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1 c edema), and kidney (disordered and shorter cilia).
2 hich we detected glycylation in many primary cilia.
3 file as a function of the distance above the cilia.
4  signaling in vertebrates depends on primary cilia.
5 SC microvilli, and glycolytic enzymes in rat cilia.
6 n 6 mediate ectosome release from the tip of cilia.
7 rrectly orient structures, such as hairs and cilia.
8 lity of glucose uptake and glycolysis in the cilia.
9 trioles do not persist at the base of mature cilia.
10 d stratified squamous epithelium with sparse cilia.
11 uired for trafficking to and function within cilia.
12 de intraflagellar transport (IFT) in primary cilia.
13 ich encode proteins that localize to primary cilia.
14 cking of a subset of these GPCRs to neuronal cilia.
15 iving internal flows using muscular pumps or cilia.
16 drocephalus are colocalized to the ependymal cilia.
17 owever, Cdk10-knockout MEFs developed longer cilia.
18  and the evolutionary conserved structure of cilia.
19 ctural features that are not seen in primary cilia.
20 rscoring a regulatory loop between FSTL1 and cilia.
21  traveling through the fluid surrounding the cilia.
22      In some tissues, they are also found in cilia.
23 , but not with regard to its function within cilia.
24 ing peptides, in Chlamydomonas and mammalian cilia.
25 f Sstr3, a ciliary GPCR, in Arl13b-deficient cilia.
26 anism to specialize the form and function of cilia.
27  cells drives the coordinated arrests of all cilia.
28 ng proteins and reduced Smoothened levels at cilia.
29 sphatidylinositol 4,5-bisphosphate in distal cilia.
30  organization and Smoothened accumulation at cilia.
31 s necessary and sufficient to specify motile cilia.
32  along microtubules (MTs) toward the tips of cilia.
33 t removes activated signaling molecules from cilia.
34 ment of the somatostatin receptor in primary cilia.
35 n IFTA function are unaffected in Ift56(hop) cilia.
36 -shaped structures that form centrosomes and cilia [1].
37 nderstanding of protein transport in primary cilia, a critically affected process in many genetic dis
38              Importantly, understanding both cilia and cilia-independent functions of the BBS protein
39  FOXJ1, a TF which promotes growth of airway cilia and effective clearance of the lung airway epithel
40                                              Cilia and flagella are microtubule-based organelles that
41 FICANCE STATEMENT How processes occurring in cilia and flagella are powered is a matter of general in
42 ed by non-assembly of dynein arm motors into cilia and flagella axonemes.
43  essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary cleara
44                     Before their import into cilia and flagella, multi-subunit axonemal dynein arms a
45 ation has so far been mostly found on motile cilia and flagella, where it is involved in the stabiliz
46 the elongation and maintenance of eukaryotic cilia and flagella.
47 he structure that templates the formation of cilia and flagellae.
48        Finally, our data indicate that BBS4, cilia and FSTL1 are coordinated during the differentiati
49 y implicated in ciliary biology localized to cilia and further investigated ENKUR, a TRP channel-inte
50 nal structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle pr
51 yphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in JBTS.
52 rotein known to remain at the base of mature cilia and is required for intraflagellar transport traff
53                    ENKUR localizes to motile cilia and is required for patterning the left-right axis
54                       We also found that the cilia and knob can incorporate and accumulate 2-deoxyglu
55 nce strongly suggests that glycolysis in the cilia and knob oxidative phosphorylation together fuel c
56 rodomains such as synapses, dendritic spine, cilia and more.
57                Inverted ALIs exhibit beating cilia and mucus production, consistent with conventional
58 inal development, most likely by trafficking cilia and outer-segment proteins.
59                           Inturned (INTU), a cilia and planar polarity effector, performs prominent c
60 omplexes direct both the assembly of primary cilia and the trafficking of signaling molecules.
61 e ependymal subpopulation (E2) with only two cilia and unique basal bodies.
62 nalyze the evolutionary relationship between cilia and various signaling pathways.
63 f this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2
64 r of immotile cilia at the expense of motile cilia, and leads to an accumulation of immotile cilia at
65 expressed Wdr34 is occasionally localized to cilia, and Wdr34 is required for the ciliary localizatio
66  novel and evolutionarily conserved protein, cilia- and flagella-associated protein 69 (CFAP69), in m
67                                              Cilia are assembled via intraflagellar transport (IFT).
68       The serotonergic cells are active when cilia are beating.
69                    In the brain, the primary cilia are crucial for early patterning, neurogenesis, ne
70       Olfactory sensory neurons chemosensory cilia are elongated, mucus embedded, fully exposed struc
71                                              Cilia are essential for Hedgehog signaling, and humans a
72                                              Cilia are found on most non-dividing cells in the human
73                                       Motile cilia are found on unicellular organisms such as the gre
74              Fluid flows generated by motile cilia are guiding the establishment of the left-right as
75                                      Primary cilia are hairlike extensions of the plasma membrane of
76                            To understand why cilia are intimately associated with cell signaling, Sig
77                                      Primary cilia are key coordinators of various signaling pathways
78                                      Primary cilia are located in the dental epithelium and mesenchym
79  target and concentrate membrane proteins in cilia are not well understood.
80                                      Primary cilia are organelles that have recently been implicated
81                We also found that the motile cilia are polarized coordinately and display a planar ce
82 sses targeting integral membrane proteins to cilia are poorly understood.
83                                          The cilia are present when interactions between both the epi
84 ndicate that structurally integrated primary cilia are required for detection of electrical field sig
85                                      Primary cilia are sensors of electrical field stimulation to ind
86                                      Primary cilia are sensory organelles located at the cell surface
87                                              Cilia are small, antenna-like structures on the surface
88 structure and accessory kinesin-3 motor, CEM cilia are specialized to produce extracellular vesicles.
89 ilia signaling and the function of INPP5E at cilia are still emerging.
90                      We show that Ift56(hop) cilia are unable to accumulate Gli proteins efficiently,
91 ndrome, particularly the function of primary cilia, are still incompletely understood.
92 mal Golgi architecture and altered levels of cilia assembly components.
93                                        While cilia assembly is absolutely dependent on centrioles, it
94 present a new family of NPHP not involved in cilia-associated functions.
95 ia, and leads to an accumulation of immotile cilia at the anterior half of the KV.
96 main (NICD) increases the number of immotile cilia at the expense of motile cilia, and leads to an ac
97 ximately two mitochondria; assuming that the cilia ATP is 1 mm and diffuses along it at approximately
98 il to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into m
99                                        These cilia beat at a native frequency and in a synchronized p
100 perties of spatial and temporal coherence of cilia beat can be recovered and distinguished, and that
101 stem that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize
102  measurements of a Newtonian flow induced by cilia beating (using micro-beads as tracers) and a mathe
103 iruses, except RV-B48 and HCoV-OC43, altered cilia beating and mucociliary clearance.
104 r index providing a direct assessment of the cilia beating efficiency.
105 t also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cili
106 own about the role of glycylation in primary cilia because of limitations in detecting this modificat
107 centrate into membranous buds at the tips of cilia before release into extracellular vesicles named e
108 ein-coupled receptor pathways were linked to cilia before the origin of bilateria and transient recep
109 monas PAM knockdown lines failed to assemble cilia beyond the transition zone, had abnormal Golgi arc
110 ed surfaces harbouring synchronously beating cilia can generate fluid flow or drive locomotion.
111 lymerisation in the photoreceptor connecting cilia cause rhodopsin mislocalisation and eventual retin
112                              However, motile cilia could sense their own motion by a yet unknown mech
113 ukin-8 (IL-8) secretion and decreased apical cilia, cystic fibrosis transmembrane conductance regulat
114                     Finally, we propose that cilia decapitation induces mitogenic signaling and const
115  we show that an acute loss of IFT-B through cilia decapitation precedes resorption.
116 hich excises cilia tips in a process we call cilia decapitation.
117 cell plasma membrane, which leads to primary cilia defects and a resultant failure to inhibit growth
118 gnaling has not been established, and actual cilia defects in the WDR34 mutant cells have also not be
119 s display phenotypes tightly associated with cilia defects, and cilia motility is lost in a number of
120 cle floor, apical profiles with only primary cilia define an additional uniciliated (E3) epithelium.
121 al abnormalities characteristic of decreased cilia-dependent Hedgehog signaling.
122  established that the final number of motile cilia depends on Notch signalling (NS).
123                                        While cilia disassembly is traditionally thought to occur sole
124          We integrated parameters describing cilia distribution and orientation obtained in vivo in z
125 dy provided a more complete understanding of cilia distribution and revealed for the first time coord
126                  Ift56(hop) mice have normal cilia distribution but display defective cilia structure
127 ing velocimetry (PTV-OCT) to investigate the cilia-driven flow field and 3D speckle variance imaging
128                            Ca(2+) enters OSN cilia during the response through the olfactory cyclic n
129 ntial to visualize the microscopic motion of cilia during their beating cycle.
130                                    Ependymal cilia dysfunction can hinder the movement of CSF leading
131 in LUSC, possibly implying the importance of cilia dysfunction in the carcinogenesis.
132 ia, implicating significant contributions of cilia dysfunction to COME.
133 ncluding Joubert syndrome (JBTS), arise from cilia dysfunction.
134 tions for human disorders related to primary cilia dysfunctions, such as ciliopathies and certain typ
135  genes modulate intraflagellar transport and cilia elongation.
136 ary structure dynamics is established by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e.
137 o T1 and T2 inflammation, neuronal function, cilia, epithelial growth, and repair mechanisms.
138 nd out of the lung by the activity of motile cilia, expelling at the same time particles trapped in i
139 ll developing OSNs including the presence of cilia extending from the apical knob and expression of N
140  proteins has evidenced their involvement in cilia, extraciliary functions for some of these proteins
141  power the physiological events occurring in cilia, flagella, and microvilli are of fundamental impor
142  and numerical model of the coupling between cilia, fluid, and micro-bead motion.
143 w these advances in our knowledge of primary cilia, focusing on brain development, and discuss the me
144                  How morphologically complex cilia form is not well understood.
145 oma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) signaling.
146 t MaSC and MaTIC EMT programs induce primary cilia formation and Hedgehog (Hh) signaling, which has p
147 formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting that Intu p
148                         Induction of primary cilia formation by serum starvation led to a two-fold re
149 ulation is likely a prerequisite for primary cilia formation during Hh-dependent tumorigenesis.
150  clinical manifestations because of abnormal cilia formation or function, and few treatments have bee
151 t while centrioles are essential to initiate cilia formation, they are dispensable for cilia maturati
152 es; there, a field of randomly beating short cilia ([Formula: see text]10 [Formula: see text]m) mixes
153                             An array of long cilia ([Formula: see text]25 [Formula: see text]m) with
154                 Thus, proteomic profiling of cilia from diverse eukaryotes defines a conserved ciliar
155                         Genetically removing cilia from FAPs inhibited intramuscular adipogenesis, bo
156 ith cilia, we characterized the proteomes of cilia from sea urchins, sea anemones, and choanoflagella
157 e, we demonstrate that disruption of primary cilia function following the selective loss of ciliary G
158 he effects of ethanol ingestion on ependymal cilia function have not been investigated in vivo.
159 iverse organisms to our current knowledge of cilia function in sensory signaling and human disease.
160     The emerging evidence implicates primary cilia function in tooth development.
161       Genetic or experimental alterations of cilia function lead to various developmental defects, in
162 eating pattern which plays critical roles in cilia function.
163                               Defects in the cilia gene RPGRIP1 cause Leber congenital amaurosis and
164                 Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a si
165                         Interestingly, three cilia genes were found selectively with high mutation ra
166  cell airway infiltration, downregulation of cilia genes, and dampening of type 2 inflammation.
167  levels correlate with the extent of sensory cilia growth and branching patterns.
168 tuents, development, and function of primary cilia has advanced considerably in recent years, reveali
169                   The transport of ODAs into cilia has been previously shown to require the transport
170                                              Cilia have evolved to function as essential sensory orga
171                                      Primary cilia have pivotal roles as organizers of many different
172                                              Cilia house signaling proteins that allow the cell to sa
173           Glycylation accumulates in primary cilia in a length-dependent manner, and depletion or ove
174 e-dimensional morphologies of sensory neuron cilia in adult C. elegans hermaphrodites at high resolut
175 n), and Wdr34 mutant cells demonstrates that cilia in both Dnchc2 and Wdr34 mutant cells are stumpy.
176 ng frequency of all three types of ependymal cilia in both the third and the lateral rat brain ventri
177 he receptor-type guanylate cyclase GCY-9, to cilia in chemosensory neurons of the nematode Caenorhabd
178 or the normal assembly of motile and primary cilia in Chlamydomonas, planaria and mice.
179 ting enzymes modulates the length of primary cilia in cultured cells.
180 ent evidence for the localization of primary cilia in dental tissues and the impact of disrupted cili
181 ons, confirming the central role for primary cilia in Hh signaling.
182                 Our data indicates defective cilia in IS bone cells, which may be linked to heterogen
183 emonstrate significant elongation of primary cilia in IS patient bone cells.
184           Sclt1-loss decreases the number of cilia in kidney; increases proliferation and apoptosis o
185                                          The cilia in mIMCD3 and MDCK cells expressing mutant IFT43 w
186 rce the presence of three types of ependymal cilia in the brain ventricles and demonstrate the involv
187  agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme.
188 d for the first time coordinated polarity of cilia in the epithelium of the mammalian middle ear, thu
189 in the photoreceptors, and to the tip of the cilia in transfected mIMCD3 and MDCK cells.
190 , retinal dystrophy, coloboma, and decreased cilia) in a CRISPR/Cas9-engineered zebrafish mutant mode
191 ble to accumulate normally within Ift56(hop) cilia, including IFT88, IFT81 and IFT27, which are cruci
192    Importantly, understanding both cilia and cilia-independent functions of the BBS proteins is key t
193  genetic cause of juvenile or late-onset and cilia-independent NPH.
194 f rhodopsin within rod photoreceptor sensory cilia, inhibited enrichment of the somatostatin receptor
195 her centrioles recruit proteins required for cilia initiation and dock onto ciliary vesicles, but axo
196 anisms that remodel the centriole to promote cilia initiation are poorly understood.
197 Our data demonstrate that T2R14 in sinonasal cilia is a potential therapeutic target for upper respir
198 easurements, the shear stress exerted by the cilia is deduced.
199 e function of the homodimeric Kif17 motor in cilia is poorly understood, whereas Kif7 is known to pla
200 s are recognized and transported into motile cilia is still unclear.
201          Moreover, ablation of these primary cilia is sufficient to repress Hh signaling, the stemnes
202 ently discovered property shared across many cilia is the ability to release small vesicles called ec
203 f membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar transport (
204 Our results show that the number of immotile cilia is too small to ensure robust left and right deter
205 , oko meduzy/crb2a, crb3a, and crb2b, affect cilia length in a subset of tissues.
206 and constitutes a molecular link between the cilia life cycle and cell-division cycle.
207 substitute for palmitoylation with regard to cilia localization of ARL13b, but not with regard to its
208 lin and SOX9 proteins, the number of primary cilia(+) LPCs, and increased active gamma-glutamyltransp
209 te cilia formation, they are dispensable for cilia maturation and maintenance.
210 pletely formed at this time, indicating that cilia maturation does not depend on intact centrioles.
211 rotein transport and/or signaling defects at cilia may contribute to LRRK2-dependent pathologies.
212 us define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal connectiv
213 aryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling.
214                                         This cilia-mediated process represents a previously unrecogni
215  ciliopathies is caused by defective primary cilia morphology or signal transduction.
216   Here, we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pont
217  risk factor for the impairment of ependymal cilia motility in the brain.
218 s tightly associated with cilia defects, and cilia motility is lost in a number of ciliated tissues a
219 sed to extract microscopic properties of the cilia motion by extrapolating the micro-bead velocity me
220                        The efficiency of the cilia motion can experimentally be assessed by measuring
221 ds, used as markers of the flow generated by cilia motion, enables us also to assess the velocity pro
222                       To traffic properly to cilia, multiple cilia proteins rely on palmitoylation, t
223   The altered morphology and connectivity of cilia mutant interneurons and the functional deficits ar
224 acterised roles at the centrosome/basal body/cilia network.
225 hannel-interacting protein identified in the cilia of all three organisms.
226 rming a knob projecting several chemosensory cilia of approximately 50 x 0.2 mum, devoid of inner mem
227 oteins examined abnormally accumulate in the cilia of both mutant cells.
228                  BK channels localize in the cilia of surface cells.
229 highly conserved function within the primary cilia of the CNC-derived mesenchyme in the lip and palat
230 family of odorant receptors expressed in the cilia of the olfactory sensory neurons.
231                                              Cilia on dendritic endings of sensory neurons organize d
232                  The architecture of primary cilia on neuroepithelial cells in Pam(-/-) mouse embryos
233 wo distinct, highly organized populations of cilia on the host tissues.
234  lacking a tectorin-based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7
235                                      Primary cilia perceive the extracellular environment through rec
236                                Comparison of cilia phenotype and function among wild type, Dnchc2 (dy
237 s cyclin-dependent kinase 5) ameliorated the cilia phenotype.
238 drome, altogether demonstrating that primary cilia play a critical role in regulation of both the ear
239                                      Primary cilia play central roles in signaling during metazoan de
240                                              Cilia play important roles in cell signaling, facilitate
241 ggest, respectively, that radial stretch and cilia play little, if any, role in determining normal co
242  gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left
243                   Ca(2+) is removed from the cilia primarily by the K(+)-dependent Na(+)/Ca(2+) excha
244              The understanding of middle ear cilia properties that are critical to OM susceptibility,
245  the mechanism of how palmitoylation affects cilia protein localization and function are unknown.
246       To traffic properly to cilia, multiple cilia proteins rely on palmitoylation, the post-translat
247                                    Ependymal cilia protrude into the central canal of the brain ventr
248                        We show that BBS4 and cilia regulate FSTL1 mRNA levels, but BBS4 also modulate
249   A new imaging technique sheds light on how cilia regulate their length and growth.
250                     Hh signaling through FAP cilia regulated the expression of TIMP3, a secreted meta
251                              The motility of cilia relies on a number of large protein complexes incl
252 onemes of these cells have dynein arms, some cilia remain immotile.
253                      Currently, the study of cilia requires expensive high speed cameras and high pow
254 the degradation of ARL13b that occurs during cilia resorption, raising the possibility that the sensi
255  affect the structure or function of primary cilia result in ciliopathies, a group of developmental a
256                 Detailed analysis of primary cilia revealed region-specific changes in ciliary morpho
257 rat and toad (Caudiverbera caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cili
258                         In addition, primary cilia seem to functionally modulate effects of EFS-induc
259 ydactyly; however, the underlying defects in cilia signaling and the function of INPP5E at cilia are
260 n dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
261 ng tubby family member TUB also localizes to cilia similar to TULP3 and determines trafficking of a s
262     Nearly all cell types in mammals contain cilia, small rod-like or more elaborate structures that
263 ubulin isotype dictates the hallmarks of CEM cilia specialization.
264 n IFTB complex integrity that is crucial for cilia structure and function and, ultimately, animal dev
265 mal cilia distribution but display defective cilia structure, including abnormal positioning and numb
266 e growth, a novel dynein 2 function in a non-cilia structure.
267      These FAPs dynamically produced primary cilia, structures that transduce intercellular cues such
268                                       In CEM cilia, tba-6 regulates velocities and cargoes of intrafl
269       Rsg1 mutant embryos have fewer primary cilia than wild-type embryos, but the cilia that form ar
270 rimary cilia than wild-type embryos, but the cilia that form are of normal length and traffic Hedgeho
271 n Hedgehog and phosphoinositide signaling at cilia that maintains TZ function and Hedgehog-dependent
272   These cells are multiciliated, with motile cilia that play key physiological roles.
273 ays in gustatory sensory neurons that extend cilia through the male nose.
274 nd out of the lung by the activity of motile cilia, thus expelling the particles trapped in it.
275 mediate the localization of GFP-Kif17 to the cilia tip and competitive binding of RP2 and Arl3 with K
276 RP2 or Arl3 reduced the level of Kif7 at the cilia tip.
277 late the trafficking of specific kinesins to cilia tips and provide additional evidence that TRIDs co
278 rther validated by reduced levels of Kif7 at cilia tips detected in fibroblasts and induced pluripote
279 lymerization in primary cilia, which excises cilia tips in a process we call cilia decapitation.
280 own to play an important role in stabilizing cilia tips.
281 nally investigate injury and regeneration of cilia to calcium chloride on ex vivo mouse trachea.
282  transducing signals received at the primary cilia to sustain embryonic and postnatal development.
283          In EV-releasing cephalic male (CEM) cilia, TTLL-11 and the deglutamylase CCPP-1 regulate rem
284  we report three distinct types of ependymal cilia, type-I, type-II and type-III classified based upo
285         Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedg
286 on in the dendrite and glycolytically in the cilia using glucose internalized from the mucus.
287 both Tgifs, the number of cells with primary cilia was significantly decreased, and we observed a red
288 on signaling pathways became associated with cilia, we characterized the proteomes of cilia from sea
289 dentifying the number of motile and immotile cilia, we now established that the final number of motil
290 echanisms and indeed, centrosome and primary cilia were altered and spindles were found to be abnorma
291 bGAP that is known to block the formation of cilia when overexpressed.
292 actory epithelium, CFAP69 is enriched in OSN cilia, where olfactory transduction occurs.
293  to a reduction in the branching patterns of cilia, whereas raising the levels of oig-8 results in an
294                                      Primary cilia, which are essential for normal development and ti
295    Here we show that this depends on primary cilia, which are nonmotile, cell-surface structures that
296 se-forbidden actin polymerization in primary cilia, which excises cilia tips in a process we call cil
297  is essential for the homeostasis of primary cilia, which has important implications for human disord
298 for the assembly and function of the primary cilia, which mediate the activity of key developmental s
299                            Theory shows that cilia will appear more than threefold brighter than the
300 ins in the 250-nm-wide shaft of live primary cilia with a spatiotemporal resolution of 2 ms and <16 n
301                Sensory neurons often possess cilia with elaborate membrane structures that are adapte

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