ライフサイエンスコーパス: ciglitazone

1 ed apoptosis induced by 15d-PGJ2, but not by ciglitazone.

2 vent B cell apoptosis induced by 15d-PGJ2 or ciglitazone.

3 lization by 15-deoxy-Delta(12,14)-PGJ(2) and ciglitazone.

4 porter gene response even in the presence of ciglitazone.

5 atment with 15-deoxy-Delta(12, 14)-PGJ(2) or ciglitazone.

6 5-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and ciglitazone.

7 by the PPARgamma agonists, troglitazone and ciglitazone.

8 4 mRNA is only expressed in cells exposed to ciglitazone.

9 one (2), as had been previously reported for ciglitazone (1).

10 and every hour thereafter, animals received ciglitazone (10 mg/kg) or vehicle intraperitoneally.

11 lls, PPAR-gamma activation by 15d-PGJ(2) and ciglitazone (a synthetic ligand) leads to reduction in b

12 ed to dexamethasone and the PPARgamma ligand ciglitazone (a thiazolidinedione) resulted in expression

13 Both sulindac sulfide and ciglitazone, a defined peroxisome proliferator-activated

14 Ciglitazone, a peroxisome proliferator-activated recepto

15 eatment of cultured human keratinocytes with ciglitazone, a PPAR-gamma activator, increases involucri

16 Ciglitazone, a PPAR-gamma agonist with anti-inflammatory

17 Ciglitazone, a PPARgamma ligand, consistently decreased

18 in vitro and in vivo antimelanoma effects of ciglitazone, a synthetic ligand-activating PPARgamma.

19 characterize the novel relationship between ciglitazone, a thiazolidinedione class of PPARgamma liga

20 l burdens were significantly lower following ciglitazone administration, which could be explained, in

21 Unexpectedly, ciglitazone also accelerated brain abscess encapsulation

22 Ciglitazone also suppressed HIV-1 mRNA levels as measure

23 Ciglitazone ameliorates the inflammatory response and ma

24 troglitazone, two other thiazolidinediones, ciglitazone and englitazone, exhibited similar inhibitor

25 bone marrow B cells with PPARgamma agonists (ciglitazone and GW347845X) resulted in rapid apoptosis.

26 The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alph

27 The induction of RAR beta expression by the ciglitazone and SR11237 combination was diminished by a

28 Our results demonstrated that ciglitazone and SR11237 cooperatively inhibited the grow

29 ll-trans-retinoic acid or the combination of ciglitazone and SR11237 was able to induce RAR beta in a

30 ncreased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E

31 RXRalpha agonist plus the PPARgamma agonist ciglitazone and the inhibition of 9-cis-RA-induced coact

32 xamined the effects of the PPAR gamma ligand ciglitazone and the RXR ligand SR11237 on growth and ind

33 In this study, both ciglitazone and troglitazone increased Src activation.

34 hat various PPARalpha (nafenopin) and gamma (ciglitazone and troglitazone) agonists rapidly induced e

35 4-PGJ2 (15d-PGJ2) and synthetic ligands like ciglitazone and troglitazone, all induce apoptosis in no

36 Our laboratory has shown that two TZDs, ciglitazone and troglitazone, rapidly induce calcium-dep

37 ha (WY14643), PPARdelta (GW1514), PPARgamma (ciglitazone), and LXR (22(R)-cholesterol or TO901317) or

38 The combination of low-dose MK886, ciglitazone, and 13-cis-retinoic acid interacted at leas

39 bited ABCA1 expression (while rosiglitazone, ciglitazone, and pioglitazone had little effect) and cho

40 Rgamma agonists 15-deoxy-prostaglandin-J(2), ciglitazone, and pioglitazone reduced intimal expansion,

41 PAR-gamma (including the TZDs rosiglitazone, ciglitazone, and pioglitazone, as well as the cyclopenta

42 s that the apoptotic effect of troglitazone, ciglitazone, and their PPARgamma-inactive analogues 5-[4

43 r kappaB protein kinase activity afforded by ciglitazone appeared to be a consequence of a physical i

44 activated receptor gamma (PPARgamma) agonist ciglitazone at high doses was able to mediate PPARgamma-

45 In addition, ciglitazone attenuated the expression of select inflamma

46 Ciglitazone, but not 15d-PGJ(2), strongly induced RAR be

47 In reporter gene assays, RXR ligands and ciglitazone, but not the PPAR gamma ligand 15d-PGJ(2), c

48 ARgamma-inactive analogs of troglitazone and ciglitazone [Delta2TG (5-[4-(6-hydroxy-2,5,7,8-tetrameth

49 the specific PPARgamma agonists LY17883 and ciglitazone, demonstrate that the PPRE element confers p

50 oliferator-activated receptor gamma-inactive ciglitazone derivative, exhibits 1- and 3-order of magni

51 t of human monocyte-derived macrophages with ciglitazone did not regulate expression of apoE.

52 port here that troglitazone and another TZD, ciglitazone, dramatically inhibited mitogen-induced cell

53 d be explained, in part, by the finding that ciglitazone enhanced S. aureus phagocytosis by microglia

54 PARgamma) agonists, such as troglitazone and ciglitazone, exhibit antitumor effects; however, the und

55 liferator-activated receptor-gamma activator ciglitazone had only a moderate effect.

56 effect on other cells of the immune system, ciglitazone has an enhancing effect on both iTregs and n

57 irst, the novel function of troglitazone and ciglitazone in targeting energy restriction provides a m

58 Treatment of cultured 3T3-L1 adipocytes with ciglitazone increased apoE mRNA levels by 2-4-fold in a

59 )-PGJ(2) and the synthetic PPARgamma agonist ciglitazone induced activation of caspase 3 and caspase

60 apacitative calcium entry by 2-APB prevented ciglitazone-induced EGFR transactivation and Erk activat

61 ation; here, Src activation by both TZDs and ciglitazone-induced EGFR transactivation were prevented

62 12,14)-prostaglandin J(2), troglitazone, and ciglitazone inhibited 17beta-estradiol-stimulated cell p

63 The PPARgamma agonist ciglitazone inhibited HIV-1 replication in a dose-depend

64 PPARgamma agonists such as rosiglitazone and ciglitazone, is coactivated by 9 cis-retinoic acid and i

65 mation and accelerate abscess encapsulation, ciglitazone may effectively sequester brain abscesses an

66 PAR gamma, 15d-PGJ2 and a thiazolidinedione, ciglitazone, mediate significant inhibition of prolifera

67 We investigated the effects of ciglitazone on lung inflammation after severe hemorrhage

68 totic mechanism, the effects of 15d-PGJ2 and ciglitazone on reactive oxygen species were investigated

69 tor-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 res

70 In vivo treatment with ciglitazone or 15d-PGJ(2) ameliorated hypotension and su

71 Furthermore, treatment with ciglitazone or 15d-PGJ(2) up-regulated the expression of

72 l cells with the PPAR gamma-specific agonist ciglitazone or azPC augmented cyclooxygenase-2 expressio

73 ver, topical treatment of hairless mice with ciglitazone or troglitazone increases loricrin, involucr

74 15d-PGJ2, but not ciglitazone, potently induced reactive oxygen species in

75 ons from intracellular stores; however, only ciglitazone produced a secondary calcium influx in the p

76 Ciglitazone rapidly activates extracellular signal-regul

77 In addition, cyPG and ciglitazone reduced HIV replication in latently infected

78 In addition, 15d-PGJ(2) but not ciglitazone reduces expression of CD69 in human NK cells

79 ost disease, the immunotherapeutic effect of ciglitazone requires the presence of nTregs that express

80 In vitro, ciglitazone significantly enhances generation of iTregs

81 Treatment with ciglitazone significantly reduced inhibitor kappaB prote

82 eatment with 9-hydroxyoctadecanoic acids and ciglitazone significantly rescued lal-/- pulmonary infla

83 lective thiazolidinedione PPARgamma agonist, ciglitazone, significantly reduced neuronal death in res

84 staglandin J2 (15d-PGJ2) or troglitazone and ciglitazone suppressed TGF-beta1-mediated alpha-smooth m

85 d Delta2CG, a PPARgamma-inactive analogue of ciglitazone, to conduct lead optimization to develop a n

86 Ciglitazone treatment ameliorated mean arterial pressure

87 ctivated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) pro

88 This neuroprotective effect of 15d-PGJ2 and ciglitazone was linked to increased PPARgamma DNA bindin