ライフサイエンスコーパス: chromosome 16

1 emonstrating its enrichment at this locus on chromosome 16.

2 deficiencies to the syntenic region of human chromosome 16.

3 6Mit211 (23.3 cM) and D16Mit51 (66.75 cM) on chromosome 16.

4 served synteny with the human counterpart on chromosome 16.

5 contigs spanning 16p11.2 to 16p13.1 of human chromosome 16.

6 t throughout 15 Mb of the short arm of human chromosome 16.

7 is located in the peak region of linkage on chromosome 16.

8 ion of PKD1 exons 1-33 as six pseudogenes on chromosome 16.

9 me 16p13.3 and in a syntenic region in mouse chromosome 16.

10 6 overgos were selected from the long arm of chromosome 16.

11 e genes in the corresponding region on mouse chromosome 16.

12 ent to the IL-4 receptor alpha chain gene on chromosome 16.

13 erage every 78 kb on the euchromatic arms of chromosome 16.

14 h span approximately 100kb of genomic DNA on chromosome 16.

15 analysis of 11.8 Mb of genomic sequence from chromosome 16.

16 veral highly homologous loci also located on chromosome 16.

17 p1 is mapped to the proximal region of mouse Chromosome 16.

18 and maps to the orthologous region on mouse chromosome 16.

19 homologous copies located more proximally on chromosome 16.

20 es were observed over a very broad region of chromosome 16.

21 in a region of conserved synteny with human chromosome 16.

22 r activity is located in the q24.2 region of chromosome 16.

23 al and functional features of this region of chromosome 16.

24 genes for MDC and TARC are encoded by human chromosome 16.

25 human homologue of Lmp10, MECL1, is found on chromosome 16.

26 oss cohort implicated a polymorphic locus on chromosome 16.

27 geny indicated that the Coc locus resides on chromosome 16.

28 other CC chemokines, MDC is encoded on human chromosome 16.

29 een isolated and localized to proximal mouse chromosome 16.

30 e of several homologous loci also located on chromosome 16.

31 om mouse cells that contained a single human chromosome 16.

32 p-Y increased with increasing copy number of chromosome 16.

33 ll hybrids, with the highest concordance for chromosome 16.

34 s each contained one normal and one abnormal chromosome 16.

35 mated 20 genes are present in this region of chromosome 16.

36 ith a substantial portion of the long arm of chromosome 16.

37 ptibility locus in the centromeric region of chromosome 16.

38 tisic acid dioxygenase (Hgd) gene located on chromosome 16.

39 deled in mice segmentally trisomic for mouse chromosome 16.

40 the contiguous TSC2 and PKD1 genes on human chromosome 16.

41 ely overlapping but smaller segment of mouse chromosome 16.

42 human chromosome 21 syntenic region on mouse chromosome 16.

43 ntrachromosomal duplications blocks on human chromosome 16.

44 ILLER gene, CLR16.2 that is located on human chromosome 16.

45 dentify two significant QTL for PPI on mouse chromosome 16.

46 n sites from four different tumors mapped to chromosome 16.

47 vel genes: HDGFL1 on chromosome 6 and MAF on chromosome 16.

48 bias-controlling quantitative trait locus on chromosome 16.

49 complex lies at the tip of the short arm of chromosome 16.

50 d the human AC9 gene to both human and mouse chromosomes 16.

51 icrocell mediated transfer of a normal human chromosome 16, 16q22-qter or 16q23-qter restored cellula

52 conserved, centromere to telomere, in mouse chromosomes 16, 17, and 10.

53 A novel observation was recurrent gain of chromosome 16 (2 patients at presentation, 4 at relapse)

54 s of greater than two were also observed for chromosomes 16, 20, and 22 with the smokers-only analysi

55 We report three novel EAE-modifying loci on chromosomes 16, 7, and 13 (eae11-13, respectively).

56 wn to function as a MHC and to be located on chromosome 16 (a microchromosome) with the single nucleo

57 ly trisomic for the distal 12-15 Mb of mouse chromosome 16, a region that shows perfect conserved lin

58 an extra copy of the distal aspect of mouse chromosome 16, a segment homologous to human chromosome

59 the case genotype for one intergenic SNP on chromosome 16 achieved genome-wide significance in the c

60 Interestingly, on chromosome 16, an RPL26 processed pseudogene was found i

61 allele sharing was found on the short arm of chromosome 16 and confirmed by conventional linkage anal

62 e is located in the proximal region of mouse chromosome 16 and contains 10 exons ranging from 54 to 1

63 n COX6AH gene is located on the short arm of chromosome 16 and facilitated the isolation of the human

64 Mouse Bex6 is on chromosome 16 and is 67% identical to mouse Bex4.

65 es that the CD1 genes are located on chicken chromosome 16 and maps to within 200 kb of the chicken M

66 e mXCP1, mXCP2 and mXCP3 genes map to murine chromosome 16 and mXCP4 is positioned on chromosome 8; t

67 The 'dehydrated' or xerocytic form maps to chromosome 16 and shows a minimal leak, and can show an

68 94.7 Mb, making it similar in size to human Chromosome 16 and significantly larger than previous est

69 emia cells containing a single copy of human chromosome 16 and targeted the insertion of different se

70 ent synteny between a 150-kb region on mouse chromosome 16 and the most commonly deleted portion of 2

71 has three copies of the distal end of mouse chromosome 16 and therefore has segmental trisomy for or

72 he beta-defensin genes mapped closely on rat chromosome 16 and were closely linked to the alpha-defen

73 ubunit genes, CACNG3, CACNG4, and CACNG5, on chromosomes 16 and 17.

74 Interestingly, the major loci on chromosomes 16 and 18 coincide with loci for psoriasis r

75 tric chromosome resulting from the fusion of chromosomes 16 and 19.

76 1 gene and have identified novel ALS loci on chromosomes 16 and 20.

77 mosomes Y, 3p, 10p, 17p, 18q and the gain of chromosomes 16 and 20.

78 equence level that the translocation between chromosomes 16 and 21 similarly results in a FUS/ERG fus

79 rodent somatic cell hybrid panel maps PP4 to chromosome 16, and comparison of the PP4 gene structure

80 ogue is the most distal gene mapped to mouse chromosome 16, and PDXK, whose orthologue is the most pr

81 nt is within the haptoglobin gene cluster on chromosome 16, and that, on chromosome 6, the break occu

82 Conditions under which segments of genes on chromosome 16 (App and Dyrk1a) could be coamplified with

83 se-activating recruitment domain 15 locus on chromosome 16 are also associated with psoriatic arthrit

84 ditional genes on the triplicated segment of chromosome 16 are also required for the Ts65Dn endosomal

85 Whereas the segmental duplications of chromosome 16 are enriched in the relatively gene-poor p

86 y examined the BCAR1-CFDP1-TMEM170A locus on chromosome 16, associated with carotid IMT and coronary

87 NP tags the copy number region CNVR6685.1 on chromosome 16 at 28.5 Mb, a gain/loss site.

88 t polycystic kidney disease locus located on chromosome 16 at band p13 (PKD1).

89 By using bacterial artificial chromosome 16 (BAC16) clone carrying the full-length KSH

90 aximum observed lod score was 2.22, also for chromosome 16, between D16S415 and D16S503 (under a mode

91 some, and we directed our efforts toward the chromosome 16 breakpoint.

92 ohn's disease susceptibility locus, IBD1, on chromosome 16, but not for IBD2 on chromosome 12.

93 STP2 was localized to human chromosome 16 by performing the PCR with DNA from NIGMS

94 nfirms the recent mapping of the FAA gene to chromosome 16 by Pronk et al.

95 57BL/6J (P = 1.6 x 10(-11)), indicating that chromosome 16 carries one or more PPI genes.

96 To link the cytogenetic map for mouse chromosome 16 (Chr 16) to the more detailed recombinatio

97 onal map spanning 56 cM across most of mouse Chromosome 16 (Chr 16).

98 Distal mouse Chromosome 16 (Chr. 16) includes a region of conserved l

99 The mouse chromosome 16/chromosome 17 evolutionary breakpoint is b

100 rker D16mit32 on the proximal part of murine chromosome 16, close to the locus of mahoganoid (md), a

101 t the HBA gene cluster on the subtelomere of chromosome 16, coinciding with the loss of alpha-globin

102 The mutation was localized to a region on chromosome 16 containing Clcn2, a gene associated with r

103 s genetically mapped to a 1.3-Mb interval on chromosome 16 containing Polq, encoding DNA polymerase t

104 A region of chromosome 16 containing the fat mass-and obesity-associ

105 .1-p13.2, was previously isolated by using a chromosome 16 cosmid library.

106 The frequent inversion of chromosome 16 creates the CBFB-MYH11 fusion gene that en

107 Also, a single QTL on chromosome 16 (D16Mit100) was identified for thalamus vo

108 the presence of a normal chromosome 11 with chromosome 16 (derived from cisplatin-resistant 2008/C13

109 equence analysis of candidate genes from the chromosome 16 disease interval excluded the presence of

110 Because mice with a larger deletion on mouse chromosome 16 do have heart defects, the results allow u

111 an chromosome 21 orthologous region on mouse chromosome 16 [Dp(16)1Yey] and Ms1Rhr.

112 osmid contigs that had been ordered on human chromosome 16 enabled its assignment to the proximal end

113 identified a recurrent cryptic inversion of chromosome 16, encoding a CBFA2T3-GLIS2 fusion transcrip

114 tated the isolation of the human gene from a chromosome 16-enriched library.

115 yeloid leukemia samples with an inversion in chromosome 16, expressing the fusion protein CBFbeta-SMM

116 Human chromosome 16 features one of the highest levels of segm

117 Further mapping with additional markers from chromosome 16 for all 103 backcrossed progeny positioned

118 ere identified on chromosome 8 for orchitis, chromosome 16 for epididymitis, and chromosome 1 for vas

119 to chromosome 5 was also found for rMBP, to chromosome 16 for rSBP, and to chromosomes 1, 5, 6, 7, a

120 tely 100-kb PAC located at the breakpoint of chromosome 16 from one patient revealed some variability

121 Microcell hybrids of A9 cells with chromosome 16 from the 2008/C13* cells did not exhibit c

122 his effort were the radiation hybrid maps of chromosome 16 from Whitehead Institute and Stanford Univ

123 is was confirmed by our finding of identical chromosome 16 haplotypes in affected and unaffected sibl

124 Therefore, chromosome 16 has a strong activity to suppress the meta

125 esses a triplication of the distal region of chromosome 16 has been developed as a putative model for

126 Because the pericentromeric region of chromosome 16 has been identified by genome scans in sev

127 and a locus in the pericentromeric region of chromosome 16 has been identified in some families.

128 th segmental trisomy for the region of mouse chromosome 16 homologous with the so-called "Down syndro

129 The detection of linkage on chromosome 16 (IBD1) led to the unequivocal identificati

130 Linkage to chromosome 16 (IBD1) was observed in Crohn's disease pai

131 tified two significant regions of linkage on chromosomes 16 (IBD1) and 12 (IBD2) and two regions with

132 ne location in the pericentromeric region of chromosome 16, IBD1, that contributes to susceptibility

133 Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP),

134 a second PKC locus (EKD2) on the long arm of chromosome 16 in a large Indian family with PKC.

135 reside in a novel KAP gene cluster on mouse chromosome 16 in a region of conserved linkage with huma

136 identified a common candidate gene region on chromosome 16 in a subset of these.

137 1, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causat

138 human chromosome 21 syntenic region on mouse chromosome 16 in mice using Cre/loxP-mediated long-range

139 cations across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cell

140 Deletions were found near the p63 locus on chromosome 16 in radiation-induced tumors, but these fre

141 Crohn's disease (CD) susceptibility locus on chromosome 16 in several but not all populations studied

142 apped to the pericentromeric region of human chromosome 16 in several Japanese families and in an Afr

143 The inversion of chromosome 16 in the inv(16)(p13q22) is one of the most

144 invariably are found to have an inversion of chromosome 16 in their leukemic cells, which results in

145 es from a highly informative region of human chromosome 16, in which information from the rapid evolu

146 ric region of the short arm of one allele of chromosome 16, including both alpha-globin genes.

147 les, we identified novel associations in the chromosome 16 interferon regulatory factor 8 (IRF8) gene

148 iated chromosome transfer to introduce human chromosome 16 into the highly metastatic Dunning rat pro

149 Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of

150 is associated with human leukemias through a chromosome 16 inversion and is essential for definitive

151 e fusion gene CBFB-MYH11 is generated by the chromosome 16 inversion associated with acute myeloid le

152 beta-SMMHC, the fusion protein produced by a chromosome 16 inversion in acute myeloid leukemia subtyp

153 fusion oncogene CBFB-MYH11 is generated by a chromosome 16 inversion in human acute myeloid leukemia

154 pe M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-

155 Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid l

156 was preferentially increased in samples with chromosome 16 inversion, suggesting that PLAG1 and PLAGL

157 Inversion of chromosome 16 is a consistent finding in patients with a

158 Loss of the q22 band of chromosome 16 is a frequent genetic event in breast canc

159 ow (k(y)), whose genetic map position on dog chromosome 16 is distinct from the predicted location of

160 The long arm of chromosome 16 is frequently deleted in human cancers, bu

161 transferred into MEL cells as part of human chromosome 16, it is appropriately expressed in an induc

162 A locus on chromosome 16 (lead single-nucleotide polymorphism rs488

163 (Bst) semidominant mutation, mapped to mouse Chromosome 16, leads to developmental defects of the eye

164 hemizygous for a 1.5-Mb homologous region of chromosome 16 (Lgdel/+) exhibit conotruncal cardiac defe

165 ative for linkage analysis and two confirmed chromosome 16-linked TSC families.

166 ntercross progeny identified two significant chromosome 16 loci with LODs of 3.9 and 4.7 (significanc

167 dence suggesting that the RAD51L1 gene and a chromosome 16 locus influence breast cancer prognosis.

168 eplication of linkage was found only for the chromosome 16 locus, IBD1, maximal at D16S769 (nonparame

169 idence of an interaction with another QTL on chromosome 16 (lod score, 2.9).

170 nkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0).

171 OD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD

172 We also compared the chromosome 16 LOH region between angiomyolipoma and pulm

173 We found that at each chromosome 16 marker, the results were concordant betwee

174 Evidence for linkage to social phobia for chromosome 16 markers was identified.

175 Five markers were linked to the X chromosome, 16 markers to chromosome 2, and 10 and 11 ma

176 pping IBD1, in the pericentromeric region of chromosome 16 (MLod = 1.69, P = 2.6 x 10(-3)), particula

177 ed through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a

178 ls generated by microdissection of the mouse chromosome 16 (MMU16) C3-C4 region.

179 Distal mouse chromosome 16 (MMU16) shares conserved linkage with huma

180 rated into a larger KAP gene domain on mouse chromosome 16 (MMU16) that is orthologous to a recently

181 -one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesi

182 A Zlr score of 3.41 was observed for chromosome 16 near marker D16S415.

183 with a P value of.0062; and a 6-cM region on chromosome 16, near D16S769, with a P value of.0086.

184 cy/+ rat is neither PKD1, localised on human chromosome 16, nor PKD2, localised on human chromosome 4

185 e: the bacterium Rhodobacter sphaeroides and chromosome 16 of the mouse genome.

186 116-R30A cells did not result from a loss of chromosome 16 or copies of the NQO1 gene.

187 s with partial trisomies of regions of mouse chromosome 16 orthologous to Hsa21.

188 for an RA susceptibility locus was found on chromosome 16 (P = 0.004).

189 0300 and P=0.0279, respectively) for LDL and chromosome 16 (P=0.0429) for TG.

190 he cholesteryl ester transfer protein locus (chromosome 16) (P=.01) and the manganese superoxide dism

191 ntical, and the PPX gene was mapped to human chromosome 16 p11.2.

192 ion of exons and RT-PCR analysis reveal that chromosome 16 paralogs likely represent pseudogenes.

193 Mapping of the Coc locus to mouse chromosome 16 provides the positional information necess

194 rminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the trans

195 once in the human genome and is localized on chromosome 16 (q24.3).

196 ene for the beta-chain signaling (located on chromosome 16) rather than the alpha-chain ligand bindin

197 Copy-number variants of chromosome 16 region 16p11.2 are linked to neuropsychiat

198 ene, localized to a region in proximal mouse chromosome 16, revealed greater than 72% identity to hum

199 ified a new genome-wide significant locus on chromosome 16 (rs10500355, P = 3.9 x 10(-9)) in a combin

200 lcetrapib arm, identifying the ADCY9 gene on chromosome 16 (rs1967309; P=2.41x10(-8)), with 8 polymor

201 ng one copy of App or a small portion of the chromosome 16 segment containing App from Ts65Dn mice el

202 UMODL1, showing there are seven genes in the chromosome 16 segment distal to Tmprss2.

203 To identify mice bearing the extra chromosome 16 segment, we developed a polymerase chain r

204 Mouse models, in particular the chromosome 16 segmental trisomies, Ts65Dn and Ts1Cje, ar

205 t here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its e

206 affected sib pair (ASP) LOD score of 3.11 on chromosome 16, several ASP LOD scores >2.00 on chromosom

207 The distal end of mouse chromosome 16 shares a large region of genetic homology

208 Because mouse chromosome 16 shares many genes with human chromosome 21

209 aploinsufficiencies involving this region of chromosome 16 should recapitulate the developmental fiel

210 Chromosome 16 showed linkage for CD at marker D16S415 (L

211 The analysis for chromosome 16 specific DNA markers, in revertant clones

212 The frequency of chromosome 16-specific aneuploidy was approximately 50%.

213 Clone end sequence data obtained from chromosome 16-specific BACs, as well as from public data

214 We determined that the chromosome 16 substitution strain has elevated PPI compa

215 ed a novel quantitative trait locus (QTL) on chromosome 16, termed Bmgr5 (logarithm of odds 6.4, at 1

216 ric rearrangement involving the short arm of chromosome 16 that gives rise to alpha-thalassaemia by d

217 el of DS in which the entire region of mouse chromosome 16 that is homologous to human chromosome 21

218 d Vital Capacity (FVC) downstream of BANP on chromosome 16 that shows evidence of replication by a ta

219 /translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specific for familial ALS.

220 replicated linkage between CD and a locus on chromosome 16 (the IBD1 locus), replicated linkage betwe

221 AS identified one SNP associated with HDL on chromosome 16 (the top meta-analysis SNP) and one on chr

222 Two regions of linkage were identified on chromosome 16, the first on 16p with an MLS of 1.7 in th

223 ion of PKD1 exons 1-32 as six pseudogenes on chromosome 16, the high level of allelic heterogeneity,

224 VCFS/DGS critical region is located on mouse chromosome 16, the relative organization of the region i

225 e segmentally trisomic for a region of mouse chromosome 16, they genetically model DS and are used to

226 me 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06.

227 sical map and radiation hybrid maps of human chromosome 16 to construct a new sequence-ready BAC map

228 onserved DGS critical region (DGCR) on mouse chromosome 16 to prospectively investigate the role of t

229 ouse possesses an extra copy of a segment of chromosome 16 translocated to chromosome 17.

230 romosome 21 and the syntenic region of mouse chromosome 16, trisomy of which is associated with conge

231 resolution haplotype map for the 99-Mb mouse Chromosome 16 using approximately 70,000 single nucleoti

232 Chrd was mapped to mouse chromosome 16 using interspecific crosses, and the cogna

233 us, termed the Gvh1 locus, was identified on chromosome 16 using linkage analysis (logarithm of the o

234 sequence extending 634 kb on proximal mouse chromosome 16 was compared to the corresponding human se

235 a2 region of the alpha-globin locus on human chromosome 16 was detected as part of an effort to bette

236 The distribution of cloned DNAs on chromosome 16 was determined by fluorescence in situ hyb

237 Similarly, our linkage evidence on chromosome 16 was diminished in the families with three

238 Strikingly, loss of chromosome 16 was dramatically enriched in all mice that

239 stribution of YAC/BACs from chromosome 5 and chromosome 16 was evaluated by fluorescence in situ hybr

240 n gene resulting from a cryptic inversion of chromosome 16 was identified in another subgroup of 31%

241 ther evidence that Rfp-Y might be located on chromosome 16 was obtained when individuals trisomic for

242 Linkage analysis at microsatellites spanning chromosome 16 was performed in 2 groups of CD pedigrees:

243 Exclusion linkage mapping of chromosome 16 was performed in a separate group of 185 m

244 he variant C allele of rs9934948, located on chromosome 16, was associated with a similarly elevated

245 ingle-nucleotide polymorphisms (SNPs) across chromosome 16 were examined for linkage and/or associati

246 6 was obtained when individuals trisomic for chromosome 16 were found to transmit three Rfp-Y haploty

247 -rich areas mapping to the target regions of chromosome 16 were identified.

248 transfer hybrid cells containing whole human chromosome 16 were injected, the number of metastatic le

249 ping with 30 hypervariable markers mapped to chromosome 16 were performed on 234 DNA samples of five

250 YAC clones generated from chromosome 16 were successfully converted into BACs by e

251 recover CEPH YACs that encode this region of chromosome 16 were unsuccessful.

252 apparent in studies of chickens trisomic for chromosome 16 when it was noted that the intensity of re

253 These results exclude one locus on chromosome 16 which causes both the ICCA and PKC syndrom

254 7 gene and mapped it to a locus on the human chromosome 16 which is in proximity to several loci asso

255 hat there may be a cluster of genes on human chromosome 16 which lead to paroxysmal disorders.

256 pressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute m

257 sease trait to the telomeric region of human chromosome 16, which includes the alpha-globin gene clus

258 is localized to the proximal region of mouse chromosome 16, which is syntenic to the proximal region

259 A (rs10740118; P=8.1x10(-9); near NRBF2), on chromosome 16 with LA, GLA, dihomo-GLA, and arachidonic

260 ap can now be drawn for a portion of chicken chromosome 16 with Rfp-Y, encompassing two MHC class I a

261 the dehydrated, xerocytic form that maps to chromosome 16, with perinatal ascites is confirmed.

262 The constructed human chromosome 16 YAC library had approximately 2.6x coverag