ライフサイエンスコーパス: chromosome instability

1 many malignancies as part of a signature of chromosome instability.

2 the formation of micronuclei, a hallmark of chromosome instability.

3 ave an increased probability of resulting in chromosome instability.

4 t are temperature sensitive and exhibit high chromosome instability.

5 large target for ionizing radiation-induced chromosome instability.

6 bout accusations of a different type of CIN, chromosome instability.

7 altered checkpoint responses, and increased chromosome instability.

8 on cancer are microsatellite instability and chromosome instability.

9 we show that compromised autophagy promoted chromosome instability.

10 he interface cause checkpoint deficiency and chromosome instability.

11 assembly, endoreduplication and significant chromosome instability.

12 po IIalpha-deficient cells and a hallmark of chromosome instability.

13 functions of R loops and ATR in suppressing chromosome instability.

14 s of methylation may provide the basis for X-chromosome instability.

15 me (ChrVII) can undergo remarkable cycles of chromosome instability.

16 rad1 yeast, but at the same time exacerbated chromosome instability.

17 onal and can exhibit a neoplastic nature and chromosome instability.

18 S: Many different types of cancer cells have chromosome instability.

19 ch as severe growth retardation and enhanced chromosome instability.

20 elomerase activity, correlate with increased chromosome instability.

21 cancer development through the generation of chromosome instability.

22 a in situ lesions for centrosome defects and chromosome instability.

23 or of cdc28(CST) temperature sensitivity and chromosome instability.

24 ion of wild-type BUB1 or MAD3 genes leads to chromosome instability.

25 aryotype and, hence, precise quantitation of chromosome instability.

26 sDNA), sensitivity to replication drugs, and chromosome instability.

27 XRCC3 mutation causes severe chromosome instability.

28 ss-linking agent mitomycin-C and spontaneous chromosome instability.

29 t YAP cooperates with FOXM1 to contribute to chromosome instability.

30 of cell cycle control, but not by increased chromosome instability.

31 ication, which leads to aberrant mitosis and chromosome instability.

32 a cellular phenotype that includes increased chromosome instability.

33 vel 20q13.2 amplification is associated with chromosome instability.

34 T-cell lymphoma samples, indicating ongoing chromosome instability.

35 ns with 18 deletion mutations known to cause chromosome instability.

36 escape, abnormal chromosome segregation, and chromosome instability.

37 tly missegregate at mitosis, driving further chromosome instability.

38 plication complexes, replication stress, and chromosome instability.

39 her mutant to H3T3ph during mitosis promotes chromosome instability.

40 or malignant progression by promoting whole chromosome instability.

41 umerous human malignancies, and is linked to chromosome instability.

42 ain of 1q12, 1q21, and Xq13.1 without global chromosome instability.

43 t, chromosome congression defects, and whole-chromosome instability.

44 ad spectrum of early-onset cancers caused by chromosome instability.

45 totic spindle, and centrosomal defects cause chromosome instability.

46 developed malignant tumors with evidence of chromosome instability.

47 ads to sister chromatid cohesion defects and chromosome instability.

48 mage-induced point mutagenesis and extensive chromosome instability.

49 both spindle poles [1], is a major cause of chromosome instability [2], which is commonly observed i

50 bility, and deletions of NAT1 and SBA1 cause chromosome instability, a phenotype not previously assoc

51 re, we report that p53 suppresses structural chromosome instability after mitotic arrest in human cel

52 tic response is the prevention of structural chromosome instability after prolonged activation of the

53 The lymphoma cells demonstrated chromosome instability along with upregulation of severa

54 brids and misincorporated ribonucleotides to chromosome instability also was uncertain.

55 rative tissues such as skin and bone marrow, chromosome instability and a predisposition to develop c

56 the abp1 null strain displays marked mitotic chromosome instability and a pronounced meiotic defect.

57 and telomere dysfunction are associated with chromosome instability and an increased risk of cancer.

58 Chromosome instability and aneuploidy are hallmarks of c

59 hese events correlated with the induction of chromosome instability and aneuploidy in nonmalignant Ma

60 ng cascade, as a means to selectively induce chromosome instability and aneuploidy in the epidermis o

61 called the spindle checkpoint contribute to chromosome instability and aneuploidy.

62 nts irs1 and irs1SF exhibit high spontaneous chromosome instability and broad-spectrum mutagen sensit

63 ication in response to DNA damage, and cause chromosome instability and cancer in humans.

64 be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest

65 the significance of telomerase activation in chromosome instability and cancer initiation.

66 n mitosis, dysregulation of which results in chromosome instability and cancer predisposition.

67 ble-strand breaks containing such termini on chromosome instability and cancer.

68 s and anti-tumor therapy on the one hand and chromosome instability and carcinogenesis on the other.

69 Here we show that chromosome instability and changes in chromosome content

70 h this, a human PICH(-/-) cell line exhibits chromosome instability and chromosome condensation and d

71 t centrosome defects occur concurrently with chromosome instability and cytologic changes in the earl

72 lomeres, these defects may contribute to the chromosome instability and disease associated with NBS p

73 Breakage-fusion-bridge cycles contribute to chromosome instability and generate large DNA palindrome

74 an msc1 mutant, a pht1 mutant also exhibits chromosome instability and genetic interactions with kin

75 ve or therapeutic effects in arsenic-induced chromosome instability and genotoxicity.

76 amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-st

77 , centrosome defects have been implicated in chromosome instability and loss of cell cycle control in

78 Disruption of POT1 function leads to chromosome instability and loss of cellular viability.

79 e, and zebrafish models are characterized by chromosome instability and low survivin expression.

80 alterations in MT assembly rates that affect chromosome instability and mitotic spindle function, but

81 lian cells induces centrosome amplification, chromosome instability and oncogenic transformation, a p

82 cers, results in abnormal mitoses leading to chromosome instability and possibly tumorigenesis.

83 stinct networks that safeguard against whole chromosome instability and reveal the differential impor

84 Nbs1 inhibited DNA break repair, leading to chromosome instability and subsequent transformation tha

85 re, the deletion of RCY1 is tied to enhanced chromosome instability and temperature-sensitive cell gr

86 de important insights into the mechanisms of chromosome instability and the development of novel appr

87 genetic factors might influence the onset of chromosome instability and the role of chromosomal insta

88 roviding insights into their contribution to chromosome instability and therefore, to genomic variati

89 when expressing telomerase, contributing to chromosome instability and tumor cell progression.

90 a prominent protooncogene that causes whole chromosome instability and tumor formation over a wide g

91 t AD and CVD also share a cell cycle defect: chromosome instability and up to 30% aneuploidy-in neuro

92 rom illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregat

93 Abro1 deficiency results in increased chromosome instability, and Abro1-null mice are tumor-pr

94 -induced oxidative stress, telomere erosion, chromosome instability, and apoptosis, suggesting that i

95 urred together with mitotic spindle defects, chromosome instability, and high cytologic grade.

96 Chromosome breakage syndromes are defined by chromosome instability, and individuals with these disea

97 ulation can induce centrosome amplification, chromosome instability, and oncogenesis.

98 temperature undergo G2/M arrest, progressive chromosome instability, and subsequent cell death.

99 ensitive to double-strand breaks, leading to chromosome instability, and that this instability can be

100 tical role in preventing replication stress, chromosome instability, and tumorigenesis.

101 Aneuploidy and chromosome instability are common abnormalities in human

102 finding that supports the potential value of chromosome instability as a prognostic predictor.

103 ility genes using the surrogate biomarker of chromosome instability as a screen.

104 We found that all tumors exhibit chromosome instability as evidenced by structural chromo

105 onstrate that genotoxic carcinogens increase chromosome instability, as evidenced by a significant in

106 a defined interstitial telomere sequence on chromosome instability, as well as other aspects of DNA

107 n genetic syndrome associated with increased chromosome instability at fragile sites following replic

108 Spindle defects are not only an impetus of chromosome instability but are also a cause of developme

109 in cell lines derived from colon tumors with chromosome instability, but not in cells from colon tumo

110 Here we show that induction of chromosome instability by overexpression of the mitotic

111 d a sensitive method to examine the level of chromosome instability by using retrovirus carrying both

112 Gene expression patterns associated with chromosome instability, called CIN25 and CIN70, were det

113 These results demonstrate how chromosome instability can arise as a by-product of defe

114 is a human genetic disease characterized by chromosome instability, cancer predisposition, and cellu

115 inverted repeats was followed by a period of chromosome instability, characterized by amplification o

116 curs at secondary structures associated with chromosome instability, chromosome remodelling, viral re

117 er is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instabil

118 Aneuploidy and chromosome instability (CIN) are hallmarks of the majori

119 sociates significantly with the induction of chromosome instability (CIN) by the likely human lung ca

120 Chromosome instability (CIN) has been detected in pNETs

121 Whole chromosome instability (CIN) is a common feature of canc

122 Chromosome instability (CIN) is a common feature of tumo

123 Chromosome instability (CIN) is a common property of can

124 Chromosome instability (CIN) is deleterious to normal ce

125 Chromosome instability (CIN) is observed in 80% to 90% o

126 Chromosome instability (CIN) is one of the most importan

127 Chromosome instability (CIN) is the most striking featur

128 mors are aneuploid because of the underlying chromosome instability (CIN) phenotype, in which a defec

129 Chromosome instability (CIN), a common feature of solid

130 on cancer: microsatellite instability (MSI), chromosome instability (CIN), and chromosome translocati

131 Cancer cells exhibit high levels of chromosome instability (CIN), and considerable interest

132 h the majority of colorectal cancers exhibit chromosome instability (CIN), only a few genes that migh

133 Chromosome instability (CIN), pulmonary dysplasia, sonic

134 One form of chromosome instability (CIN), the recurrent missegregati

135 determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide s

136 t elevated chromosome mis-segregation termed chromosome instability (CIN), which is likely to be a po

137 Chromosome instability (CIN), which is often mutually ex

138 l chromosome segregation, thereby preventing chromosome instability (CIN).

139 urs in human cancers and is a major cause of chromosome instability (CIN).

140 and human breast epithelial cells results in chromosome instability (CIN).

141 tion of human cleavage-stage embryos exhibit chromosome instability (CIN).

142 fective cell cycle exit and the emergence of chromosome instability (CIN).

143 rize the causes underlying the high rates of chromosome instability (CIN+) observed in colorectal tum

144 e function is an important mechanism for the chromosome instability commonly found in cancer.

145 kpoint control leads to more subtle rates of chromosome instability compatible with cell viability re

146 Dramatic genome dynamics, such as chromosome instability, contribute to the remarkable gen

147 Chromosome instability contributes to the multistep onco

148 ity increased and when telomeres lengthened, chromosome instability decreased.

149 past few years, study of the rare inherited chromosome instability disorder, Fanconi Anemia (FA), ha

150 ene mutated in Nijmegen breakage syndrome, a chromosome instability disorder, has been identified and

151 tardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiatio

152 high levels of copy number heterogeneity in chromosome instability-driven murine T-cell lymphoma sam

153 e a source for both numerical and structural chromosome instability during HPV-associated carcinogene

154 els of nuclear YAP correlated with increased chromosome instability gene expression patterns and aneu

155 ibiting FOXM1 with thiostrepton, reduced the chromosome instability gene expression patterns.

156 We conclude that chromosome instability generates the necessary chromosom

157 hese simulations lead us to suspect that the chromosome instability genes cause cell-cycle perturbati

158 between retroelements, DNA methylation, and chromosome instability has yet been identified.

159 weight isoforms (LMW-E) of cyclin E induces chromosome instability; however, the degree to which the

160 ifferently and leads to different degrees of chromosome instability in a breast cancer model system.

161 igating aneuploidy in human cancers, rate of chromosome instability in aneuploidy tumor cells, and ge

162 multiple DNA repair processes to potentiate chromosome instability in both monocytes and hepatocytes

163 Here, we show that Akt1 promotes chromosome instability in Brca1-deficent cells.

164 ssue fragility, defective cell migration and chromosome instability in Caenorhabditis elegans.

165 ene-induced replication stress, but promotes chromosome instability in cancer cells that lack cell cy

166 r, is the major cause of mitotic defects and chromosome instability in cancer cells.

167 es is the major cause of mitotic defects and chromosome instability in cancer cells.

168 le elongation forces might be used to reduce chromosome instability in cancer cells.

169 consequential mitotic defects contribute to chromosome instability in cancers.

170 8 and spt4 delta strains exhibit synergistic chromosome instability in combination with CEN DNA mutat

171 3, induced centrosome hyperamplification and chromosome instability in cultured cells.

172 We found that Wwox loss is followed by mild chromosome instability in genomes of mouse embryo fibrob

173 tic mutations may represent a major cause of chromosome instability in human cancers.

174 ons and altered function with aneuploidy and chromosome instability in human lymphocytes and in Droso

175 e the relationship between telomere loss and chromosome instability in mammalian cells, we investigat

176 nstitutes a previously overlooked source for chromosome instability in mitosis and meiosis.

177 Cdk2 abrogates centrosome amplification and chromosome instability in p53-null MEFs.

178 orks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and c

179 ly, Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brc

180 tify 19 genes that when over-expressed cause chromosome instability in the yeast Saccharomyces cerevi

181 xcess centrosomes can lead to aneuploidy and chromosome instability in tumor cells, how untransformed

182 oint signaling system that may contribute to chromosome instability in tumors.

183 Thus, chromosome instability in vivo may be associated with ab

184 n this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced level

185 Lastly, we show that TSI is associated with chromosome instabilities including chromosome loss, micr

186 rstrand cross-links, and exhibited extensive chromosome instability including aneuploidy, chromosome

187 As a result, KSHV-infected cells manifest chromosome instability, including chromosomal misalignme

188 notypes, such that when telomeres shortened, chromosome instability increased and when telomeres leng

189 Moreover, we show that the chromosome instability induced by the loss of p53 is gre

190 This study examined the extent of chromosome instability induced in cultured human colon c

191 mong the diploid nuclei, which suggests that chromosome instability is a result of altered genetic co

192 Volumes of data indicate that chromosome instability is an early event of carcinogenes

193 We not only demonstrate that chromosome instability is conserved between bovine and h

194 ction, the significance of APC in regulating chromosome instability is less well established.

195 The induced chromosome instability is linked to an evolutionarily co

196 The increased chromosome instability is observed irrespective of cellu

197 This suggests that chromosome instability is somehow suppressed in the aneu

198 Chromosome instability is thought to be a major contribu

199 Despite the observed chromosome instabilities, Ku80-/- mice have only a sligh

200 Aneuploidy-chromosome instability leading to incorrect chromosome n

201 AD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung

202 Chromosome instability leads to aneuploidy, a state in w

203 bility, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are

204 e genetic features that lead to sporadic CRC-chromosome instability, microsatellite instability, and

205 As chromosome instability might drive tumour evolution, kar

206 y identified in a phenotype-based screen for chromosome instability mutants in mice.

207 ed a phenotype-driven mutagenesis screen for chromosome instability mutants using a flow cytometric p

208 Here, we report that the mouse chromosome instability mutation Chaos3 (chromosome aberr

209 est exhibited neither significant structural chromosome instability nor p53-dependent cell cycle arre

210 plication provides a potential mechanism for chromosome instability observed as a consequence of cycl

211 Chromosome instability of cbf1Delta cells is suppressed

212 inker, mitomycin C (MMC), thus mimicking the chromosome instability of FA cells.

213 s normal yeast chromosome may be relevant to chromosome instability of mammalian fragile sites and of

214 suppressed both the frequency and structural chromosome instability of spontaneous polyploids in HCT1

215 to suppress the proliferation and structural chromosome instability of the resulting polyploid cells.

216 ls and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tum

217 tion-induced gene expression, DNA repair and chromosome instability, oxidative damage, cell cycle arr

218 with high-grade invasive carcinomas and with chromosome instability, particularly gains of chromosome

219 light on the initial molecular events in the chromosome instability phenotype.

220 ctions (G2/M), which may explain some of the chromosome instability phenotypes attributed to loss of

221 mere length and fluctuations in the rates of chromosome instability phenotypes, such that when telome

222 chromosomes are distinct forms of structural chromosome instability precipitated by replication inhib

223 e characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure

224 stress conditions can induce an increase in chromosome instability, proteotoxic stress, caused by tr

225 ome (NBS) is a rare human disease displaying chromosome instability, radiosensitivity, cancer predisp

226 transient Mad2 overexpression and consequent chromosome instability recur at markedly elevated rates.

227 Telomere shortening can lead to chromosome instability, replicative senescence, and apop

228 Sister chromatid fusion is followed by chromosome instability resulting from breakage-fusion-br

229 the sites of DSBs, a mechanism that prevents chromosome instability resulting from DSBs near telomere

230 in a human tumor cell line, suggesting that chromosome instability resulting from telomere loss play

231 ithin a single tissue respond differently to chromosome instability: some proliferating cell lineages

232 that increased genetic variation, including chromosome instability, starts at the initiation stage o

233 There are two types of chromosome instability, structural and numerical, and th

234 oticeable for the suppression of spontaneous chromosome instability such as micronuclei and 53BP1 nuc

235 FA is a chromosome instability syndrome characterized by childho

236 Fanconi anemia (FA) is a chromosome instability syndrome characterized by increas

237 anconi anemia (FA) is an autosomal recessive chromosome instability syndrome characterized by progres

238 proteins and responsible proteins for other chromosome instability syndromes (BLM, NBS1, MRE11, ATM,

239 ion, in events that may ultimately drive the chromosome instabilities that underpin early-onset cance

240 This suggests ongoing chromosome instability that other platforms fail to dete

241 been reported to display an elevated rate of chromosome instability, thereby indicating that aneuploi

242 This chromosome instability, therefore, is a consequence of m

243 inactivation of p53 has been shown to induce chromosome instability through centrosome hyperamplifica

244 lication stress and minimizing its impact on chromosome instability, thus preventing diseases, includ

245 inhibition or heat shock, markedly increased chromosome instability to produce a cell population with

246 enerates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis.

247 oduces extracellular superoxide and promotes chromosome instability via macrophage-induced bystander

248 ysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or hav

249 To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spi

250 Intratumor heterogeneity mediated through chromosome instability was associated with an increased

251 adult tissue, we engineered a mouse in which chromosome instability was selectively induced in T cell

252 y, parameters for cell cycle progression and chromosome instability were analysed in deltabetaRII tum

253 A double-strand-break (DSB) repair can cause chromosome instability, which may result in cancer.

254 urrent knowledge regarding radiation-induced chromosome instability with the emerging molecular infor