ライフサイエンスコーパス: chromosome aberration

1 way is required to prevent DNA mutations and chromosome aberrations.

2 reases in both spontaneous mutation rate and chromosome aberrations.

3 CD2 repair factor, and a higher frequency of chromosome aberrations.

4 mples while enhancing the detection of fetal chromosome aberrations.

5 henotypes are due to genetic inheritance and chromosome aberrations.

6 ical advances that have come from studies of chromosome aberrations.

7 which showed a nonrandom pattern of multiple chromosome aberrations.

8 cells, which continue proliferating despite chromosome aberrations.

9 Ionizing radiation produces many chromosome aberrations.

10 cell killing, sister chromatid exchange, and chromosome aberrations.

11 cies by analysing 15 cases with unidentified chromosome aberrations.

12 A double-strand break repair [3] and develop chromosome aberrations [4].

13 of BRIP1 leads to a substantial increase in chromosome aberrations, a characteristic phenotype of ce

14 Chromosome aberration analysis reveals numerous incomple

15 eterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on

16 as evidenced by the presence of aneuploidy, chromosome aberration and centrosome amplification.

17 y biological endpoints (DNA repair kinetics, chromosome aberration and mutation formation, survival)

18 irradiation of these cells led to increased chromosome aberrations and aneuploidy when compared with

19 susceptible to 3MeA-induced S phase arrest, chromosome aberrations and apoptosis, but it is not know

20 RD reduced the frequency of both G1 and S/G2 chromosome aberrations and enhanced the disappearance of

21 Cells from A-T patients exhibit chromosome aberrations and excessive spontaneous apoptos

22 sion of Myc resulted in increased numbers of chromosome aberrations and gammaH2AX foci in non-transfo

23 emonstrated a marked increase in spontaneous chromosome aberrations and HPRT mutations, indicating a

24 ible for male infertility, sex and autosomal chromosome aberrations and possible mental, physical and

25 y, and suggest mechanisms by which T induces chromosome aberrations and promotes the immortalization

26 onsidered by workers in the field concerning chromosome aberrations and psychoses etiology.

27 including transposon activation and various chromosome aberrations and rearrangements, that unfolded

28 on, severe G(2)/M cell cycle arrest, massive chromosome aberration, and defects in ionizing radiation

29 e complex proteins, (4) elevated MMC-induced chromosome aberrations, and (5) sensitivity to MMC and c

30 eased number of centrosomes, acquire complex chromosome aberrations, and lack Rad51 nuclear foci in t

31 ypersensitivity to DNA cross-linking agents, chromosome aberrations, and reduced FANCD2 monoubiquitin

32 imizing the generation of DNA strand breaks, chromosome aberrations, and the ensuing apoptotic respon

33 Complex chromosome aberrations are characteristically induced af

34 Chromosome aberrations are common outcomes of exposure t

35 Microscopically visible chromosome aberrations are due to mutations that distort

36 Mutations in genes on the X chromosome rival chromosome aberrations as a cause of mental retardation.

37 ion is a new approach to identify structural chromosome aberrations associated with cancer.

38 , there were significantly more BPDE-induced chromosome aberrations at the 3p21.3 locus in cases (51.

39 Over 650 chromosome aberration breakpoints map to this chromosome

40 Induction of chromosome aberrations by DNA damage generates cells wit

41 opoisomerase I has been suspected of causing chromosome aberrations by mediating illegitimate recombi

42 This order was consistent with the extent of chromosome aberrations (caMCF > bcMCF >>> trMCF).

43 other cytogenetic-based information such as chromosome aberrations can be linked to this framework.

44 nizing radiation is an established source of chromosome aberrations (CAs).

45 e subcultured strains had very high rates of chromosome aberrations: duplications, deletions, and tra

46 f both Rad52 and BRCA2 resulted in extensive chromosome aberrations, especially chromatid-type aberra

47 se observations advance our understanding of chromosome aberration formation and have implications fo

48 c instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosom

49 ll as genetic and epigenetic alterations and chromosome aberrations, have been shown to contribute to

50 ion and assay design of inversions and other chromosome aberrations in diverse taxa.

51 anding in this study and resolved additional chromosome aberrations in every patient studied except t

52 Chromosome aberrations in human solid tumors are hallmar

53 ach by demonstrating that elevated levels of chromosome aberrations in lymphocytes are associated wit

54 ed clustered damage manifested a spectrum of chromosome aberrations in mitosis.

55 Chromosome aberrations in peripheral blood lymphocytes h

56 performed three-color FISH to detect numeric chromosome aberrations in testicular tissue samples from

57 ammed but may result from the segregation of chromosome aberrations in the postirradiation generation

58 Cytogenetic analysis revealed clonal chromosome aberrations in three of the five cell lines.

59 f the G-rich telomeric strand contributes to chromosome aberrations in WS cells, demonstrating a link

60 alysis demonstrated the presence of numerous chromosome aberrations including dicentric chromosomes,

61 rs or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring fo

62 retrovirus suffered numerical and structural chromosome aberrations, including increases in aneuploid

63 Loss of both helicases exacerbates TDs and chromosome aberrations, indicating that BLM and WRN func

64 We found clonal chromosome aberrations involving 2p23 upon metaphase ana

65 ing is not sensitive enough to detect subtle chromosome aberrations (<5-10 Mb).

66 Human tumors frequently display recurrent chromosome aberrations, many of which are hallmarks of p

67 th the hypothesis that detection of specific chromosome aberrations may be a powerful approach to ide

68 Chromosome aberrations may cause cancer and many heritab

69 We hypothesize how chromosome aberrations might cause disease but the gene

70 transposons (Ty or delta-repeats), and these chromosome aberrations nonrandomly involved chromosome I

71 mulation of DNA strand breaks and results in chromosome aberrations observed in mitosis, ultimately r

72 This mutation, named chaos1 (chromosome aberration occurring spontaneously 1), was ge

73 chaos1 (for chromosome aberrations occurring spontaneously 1) is a r

74 ouse chromosome instability mutation Chaos3 (chromosome aberrations occurring spontaneously 3), isola

75 to cancer are known to result in large-scale chromosome aberrations, our results suggest that small-

76 Two new recurring chromosome aberrations previously not reported in T-ALL

77 n of 1 alpha-particle/cell) and analyzed the chromosome aberrations produced by using 24-color multip

78 p'99, Davis Human-Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP) pages, Entrez Genom

79 e, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and

80 ms (dbSNP), Human/Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and

81 exclamation markVMouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes, Cl

82 GeneMap'99, Human-Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes, Cl

83 l rearrangements within cancer cells (Cancer Chromosome Aberration Project) are also being cataloged

84 Exposure to IR led to more residual chromosome aberrations, radioresistant DNA synthesis (a

85 udies revealed an unusually high spontaneous chromosome aberration rate, contrasting with other FA su

86 The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in h

87 ent thymocytes are susceptible to developing chromosome aberrations that predispose to malignant tran

88 P1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a

89 Chromosome aberrations were enumerated during in vitro a

90 Interestingly, although chromosome aberrations were evident, aneuploidy was not

91 be to telomeric DNA, spontaneously occurring chromosome aberrations were examined for telomere signal

92 In contrast, chromosome aberrations were seen in 79% of early MDS sam

93 F96-224 cells also display elevated chromosome aberrations when compared with control cells.

94 All samples showed complex karyotypes with chromosome aberrations which, in most cases, were not fu

95 biological dosimeters (e.g., cell survival, chromosome aberrations), which can be used to measure th

96 diploid or near diploid but exhibit multiple chromosome aberrations with an average of 4 abnormal chr

97 ities of all agents were tested by examining chromosome aberration yields in first-division metaphase