ライフサイエンスコーパス: chromosome 21

1 ons in hypermutable CpG regions across human chromosome 21.

2 231 supernumerary genes on the extra copy of chromosome 21.

3 d in rodent cells that contain part of human chromosome 21.

4 iated with a region on the long arm of human chromosome 21.

5 syndrome (DS) is caused by trisomy of human chromosome 21.

6 ly located TMPRSS2 and ERG gene sequences on chromosome 21.

7 n the Down syndrome critical region of human chromosome 21.

8 or nearly half of the genes located on human chromosome 21.

9 of megakaryocytic differentiation located on chromosome 21.

10 rthologs of about half of the genes on human chromosome 21.

11 a high density from a 2.5-Mb region of human chromosome 21.

12 f the Down syndrome critical region of human chromosome 21.

13 ondition caused by the triplication of human chromosome 21.

14 primer plex MARA to genotype SNPs from human chromosome 21.

15 in the Down syndrome (DS) critical region of chromosome 21.

16 gle-nucleotide polymorphisms (SNPs) on human chromosome 21.

17 atients with complex karyotypes and abnormal chromosome 21.

18 yloid precursor protein cleavage enzyme 2 on chromosome 21.

19 regulation of gene expression is specific to chromosome 21.

20 me number of the >300 genes encoded by human chromosome 21.

21 om complete or partial triplication of human chromosome 21.

22 ne from the Down syndrome critical region on chromosome 21.

23 diate 5' region flanking 38 mRNAs mapping to chromosome 21.

24 ported for meiosis II (MII) errors involving chromosome 21.

25 apped to the Down's critical region of human chromosome 21.

26 e superoxide dismutase gene, also located on chromosome 21.

27 finished sequence from five regions on human chromosome 21.

28 like influence of a small subset of genes on chromosome 21.

29 syndrome results from triplication of human chromosome 21.

30 inear YACs containing genomic DNA from human chromosome 21.

31 iotic recombination on the long arm of human chromosome 21.

32 ttributed to the presence of three copies of chromosome 21.

33 the Down syndrome 'critical region' of human chromosome 21.

34 e resulting from the presence of 3 copies of chromosome 21.

35 282 trios that include a child trisomic for chromosome 21.

36 ical and social costs, caused by trisomy for chromosome 21.

37 rome results from full or partial trisomy of chromosome 21.

38 tion are rapidly reversed upon silencing one chromosome 21.

39 eby generating subclones isogenic except for chromosome 21.

40 e pattern observed among normally disjoining chromosomes 21.

41 rs and positions of foci were determined for chromosomes 21, 18, 13, and X.

42 Detailed examination of two such clusters on chromosome 21 (21q22) and chromosome X (Xp11) reveals th

43 vealed a human genomic sequence derived from chromosome 21 (21q22) bearing significant homology to th

44 ne content of the finished sequence of human chromosome 21 (364 genes and putative genes) with the ge

45 The candidate region of genes on chromosome 21 affecting cerebellar development in DS is

46 on human chromosome 8 with the AML1 gene on chromosome 21 (AML1-ETO), is one of the most frequent cy

47 y complex sequence, longest contigs in human chromosome 21 and 22) by recursive segmentations at diff

48 to derive the pig homolog, and a fission of chromosome 21 and a pericentric inversion is needed to d

49 1A , lie within the critical region of human chromosome 21 and act synergistically to prevent nuclear

50 deficit of slightly deleterious variants on Chromosome 21 and decreased transcriptome-wide variation

51 that are specific to many genes assigned to chromosome 21 and do not directly measure the clinical p

52 21 chromosomal breakpoint identified AML1 on chromosome 21 and ETO (MTG8) on chromosome 8, and the re

53 s for generating complete transcript maps of chromosome 21 and for the entire human genome, and for d

54 n cohort, we fine-mapped a new risk locus on chromosome 21 and identified C21orf2 as a gene associate

55 The GART gene is located on human chromosome 21 and is aberrantly regulated and overexpres

56 d progenitors (MEPs) triggered by trisomy of chromosome 21 and is further enhanced by the somatic acq

57 tathionine beta-synthase (CBS) is located on chromosome 21 and is overexpressed in children with Down

58 f chromatin, is encoded by a gene located on chromosome 21 and is overexpressed in Down syndrome, one

59 The underlying gene, SYNJ1, maps to human chromosome 21 and is thus a candidate for involvement in

60 The gene for S100B is located on chromosome 21 and levels of the protein are elevated in

61 total genome of an egg with a non-disjoined chromosome 21 and no detectable recombination.

62 th Down syndrome, who carry an extra copy of chromosome 21 and overexpress APP several-fold in the br

63 r caused by full or partial trisomy of human chromosome 21 and presents with many clinical phenotypes

64 rthologs of about half of the genes on human chromosome 21 and provide a genetic model for DS.

65 (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic c

66 tein (CBF alpha), and PEBP2 alpha B) gene on chromosome 21 and the ETO (eight-twenty one, also called

67 binding transcription factor AML1 (RUNX1) on chromosome 21 and the ETO (MTG8) gene on chromosome 8, g

68 It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromo

69 anslocation, which involves the AML1 gene on chromosome 21 and the ETO gene on chromosome 8, generate

70 e pathogenic role of trisomic genes on human chromosome 21 and the genotype-phenotype relationship st

71 syndrome is caused by an extra copy of human chromosome 21 and the resultant dosage-related overexpre

72 SCR1) gene is present in the region of human chromosome 21 and the syntenic region of mouse chromosom

73 The sequencing of chromosome 21 and the use of models of Down's syndrome i

74 The XIST non-coding RNA coats chromosome 21 and triggers stable heterochromatin modifi

75 normal transformed cutoff value of z = 3 for chromosome 21 and z = 3.95 for chromosomes 18 and 13.

76 In a few cells, chromosomes 21 and 18 did not have any foci (i.e., were

77 Human chromosomes 21 and 22 (mainly the q-arms) were the first

78 n across the nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4

79 plying it to the finished sequences of human chromosomes 21 and 22 as well as by comparing the predic

80 the complete nonrepetitive sequence of human chromosomes 21 and 22 by combining chromatin immunopreci

81 ieved a richer view of the transcriptome for Chromosomes 21 and 22 by using high-density oligonucleot

82 To identify novel STAT5 targets, we searched chromosomes 21 and 22 for clusters of STAT5 binding site

83 The sequences of the human chromosomes 21 and 22 indicate that there are approximat

84 e in the fly, worm, yeast and human genomes (chromosomes 21 and 22 only).

85 otic genomes-the worm, yeast, fly and human (chromosomes 21 and 22 only).

86 used the complete genomic sequences of human chromosomes 21 and 22 to examine the properties of CpG i

87 parated by an average of 29.2 and 22.3 kb on chromosomes 21 and 22, respectively.

88 tic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabido

89 We have applied our approach to chromosomes 21 and 22, the first parts of the human geno

90 In total, on chromosomes 21 and 22, there are 189 processed pseudogen

91 On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a ti

92 ntially all nonrepetitive sequences on human chromosomes 21 and 22, we map the binding sites in vivo

93 n populations and clusters of pseudogenes on chromosomes 21 and 22.

94 isiae, and D. melanogaster, as well as human chromosomes 21 and 22.

95 ased integrated maps have been completed for chromosomes 21 and 22.

96 contributing to the reduced recombination on chromosome 21, and hence, the nondisjunction event.

97 inase 1A (DYRK1A) gene is localized in human chromosome 21, and its overexpression has been associate

98 yo-inositol cotransporter gene is located on chromosome 21, and myo-inositol affects neuronal surviva

99 of the four interferon receptors encoded on chromosome 21, and proposed that DS could be understood

100 Chromosome 21 aneuploid cells constitute approximately 4

101 arison, human interphase lymphocytes present chromosome 21 aneuploidy rates of 0.6%.

102 arranges with 11q23, and the DNA sequence of chromosome 21 appears to be less susceptible than 22q11

103 The findings with chromosome 21 are confirmed by independent evidence from

104 Segments of the long arm of human chromosome 21 are conserved, centromere to telomere, in

105 Robertsonian translocations (ROBs) involving chromosome 21 are found in approximately 5% of patients

106 The regions on human chromosome 21 are syntenically conserved in three region

107 he male-only data subset (LOD = 2.99) and on chromosome 21 at 34 cM in the female-only data subset (L

108 nal silencing and DNA methylation to form a 'chromosome 21 Barr body'.

109 There have been 28 genes identified in human chromosome 21 between TMPRSS2, whose orthologue is the m

110 are caused by the overexpression of genes on chromosome 21, but this hypothesis has not yet been asse

111 ntroduced a TKNEO transgene into one copy of chromosome 21 by gene targeting.

112 cence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with

113 ected-sib-pair linkage method to analyze the chromosome 21 clinical and genetic data obtained on affe

114 Chromosome 21 CNA shared a common region of gain, with a

115 he algorithms to a data set of SNPs on human chromosome 21, combining the information of coding and n

116 To aid the Down syndrome and chromosome 21 community, and researchers interested in t

117 The unique profile of up-regulation on chromosome 21, consistent with primary dosage effects, w

118 voring genetic linkage [LOD] = 2.4), whereas chromosome 21 contained markers with the strongest linka

119 We identified a 3-megabase region on human chromosome 21 containing 6 candidate genes associated wi

120 had trisomy 21 resulting from duplication of chromosome 21 containing the RUNX1 deletion.

121 This region of human chromosome 21 contains 6 candidate genes for herpes susc

122 of the four interferon receptors encoded on chromosome 21, contributes to many of the clinical impac

123 For example, the published human chromosome 21 data by Patil et al. contains about 20% mi

124 ed by reanalyzing a recently published human chromosome 21 dataset.

125 coding MxA, MX1, is located in the region of chromosome 21 deleted as a consequence of fusion of TMPR

126 fusion between TMPRSS2 and ERG suggested by chromosome 21 deletions detected by array CGH.

127 copy of the Abeta precursor protein gene on chromosome 21, Down syndrome (DS) individuals develop hi

128 In oocytes with nondisjoined chromosomes 21 due to a meiosis I (MI) error, recombinat

129 rant folate metabolism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxi

130 Previously, we have shown that DYRK1A, a chromosome 21-encoded kinase implicated in the mental re

131 syndrome causes overexpression of miR-155, a chromosome 21-encoded microRNA that negatively regulates

132 ombination patterns were used to predict the chromosome 21 exchange patterns established during meios

133 AD, we examined splicing factors located on chromosome 21 for their effect on tau exon 10.

134 ymorphic tetranucleotide repeat sequences on chromosome 21, four primer pairs for sequences on chromo

135 mouse models to improve our understanding of chromosome 21 gene dosage effects in human hematologic m

136 ased expression of the kinase encoded by the chromosome 21 gene DYRK1A suppresses the nuclear factor

137 rin activity by DSCR1, together with another chromosome 21 gene Dyrk1a, may be sufficient to markedly

138 dentate gyrus-CA3 networks to aberrant human chromosome 21 gene expression and delineate hippocampal

139 ps are distinct from DS-AMKL, independent of chromosome 21 gene expression.

140 d researchers interested in the study of any chromosome 21 gene or ortholog, we are developing a comp

141 Surprisingly, expression of the chromosome 21 gene RUNX1, a known regulator of megakaryo

142 s for these genes plus nine additional novel chromosome 21 genes and four paralogous genes mapping el

143 aps with human DS-DM and shows that multiple chromosome 21 genes contribute to the downstream epigene

144 step pathogenesis of DS-AMKL and to identify chromosome 21 genes that promote megakaryoblastic leukem

145 also ranked among the most highly expressed chromosome 21 genes.

146 For these, a ROB DS chromosome 21 genetic map was constructed and compared t

147 gramming algorithm is applied to analyze the chromosome 21 haplotype data of Patil et al., who search

148 se chromosome 16 that is homologous to human chromosome 21 has been triplicated.

149 Several genes in chromosome 21 have been linked to neuronal death, includ

150 drome), but the responsible gene or genes on chromosome 21 have not been identified.

151 junction of material represented in human on chromosomes 21 (HSA 21) and 22 (HSA 22) that occurred in

152 rt disease (CHD); however, trisomy for human chromosome 21 (Hsa21) alone is insufficient to cause CHD

153 Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of

154 ed by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genetic cau

155 Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and presents a complex phenotype t

156 from an extra copy of the long arm of human chromosome 21 (HSA21) and the increased expression of tr

157 nclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient to cause DS and its

158 The genomic regions on human chromosome 21 (Hsa21) are syntenic to three regions in t

159 temporally with increased expression of the chromosome 21 (HSA21) associated, oligodendrocyte transc

160 Copy number variations to chromosome 21 (HSA21) cause intellectual disability and

161 ionally trisomic for approximately 120 human chromosome 21 (HSA21) classical protein-coding genes.

162 Moreover, human chromosome 21 (Hsa21) encodes several negative regulator

163 creation of mice that carry different human chromosome 21 (Hsa21) fragments as a freely segregating

164 that trisomy for only 33 orthologs of human chromosome 21 (Hsa21) genes was sufficient to cooperate

165 rmatic annotation has established that human chromosome 21 (Hsa21) harbors five microRNA (miRNAs) gen

166 The DNA sequence of human chromosome 21 (HSA21) has opened the route for a systema

167 or orthologues of about half of the genes on chromosome 21 (Hsa21) in Ts65Dn mice or just 33 of these

168 Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS), a d

169 Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS).

170 The factors on human chromosome 21 (Hsa21) that confer this predisposing effe

171 The Tc1 human chromosome 21 (Hsa21) transchromosomic mouse model of Do

172 ic stem cells (ESCs)) bearing an extra human chromosome 21 (HSA21)) we analyzed the early stages of h

173 has orthologues of about 50% of the genes on chromosome 21 (Hsa21), has indicated that three copies o

174 wn syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of conge

175 are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in huma

176 (MMU16) shares conserved linkage with human chromosome 21 (HSA21), trisomy for which causes Down syn

177 syndrome (DS) is caused by a triplication of chromosome 21 (HSA21).

178 a freely segregating, almost complete human chromosome 21 (Hsa21).

179 n isogenic control that is disomic for human chromosome 21 (HSA21).

180 mice carrying a genetically rearranged Human Chromosome 21 (Hsa21).

181 LL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct bio

182 Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic su

183 Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of ch

184 defined by intrachromosomal amplification of chromosome 21 (iAMP21), is restricted to older children

185 current amplification of megabase regions of chromosome 21 (iAMP21).

186 ntrachromosomal amplification of a region of chromosome 21 (iAMP21; three or more extra copies of RUN

187 f relapse (intrachromosomal amplification of chromosome 21 [iAMP21], 6.04, 3.90-9.35; t(9;22), 3.55,

188 ed in aneuploid mouse neurons carrying human chromosome-21, implicating promoter/enhancer sequence di

189 The human DYRK1A gene is located on trisomic chromosome 21 in Down syndrome (DS) patients, leading to

190 s a developmental disorder caused by a third chromosome 21 in humans (Trisomy 21), leading to neurolo

191 st a pathogenic role for splicing factors on chromosome 21 in neurodegenerative diseases with tangles

192 s were recapitulated across the entire human chromosome 21 in the mouse hepatocyte nucleus.

193 -rich basic protein (WRB), a gene located on chromosome 21 in the proposed region responsible for con

194 The second locus was at chromosome 21 in the proximity of CRYAA (rs11911275, fix

195 ible XIST transgene into the DYRK1A locus on chromosome 21, in Down's syndrome pluripotent stem cells

196 terized by intrachromosomal amplification of chromosome 21 including the RUNX1 gene (iAMP21).

197 n the fetal DNA ratios for chromosome 13 and chromosome 21, indicative of trisomy 21; the remaining 5

198 This study has provided evidence that chromosome 21 instability is the only anomaly among thos

199 alled Down syndrome critical region of human chromosome 21 is an important region for this phenotype,

200 In the t(8;21) the AML1 gene on chromosome 21 is fused to ETO on chromosome 8.

201 e show that expression of genes localized to chromosome 21 is globally up-regulated in human fetal tr

202 Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translo

203 homogeneous than yeast chromosome III, human chromosome 21 is more homogeneous than human chromosome

204 or more extra copies of RUNX1 on an abnormal chromosome 21) is a recently identified recurrent genomi

205 Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunct

206 Down's syndrome candidate region interval on chromosome 21, is highly expressed in the heart and cent

207 DS critical region 1 (DSCR1), located on chromosome 21, is overexpressed in the brain of DS fetus

208 Down syndrome, trisomy of human chromosome 21, is the most common genetic cause of intel

209 's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intel

210 Down syndrome (DS), or trisomy of chromosome 21, is the most common genetic disorder assoc

211 ved a duplication of the gene PDXK, which on chromosome 21 lies immediately distal to the KIAA0179 ge

212 large pedigree, identified a single locus on Chromosome 21 linked to the disease (LOD > 9).

213 ll analysis to show that increased dosage of chromosome 21-localized Dyrk1a steeply increases G1 cell

214 sitivity and higher transcript levels of the chromosome 21-localized gene, cystathionine-beta-synthas

215 AML patients by examining the expression of chromosome 21-localized genes in myeloblasts from newly

216 We show here that the relevant activity on chromosome 21 maps to RUNX1.

217 hybridization signals on the majority of the chromosome 21 markers, and cffDNA from a fetus with mono

218 = 2.00), chromosome 20 (MaxLOD = 1.82), and chromosome 21 (MaxLOD = 2.21).

219 Other factors, possibly including genes on chromosome 21, may increase the penetrance of type 1 dia

220 is Down syndrome (DS), where a third copy of chromosome 21 mediates neurogenesis defects and lowers t

221 A single locus of four linked SNPs on chromosome 21 met genome-wide significance criteria for

222 The chromosome 21 microRNA (miR)-125b cluster has been previ

223 rom 20 partially resequenced copies of human chromosome 21-more than 20,000 polymorphic sites-were an

224 fit the overall short-range data (0-5 kb) of chromosome 21 much better than do models including cross

225 = 21) or high hyperdiploidy with additional chromosomes 21 (n = 23).

226 n 83% of cases, and most frequently involved chromosomes 21 (n=42), 9 (n=21), 6 (n=16), 12 (n=11), 15

227 ouse nucleus, hundreds of locations on human chromosome 21 newly associate with activating histone mo

228 nation rate in these eggs with non-disjoined chromosomes 21; no specific chromosomes were driving thi

229 ns in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia

230 The end-product is a derivative of chromosome 21 or the rob(15;21)c chromosome with gene do

231 ead PDE9A was fused to intergenic regions of chromosome 21 or to genes on other chromosomes.

232 es almost twice as far in chromosome 6 as in chromosomes 21 or 22, in agreement with their difference

233 e to cancer risk, tumour-suppressor genes on chromosome 21, or a slower rate of replication or higher

234 arry a duplication spanning the entire human chromosome 21 orthologous region on mouse chromosome 16

235 t association with the HMGN1 gene located on chromosome 21 (P=1 x 10(-6)).

236 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochem

237 synj/synj1, and nla/dscr1, located on human chromosome 21 play important roles in DS neurons.

238 in (AIRE), a transcription factor located on chromosome 21, plays a crucial role in autoimmunity by r

239 ybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "

240 ases, DS results from an extra copy of human chromosome 21 producing deregulated gene expression in b

241 close to 11q23 as does 22q11 during meiosis, chromosome 21 rarely rearranges with 11q23, and the DNA

242 Because it is located on human chromosome 21, RCAN1 has been postulated to contribute t

243 malities, and P2RY8-CRLF2, were secondary to chromosome 21 rearrangements.

244 determine whether an association does exist, chromosome 21 recombination patterns were examined in 40

245 ive clinical features associated with CNI of chromosome 21 reflect generalized aneuploidy and are not

246 10 region encoding pericentrin and the human chromosome 21 region encoding kendrin indicates that the

247 e nucleotide polymorphism (SNP) scans of the chromosome 21 region to define which of 6 possible candi

248 Most copy number alterations targeted chromosome 21, reinforcing the complexity of this chromo

249 "Down syndrome critical region" (DSCR) is a chromosome 21 segment purported to contain genes respons

250 approximately 22.5 Mb of nonrepetitive human chromosome 21 sequence were synthesized and then hybridi

251 udy in this issue of Oncogene, defines human chromosome 21 sequences that alter hematopoiesis and ind

252 f childhood leukemias, and identification of chromosome 21 sequences that have a role in leukemogenes

253 recombination is significantly reduced along chromosome 21; several lines of evidence indicate that t

254 dentify a large fraction of all common human chromosome 21 SNPs and to directly observe the haplotype

255 ortholog, we are developing a comprehensive chromosome 21-specific database with the goals of (i) da

256 2.9 Mb duplication spanning the entire human chromosome 21 syntenic region on mouse chromosome 16 in

257 risomic for approximately 56.5% of the human chromosome 21 syntenic region on mouse chromosome 16.

258 The chl gene is on a region of chromosome 21 syntenic with the area of murine chromosom

259 conserved elements are present in regions on chromosome 21 that do not encode known genes.

260 BHLHB1 mapped to the region of chromosome 21 that has been proposed to be responsible,

261 istence of an activity associated with human chromosome 21 that permits the E1B-55K and E4orf6 protei

262 rt the presence of dosage-sensitive genes on chromosome 21 that regulate leukemogenesis and hematopoi

263 We have identified a gene located on chromosomes 21 that is expressed in normal and neoplasti

264 th mice derived from female passage of human chromosome 21, the chromatin condensation during spermat

265 reakthroughs, it is not clear which genes on chromosome 21, the chromosome that is trisomic in indivi

266 evant published datasets that included human Chromosome 21, the human lipoprotein lipase (LPL) gene l

267 On chromosome 21, there was evidence for LD (P = 0.02) betw

268 rain produce viable sperm and transmit human chromosome 21 to create aneuploid offspring.

269 rom an aneuploid mouse strain carrying human chromosome 21 to determine, on a chromosomal scale, whet

270 elogenous leukemia, joining the AML1 gene on chromosome 21, to the ETO gene on chromosome 8, forming

271 Yet the mechanistic links between chromosome 21 triplication and B-ALL remain undefined.

272 c for 132 genes homologous to genes on human chromosome 21, triplication of Usp16 reduces the self-re

273 er caused by the presence of three copies of chromosome 21 (trisomy 21), is characterized by impairme

274 sults from the presence of an extra maternal chromosome 21 (trisomy 21), which comprises the Kcnj6 ge

275 a model system that contains full trisomy of chromosome 21 (Ts21) in a human genome that enables norm

276 d other complex structural rearrangements of chromosome 21 underlie the mechanism giving rise to iAMP

277 en applied to >23,000 transcripts from human chromosome 21, using biologically reasonable filters, RC

278 , and 9 patients manifested abnormalities of chromosome 21 (usually trisomy 21).

279 mits an almost complete single copy of human chromosome 21 via the female germline, we show that a he

280 the Tc1 mouse, which carries a copy of human chromosome 21 was produced in 2005.

281 The common region of amplification on chromosome 21 was refined to a 5.1-mb region that includ

282 Methylation of a CpG site in ABCG1 on chromosome 21 was significantly associated with insulin

283 ical Alzheimer disease gene, APP, located on chromosome 21, was not found to be up-regulated in adult

284 and analysis of published haplotype data on chromosome 21, we find that (1) the combined effects of

285 Since hsa-miR-155 is on chromosome 21, we hypothesize that the observed lower bl

286 Over 25% of genes on chromosome 21 were differentially expressed in compariso

287 Genes on chromosome 21 were overexpressed in Down's syndrome, and

288 ional hybrid cells bearing portions of human chromosome 21 were used to map this activity to a 10-meg

289 that all translocations and all nondisjoined chromosomes 21 were maternally derived.

290 me is caused by a genomic imbalance of human chromosome 21 which is mainly observed as trisomy 21.

291 ed by amplification of a 5.1-24 Mb region of chromosome 21, which includes the RUNX1 gene.

292 t for people with trisomy of the APP gene on chromosome 21, which is a phenotype long associated with

293 autoimmune regulator (AIRE) gene, located on chromosome 21, which regulates the expression of tissue-

294 Here we compare approximately 27 Mb of human chromosome 21 with chimpanzee DNA sequences identifying

295 ingle-minded 2 (SIM2) gene interval on human chromosome 21 with horse, cow, pig, dog, cat, and mouse

296 Comparison of approximately 9 Mb of human chromosome 21 with orangutan, rhesus macaque, and woolly

297 to gene dosage, of the >300 genes encoded by chromosome 21 with specific phenotypic features is a goa

298 region of interest on the long arm of human chromosome 21, with a multipoint logarithm of odds score

299 s are distributed along the entire length of chromosome 21, with approximately 35% found in genomic i

300 In humans, the gene for S100B is found on chromosome 21, within what is considered the obligate re