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1 c edema), and kidney (disordered and shorter cilia).
2 hich we detected glycylation in many primary cilia.
3 file as a function of the distance above the cilia.
4 signaling in vertebrates depends on primary cilia.
5 SC microvilli, and glycolytic enzymes in rat cilia.
6 n 6 mediate ectosome release from the tip of cilia.
7 rrectly orient structures, such as hairs and cilia.
8 lity of glucose uptake and glycolysis in the cilia.
9 trioles do not persist at the base of mature cilia.
10 d stratified squamous epithelium with sparse cilia.
11 uired for trafficking to and function within cilia.
12 de intraflagellar transport (IFT) in primary cilia.
13 ich encode proteins that localize to primary cilia.
14 cking of a subset of these GPCRs to neuronal cilia.
15 iving internal flows using muscular pumps or cilia.
16 drocephalus are colocalized to the ependymal cilia.
17 owever, Cdk10-knockout MEFs developed longer cilia.
18 and the evolutionary conserved structure of cilia.
19 ctural features that are not seen in primary cilia.
20 rscoring a regulatory loop between FSTL1 and cilia.
21 traveling through the fluid surrounding the cilia.
22 In some tissues, they are also found in cilia.
23 , but not with regard to its function within cilia.
24 ing peptides, in Chlamydomonas and mammalian cilia.
25 f Sstr3, a ciliary GPCR, in Arl13b-deficient cilia.
26 anism to specialize the form and function of cilia.
27 cells drives the coordinated arrests of all cilia.
28 ng proteins and reduced Smoothened levels at cilia.
29 sphatidylinositol 4,5-bisphosphate in distal cilia.
30 organization and Smoothened accumulation at cilia.
31 s necessary and sufficient to specify motile cilia.
32 along microtubules (MTs) toward the tips of cilia.
33 t removes activated signaling molecules from cilia.
34 ment of the somatostatin receptor in primary cilia.
35 n IFTA function are unaffected in Ift56(hop) cilia.
37 nderstanding of protein transport in primary cilia, a critically affected process in many genetic dis
39 FOXJ1, a TF which promotes growth of airway cilia and effective clearance of the lung airway epithel
41 FICANCE STATEMENT How processes occurring in cilia and flagella are powered is a matter of general in
43 essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary cleara
45 ation has so far been mostly found on motile cilia and flagella, where it is involved in the stabiliz
49 y implicated in ciliary biology localized to cilia and further investigated ENKUR, a TRP channel-inte
50 nal structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle pr
52 rotein known to remain at the base of mature cilia and is required for intraflagellar transport traff
55 nce strongly suggests that glycolysis in the cilia and knob oxidative phosphorylation together fuel c
63 f this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2
64 r of immotile cilia at the expense of motile cilia, and leads to an accumulation of immotile cilia at
65 expressed Wdr34 is occasionally localized to cilia, and Wdr34 is required for the ciliary localizatio
66 novel and evolutionarily conserved protein, cilia- and flagella-associated protein 69 (CFAP69), in m
84 ndicate that structurally integrated primary cilia are required for detection of electrical field sig
88 structure and accessory kinesin-3 motor, CEM cilia are specialized to produce extracellular vesicles.
96 main (NICD) increases the number of immotile cilia at the expense of motile cilia, and leads to an ac
97 ximately two mitochondria; assuming that the cilia ATP is 1 mm and diffuses along it at approximately
98 il to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into m
100 perties of spatial and temporal coherence of cilia beat can be recovered and distinguished, and that
101 stem that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize
102 measurements of a Newtonian flow induced by cilia beating (using micro-beads as tracers) and a mathe
105 t also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cili
106 own about the role of glycylation in primary cilia because of limitations in detecting this modificat
107 centrate into membranous buds at the tips of cilia before release into extracellular vesicles named e
108 ein-coupled receptor pathways were linked to cilia before the origin of bilateria and transient recep
109 monas PAM knockdown lines failed to assemble cilia beyond the transition zone, had abnormal Golgi arc
111 lymerisation in the photoreceptor connecting cilia cause rhodopsin mislocalisation and eventual retin
113 ukin-8 (IL-8) secretion and decreased apical cilia, cystic fibrosis transmembrane conductance regulat
117 cell plasma membrane, which leads to primary cilia defects and a resultant failure to inhibit growth
118 gnaling has not been established, and actual cilia defects in the WDR34 mutant cells have also not be
119 s display phenotypes tightly associated with cilia defects, and cilia motility is lost in a number of
120 cle floor, apical profiles with only primary cilia define an additional uniciliated (E3) epithelium.
125 dy provided a more complete understanding of cilia distribution and revealed for the first time coord
127 ing velocimetry (PTV-OCT) to investigate the cilia-driven flow field and 3D speckle variance imaging
134 tions for human disorders related to primary cilia dysfunctions, such as ciliopathies and certain typ
136 ary structure dynamics is established by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e.
138 nd out of the lung by the activity of motile cilia, expelling at the same time particles trapped in i
139 ll developing OSNs including the presence of cilia extending from the apical knob and expression of N
140 proteins has evidenced their involvement in cilia, extraciliary functions for some of these proteins
141 power the physiological events occurring in cilia, flagella, and microvilli are of fundamental impor
143 w these advances in our knowledge of primary cilia, focusing on brain development, and discuss the me
145 oma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) signaling.
146 t MaSC and MaTIC EMT programs induce primary cilia formation and Hedgehog (Hh) signaling, which has p
147 formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting that Intu p
150 clinical manifestations because of abnormal cilia formation or function, and few treatments have bee
151 t while centrioles are essential to initiate cilia formation, they are dispensable for cilia maturati
152 es; there, a field of randomly beating short cilia ([Formula: see text]10 [Formula: see text]m) mixes
156 ith cilia, we characterized the proteomes of cilia from sea urchins, sea anemones, and choanoflagella
157 e, we demonstrate that disruption of primary cilia function following the selective loss of ciliary G
159 iverse organisms to our current knowledge of cilia function in sensory signaling and human disease.
168 tuents, development, and function of primary cilia has advanced considerably in recent years, reveali
174 e-dimensional morphologies of sensory neuron cilia in adult C. elegans hermaphrodites at high resolut
175 n), and Wdr34 mutant cells demonstrates that cilia in both Dnchc2 and Wdr34 mutant cells are stumpy.
176 ng frequency of all three types of ependymal cilia in both the third and the lateral rat brain ventri
177 he receptor-type guanylate cyclase GCY-9, to cilia in chemosensory neurons of the nematode Caenorhabd
180 ent evidence for the localization of primary cilia in dental tissues and the impact of disrupted cili
186 rce the presence of three types of ependymal cilia in the brain ventricles and demonstrate the involv
188 d for the first time coordinated polarity of cilia in the epithelium of the mammalian middle ear, thu
190 , retinal dystrophy, coloboma, and decreased cilia) in a CRISPR/Cas9-engineered zebrafish mutant mode
191 ble to accumulate normally within Ift56(hop) cilia, including IFT88, IFT81 and IFT27, which are cruci
192 Importantly, understanding both cilia and cilia-independent functions of the BBS proteins is key t
194 f rhodopsin within rod photoreceptor sensory cilia, inhibited enrichment of the somatostatin receptor
195 her centrioles recruit proteins required for cilia initiation and dock onto ciliary vesicles, but axo
197 Our data demonstrate that T2R14 in sinonasal cilia is a potential therapeutic target for upper respir
199 e function of the homodimeric Kif17 motor in cilia is poorly understood, whereas Kif7 is known to pla
202 ently discovered property shared across many cilia is the ability to release small vesicles called ec
203 f membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar transport (
204 Our results show that the number of immotile cilia is too small to ensure robust left and right deter
207 substitute for palmitoylation with regard to cilia localization of ARL13b, but not with regard to its
208 lin and SOX9 proteins, the number of primary cilia(+) LPCs, and increased active gamma-glutamyltransp
210 pletely formed at this time, indicating that cilia maturation does not depend on intact centrioles.
211 rotein transport and/or signaling defects at cilia may contribute to LRRK2-dependent pathologies.
212 us define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal connectiv
216 Here, we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pont
218 s tightly associated with cilia defects, and cilia motility is lost in a number of ciliated tissues a
219 sed to extract microscopic properties of the cilia motion by extrapolating the micro-bead velocity me
221 ds, used as markers of the flow generated by cilia motion, enables us also to assess the velocity pro
223 The altered morphology and connectivity of cilia mutant interneurons and the functional deficits ar
226 rming a knob projecting several chemosensory cilia of approximately 50 x 0.2 mum, devoid of inner mem
229 highly conserved function within the primary cilia of the CNC-derived mesenchyme in the lip and palat
234 lacking a tectorin-based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7
238 drome, altogether demonstrating that primary cilia play a critical role in regulation of both the ear
241 ggest, respectively, that radial stretch and cilia play little, if any, role in determining normal co
242 gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left
245 the mechanism of how palmitoylation affects cilia protein localization and function are unknown.
254 the degradation of ARL13b that occurs during cilia resorption, raising the possibility that the sensi
255 affect the structure or function of primary cilia result in ciliopathies, a group of developmental a
257 rat and toad (Caudiverbera caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cili
259 ydactyly; however, the underlying defects in cilia signaling and the function of INPP5E at cilia are
260 n dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
261 ng tubby family member TUB also localizes to cilia similar to TULP3 and determines trafficking of a s
262 Nearly all cell types in mammals contain cilia, small rod-like or more elaborate structures that
264 n IFTB complex integrity that is crucial for cilia structure and function and, ultimately, animal dev
265 mal cilia distribution but display defective cilia structure, including abnormal positioning and numb
267 These FAPs dynamically produced primary cilia, structures that transduce intercellular cues such
270 rimary cilia than wild-type embryos, but the cilia that form are of normal length and traffic Hedgeho
271 n Hedgehog and phosphoinositide signaling at cilia that maintains TZ function and Hedgehog-dependent
275 mediate the localization of GFP-Kif17 to the cilia tip and competitive binding of RP2 and Arl3 with K
277 late the trafficking of specific kinesins to cilia tips and provide additional evidence that TRIDs co
278 rther validated by reduced levels of Kif7 at cilia tips detected in fibroblasts and induced pluripote
279 lymerization in primary cilia, which excises cilia tips in a process we call cilia decapitation.
281 nally investigate injury and regeneration of cilia to calcium chloride on ex vivo mouse trachea.
282 transducing signals received at the primary cilia to sustain embryonic and postnatal development.
284 we report three distinct types of ependymal cilia, type-I, type-II and type-III classified based upo
287 both Tgifs, the number of cells with primary cilia was significantly decreased, and we observed a red
288 on signaling pathways became associated with cilia, we characterized the proteomes of cilia from sea
289 dentifying the number of motile and immotile cilia, we now established that the final number of motil
290 echanisms and indeed, centrosome and primary cilia were altered and spindles were found to be abnorma
293 to a reduction in the branching patterns of cilia, whereas raising the levels of oig-8 results in an
295 Here we show that this depends on primary cilia, which are nonmotile, cell-surface structures that
296 se-forbidden actin polymerization in primary cilia, which excises cilia tips in a process we call cil
297 is essential for the homeostasis of primary cilia, which has important implications for human disord
298 for the assembly and function of the primary cilia, which mediate the activity of key developmental s
300 ins in the 250-nm-wide shaft of live primary cilia with a spatiotemporal resolution of 2 ms and <16 n
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