ライフサイエンスコーパス: chromosome 19

1 of linkage of the trait to the LDL receptor (chromosome 19).

2 ma cells despite retention of both copies of chromosome 19.

3 structed a first-generation haplotype map of chromosome 19.

4 gh frequency of genetic alterations on mouse chromosome 19.

5 one village) using 22 polymorphic markers on chromosome 19.

6 ene insertion maps to the proximal region of chromosome 19.

7 c integration of the viral genome into human chromosome 19.

8 n of the entire PLP1 gene to the telomere of chromosome 19.

9 (KIR) genes are a multigene family on human chromosome 19.

10 mes, we sequenced mouse DNA related to human chromosome 19.

11 e-gated P/Q-type Ca(2+) channel (CACNA1A) on chromosome 19.

12 tein MGC2663 by GenBank, is encoded by human chromosome 19.

13 suggestive linkage evidence for a marker on chromosome 19.

14 PCL, was recently described and localized to chromosome 19.

15 7, syntenic with human CEBPA and G genes on chromosome 19.

16 the presence of another unrearranged gene on chromosome 19.

17 uggested the localization of MIP-2A at human chromosome 19.

18 They appear to be located together on chromosome 19.

19 located 16 kb upstream of the CYP4F2 gene on chromosome 19.

20 me order that these genes are found on human chromosome 19.

21 n cytochrome P450 4F genes form a cluster on chromosome 19.

22 s to the murine dn (deafness) locus on mouse chromosome 19.

23 ats and the AAVS1 integration locus on human chromosome 19.

24 orresponding human genomic sequence on human chromosome 19.

25 of the mouse tauCstF-64 cDNA, which maps to chromosome 19.

26 by integration into a specific site on human chromosome 19.

27 suggested possible linkage to loci on mouse chromosome 19.

28 ion of the AAV genome into a region of human chromosome 19.

29 aps the murine Hells gene to region C3-D1 on chromosome 19.

30 nsion of a CTG trinucleotide repeat on human chromosome 19.

31 ressor gene, we mapped Lvis1 to distal mouse chromosome 19.

32 a 4-Mb region around the human APOE locus on chromosome 19.

33 ink between familial leukoencephalopathy and chromosome 19.

34 -specifically into a defined region of human chromosome 19.

35 a syntenic region close to the centromere on chromosome 19.

36 cosmids in the metric physical map of human chromosome 19.

37 in a region of conserved synteny with human chromosome 19.

38 s (oc), which is localized to proximal mouse chromosome 19.

39 ed both Gng3 and Gng3lg to the same locus on chromosome 19.

40 s to the murine dn (deafness) locus on mouse chromosome 19.

41 ocus for the brachymorphic mutation on mouse chromosome 19.

42 (AD) is the apolipoprotein E (APOE) locus on chromosome 19.

43 tandem repeats in the DNA sequence of human chromosome 19.

44 ers and 15 Yb8 Alu family members from human chromosome 19.

45 phia myotonica-protein kinase gene (DMPK) on chromosome 19.

46 as the result of a ~400-kilobase deletion on chromosome 19.

47 novel gene disrupted by the translocation on chromosome 19.

48 ion of the AAV genome into a region of human chromosome 19.

49 Pitx3 was mapped close to aphakia on mouse chromosome 19.

50 hromosome 10 and in the ERCC1 locus on human chromosome 19.

51 a syntenic region on the proximal region of chromosome 19.

52 a major suppressor locus (Mvb-1) to proximal chromosome 19.

53 novel microsatellite polymorphisms on human chromosome 19.

54 quences within the viral genome and in human chromosome 19.

55 mouse chromosome 7 and the long arm of human chromosome 19.

56 csf-chr12 in chromosome 12 and gcsf-chr19 in chromosome 19.

57 site-specific integration of AAV into human chromosome 19.

58 he functional gene maps to the MANB locus on chromosome 19.

59 marker in all the affected family members on chromosome 19.

60 atic cell hybrids assigned the human gene to chromosome 19.

61 pecifically into PPP1R12C, a gene located on chromosome 19.

62 he highly repetitive KIR region on the Human chromosome 19.

63 globin transgene in the AAVS1 site on human chromosome 19.

64 rs187848990 on chromosome 2 and rs8100891 on chromosome 19.

65 ther genes, most frequently the BRD4 gene on chromosome 19.

66 number of differentially methylated loci on chromosome 19.

67 vicinity of interferon (IFN)-lambda genes on chromosome 19.

68 SNP data from the HLA region, the MS32, and chromosome 19.

69 n superfamily inhibitory receptor encoded on chromosome 19.

70 to the region previously localized on baboon chromosome 19.

71 tion hot spots have been identified on mouse chromosome 19.

72 tes its genome into the AAVS1 locus on human chromosome 19.

73 r chromosome Y and segmental duplication for chromosome 19.

74 including two remaining euchromatic gaps on chromosome 19.

75 in two inverted regions of tandem repeats on chromosome 19.

76 out 2/3rds of cases, NUT is fused to BRD4 on chromosome 19.

77 epresents a new, not yet identified locus on chromosome 19.

78 BPA gene coincided with a large-scale UPD on chromosome 19.

79 4S1644 using the same covariate model as for chromosome 19.

80 o close the four remaining gaps on the human chromosome 19.

81 within a 1-cM region near the centromere of chromosome 19.

82 hich are located in a 5.5-megabase region on chromosome 19.

83 e site specifically into the AAVS1 region of chromosome 19.

84 G-isl 6, and CAG-isl 7, were mapped to human chromosomes 19, 16, 12, and 3, respectively, via somatic

85 en introns and eight exons and is located on chromosome 19 (19C2-3).

86 ecifically integrating its genome into human chromosome 19 (19q13.3-qter) at a locus designated AAVS1

87 ization, the murine Kcnk8 gene was mapped to chromosome 19, 2B, the locus of the murine dancer phenot

88 experiments we mapped the Bam gene to distal chromosome 19, a locus syntenic to human chromosome 10q2

89 r AAV replication, targeted integration into chromosome 19 AAVS1 DNA may involve a replicative type o

90 its genome into a defined sequence on human chromosome 19 (AAVS1) makes it of particular interest fo

91 n a site-specific manner in a locus on human chromosome 19 (AAVS1).

92 On chromosome 19, all exons and the exon-intron borders of

93 On chromosome 19, allele frequency differences localized ne

94 both subfamilies of Alu elements along human chromosome 19 also appears to be random.

95 rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integrat

96 eractions occur between a C57BL/6J allele on chromosome 19 and an A/J allele on chromosome 8.

97 Interestingly, the chromosome 19 and chromosome 11 QTLs, but not the chromo

98 approximately 5 kb upstream of Fgf8 on mouse Chromosome 19 and consists of six exons spanning 2 kb.

99 ntegration site known as AAVS1 is located in chromosome 19 and contains multiple GCTC repeats that ar

100 lysis between short-tandem repeat markers on chromosome 19 and COPD phenotypes was followed by associ

101 rous clustered ZNF families located on human chromosome 19 and elsewhere in the human and mouse genom

102 56, ISG54, and ISG49, which are clustered on chromosome 19 and encode the corresponding proteins p56,

103 tudy refines the gene order for distal mouse chromosome 19 and expands the comparative map between mo

104 e performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped

105 ly within the detailed physical map of human chromosome 19 and genetic data that assign Rfx1 and Rfx2

106 Psl4 maps near D19Mit38 on distal chromosome 19 and inheritance of the dominant C57BL/6 al

107 ne locus mapped to the proximal end of mouse chromosome 19 and is inherited as a fully penetrant auto

108 Human PIASgamma spans approximately 23 kb on chromosome 19 and is organized into ten exons.

109 metalloprotease encoded by a locus on human chromosome 19 and mouse chromosome 17.

110 We detect significant genomewide linkage on chromosome 19 and suggestive evidence of QTLs on chromos

111 analyses mapped the location of the gene to chromosome 19 and targeted MPS of the linkage region ide

112 ed major histocompatibility complex locus on chromosome 19 and tested functional significance through

113 esents the largest deletion yet described on chromosome 19 and the first report of the involvement of

114 nd expands the comparative map between mouse chromosome 19 and the human chromosome 10q23-q26 homolog

115 2 endogenous loci, the PPP1R12C/p84 gene on chromosome 19 and the IL2Rgamma gene on the X chromosome

116 ids coded by five, seven, and eight exons on chromosomes 19 and 1, and they all have two predicted tr

117 were not consistent among chromosomes, with Chromosomes 19 and 22 standing out as different from the

118 The associations in chromosomes 19 and 6 were independent and additive and e

119 e clusters near centromeric regions of human chromosomes 19 and 7 with smaller clusters or isolated c

120 Chromosomes 19 and Y are exceptions, possessing more ele

121 ended existing synteny between LG7 and human chromosome 19, and confirmed the synteny between LG24 an

122 en associated with the DM phenotype: DM1, on chromosome 19, and DM2, on chromosome 3.

123 6,7), which is syntenic to the Dac region on chromosome 19, and may disrupt the orthologue of Dac.

124 Both CNVs span genes encoded on chromosome 19, and quantitative RT-PCR demonstrated that

125 disruption at the AAVS1 integration locus on chromosome 19 ( approximately 100% of infected cells).

126 Many of the loci on chromosome 19 are associated with genes belonging to the

127 tory receptors and map to the same region of chromosome 19 as these genes.

128 ene include a transcribed retropseudogene on chromosome 19, as well as expressed genes in mouse, rat,

129 sociation studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) c

130 mechanism to integrate its genome into human chromosome 19 at 19q13.4 (termed AAVS1), thereby establi

131 t of the human gene; (ii) it is localized on chromosome 19 at bands C2-C3 that is syntenic to human c

132 about 500-kb pairs on the long arm of human chromosome 19 at q13.3.

133 Although ENL and ELL localize to chromosome 19, bands p13.3 and p13.1, respectively, thes

134 int contigs were directly anchored to cattle chromosome 19 [Bos taurus, (BTA) 19].

135 ZNF320 is oriented toward the centromere of chromosome 19, both genes appeared on the same derivativ

136 sociated parvovirus into its target on human chromosome 19, both of which involve stretches of G-G-G-

137 tween human chromosome 17 (HSA17) and bovine chromosome 19 (BTA19), two chromosomes known previously

138 struct a radiation hybrid (RH) map of bovine chromosome 19 (BTA19).

139 f a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggre

140 ntegrates in a site-specific manner on human chromosome 19, but this has never been demonstrated dire

141 elper virus, the AAV genome is released from chromosome 19 by a process termed rescue, and productive

142 obtained, fine-mapped to the physical map of chromosome 19 by hybridization to a chromosome-specific

143 Limatin was mapped to mouse Chromosome 19 by restriction fragment length polymorphis

144 gene (gene symbols KHSRP and Khsrp) to human chromosome 19 by using radiation hybrid panels and to mo

145 the preferred AAV integration site in human chromosome 19, called AAVS1.

146 AAV integration to a specific site on human chromosome 19, called AAVS1.

147 3' UTR of the gene DMPK at the DM1 locus on chromosome 19 causes myotonic dystrophy, a dominantly in

148 rget viral integration to a specific site on chromosome 19 (ch-19).

149 This TGT cDNA sequence is encoded in human chromosome 19 clone CTC-539A10 (GenBank accession no. AC

150 expressed in the developing lens and maps to chromosome 19 close to ak in mouse.

151 with >60 mutations within the MHS-1 locus on chromosome 19 coding for ryanodine receptor type 1 (RyR1

152 ean Americans: rs1061477 in the KLK3 gene on chromosome 19 (combined odds ratio = 1.18; 95% CI, 1.10-

153 ound frequent deletion of a small segment of chromosome 19 containing MBD3, also a member of the NuRD

154 We characterized 102 kb of chromosome 19 containing the apolipoprotein (APO) E/C1/C

155 he leukocyte receptor complex (LRC) on human chromosome 19 contains related Ig superfamily killer cel

156 A region on chromosome 19 continues to show evidence for linkage, by

157 istatic effects located at distinct sites on chromosome 19 control susceptibility.

158 ly, amplification of the human RHPN2 gene on chromosome 19 correlates with a dramatic decrease in the

159 and cardiac arrhythmias) but do not have the chromosome-19 D CTG expansion.

160 Detailed microsatellite analysis of chromosome 19 deletions identified three independent reg

161 ntegrate its DNA into a 4-kb region of human chromosome 19, designated AAVS1.

162 dults, can be caused by a mutation on either chromosome 19 (DM1) or 3 (DM2).

163 and Yb8 Alu family members located on human chromosome 19 does not differ from that expected based u

164 e 3' untranslated region of the DMPK gene on chromosome 19 (dystrophia myotonica type 1 [DM1]), or an

165 An additional chromosome 19 element, which is responsible for DNA rear

166 that a cluster of 5 galectin genes on human chromosome 19 emerged during primate evolution as a resu

167 Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, w

168 modest evidence that MOLF-derived alleles on chromosome 19 enhance development of bilateral TGCTs.

169 ease in this cross was the Fas gene on mouse chromosome 19, exhibiting a lod score of 60.

170 and integrates into a preferred location on chromosome 19, features that have fostered development o

171 ivergent haplotype of the core MHC region on chromosome 19 for six expressed genes not found in the z

172 scription units, juxtaposed to snaR genes on chromosome 19, formed by a promoter-containing left mono

173 is causally related to a previously reported chromosome 19 GWAS signal that was ascribed to the gene

174 th our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

175 Chromosome 19 has the highest gene density of all human

176 Allelic losses of the q13.3 region of chromosome 19 have been documented in malignant gliomas,

177 mon site-specific integration locus on human chromosome 19; however, most AAV vectors do not appear t

178 46-Mb gene-rich euchromatic portion of human chromosome 19 (HSA19) was utilized to generate a sequenc

179 Evidence for linkage to chromosome 19 (IBD6) was observed in Crohn's disease pai

180 gene encoding the ribosomal protein RPS19 on chromosome 19 in 25% of patients with DBA.

181 ch affects fasting insulin levels, to distal chromosome 19 in a leptin-deficient obese F2 intercross

182 rt the existence of a major modifier gene on chromosome 19 in a region previously linked to MI.

183 ting the sequence-based linkage approach for chromosome 19 in CEPH pedigrees.

184 hybridization, to chromosome 7 in mouse and chromosome 19 in human.

185 ated on X and Y chromosomes in humans but on chromosome 19 in mice.

186 d1 and Scd2, respectively, and maps to mouse chromosome 19 in very close proximity to Scd1 and Scd2.

187 t leads to the integration of AAV into human chromosome 19 in vivo.

188 d localized a gene causing EEC to a locus on chromosome 19, in a region defined by D19S894 and D19S41

189 ansport functions and maps to proximal mouse chromosome 19, in a region to which the oc mutation has

190 ated Ucp1 expression, the C57BL/6J allele on chromosome 19 increased Ucp1 mRNA to levels higher than

191 s in the AAV2 ITR, the AAV5 ITR, and the AAV chromosome 19 integration locus identified some conserve

192 Introgression of a 7-Mb segment of the B6 chromosome 19 into the BTBR background (strain 1339A) re

193 The single copy gene that was mapped to chromosome 19 is intronless and encodes a 92-kDa protein

194 This region of chromosome 19 is known to contain genes involved in vari

195 e have demonstrated that the gene-rich human chromosome 19 is located in a more central position in t

196 urth, whereas the Siglec-11 gene is on human chromosome 19, it lies outside the previously described

197 Chromosome 19, known to have a high gene density, contai

198 ation of Casp7 to the distal region of mouse chromosome 19, linked to Mxi1, Adra2a, and Aop1.

199 A variant in the chromosome 19 locus (rs838145) was associated with highe

200 three most plausible candidate genes for the chromosome 19 locus, our only genome-wide significant th

201 linkage was also detected at two regions on chromosome 19 (LOD = 2.84 and 2.54).

202 LOD = 1.09) for mild airflow obstruction and chromosomes 19 (LOD = 1.21) and 22 (LOD = 1.37) for chro

203 ree of the identified markers are located on chromosome 19 (meta-analysis: full sample P = 6.94E - 81

204 cies include miRNA from the primate-specific chromosome 19 miRNA cluster (C19MC), which is expressed

205 onging to the primate- and placenta-specific chromosome 19 miRNA cluster (C19MC)-were significantly d

206 rate a unique oncogenic amplification of the chromosome 19 miRNA cluster, C19MC.

207 We show that miRNA members of the chromosome 19 miRNA cluster, which are almost exclusivel

208 tion of seven new meiotic hot spots on mouse chromosome 19, more than doubling the number of currentl

209 nce-tagged site mapping places cPLA2gamma on chromosome 19 near calmodulin.

210 strain (CSS; or 'consomic strain') in which chromosome 19 of 129/Sv+/+ was replaced by its MOLF-deri

211 . latifolia X chromosome, was applied to the chromosome 19 of Populus trichocarpa, an incipient sex c

212 VI, fatty acid 2-hydroxylase, ceruloplasmin, chromosome 19 open reading frame 12 and ATPase type 13A2

213 current changes detected by CGH were gain of chromosome 19 or 19p and complete or partial deletions o

214 hort arm of chromosome 1 and the long arm of chromosome 19, or 1p19q codeletion; and (c) methylguanin

215 ) or balanced for at least one participating chromosome (19 paired breakpoints).

216 emphasis on genes also included in the human chromosome 19 physical map.

217 y low retention frequency of markers on this chromosome (19%) prevented unambiguous ordering of the o

218 to the high-resolution physical map of human chromosome 19 provides a framework for isolation of dise

219 of schizophrenia, the identification of the chromosome 19 quantitative trait locus is a novel findin

220 2 million bp of raw sequence data from human chromosome 19 region q13.

221 A type 5 locus on chromosome 11; and 11) the chromosome 19 region that contains several ion channels

222 The chromosome 19 region was identified in our data despite

223 carry a deletion of approximately 400 kb in chromosome 19, resulting in a fusion of the genes for th

224 o an atherosclerosis susceptibility locus on chromosome 19 revealed in an intercross between atherosc

225 nt locus was also found in or near ZNF626 on chromosome 19 (rs11085374; OR, 0.77; 95% CI, 0.70-0.85;

226 we generated congenic strains harboring MOLF chromosome 19 segments on 129 strain background and moni

227 The AML1 gene is fused out of frame to chromosome 19 sequences, resulting in a truncated AML pr

228 CblR is located at p13.2 on the short arm of chromosome 19, spans a length of 6.224 kb, and is compos

229 discovery project focused on characterizing chromosome 19-specific cDNAs.

230 We have screened a human chromosome 19-specific cosmid library for the presence o

231 eotide repeat polymorphisms were detected in chromosome 19-specific cosmids that were physically mapp

232 All of the chromosome 19-specific Ya5/8 and Yb8 Alu family members

233 together in the homologous region of murine chromosome 19, suggesting that one of these loci might b

234 C-G was mapped to the distal region of mouse chromosome 19 (syntenic with human chromosome 10q), but

235 gene identified as responsible for the mouse chromosome 19 T2dm2 quantitative trait locus for fasting

236 nic cycle, AAV integrates at a site on human chromosome 19 termed AAVS1.

237 specifically into a defined region of human chromosome 19 (termed AAVS1).

238 A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock pro

239 report we present a gene map of a section of chromosome 19 that has been derived by combining the use

240 gain (duplication) of the genomic region on chromosome 19 that includes PRKACA.

241 e localized (MMU)Minpp1 to a region of mouse chromosome 19 that includes the murine homolog of Pten.

242 The Krd mouse has a deletion in chromosome 19 that includes the Pax2 gene locus.

243 carries a 7-cM transgene-induced deletion on chromosome 19 that includes the Pax2 locus.

244 Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q

245 as mapped by linkage disequilibrium to mouse chromosome 19, the same site to which several mouse muta

246 dergoes site-specific integration into human chromosome 19 through a deletion-substitution mechanism

247 rosses across the proximal 10 cM of proximal Chromosome 19 to identify haplotype blocks that segregat

248 this locus interacted with BALB/c alleles on chromosome 19 to increase the severity of infection.

249 eal a novel oncogenic mechanism in which the chromosome 19 translocation breakpoint interrupts the co

250 The chromosome 19 translocation breakpoint targets the BRD4

251 The human ELL gene on chromosome 19 undergoes frequent translocation with the

252 The human ELL gene on chromosome 19 undergoes frequent translocations with the

253 We mapped the NRAP gene to mouse chromosome 19 using interspecific crosses and to human c

254 nd the four-exon cathelicidin genes to sheep chromosome 19 using sheep-hamster somatic cell hybrids i

255 An amplicon on chromosome 19 was detected in 26% of ABC DLBCLs but in o

256 mutation at the pale ear (ep) locus on mouse chromosome 19 was found to be the homologue of human Her

257 lagen-binding inhibitory receptor encoded on chromosome 19, was inserted between the V and DJ segment

258 L on chromosome 5 and rs2302188/NM_033543 on chromosome 19), we provide strong evidence for associati

259 e high-resolution cosmid contig map of human chromosome 19, we found that the previous report was inc

260 romosomes 15 and 16 and one affecting LDL on chromosome 19 were identified.

261 osomes 2, 3, and 8 and one C57BL/6J locus on chromosome 19 were linked to Ucp1 induction in retroperi

262 Rep-mediated site-specific integration into chromosome 19 when present in inverted terminal repeat-c

263 ved in the apolipoprotein E (APOE) region on chromosome 19 where several SNPs surpassed the conservat

264 in smokers only, the maximum LOD was 1.64 at chromosome 19, whereas for chronic bronchitis in smokers

265 Additionally, chromosome 19, which contains Pten, was also selectively

266 o the Siglec-3-related gene cluster on human chromosome 19, which, in contrast, contains seven Siglec

267 The localization of MLIV to chromosome 19 will permit genetic prenatal diagnosis in

268 marker D19S433 at 51.88 centimorgans (cM) on chromosome 19 with 36 families (75 ARPs) when including

269 Human IGFL genes are clustered together on chromosome 19 within a 35-kb interval.

270 significant associations were identified on chromosome 19 within APOE (apolipoprotein E) (rs429358,