ライフサイエンスコーパス: chromosome structure

1 mplex is a key determinant of higher-ordered chromosome structure.

2 ole in the control of higher-order bacterial chromosome structure.

3 or clonal subpopulation with a highly stable chromosome structure.

4 xpression and maintain genomic integrity and chromosome structure.

5 complex that links RBF1 to the regulation of chromosome structure.

6 th its proposed function in promoting normal chromosome structure.

7 c elements and for the study of higher-order chromosome structure.

8 lated to fiber-fiber interactions and global chromosome structure.

9 out severely deforming or damaging the local chromosome structure.

10 he genome, perhaps reflecting some aspect of chromosome structure.

11 role for Nse4 in maintenance of higher order chromosome structure.

12 has been difficult to relate linkage maps to chromosome structure.

13 xpression patterns with base composition and chromosome structure.

14 est in the molecular mechanisms that control chromosome structure.

15 hysical contig maps with mitotic and meiotic chromosome structure.

16 y forms, including aneuploidy and changes in chromosome structure.

17 ts constrain models for higher order mitotic chromosome structure.

18 e existence of a novel mechanism controlling chromosome structure.

19 disentanglement, and maintenance of mitotic chromosome structure.

20 een designed to identify genes important for chromosome structure.

21 and elasticity, and provide new insight into chromosome structure.

22 thways that participate in preserving intact chromosome structure.

23 the postreplicative repair pathway influence chromosome structure.

24 limited by the conservation of the existing chromosome structure.

25 r as replicon clusters, form stable units of chromosome structure.

26 fewer cytogenetically evident alterations of chromosome structure.

27 d in genetic screens for genes important for chromosome structure.

28 been proposed as the backbone of interphase chromosome structure.

29 wn to be required for maintenance of correct chromosome structure.

30 can be used as a tool for probing bacterial chromosome structure.

31 hisms in genes affecting recombination or in chromosome structure.

32 are established by higher order features of chromosome structure.

33 y and the establishment of a normal polytene chromosome structure.

34 y and mechanisms that determine higher-order chromosome structure.

35 om forests can generate useful insights into chromosome structure.

36 has important functions in relation to basic chromosome structure.

37 riability in nuclear genome organization and chromosome structure.

38 he interaction between TRF2 and lamin A/C on chromosome structure.

39 evisiae to changes in gene order and overall chromosome structure.

40 ild-type cells and in mutants with disrupted chromosome structure.

41 of cell identity genes and control of local chromosome structure.

42 y reduced cell division and altered polytene chromosome structure.

43 where retrotransposons have a vital role in chromosome structure.

44 chia coli, indicating that the alteration of chromosome structure after DNA damage may be a widesprea

45 We have imaged remodeling of meiotic chromosome structures after pachytene exit in Caenorhabd

46 ybridization under conditions that preserved chromosome structure, allowing identification of stage-d

47 Comparisons of chromosome structure among percomorphs show that chromos

48 Identification of components essential to chromosome structure and behaviour remains a vibrant are

49 rangements (GCRs) are large scale changes to chromosome structure and can lead to human disease.

50 cate Orc2 protein in chromosome duplication, chromosome structure and centrosome copy number control,

51 Despite many decades of study, mitotic chromosome structure and composition remain poorly chara

52 Mitotic chromosome structure and DNA sequence requirements for n

53 ources to gain insight into the questions of chromosome structure and dynamics.

54 DNA topoisomerases are major determinants of chromosome structure and dynamics.

55 rm-line cells for cyst formation, nurse cell chromosome structure and egg maturation.

56 parallel roles for titin in both muscle and chromosome structure and elasticity, and provide new ins

57 mal component provides a molecular basis for chromosome structure and elasticity.

58 that are useful for comparative analysis of chromosome structure and evolution and facilitates compa

59 ow-sorted chromosomes enables an overview of chromosome structure and evolution at a resolution never

60 broad community of scientists focused on sex chromosome structure and evolution.

61 Condensin complexes organize chromosome structure and facilitate chromosome segregati

62 d related the findings to various aspects of chromosome structure and function (DNA sequence organiza

63 ms will provide avenues for studies on plant chromosome structure and function and for future develop

64 ercoiling may modulate epigenetic effects on chromosome structure and function and on prophage behavi

65 ificance of replication-timing boundaries to chromosome structure and function and support the replic

66 Chromosome structure and function are influenced by tran

67 that Su(var2-10 controls multiple aspects of chromosome structure and function by establishing/mainta

68 The model of chromosome structure and function in cereals with large

69 al interactions play an important role in 3D chromosome structure and function, but our understanding

70 To learn more about holocentric chromosome structure and function, we generated a monocl

71 rticipates in several fundamental aspects of chromosome structure and function.

72 pression, introducing mutations, and probing chromosome structure and function.

73 ombination and the impact of mobile genes on chromosome structure and function.

74 condensin's role in both meiotic and mitotic chromosome structure and function.

75 extract systems to characterize higher-order chromosome structure and function.

76 tegy for assessing human gene expression and chromosome structure and function.

77 factor appears to have a more global role in chromosome structure and function.

78 ster chromatid cohesion and other aspects of chromosome structure and function.

79 ns and offer a unified model for large-scale chromosome structure and function.

80 egions are organized is a critical aspect of chromosome structure and function; however, the sequence

81 e interrogation of the relationships between chromosome structure and gene control in development and

82 ting a mechanism for DNA tension to regulate chromosome structure and gene expression.

83 dies have shown strong conservation of gross chromosome structure and gene order in mammals.

84 precipitation is providing new insights into chromosome structure and gene regulation and control thr

85 protein plays important roles in maintaining chromosome structure and in partitioning.

86 st silencing protein Sir3p functions in both chromosome structure and in transcriptional regulation.

87 Mitosis entails global alterations to chromosome structure and nuclear architecture, concomita

88 I argue that the instability in chromosome structure and number provoked by inactivation

89 epithelial cancers, triggers instability in chromosome structure and number, which are thought to ar

90 omic stability by a mechanism that preserves chromosome structure and number.

91 Research into chromosome structure and organization is an old field th

92 ant nonlinear DNA structures that may define chromosome structure and organization, as well as interm

93 tic interactions between mutations affecting chromosome structure and partitioning in Bacillus subtil

94 tative DNA translocase) and smc (involved in chromosome structure and partitioning) caused a syntheti

95 otic counterpart, plays an important role in chromosome structure and partitioning.

96 Mitotic chromosome structure and pathways of mitotic condensatio

97 mmon mechanism for establishing higher order chromosome structure and proper X chromosome gene expres

98 g the influence of two major forces, spatial chromosome structure and purifying (or negative) selecti

99 3's critical regulatory functions in meiotic chromosome structure and recombination.

100 ils DNA in vitro and is required for mitotic chromosome structure and segregation in vivo.

101 nce of Ki-67 and the chromosome periphery in chromosome structure and segregation, but little is know

102 etion of SMC-4/MIX-1 causes aberrant mitotic chromosome structure and segregation, but not dramatic d

103 -box proteins have been shown to function in chromosome structure and segregation.

104 Large-scale chromosome structure and spatial nuclear arrangement hav

105 s been a useful phenomenon by which to study chromosome structure and the genes that modify it.

106 monstrate the importance of transcription in chromosome structure and the plasticity of supercoil dom

107 ed in polyacrylamide to maintain both native chromosome structure and the three dimensionality of the

108 microscopy approaches that directly examine chromosome structure and then on population-averaged bio

109 al domains and how they function to regulate chromosome structure and transcription.

110 e1's pivotal role in regulating higher-order chromosome structure and X-chromosome-wide gene expressi

111 ve chromatin mesh that organizes large-scale chromosome structures and protects the genome from insta

112 enter M phase without repair of the aberrant chromosome structures and undergo cell death during mito

113 ing, chromatin modification, organization of chromosome structure, and ATP-dependent nucleosome slidi

114 gene expression, connect gene expression to chromosome structure, and contribute to human disease.

115 e nucleus, where it regulates transcription, chromosome structure, and DNA damage repair.

116 nto the relationships between recombination, chromosome structure, and genome evolution.

117 g how modular organization underlies dynamic chromosome structure, and how this structure is probabil

118 n the control of transcription, development, chromosome structure, and human leukemia.

119 lays several key roles in DNA metabolism and chromosome structure, and it is the primary cytotoxic ta

120 chore positions shift in response to altered chromosome structure, and kinetochore complex numbers ch

121 neral roles of sumoylation in transcription, chromosome structure, and RNA processing.

122 by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible

123 d for gene silencing, as cellular probes for chromosome structure, and therapeutic applications.

124 Thus, some aspects of chromosome structure appear to be revealed directly with

125 Current models of mitotic chromosome structure are based largely on the examinatio

126 maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer

127 The simulated chromosome structures are largely free of knots.

128 chromosome number, and the same stability of chromosome structure, as the RER colon cancers with wild

129 ong DNA sequence, meiotic recombination, and chromosome structure at a genome-wide scale has been dif

130 gabase scale, but show variable cell-to-cell chromosome structures at larger scales.

131 tion-averaged biochemical methods that infer chromosome structure based on the interaction frequencie

132 arrest followed by repair of these aberrant chromosome structures before entering M phase.

133 her order folding transitions that stabilize chromosome structure beyond the 30-nm diameter fiber.

134 comparative genomics framework for studying chromosome structure, broadly applicable to other organi

135 dence that the establishment of higher-order chromosome structure by a condensin complex regulates cr

136 major NAP, HU, acting together organize the chromosome structure by establishing multiple DNA-DNA co

137 protein complexes that mediates higher-order chromosome structure by tethering different regions of c

138 nce that the control of key genes depends on chromosome structures called insulated neighborhoods, we

139 This unexpected property of chromosome structure can be portrayed as an operon-like

140 The compact chromosome structure can be preserved and anaphase chrom

141 and provide evidence that defective mitotic chromosome structure can promote tumorigenesis.

142 evolution of mutation rate, genome size, and chromosome structure can therefore be extremely rapid an

143 SB distribution is influenced by large-scale chromosome structures, chromatin, transcription factors,

144 Long considered an intriguing component of chromosome structure, common fragile sites have taken on

145 Long considered an interesting component of chromosome structure, common fragile sites have taken on

146 ic) genes, RED1 and MEK1/MRE4, that encode a chromosome structure component and a protein kinase, res

147 (v) Comparison of chromosome structures confirms the polyploid event that

148 A chromosome structure consistent of many stacked layers o

149 Nucleosomes, the basic unit of eukaryotic chromosome structure, cover most of the DNA in eukaryote

150 meiotic cells, and that features of meiotic chromosome structure determine whether one or the other

151 d to developmental problems or underdominant chromosome structure differences between the parents.

152 These visible alterations in chromosome structure do not affect polarity by altering

153 to chromatin at anaphase onset and regulates chromosome structure during mitotic exit.

154 stinct chromosomal subdomains and remodeling chromosome structure during prophase.

155 tion requires highly orchestrated changes of chromosome structure during the mitotic cell cycle.

156 eristic size pertinent to the description of chromosome structure, e.g. there does not exist any sing

157 s as a self-limiting system in which meiotic chromosome structures establish an environment that prom

158 current arsenal of techniques used to query chromosome structure, focusing first on single-cell fluo

159 lement recognition allow decoupling of local chromosome structure from transcription initiation.

160 DNA segments called transposable elements to chromosome structure, function, and evolution in virtual

161 to ask otherwise intractable questions about chromosome structure, function, and evolution with a bot

162 ies, most or all of which are connected with chromosome structure/function.

163 ur understanding of the relationship between chromosome structure, gene activity, and recombination.

164 reated during recombination are repaired and chromosome structure has been restored.

165 ery few proteins involved in the assembly of chromosome structure have been discovered.

166 exhibit phenotypic similarities in terms of chromosome structure in both diploid and polyploid cells

167 n the evolution of sex determination and sex chromosome structure in eukaryotes.

168 ssociation is a conserved feature of meiotic chromosome structure in eukaryotes.

169 ween chromatin modification and higher-order chromosome structure in long-range regulation of gene ex

170 atment and the role of programmed changes in chromosome structure in replication control are discusse

171 The biological role of higher-order chromosome structure in S. cerevisiae is discussed.

172 ely separated target genes, and organize the chromosome structure in space, thereby likely contributi

173 Our data implicate higher-order chromosome structure in the regulation of CO recombinati

174 We propose a unified model of chromosome structure in which hierarchical levels of chr

175 By comparing chromosome structure in wild-type and DCC-defective embr

176 These somatic changes in chromosome structure include duplication of entire chrom

177 ns not only of chromosome number but also of chromosome structure including chromosomal deletions, in

178 ost extreme differences relate to changes in chromosome structure, including the emergence of African

179 s studies of effects of nucleases on mitotic chromosome structure, indicate that mild proteolysis gra

180 eckpoint, further supporting the notion that chromosome structure influences spindle assembly.

181 tiate recombination in meiosis, we show that chromosome structure influences the choice of proteins t

182 Polytene chromosome structure is a characteristic of some polyplo

183 We propose that met1 chromosome structure is altered, causing centromere-prox

184 The regulation of higher-order chromosome structure is central to cell division and sex

185 ng late S phase and that nurse cell polytene chromosome structure is controlled by regulating whether

186 Control of chromosome structure is important in the regulation of g

187 Our results indicate that local chromosome structure is more important than DNA sequence

188 Mitotic chromosome structure is pivotal to cell division but dif

189 We conclude that the chromosome structure is supercoiled locally and elongate

190 opoisomerase II mutant, defective in mitotic chromosome structure, is also due to the retention of co

191 le element shown to have a bona fide role in chromosome structure, maintenance of telomeres in Drosop

192 limited amount of structural data on mitotic chromosome structure makes it impossible to distinguish

193 ity, proximity to centromeric sequences, and chromosome structure may all play a role in low recombin

194 regulating chromosome segregation as well as chromosome structure may be governed by the conserved BR

195 specific genes, establishment of the meiotic chromosome structure, meiosis-specific telomere behavior

196 Beyond being a basic component of chromosome structure, no biological effects of common fr

197 ided early insight into the consequences for chromosome structure of an ancient large-scale duplicati

198 All three analyzed species share the chromosome structure of six out of seven chromosomes and

199 ic intake on expression as well as the local chromosome structure of the intact GH1 locus.

200 The subgenomes have largely maintained the chromosome structures of their diploid progenitors.

201 O, we investigated the effects of disrupting chromosome structure on Z-ring positioning.

202 the suggestion that features of higher-order chromosome structure or chromosome dynamics act in a tar

203 ese results suggest that the requirements of chromosome structure place significant constraints on eu

204 Chromatin modification and higher-order chromosome structure play key roles in gene regulation,

205 otspots, including HIS2, suggest that global chromosome structure plays a significant role in recombi

206 There is considerable evidence that chromosome structure plays important roles in gene contr

207 has been recognized for several decades that chromosome structure regulates the capacity of replicati

208 the cytoplasmic filaments may be involved in chromosome structure, segregation, or the cell division

209 exually reproducing single-cell organisms to chromosome-structured sexually reproducing species.

210 mbles a holocentric chromosome, which is the chromosome structure shared by the closest relatives of

211 ing method for measuring gene expression and chromosome structure simultaneously on single chromosome

212 bination and development of meiosis-specific chromosome structure (SPO11).

213 n Drosophila exhibit disrupted sarcomere and chromosome structure, suggesting that giant proteins may

214 ually fast rate of evolution with respect to chromosome structure, suggesting that this classic case

215 facilitates the formation of a higher-order chromosome structure that could also influence gene expr

216 We present a model for mitotic chromosome structure that incorporates this previously u

217 rposes and for investigations of features of chromosome structure that influence gene expression.

218 ion fork, thereby leading to a disruption in chromosome structure that interferes with the meiotic di

219 identifies an activity critical for mitotic chromosome structure that is inactivated by Repo-Man-PP1

220 ntial tissue or developmental differences in chromosome structure that might be informative for compa

221 enhancer-driven genes generally occur within chromosome structures that are formed by the looping of

222 landscape is locally funneled toward "ideal" chromosome structures that represent hierarchical fibril

223 stribution of meiotic recombination, such as chromosome structure, that influences meiotic recombinat

224 To clarify the role of E(var)3-9 in chromosome structure, the gene has been cloned and its m

225 methylation and chromatin remodeling affect chromosome structure, their impact on meiotic recombinat

226 Cohesin helps orchestrate higher-order chromosome structure, thereby promoting sister chromatid

227 lue of microfluidics as a tool for examining chromosome structure, these results lend support to cert

228 ates Ca2+, Mg2+, Na+, and K+ in higher order chromosome structure through electrostatic neutralizatio

229 erstanding of gene function, gene order, and chromosome structure through the de novo synthesis of ge

230 -associated COH-3/4 cohesin, WAPL-1 controls chromosome structure throughout meiotic prophase.

231 oxygen and nutrient availability with global chromosome structure, thus providing a mechanistic insig

232 mechanism involving changes in higher-order chromosome structure to achieve chromosome-wide effects.

233 es crossover formation, which in turn alters chromosome structure to inhibit other crossovers at addi

234 t the natural stochastic fluctuations of the chromosome structure to map both the spatial and tempora

235 examined at a scale of less than 100 kb, and chromosome structures to be validated.

236 that EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sist

237 ocesses, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosi

238 f Su(Hw) causes global defects in nurse cell chromosome structure, we demonstrate that these architec

239 regulators of viral oncogene expression and chromosome structure were identified and validated, reve

240 eas virulence determinants, transposons, and chromosome structure were unaltered.

241 objective function was designed for modeling chromosome structures, which was optimized by a gradient

242 involved in the organization of higher-order chromosome structure-which is essential for accurate chr

243 tive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 comp

244 We report a detailed analysis of maize chromosome structure with respect to seven histone H3 me

245 of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal resolut

246 mbination requires continuity of the meiotic chromosome structure within each of these domains.

247 nd two genes that may influence higher order chromosome structure, ZDS1 and ZDS2.