ライフサイエンスコーパス: chromosome breakage

1 omosome condensation, with or without actual chromosome breakage.

2 the liver is correlated with aneuploidy and chromosome breakage.

3 in direct or reverse orientation can induce chromosome breakage.

4 CRs), indicating a possible role for LCRs in chromosome breakage.

5 replication forks collapse and give rise to chromosome breakage.

6 xpansion causes several genetic diseases and chromosome breakage.

7 lting in dicentric chromosomes), followed by chromosome breakage.

8 quantitative differences in their degree of chromosome breakage.

9 eads to genomewide fork stalling followed by chromosome breakage.

10 e 1 (SOD1), in a transgenic mouse, increases chromosome breakage.

11 ate in the nucleus and are unable to prevent chromosome breakage.

12 G and F) is essential for protection against chromosome breakage.

13 function in suppressing GCR formation after chromosome breakage.

14 esult in a G(2)/M arrest, mitotic arrest, or chromosome breakage.

15 y an important role in a common mechanism of chromosome breakage.

16 accompanied by a rapid loss of viability and chromosome breakage.

17 e competition among gametes with and without chromosome breakage.

18 ely to further investigate the mechanisms of chromosome breakage, a 40-Mb YAC contig covering the dis

19 d (RH) mapping is based on radiation-induced chromosome breakage and analysis of chromosome segment r

20 through S phase was required to trigger both chromosome breakage and arrest in the next cell cycle.

21 Chromosome breakage and break-fusion-bridge (BFB) cycles

22 ns caused by the depletion of Mcm10 leads to chromosome breakage and cell cycle checkpoint activation

23 lived or dead-end product that can result in chromosome breakage and cell death.

24 morphology, but their cells had the expected chromosome breakage and DNA cross-linker sensitivity.

25 netic reorganization including site-specific chromosome breakage and DNA deletion.

26 lpha interaction is important for preventing chromosome breakage and elucidate a DNA repair mechanism

27 epeats, which are preferentially involved in chromosome breakage and exchange, rendering it an intere

28 and inter- and intragenomic rearrangements, chromosome breakage and fusion, rDNA changes, and loss o

29 ssive disorders characterized by spontaneous chromosome breakage and hematological cancers.

30 sition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to gen

31 chromothripsis-like pattern generated after chromosome breakage and illegitimate rejoining.

32 the Fancg(-/-) mice demonstrated spontaneous chromosome breakage and increased sensitivity to mitomyc

33 Diminished folate status results in chromosome breakage and is associated with several disea

34 demonstrating that FRA3B does play a role in chromosome breakage and loss in RCC.

35 ous mitotic recombinations, a translocation, chromosome breakage and loss, chromosomal fusion or telo

36 treatment with these agents, have pronounced chromosome breakage and other cytogenetic abnormalities.

37 duced DNA damage and ameliorated spontaneous chromosome breakage and radials in human FA patient-deri

38 eir dysfunction could precipitate widespread chromosome breakage and rearrangement in the course of m

39 stigated the relationship between programmed chromosome breakage and telomere formation in Tetrahymen

40 ts suggest a strong mechanistic link between chromosome breakage and telomere formation.

41 uces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by

42 Stalled replication forks are sites of chromosome breakage and the formation of toxic recombina

43 fic histone modifications as facilitators of chromosome breakage and translocations.

44 e modifications predispose genome regions to chromosome breakage and translocations.

45 ternative transposition reactions leading to chromosome breakage and various types of stable chromoso

46 promote: transposition, insertion, excision, chromosome breakage, and ectopic recombination.

47 gurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined.

48 and/or 5-azadeoxycytidine treatment reduced chromosome breakage at CFSs.

49 licative stress treatment known to result in chromosome breakage at common fragile sites.

50 nt inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from

51 source of genome instability resulting from chromosome breakage at selective sites.

52 Specifically, while MEC1 cells exhibited chromosome breakage at stress-response transcription fac

53 n factors, mec1 cells predominantly suffered chromosome breakage at transporter genes, many of which

54 mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of A

55 is, they form anaphase bridges, resulting in chromosome breakage by an unknown mechanism.

56 t the FRA16D Flex1 sequence causes increased chromosome breakage by forming secondary structures that

57 The region is more prone to chromosome breakage by gametocidal gene action than gene

58 Collectively, these data implicate chromosome breakage by TOP2 as an endogenous threat to g

59 The elevated chromosome breakage correlates histologically with a sig

60 in chromosome maintenance are linked to rare chromosome breakage disorders.

61 retained in the macronucleus does not induce chromosome breakage during vegetative growth and that ex

62 ying the SCKL1 mutation would show increased chromosome breakage following replication stress.

63 The distributions of radiation-induced chromosome breakage for the GB4 and the G3 radiation hyb

64 274 (948h1) and D9S285 (767f2), suggesting a chromosome-breakage hotspot.

65 aics were created using gamma-rays to induce chromosome breakage in a cr4/Cr4+ heterozygote.

66 Deletion of the RFB inhibits chromosome breakage in a sub-population of developing ma

67 These results demonstrate that chromosome breakage in evolution is nonrandom and that H

68 ent advances in chromatin changes induced by chromosome breakage in mammalian cells and their implica

69 tocidal (Gc) factors carried in 4S(L) induce chromosome breakage in meiospores not containing them, e

70 es and 4Ssh of Ae. sharonensis induce severe chromosome breakage in pollen lacking them.

71 hypomethylating agent 5-azacytidine induces chromosome breakage in root tips.

72 sical assays to be length-dependent sites of chromosome breakage in Saccharomyces cerevisiae.

73 tantly, these regions were not only prone to chromosome breakage in the presence of exogenous stress

74 radiation and show an increased frequency of chromosome breakage in the subsequent anaphase.

75 functionally distinct from ends generated by chromosome breakage, in that telomeres, unlike double-st

76 We explore how chromosome breakage is integrated with meiotic progressi

77 By contrast, no chromosome breakage is observed with alleles containing

78 s the construction of a library enriched for chromosome breakage junctions and the development of a s

79 genetic characterization of these functional chromosome breakage junctions is reported in the accompa

80 nd genetic characterization of 30 functional chromosome breakage junctions.

81 D-Titin cause chromosome undercondensation, chromosome breakage, loss of diploidy, and premature sis

82 mena suggest a novel mechanism that requires chromosome breakage next to short inverted repeats.

83 Programmed chromosome breakage occurs at 50-200 specific sites in t

84 Extensive, programmed chromosome breakage occurs during formation of the somat

85 The majority of spontaneous chromosome breakage occurs during the process of DNA rep

86 Programmed chromosome breakage occurs in many ciliated protozoa and

87 omain from BLM fails to correct the elevated chromosome breakage of transfected BLM-deficient cells.

88 nducing agent mitomycin C but do not exhibit chromosome breakage or cell cycle arrest after diepoxybu

89 cross-links (ICLs), mammalian cells display chromosome breakage or cell cycle delay with a 4N DNA co

90 ource of genome instability that may lead to chromosome breakage or nondisjunction during mitosis.

91 Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: e

92 indicates that chromosome 11 is a target for chromosome breakage, rearrangement, and loss during the

93 Suppression of dicentric chromosome breakage reflects loss of kinetochore functio

94 on is site specific, directed by a conserved chromosome breakage sequence (Cbs element).

95 e specific and directed by a conserved 15-bp chromosome breakage sequence (Cbs element).

96 ar chromosome 1 by site-specific cleavage at chromosome breakage sequence (Cbs) elements, rearranged

97 ve identified a 15 bp sequence, the Cbs (for chromosome breakage sequence), that is necessary and suf

98 ts of a 15-bp DNA sequence known as Cbs, for chromosome breakage sequence.

99 Chromosome breakage sequences (Cbs) that determine the s

100 Two distinct previously unreported variant chromosome breakage sequences were found, each in two or

101 f internal eliminated sequences, excision of chromosome breakage sequences, and endoreplication of th

102 ces, while fragmentation occurs at conserved chromosome breakage sequences, generating macronuclear c

103 ons in the Cbs on its ability to specify the chromosome breakage site and promote new telomere format

104 ide cloning and identification of functional chromosome breakage sites.

105 more, ultraviolet exposure results in marked chromosome breakage, suggesting that replication gaps cr

106 Here, we have identified a chromosome breakage syndrome associated with severe lung

107 ations in NSMCE3 with an autosomal recessive chromosome breakage syndrome that leads to defective T a

108 Chromosome breakage syndromes are defined by chromosome

109 th the emerging molecular information on the chromosome breakage syndromes.

110 g chromosome loss, micronuclei formation and chromosome breakage that are further elevated by replica

111 artificial chromomosme (YAC)-based assay for chromosome breakage to analyze fragility of CAG/CTG trac

112 sed sequence targeting and telomere-directed chromosome breakage to dissect the sequence requirements

113 formed a mosaic analysis using X-ray induced chromosome breakage to generate wild-type (gn1+/-) secto

114 Ds-induced chromosome breakage was used to generate Dek1 loss-of-fu

115 into the mechanism of transposition-induced chromosome breakage, which is one outcome of the chromos