ライフサイエンスコーパス: chromosome-wide

1 s that establish and maintain gene silencing chromosome wide.

2 position of histone H3 lysine 27 methylation chromosome-wide.

3 chromosomes while regulating gene expression chromosome-wide.

4 However, chromosome-wide analyses indicated that the vast majorit

5 Both chromosome-wide and genome-wide statistical tests were c

6 Biological processes that function chromosome-wide are not well understood.

7 However, in a chromosome-wide assay of nucleotide variation in natural

8 number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand

9 is hypothesis has not yet been assessed on a chromosome-wide basis.

10 human genome by generating high-resolution, chromosome-wide binding maps of human nucleoporin 93 (Nu

11 Moreover, ectopic Xic action resulted in chromosome-wide changes that are characteristic of the X

12 st molecules per Xi and contrasting with the chromosome-wide "coat" observed by deep sequencing and c

13 etion smaller than 1 kb with high-resolution chromosome-wide comparative genomic hybridization.

14 Chromosome-wide comparisons revealed a difference betwee

15 t is widespread throughout the genome, lacks chromosome-wide coordination, and varies between cell ty

16 A robust, chromosome-wide crossover control system limits chromoso

17 ow the SC might act as a conduit to regulate chromosome-wide crossover distribution.

18 Animal Y chromosomes have undergone chromosome-wide degeneration in response to a lack of re

19 lls exposed to ionizing radiation, exhibit a chromosome-wide delay in replication timing (DRT) that i

20 mechanism underlying the recognition of the chromosome-wide domain in the male germline.

21 The mechanism by which the chromosome-wide domain is recognized and gene silencing

22 ylated histone H2AX (gammaH2AX), defines the chromosome-wide domain, initiates meiotic sex chromosome

23 Our results also suggest that chromosome-wide dosage compensation does not occur in th

24 lies, thus defining a minimal RNA domain for chromosome-wide dosage compensation.

25 omorphic ZW chromosomes in rattlesnakes lack chromosome-wide dosage compensation.

26 We show that chromosome-wide downregulation initiates the processes o

27 llenging owing to the small magnitude of the chromosome-wide effect and the lack of an in vitro syste

28 The chromosome-wide effects of ASAR6 map to the antisense st

29 higher-order chromosome structure to achieve chromosome-wide effects.

30 Drosophila testes reflects a balance between chromosome-wide epigenetic transcriptional suppression a

31 imately 8% of the mutants profiled exhibited chromosome-wide expression biases, leading to spurious c

32 ruitment elements on X (rex sites) to reduce chromosome-wide gene expression by half.

33 ion proteins to the new task of regulating X-chromosome-wide gene expression points to the evolutiona

34 ting higher-order chromosome structure and X-chromosome-wide gene expression.

35 One paradigm of chromosome-wide gene regulation is Caenorhabditis elegan

36 Thus, the potential for chromosome-wide gene regulation is not intrinsic to X-ch

37 reads to neighboring X regions to accomplish chromosome-wide gene repression.

38 There was no evidence of chromosome-wide genomic rearrangements between the chrom

39 by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling

40 Our algorithm, cnvHap, jointly learns a chromosome-wide haplotype model of CNVs and cluster-base

41 tes, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one poly

42 eotide (SNV), and structural variations into chromosome-wide haplotypes in humans has been challengin

43 Chromosome-wide inactivation is an epigenetic signature

44 Xist-induced Jarid2 recruitment occurs chromosome-wide independently of a functional PRC2 compl

45 Five DE QTL, significant at a chromosome wide level (alpha = 0.05), were detected, wit

46 FourME QTL significant at the chromosome wide level were detected, with three signific

47 At the chromosome-wide level, a total 122 QTNs were associated

48 toire, and show that biases are evident on a chromosome-wide level.

49 that is apparent at both the nucleosome and chromosome-wide levels, and discuss the emerging importa

50 on of the results both at single-loci and at chromosome-wide levels.

51 Thus, the X(D) in D. recens appears to be in chromosome-wide linkage disequilibrium and in the early

52 In contrast, no analogous X-chromosome-wide mechanism balances transcription between

53 Both species appear to lack a Z chromosome-wide mechanism of dosage compensation, becaus

54 dosage compensation, and the DCC acts via a chromosome-wide mechanism to balance transcription betwe

55 Gene-specific and chromosome-wide mechanisms of transcriptional regulation

56 ill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000

57 Chromosome-wide methylation patterns were similar among

58 e of our method is that it provides a global chromosome-wide nominal control level to clustering, as

59 omatin composition during XCI and generate a chromosome-wide profile of Xi and Xa (active X) at nucle

60 PAR or autosomes, culminating in an elevated chromosome-wide rate.

61 to both X chromosomes of hermaphrodites for chromosome-wide reduction of gene expression.

62 throughout Xi, providing direct evidence for chromosome-wide regulation of "junk" DNA transcription.

63 ena, including sex determination, epigenetic chromosome-wide regulation of gene expression, the distr

64 ues by modulating signaling pathways through chromosome-wide regulation of gene expression.

65 ng the importance of primary DNA sequence in chromosome-wide regulation.

66 me gene expression between the sexes through chromosome-wide regulatory mechanisms that function in o

67 expression in C. elegans is controlled by a chromosome-wide regulatory process called dosage compens

68 In C. elegans, an X-chromosome-wide regulatory process compensates for the d

69 L1 antisense RNA plays a functional role in chromosome-wide replication timing of mammalian chromoso

70 ontain discrete cis-acting loci that control chromosome-wide replication timing, mono-allelic express

71 Our results further demonstrate that the chromosome-wide repression imposed by MSCI is limited to

72 omosome dosage compensation in the soma, and chromosome-wide repression of X in the germline.

73 e complex that achieves gene-specific versus chromosome-wide repression.

74 strong gene-specific repressor and a weaker chromosome-wide repressor.

75 ng the effects of linkage and selection on a chromosome-wide scale.

76 ur of DSBs controlled by the other allele at chromosome-wide scales.

77 ic regulatory elements, rather than a simple chromosome-wide separation from transcription machinery,

78 n chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-b

79 occurred on chromosome 1q21.3-q32.1, with a chromosome-wide significant likelihood ratio Z score (Z(

80 omosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-di

81 Sex chromosomes are uniquely subject to chromosome-wide silencing during male meiosis, and silen

82 tivation center and the molecular aspects of chromosome-wide silencing has greatly improved recently.

83 escape gene activation in an environment of chromosome-wide silencing in murine germ cells.

84 d at serine 139 (gammaH2AX), which initiates chromosome-wide silencing.

85 spread along the inactive X (Xi) to initiate chromosome-wide silencing.

86 SNPNB can efficiently handle genome-wide or chromosome-wide SNP data analysis in a PC or a workstati

87 The second step is the MDC1-dependent chromosome-wide spreading of DDR factors to the entire c

88 We carried out a chromosome-wide survey of ASM across 16 human pluripoten

89 of origin firing, allowing us to reconstruct chromosome-wide timing profiles from an asynchronous cul

90 ctive X chromosomes with XIST expression and chromosome-wide transcriptional dampening and initiated

91 this genus and can be directly attributed to chromosome-wide transcriptional regulation that de-mascu

92 iggers stable heterochromatin modifications, chromosome-wide transcriptional silencing and DNA methyl

93 ent spermatocytes are profoundly impaired in chromosome-wide transcriptional silencing of genes linke

94 In wild-type testes, this sex chromosome-wide transcriptional suppression is generally

95 died as a hallmark of imprinted genes, and a chromosome-wide version of this phenomenon occurs, in a

96 Here we present a chromosome-wide view of the structure and evolution of t

97 ely correlated with the other X-linked genes chromosome-wide, which is consistent with the XIST-media

98 We conclude that chromosome-wide X silencing continues from meiosis to th