ライフサイエンスコーパス: chromosome arm

1 the centromere polymerized outward along the chromosome arm.

2 epaired to create at least one crossover per chromosome arm.

3 de I (GI) IDCs and ILCs often lost the whole chromosome arm.

4 number increase of a restricted region of a chromosome arm.

5 ned to a specific micronuclear chromosome or chromosome arm.

6 re amplified and used to map each clone to a chromosome arm.

7 igins, and map protein-binding sites along a chromosome arm.

8 es are entirely homozygous for a mutagenized chromosome arm.

9 ase in recombination rates along the average chromosome arm.

10 nly encompassed all informative markers on a chromosome arm.

11 cruitment and activity of Aurora B kinase on chromosome arms.

12 y reduced from those of genes located on the chromosome arms.

13 g 181 SNP markers spanning two of five major chromosome arms.

14 spread in tandem to ectopic locations on the chromosome arms.

15 ed to unique and shared sites along polytene chromosome arms.

16 cohesin's alpha-kleisin subunit (Rec8) along chromosome arms.

17 ons over cohesin-associated regions (CAR) on chromosome arms.

18 -7 gets redistributed and upregulated on the chromosome arms.

19 encompasses multiple genetic loci and whole chromosome arms.

20 nished binding of the chromokinesin Kif4A to chromosome arms.

21 due to the retention of cohesin on undamaged chromosome arms.

22 tified mega-haplotypes that encompass entire chromosome arms.

23 eres interact before pairing commences along chromosome arms.

24 polar ejection forces by severing vertebrate chromosome arms.

25 absolute) positions within their respective chromosome arms.

26 with occasional alterations in 13 additional chromosome arms.

27 spread in tandem to ectopic locations on the chromosome arms.

28 mplicons, or "firestorms," limited to single chromosome arms.

29 and frequently extending the length of whole chromosome arms.

30 separase and thereby destroys cohesion along chromosome arms.

31 acterization has often lagged behind that of chromosome arms.

32 the speed and force of the PEFs developed on chromosome arms.

33 he chromosome, between centromeres and along chromosome arms.

34 ard higher densities in the distal halves of chromosome arms.

35 al halves than on the proximal halves of the chromosome arms.

36 association of cohesin with centromeres and chromosome arms.

37 h at centromeres and at discrete sites along chromosome arms.

38 n, provided by the cohesin complex along the chromosome arms.

39 e regions of high-mapped-EST density on both chromosome arms.

40 ve in Ndc10p binding, are also present along chromosome arms.

41 nd the gradient of recombination rates along chromosome arms.

42 ncompass multiple genetic loci or even whole chromosome arms.

43 shuffling of gene order along corresponding chromosome arms.

44 centromere is distinct from cohesion at the chromosome arms.

45 these constitutive immunity (cim) mutants to chromosome arms.

46 regions and a banded distribution along the chromosome arms.

47 A for LOH at 21 microsatellite markers on 10 chromosome arms.

48 hores and in axial lines extending along the chromosome arms.

49 ndiscovered role in the poleward movement of chromosome arms.

50 is required for the juxtaposition of the two chromosome arms.

51 ion by promoting the loading of condensin on chromosome arms.

52 9 (H3K9me3)-modified chromatin sites on the chromosome arms.

53 to the postanaphase retention of cohesin on chromosome arms.

54 e species occur within, rather than between, chromosome arms.

55 tends progressively along the full length of chromosome arms.

56 the cross section, balanced by the parallel chromosome arms.

57 ial proximity of homologous sites throughout chromosome arms.

58 plicon pairs, even those located on opposing chromosome arms.

59 he centromere after it disassembles from the chromosome arms.

60 ity regions, and phased variants across full chromosome arms.

61 ub1 inactivation delocalizes cohesin-Sgo1 to chromosome arms.

62 sated by increased recombination activity in chromosome arms.

63 lus end-directed motor proteins that bind to chromosome arms.

64 able to map most of our H-probes to specific chromosome arms.

65 ated by PLK1, leading to SA2 dissociation at chromosome arms.

66 centromeric histone variant Cse4 to sites on chromosome arms.

67 n of variation at the most distal regions of chromosomes arms.

68 ts (S/I) is significantly lower than that of chromosome arms (1.62).

69 GFR amplification, loss of chromosome 10 and chromosome arm 10q, gain of chromosome 7, and hypermethy

70 nstrated a high frequency of allelic loss on chromosome arm 11p and mutations in the APC/beta-catenin

71 n this sample set were uniparental disomy of chromosome arms 11p, 1q, 14q, and 15q and a novel area o

72 Gains of chromosome arm 12p and aneuploidy are nearly universal i

73 rable frequency within the telomere of mouse chromosome arm 14q.

74 pe for p53, had two p53 genes, two copies of chromosome arm 17p and showed functional p53 after irrad

75 ozygosity (LOH) for DNA sequences located on chromosome arm 17p.

76 ost common malignant brain tumor in children.Chromosome arm 17p13.3 is reduced to homozygosity in 35-

77 d to a gene-rich region at the distal end of chromosome arm 1DS of bread wheat (Triticum aestivum L.)

78 ed for the cannabis problems factor score on chromosome arm 1p.

79 ons in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletion) have been

80 romoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q (1p/19q codeletion).

81 n situ hybridization probes are specific for chromosome arm 1q, the c-MYC and HER2 oncogenes, the tum

82 c loss in 17 patients (32%) were detected on chromosome arms 1q, 3q, 5q, 7q (n = 2), 9q (n = 4), 11p

83 20 paired families that involved one of the chromosome arms 1S, 1L, 4L, 5S, and 10L.

84 containing the tenacious glume gene Tg-D1 on chromosome arm 2 DS from Aegilops tauschii, the D genome

85 mapped to a sub-cM genetic interval on wheat chromosome arm 2BS, which includes a single collinear ge

86 Burs124 on chromosome arm 2L contains exons 1, 2, and 4, while burs

87 site (line 1198; insertion near the base of chromosome arm 2L) has been investigated in detail.

88 locations, which included the involvement of chromosome arms 2L, 3L, 5L, 6L, and 7L.

89 is located in the centric heterochromatin of chromosome arm 2R and is identical to a previously ident

90 lation genetic data from several loci across chromosome arm 2R in Drosophila simulans.

91 the PCNA and RpS18 genes at position 56F on chromosome arm 2R.

92 Autosomal inversions in one chromosome arm (2R), an insecticide resistance gene on 2

93 Most chromosome arms (35 out of 43) show a gradient of dwindl

94 ping, we identified several small regions on chromosome arms 3L and 3R that contribute to differences

95 Somatically acquired alterations at chromosome arms 3p and 11q are highly correlated with ac

96 es of loss (at any one locus) were noted for chromosome arms 3p, 6q, 8p, 17q, 18p, 21q, and 22q (40-6

97 omas almost invariably carry extra copies of chromosome arm 3q, resulting in a gain of the human telo

98 e disequilibrium on the X chromosome than on chromosome arm 3R and much more linkage disequilibrium o

99 a large cluster of cytochrome P450 genes in chromosome arm 3R of An. gambiae, is expressed approxima

100 The gene on chromosome arm 4HL encodes the previously identified pro

101 ct colinearity with the genetic map of wheat chromosome arm 5AL.

102 o ToxA is governed by the Tsn1 gene on wheat chromosome arm 5BL.

103 ensitivity/susceptibility gene identified on chromosome arm 5BS, which we designated as Snn3.

104 n to be recognized by the wheat gene Snn3 on chromosome arm 5BS.

105 rs commonly acquire numerous extra copies of chromosome arms 7p, 8q, 13q, and 20q.

106 n SAMD9L, a tumor suppressor gene located on chromosome arm 7q.

107 enes that may mediate the effects of gain of chromosome arm 8q in human colon, liver, and pancreatic

108 One site near the centromere on chromosome arm 9L was identified by a majority of the co

109 ted across the genome and most prevalent for chromosome arms 9p, 17p, and 18q (>60%), sites of the kn

110 condensin mediates the axial contraction of chromosome arms, a process peaking later in anaphase.

111 the conservation of genes within homologous chromosome arms across species, the karyotypes of these

112 rigins are maintained at opposite poles with chromosome arms adjacent to each other, in an ori-ter co

113 homologs through recombinational exchange of chromosome arms after sister-chromatid cohesion is estab

114 Release of SSC along chromosome arms allows first a reductional segregation o

115 ents resulting in deletion of a portion of a chromosome arm along with the addition of a new telomere

116 knockdown results in a loss of Plk1 from the chromosome arm and an increase in highly disorganized "w

117 ated by Aurora B and that Aurora B-dependent chromosome arm and centromere localization is regulated

118 dicative of rapid elastic recoil between the chromosome arm and the centromere.

119 ics by measuring the histone turnover of the chromosome arm and the pericentromere during metaphase i

120 to identify the junction between the unique chromosome arm and the pericentromeric repeats.

121 nrepaired DSB leads to removal of the broken chromosome arm and to break-induced replication of the i

122 some structure include duplication of entire chromosome arms and aneuploidy where chromosomes are dup

123 have distinct localizations, for example on chromosome arms and at kinetochores.

124 allelic homologous recombination (HR) along chromosome arms and between different ectopic locations.

125 Active genes in chromosome arms and centers have very similar histone ma

126 d histone modification were revealed between chromosome arms and centers, with similarly prominent di

127 omposition between the autosomes and between chromosome arms and centers.

128 e that the stepwise loss of cohesion between chromosome arms and centromeres is caused by local regul

129 However, the relative contributions of chromosome arms and centromeres/kinetochores in this pro

130 re highly continuous, include fully resolved chromosome arms and close persistent gaps in these refer

131 eading to release of acetylated cohesin from chromosome arms and loss of cohesion.

132 bring about the lateral interaction between chromosome arms and MTs in vitro to directly measure the

133 tumor cells maintain cohesion in mitosis at chromosome arms and telomeres.

134 on is not simply a consequence of compacting chromosome arms and that overall rDNA compaction is nece

135 cations showing their distribution among the chromosome arms and the 163 cytologically defined chromo

136 ell division, condensation and resolution of chromosome arms and the assembly of a functional kinetoc

137 opose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT

138 studies showed that the removal of SYN1 from chromosome arms and the centromeres is inhibited in the

139 hromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respec

140 ct pathways dissociate cohesins, one acts on chromosome arms and the other on centromeres.

141 slocations have been used to locate genes to chromosome arms and to study the dosage effects of speci

142 Rad21-cohesin with centromeres but not along chromosome arms and, thus, acts to distinguish centromer

143 romosomes to generate embryos lacking entire chromosome arms and, thus, all zygotic gene products der

144 Cohesin binds to discrete sites along chromosome arms, and is especially enriched surrounding

145 Most alien wheat lines carry whole chromosome arms, and it is notable that these lines show

146 eudogenes tend not to occur in the middle of chromosome arms, and tend to be associated with lineage-

147 965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stoc

148 investigated in three scales: whole-genome, chromosome/arm, and focal regions.

149 re in a metaphase-like conformation, whereas chromosome arms are neither aligned nor separated before

150 r and orientation of sequence scaffolds into chromosome arm assemblies.

151 Active genes widely separated on different chromosome arms associate with the same domain frequentl

152 o be essential for cell division, only a few chromosome arm-associated motors have been described.

153 e essential for mitotic function, only a few chromosome arm--associated motors have been described.

154 inhibited dissociation of HP1alpha from the chromosome arms at the G2-M transition.

155 improper attachments by pushing mal-oriented chromosome arms away from spindle poles.

156 on, which is required to remove cohesin from chromosome arms but not centromeres.

157 in rsc mutants Mcd1p fails to associate with chromosome arms but still binds to centromeres, and that

158 one H3 at serine-10 (H3S10ph) by Aurora B on chromosome arms but, in Aurora B reactivation assays, re

159 f Drosophila genes have remained on the same chromosome arm, but within each arm gene order has been

160 chromatid cohesion and its dissolution along chromosome arms, but its protection at centromeric regio

161 etion of Plk1 rescues the cohesion along the chromosome arms, but not at the centromeres.

162 Cohesin association on chromosome arms, but not pericentromeric regions, is red

163 during mitosis most cohesin is stripped from chromosome arms by early prophase, while the remaining c

164 phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, duri

165 ecessary for the removal of shugoshin-2 from chromosome arms by the Aurora B/C kinase, an event cruci

166 The pattern of exchanges along this chromosome arm can be represented by a counting model in

167 Breakage and loss of the chromosome arm carrying the wild-type alleles created a

168 Chromosome arm cohesion was weakened, and the fraction o

169 ed" configuration, consistent with a loss of chromosome arm cohesion.

170 Instead, H3K9 methylation is enriched on chromosome arms, coincident with zones of elevated meiot

171 ssembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to

172 ene chromosomes are severely reduced and the chromosome arms condensed.

173 is centromere depolarization were homologous chromosome arms connected, as observed by the alignment

174 When RE is inactive, the two chromosome arms constitute separate domains inaccessible

175 We targeted ER to gene-amplified chromosome arms containing large numbers of lac operator

176 Validation of the observed gene and chromosome arm copy number changes in a larger cohort of

177 xhibited poleward movement, long and tangled chromosome arms could not be segregated in anaphase.

178 We show that in mukB mutant cells, the two chromosome arms do not separate into distinct cell halve

179 rise solely from the polymeric nature of the chromosome arms due to entropic interactions and nuclear

180 ble to visualize linear condensation of this chromosome arm during G2/M phase.

181 sister chromatids together, dissociates from chromosome arms during meiosis I and from centromeric re

182 Cohesins are removed from chromosome arms during meiosis I but are maintained arou

183 rotubule flux exerts pole-directed forces on chromosome arms during meiosis in crane fly spermatocyte

184 y kinetochore-independent forces that act on chromosome arms during meiosis in crane fly spermatocyte

185 ic heterochromatin, and also localizes along chromosome arms during meiosis.

186 itude of the polar ejection force exerted on chromosome arms during metaphase by individual microtubu

187 cleoplasm during interphase and on condensed chromosome arms during mitosis.

188 an cells a good part of them dissociate from chromosome arms during mitotic prophase.

189 ated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromos

190 osomes during interphase and from neuroblast chromosome arms during prophase is blocked by translatio

191 at facilitates cohesin's timely release from chromosome arms during prophase.

192 gins near the telomeres and progresses along chromosome arms during zygotene.

193 rge fraction of sequences in the euchromatic chromosome arms exhibits a heterochromatic chromatin sig

194 idate tumour suppressor genes located on the chromosome arms frequently deleted in oligodendrogliomas

195 construction of a completely synthetic 91-kb chromosome arm from Saccharomyces cerevisiae.

196 on lines (CS-B) with specific chromosomes or chromosome arms from G. barbadense L. substituted into G

197 per case), predominantly whole chromosome or chromosome arm gains and losses, whereas malignant melan

198 ylated forms partitioned together within the chromosome arms; however, the mono- and dimethylated mod

199 tion rate and loss of heterozygosity along a chromosome arm in diploid yeast that lacked telomerase t

200 t "wanderer" genes (present in a euchromatic chromosome arm in one species and on the dot chromosome

201 sed distinguishable amplifications in the 3q chromosome arm in squamous cell carcinomas and pointed t

202 prophase when most cohesin dissociates from chromosome arms in a process dependent on the regulatory

203 mally localized together along the metaphase chromosome arms in Aurora-B/AIM-1-depleted cells.

204 I hypothesize that autosomal chromosome arms in C. elegans undergo frequent local gen

205 this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage co

206 Most SMC1beta dissociates from the chromosome arms in late-pachytene-diplotene cells.

207 sed to create dosage series for 14 different chromosome arms in maize plants with normal cytoplasm.

208 s recruited to centromeres, kinetochores and chromosome arms in mid-meiosis I, and that MCAK depletio

209 his, the majority of cohesin is removed from chromosome arms in prophase and prometaphase in a manner

210 aphase because of the loss of cohesion along chromosome arms in prophase.

211 presenting the telomeres of their respective chromosome arms in the P036 assay, were frequently ampli

212 no defect in pairing in embryos lacking any chromosome arm, indicating that no zygotic gene product

213 a common genetic alteration in ESCC and that chromosome arm instability is related to both telomere a

214 ngth in cancer cells was not associated with chromosome arm instability, telomere attrition in cancer

215 l crossover patterning processes, both along chromosome arms (interference and the centromere effect)

216 We report that lack of crossover along one chromosome arm is associated with high-frequency occurre

217 urora B, although their association with the chromosome arm is not.

218 ge in oscillation amplitude and the amount a chromosome arm is shortened, we are able to map the dist

219 Here, we show that the binding of MCAK to chromosome arms is also regulated by Aurora B and that A

220 is enriched for repetitive sequences, and on chromosome arms is anticorrelated with centromeres.

221 original centromere-telomere polarity of the chromosome arms is maintained in the new chromosome.

222 Loss of cohesins from chromosome arms is necessary for homologous chromosomes

223 at the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activit

224 uited by Shugoshin (Sgo1), whereas SA2 along chromosome arms is phosphorylated by PLK1, leading to SA

225 MCAK association with chromosome arms is promoted by phosphorylation of T95 on

226 Execution of this screen on two chromosome arms led to the identification of mutations i

227 somatic feature of GCTs is highly recurrent chromosome arm level amplifications and reciprocal delet

228 gration methods, assembly contiguity reached chromosome-arm-levels.

229 d exemplified by Caulobacter crescentus, the chromosome arms lie side-by-side, with the replication o

230 When chromosome arms located within one of the half-spindles

231 ete bands interspersed along the euchromatic chromosome arms, many of which are coincident with known

232 th recombination events spaced along a yeast chromosome arm, mapping trait variation, and then target

233 A similar type of polymeric structure on chromosome arms may mediate other chromosome-spindle int

234 Released kinetochores with attached chromosome arms moved poleward at rates at least two tim

235 ptions to the general rule of maintenance of chromosome arm (Muller element) association for most Dro

236 During mitosis, the longest chromosome arm must be shorter than half of the mitotic

237 microtubule (MT)-based motor proteins on the chromosome arms, namely chromokinesins, and (ii) the pol

238 r microirradiation to damage mitotic TIPs or chromosome arms (non-TIPs) in PtK2 kidney epithelial cel

239 icentromeres from either centromeres or from chromosome arms, nor did we identify an epigenetic signa

240 in Ambystoma is not strongly correlated with chromosome arm number.

241 of homologs and sister chromatids along the chromosome arms occurs in mid-G2, several hours before t

242 phase and prometaphase, cohesin release from chromosome arms occurs under the control of Polo-like ki

243 st always found at a similar location on the chromosome arm of two different chromosome pairs, sugges

244 ines that are deficient for 6AS, 6BS, or 6DS chromosome arms of cultivated, hexaploid bread wheat sho

245 y 'octasomes', which are observed in vivo on chromosome arms only when Cse4 (yeast cenH3) is overprod

246 rabidopsis satellites than in genes from the chromosome arms or from the recombinationally suppressed

247 Depletion of hKID caused abnormal chromosome arm orientation, delayed chromosome congressi

248 imum one chiasma per chromosome (PC) and per chromosome arm (PA).

249 t of at least one chiasma per chromosome (or chromosome arm) per meiosis.

250 that gradients of recombination rates along chromosome arms promote more rapid rates of genome evolu

251 g around the chromosome center and dynein on chromosome arms provides a minus-end force.

252 al centromere and octamer-sized particles on chromosome arms, reconcile seemingly conflicting in vivo

253 s distributed over an approximately 1 microm chromosome arm region to determine positioning reproduci

254 with the large majority located on autosomal chromosome arms, regions characterized by higher genetic

255 loci is the outcome of the formation of two chromosome arms (replichores) by replication, followed b

256 ructures with the left (L) and the right (R) chromosome arms (replichores) on opposite cell halves an

257 Escherichia coli ("left-ori-right"), the two chromosome arms reside in separate cell halves, on eithe

258 equently, inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects

259 Each autosomal chromosome arm responded to 2L trisomy similarly, but th

260 mutants, following DNA damage in interphase, chromosome arm segregation fails due to an aberrant pers

261 gs reveal an essential role for telomeres in chromosome arm segregation.

262 We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number

263 The distal regions of chromosome arms showed higher numbers of loci than the p

264 opoII alpha associated with kinetochores and chromosome arms showed that the majority of the protein

265 entirely concentrated at kinetochores and on chromosome arms, sites where the APC/C, a target of Nup9

266 nt events, including 16-18 broad events near chromosome-arm size and 16-21 focal events.

267 horoidal chromosomal abnormalities including chromosome-arm-sized as well as focal events of amplific

268 On chromosome arms, small regions of chromatin locally inte

269 red tumor and cfDNA clustered in a number of chromosome arms, some of which harbor genes with oncogen

270 Chromosome arm-specific telomere lengths were measured b

271 t the kinetochore, not at damage sites along chromosome arms, such that the APC is fully inhibited wi

272 The deletions usually involve whole chromosome arms, suggesting a t(1;19)(q10;p10).

273 an genes in the 1.5 Mb left and 2.3 Mb right chromosome arms, supporting the notion of the core versu

274 We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then us

275 A-based duplications and duplications within chromosome arms tend to produce longer duplication tract

276 At the level of the chromosome arm, the MSI-CIN- cancers had significantly f

277 seven showed heterogeneity for at least one chromosome arm; the most frequently heterogeneous chromo

278 ing the loading of cohesin specifically onto chromosome arms, thereby ensuring sister chromatid cohes

279 nsin also acts within the mostly euchromatic chromosome arms to suppress conditionally expressed gene

280 -shaped assemblies tether the left and right chromosome arms together while traveling from the origin

281 prometaphase chromosome movements by pushing chromosome arms toward the spindle equator.

282 tal disorders, where isolated chromosomes or chromosome arms undergo massive local DNA breakage and r

283 n mechanisms, shed light on the dual role of chromosome arm volume, and compare well with experimenta

284 osome arm; the most frequently heterogeneous chromosome arm was 6p.

285 A molecular-ruler clone panel for each chromosome arm was developed and used for the design of

286 The distribution of ESTs along chromosome arms was nonrandom with EST clusters occurrin

287 on; however, the spreading of H3K9me2 to the chromosome arms was unaffected, strongly indicating that

288 ssing over, which can lead to LOH of a whole chromosome arm, was not observed, implying that there ar

289 of embryos deficient for each chromosome or chromosome arm, we were able to map most of our H-probes

290 taining two homeologous segments on opposite chromosome arms were synthesized to increase their combi

291 Most cohesin dissociates from chromosome arms when the cell enters mitotic prophase, l

292 centromeres, as well as discrete sites along chromosome arms where transcription positions the comple

293 ntitative trait loci (QTL) located on the 2L chromosome arm, which is homologous to the 3R of D. mela

294 "Indeed, the role in mitosis of the chromosome arms, which carry most of the genetic materia

295 required for efficient cohesin removal from chromosome arms, which is a prerequisite for meiosis I c

296 berrations are extensive, encompassing whole chromosome arms, which makes identification of candidate

297 n was further promoted in the hypomethylated chromosome arms while it was inhibited in heterochromati

298 CRs including translocations and deletion of chromosome arms with associated de novo telomere additio

299 of low density in the proximal region of the chromosome arms, with the exception of 3DS and 3DL.

300 hyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on th