149 Telomerase maintains chromosome ends from humans to yeasts.

150 ase II is not the major component of meiotic chromosomes, even though mitosis and meiosis share many

151 opo-II localized to the perimeter of mitotic chromosomes, excluded from the centromere regions, and d

152 An X-chromosome exome screen identified a missense mutation,

153 n conflict is especially bitter in bacterial chromosomes, explaining why actively transcribed genes a

154 ocytes during meiotic resumption, homologous chromosomes failed to segregate accurately during meiosi

155 ng protein SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1) was prev

156 Beyond defining the functions of CTCF in chromosome folding, these results provide new fundamenta

157 The cohesin complex prevents separation of chromosomes following their duplication until the approp

158 tability, causing replication fork stalling, chromosome fragility, and impaired repair.

159 up to 65 breakpoints and 60.6 Mb across four chromosomes, further defining rare categories of extreme

160 iability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and c

161 ung male with a hemizygous mutation in the X-chromosome gene FIGF (c.352 G>A) associated with early c

162 ix of 783 non-pseudoautosomal region (PAR) X-chromosome genes (ATRX, CNKSR2, DDX3X, KDM5C, KDM6A, and

163 The X-chromosome harbors hundreds of disease genes whose assoc

164 The Drosophila Y chromosome has been gradually acquiring genes from the r

165 ary selectivity of the MSL complex for the X chromosome has never been explained.

166 Sex-chromosomes have formed repeatedly across Diptera from o

167 n COSMIC noncoding datasets across all human chromosomes, higher than previously reported.

168 s harbored an additional chromosome, such as chromosome I.

169 ncluding at genes silenced on the inactive X chromosome in females.

170 ing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes i

171 to pericentromeric regions of two homologous chromosomes in glyphosate sensitive A tuberculatus In gl

172 pared with low nucleotide diversity on these chromosomes in landrace G. hirsutum.

173 n species with male heterogamety (XY), and W chromosomes in species with female heterogamety (ZW), ar

174 Indeed, haploid and repetitive Y chromosomes in species with male heterogamety (XY), and

175 The organization of chromosomes in sperm nuclei has been proposed to possess

176 iquitin ligase important for initiation of X-chromosome inactivation and XIST transcription in ES cel

177 ysis revealed distinct transcriptional and X chromosome inactivation changes associated with the earl

178 Furthermore, skewed X chromosome inactivation has been found in the thyroid co

179 previously shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand br

180 y and sufficient for Xist spreading during X-chromosome inactivation.

181 123 (DHR) oxidation data for percentage of X-chromosome inactivation.

182 The lymphoma cells demonstrated chromosome instability along with upregulation of severa

183 ity increased and when telomeres lengthened, chromosome instability decreased.

184 notypes, such that when telomeres shortened, chromosome instability increased and when telomeres leng

185 mere length and fluctuations in the rates of chromosome instability phenotypes, such that when telome

186 Gene expression patterns associated with chromosome instability, called CIN25 and CIN70, were det

187 lication stress and minimizing its impact on chromosome instability, thus preventing diseases, includ

188 umerous human malignancies, and is linked to chromosome instability.

189 many malignancies as part of a signature of chromosome instability.

190 also involves the generation of a dicentric chromosome intermediate, which subsequently undergoes a

191 c2.0 specifies consolidation of 16 synthetic chromosomes into a single strain.

192 tion and precisely regulated partitioning of chromosomes into daughter cells.

193 The Y chromosome is a unique genetic environment defined by a

194 (LOI) at the IGF2/H19 locus on the maternal chromosome is associated with the developmental disorder

195 Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymp

196 t the nature of the gene repertoire of fly Y-chromosomes is largely unknown.

197 nds and quantify the immediate relaxation of chromosomes, k-fibers, and microtubule speckles.

198 ires zygotic gene expression to read the sex chromosome karyotype, early embryos must remain gender-n

199 additional scaffolding is needed to achieve chromosome-level assemblies.

200 ) and peregrine falcon (Falco peregrinus) to chromosome levels comparable, in continuity, to avian re

201 Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (

202 lexity of the mechanisms required to prevent chromosome loss during cell division.

203 Cumulatively, these loci also predicted X chromosome loss in women (n = 96,123; P = 4 x 10(-6)).

204 Here, we used a Cre recombinase-mediated chromosome loss strategy to individually delete mouse ch

205 the Guanches carried common North African Y chromosome markers (E-M81, E-M78, and J-M267) and mitoch

206 Murine Gravin rescued chromosome misalignment and micronuclei formation, but a

207 BCL9L deficiency promoted tolerance of chromosome missegregation events, propagation of aneuplo

208 kpoint is a cellular safeguard that prevents chromosome missegregation in eukaryotic cells [1, 2].

209 degradation of ATR in mitosis induces whole-chromosome missegregation.

210 cross Diptera from ordinary autosomes, and X-chromosomes mostly conserve their ancestral genes.

211 especially at kinetochores where they drive chromosome motility.

212 ment sites prior to anaphase onset to dampen chromosome motion.

213 ogous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope protein

214 The properties of the human Y chromosome - namely, male specificity, haploidy and esca

215 Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results

216 We found that chromosome numbers possess a strong phylogenetic signal.

217 alyses point to a complex origin for the sex chromosome of C. gomesi and highlight the utility of RAD

218 the fusion gene BCR-ABL1 in the Philadelphia chromosome of leukemia cancer cells.

219 ed DNA sequencing (RAD-seq) to study the sex chromosomes of Characidium gomesi, a species with conspi

220 Sex chromosomes often differ between closely related species

221 rate the genome with point mutations without chromosome or nucleotide sequence context bias would ope

222 Condensin plays crucial roles in chromosome organization and compaction, but the mechanis

223 binding proteins involved in gene silencing, chromosome packaging, and chromosome segregation.

224 In meiotic prophase I, homologous chromosome pairing is promoted through chromosome moveme

225 gle-stranded DNA fragments of the homologous chromosome pairs allows for the independent sequencing o

226 nti-parallel microtubule bundles coated with chromosome passenger complex (CPC) and centralspindlin t

227 Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL),

228 d or refractory, CD22-positive, Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lym

229 fluorescent reporters of DNA replication and chromosome positioning to examine the coordination of gr

230 ance: MYB blockade can suppress Philadelphia chromosome-positive leukemia in mice, suggesting that th

231 Active and inactive arrays on the same chromosome produce discrete sets of transcripts in cis.

232 ect evidence that endogenous Rspo2 and Rspo3 chromosome rearrangements can initiate and maintain tumo

233 r beet suggests substantial inter- and intra-chromosome rearrangements during the Caryophyllales geno

234 Chromosome rearrangements involving the mixed-lineage le

235 latory sequences residing in episomes versus chromosomes remain almost completely unknown.

236 ion and transcription factor localization to chromosome reorganization and membrane dilation up to ru

237 on and may help coordinate its assembly with chromosome replication and segregation.

238 nvariance principle to coordinate growth and chromosome replication.

239 ood, preventing a molecular understanding of chromosome replication.

240 ally unaffected by the presence of synthetic chromosome(s).

241 mimics are almost completely homozygous with chromosome segments from each parent.

242 ndle microtubules and ensuring high-fidelity chromosome segregation [1-3].

243 Chromosome segregation and anaphase onset are initiated

244 des a unique mechanism by which cells ensure chromosome segregation and preserve genome integrity.

245 bipolar spindles exhibit reduced fidelity of chromosome segregation and promote genetic instability.

246 orphology and a maternal-effect on embryonic chromosome segregation and survival, which was completel

247 on plane positioning is crucial for faithful chromosome segregation but also influences cell size, po

248 cytotoxic analog (SM15) was shown to produce chromosome segregation defects in cancer cells by inhibi

249 that capture spindle microtubules to promote chromosome segregation during mitosis.

250 nderstand how the mitotic kinase PLK1 drives chromosome segregation errors, with a specific focus on

251 d DDR during mitosis, which leads to ongoing chromosome segregation errors.

252 The underlying mechanisms that govern chromosome segregation have been thoroughly investigated

253 conserved positional guide proteins used for chromosome segregation in bacteria.

254 Faithful chromosome segregation in meiosis requires crossover (CO

255 The fidelity of chromosome segregation in mitosis is safeguarded by the

256 eltapkl1Delta spindle is fully competent for chromosome segregation independently of motor activity,

257 ific factors to drive the unique reductional chromosome segregation of meiosis I, which also results

258 r providing a surprising link between H2A.Z, chromosome segregation, and organ development.

259 To ensure accurate chromosome segregation, it performs three major function

260 Human NIAM is involved in chromosome segregation, p53 regulation and cell prolifer

261 les spore morphogenesis to the completion of chromosome segregation.

262 unresolved replication intermediates impair chromosome segregation.

263 in gene silencing, chromosome packaging, and chromosome segregation.

264 esolve mitotic interlinks, thus facilitating chromosome segregation.

265 ect improper attachments and ensure faithful chromosome segregation.

266 ponsible for force generation during meiotic chromosome separation in oocytes is unclear.

267 Analysis of the chromosome sequences identified 49 putative specialized

268 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime

269 ed by condensin, a structural maintenance of chromosomes (SMC) family member.

270 the end of chromosomes and are important for chromosome stability.

271 ster chromatid cohesion and other aspects of chromosome structure and function.

272 Chromatin modification and higher-order chromosome structure play key roles in gene regulation,

273 of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal resolut

274 to ask otherwise intractable questions about chromosome structure, function, and evolution with a bot

275 has important functions in relation to basic chromosome structure.

276 ral [PSI (+)] strains harbored an additional chromosome, such as chromosome I.

277 tudying the composition and evolution of sex chromosomes systems in wild populations.

278 kers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capable of c

279 The house fly has sex chromosomes that resemble the ancestral fly karyotype th

280 m is used to initiate replication of primary chromosomes throughout the bacterial kingdom; however, b

281 to be localized near cell poles of dividing chromosomes, thus mediating equipartition of attached Pa

282 ale-specific lethal (MSL) complexes to the X chromosome to upregulate expression of X-linked genes in

283 roteinaceous structure that holds homologous chromosomes together and is required for the stabilizati

284 -strand breaks is associated with deletions, chromosome translocations, and genome instability.

285 Sex chromosome trisomy affects 0.1% of the human population

286 During meiosis, homologous chromosomes undergo crossover recombination, which creat

287 dels revealed that the mechanosensitivity of chromosomes was correlated with their orientation in the

288 centromeric region on one pair of homologous chromosomes was detected.

289 Markers on one chromosome were included simultaneously in a multilocus

290 Marker chromosomes were associated with a poorer prognosis comp

291 sms (SNPs), whereas the markers on the other chromosomes were used to calculate kinship matrix as pol

292 o a state that contains an unusual number of chromosomes when they are grown in culture.

293 SNPs were detected on the A and the B genome chromosomes, which formed 878 haplotype blocks.

294 by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling

295 At the chromosome-wide level, a total 122 QTNs were associated

296 position of histone H3 lysine 27 methylation chromosome-wide.

297 e, the house fly is expected to have X and Y Chromosomes with different gene content.

298 mosome arose through fusion of six ancestral chromosomes, with extensive rearrangement among neighbor

299 xpressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in female cells, w

300 Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive