ライフサイエンスコーパス: ciliary

1 culpts 18 A- and B-tubule singlets from nine ciliary A-B doublet microtubules in cephalic male (CEM)

2 (mSmo) and promotes its phosphorylation and ciliary accumulation.

3 ntrast, none of those mutations affected the ciliary activity of the epithelial cells which is charac

4 However, none of the mutations affected the ciliary activity which serves as a virulence marker.

5 cin secretion, airway surface hydration, and ciliary-activity) which function coordinately to clear i

6 r striated rootlets and form complexes named ciliary adhesions (CAs).

7 ounts for the differences in sampling of the ciliary and apical membranes inherent to confocal micros

8 e in apoptotic pathways and a suppression of ciliary and flagellar biosynthetic pathways.

9 C) plays a central role in the regulation of ciliary and flagellar motility.

10 the "9 + 2" axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to

11 hat Tuba deficiency causes an abnormal renal ciliary and morphogenetic phenotype.

12 Ciliary and rhabdomeric opsins are employed by different

13 at regularly display spontaneous coordinated ciliary arrests.

14 erity of ischemic damage following posterior ciliary artery (PCA) occlusion in old, atherosclerotic,

15 first demonstration of a role for BLOC-1 in ciliary assembly and highlights the complexity of pathwa

16 ly conserved link between PAM, amidation and ciliary assembly.

17 equently grow asynchronously to template the ciliary axoneme, visualize degeneration of the centriole

18 ciliary vesicle that allows extension of the ciliary axoneme.

19 organizer (LRO) cells express foxj1a and the ciliary axonemes of these cells have dynein arms, some c

20 cilia, and localizes to both 9 + 2 and 9 + 0 ciliary axonemes.

21 nd Sp-Efn is expressed throughout dorsal and ciliary band ectoderm.

22 ogenic epithelial sphere expressing the Hnf6 ciliary band marker.

23 owing instead that pore proteins localize to ciliary basal bodies and that their perturbation leads t

24 dly, kif3a function precedes ciliogenesis as ciliary basal bodies are mispositioned in mutant photore

25 We discover that CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and th

26 d by PIPKIgamma and INPP5E at the centrosome/ciliary base, is vital for ciliogenesis by regulating th

27 auses apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary c

28 man sinonasal and bronchial cells, we imaged ciliary beat frequency (CBF), intracellular calcium, and

29 It is shown that the ciliary beat frequency can be recovered to match convent

30 hibits the cholinergic rhythm, and increases ciliary beat frequency.

31 recorded by high-speed video-microscopy and ciliary beat pattern is inferred.

32 Gle1-depleted zebrafish revealed compromised ciliary beating and developmental defects.

33 activate nitric oxide production to increase ciliary beating and mucociliary clearance.

34 A better understanding of the regulation of ciliary beating and mucociliary transport is necessary f

35 bility approximately 3-5-fold, and increases ciliary beating approximately 20-50%.

36 e required to stabilize basal bodies against ciliary beating forces.

37 In ciliary swimmers, ciliary beating, arrests, and changes in beat frequency

38 cociliary clearance, driven by the engine of ciliary beating, is the primary physical airway defense

39 membrane chloride permeability and increases ciliary beating.

40 w index for characterizing the efficiency of ciliary beating.

41 d contribute importantly to CSF flow through ciliary beating.

42 that candidates not previously implicated in ciliary biology localized to cilia and further investiga

43 research fields including algal, plant, and ciliary biology.

44 lanoma involved the choroid (938/1059, 89%), ciliary body (85/1059, 8%), or iris (36/1059, 3%), with

45 nce between aqueous humor secretion from the ciliary body (CB) and its drainage through the trabecula

46 Of 3809 total entries, 3217 patients with ciliary body and choroidal (CBC) melanoma and 160 with i

47 horts had a diagnosis of UM arising from the ciliary body and/or choroid.

48 chronic angle- closure glaucoma secondary to ciliary body cysts can be difficult to manage in a patie

49 chronic angle- closure glaucoma secondary to ciliary body cysts in a patient with oculodentodigital d

50 We believe that early screening for ciliary body cysts is important in patients with oculode

51 chronic angle- closure glaucoma secondary to ciliary body cysts presented to our clinic.

52 tion in ex vivo study or through cryopexy of ciliary body in vivo studies before subtenon TA injectio

53 amination revealed solid iris tumor (n = 3), ciliary body involvement (n = 2), and anterior chamber s

54 ickness, largest basal tumor diameter (LBD), ciliary body involvement, and pathologic cell type.

55 whereas for 8q gain, the OR was highest for ciliary body location (102.87, P = 0.001), thickness >8

56 poor VA (</=20/200) (9% vs. 15%, P = 0.041), ciliary body location (5% vs. 11%, P < 0.001), extramacu

57 r chromosome 8p loss, the OR was highest for ciliary body location (53.91, P = 0.008), ocular melanoc

58 primary proton beam therapy for choroidal or ciliary body melanoma between June 1998 and June 2015 we

59 All patients with primary ciliary body or choroidal melanoma treated with iodine 1

60 collaterals of ipRGCs traveling to the eye's ciliary body or even to the iris [20-22].

61 cemose hemangioma without associated iris or ciliary body solid tumor on clinical examination and ult

62 he aqueous humor and the target tissue (iris-ciliary body) up to 24weeks.

63 in human tissues relevant to glaucoma (e.g., ciliary body).

64 (PVRL) or the eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphom

65 nsory ligaments that connect the lens to the ciliary body, providing a potential mechanism for the im

66 f anterior chamber seeds, iris infiltration, ciliary body/muscle infiltration, massive (>/=3 mm) chor

67 anterior structures (anterior chamber, iris, ciliary body/muscle) was detected significantly more aft

68 An artificial ciliary bundle is achieved by fabricating bundled polydi

69 We identified 437 high-confidence ciliary candidate proteins conserved in mammals and disc

70 This ciliary cap is critical to recruit the tubulin-depolymer

71 k between olfaction and the requirement of a ciliary compartment for Hedgehog signaling.

72 accumulation of other Crumbs proteins in the ciliary compartment.

73 ritical to determine the particular role for ciliary compartmentalization in sensory reception and si

74 ficking mechanisms that underlie the role of ciliary compartmentalization in signaling might provide

75 questions regarding the role that defects in ciliary compartmentalization might play in disease patho

76 I3K-C2alpha is required for the transport of ciliary components such as polycystin-2, and partial los

77 elanogaster wings and Schmidtae mediterranea ciliary components.

78 naling pathways essential for odontogenesis, ciliary defects can interrupt the latter process.

79 Ciliary defects can result in severe disorders called ci

80 tudy provides new insights into the range of ciliary defects that can lead to PCD.

81 of SYNE1 [13-15] may originate in part from ciliary defects.

82 5-bisphosphate (PI(4,5)P2)-dependent manner, ciliary delivery by intraflagellar transport complex A b

83 me-related organelles complex-1 (BLOC-1) for ciliary delivery.

84 Decreased PAM gene expression reduced motile ciliary density on the ventral surface of planaria and r

85 on of these modules and their links to human ciliary disease are not completely understood.

86 predicted, disruptive, genetic variants from ciliary disease patients.

87 s provide insight into mechanisms generating ciliary diversity and lay a foundation for further under

88 he animal kingdom, yet mechanisms generating ciliary diversity are poorly understood.

89 importance for understanding how the unique ciliary domain is established.

90 o ciliary function, this study suggests that ciliary dysfunction might represent a novel mechanism un

91 mutations in PKHD1, has been associated with ciliary dysfunction.

92 f outer segments in mutant cones indicates a ciliary dysfunction.

93 features and underlying mechanisms involving ciliary dysfunction.

94 or and describe a syndromic LCA unrelated to ciliary dysfunction.

95 he standard approach to diagnosis of primary ciliary dyskinesia (PCD) in the United Kingdom consists

96 Primary ciliary dyskinesia (PCD) is an autosomal recessive disor

97 1, 3, 4a and 9 have been linked with primary ciliary dyskinesia (PCD), a disorder characterized by ci

98 ns and lead to a ciliopathy known as primary ciliary dyskinesia (PCD).

99 ally, COME is highly associated with Primary Ciliary Dyskinesia, implicating significant contribution

100 yskinesia (PCD), a disorder characterized by ciliary dysmotility; yet, radial spoke functions remain

101 In this study, we report a novel role for ciliary ectosomes in building the elaborate photorecepto

102 as agglutinin and ubiquitinated proteins in ciliary ectosomes suggests that they are involved in cel

103 Ciliary enrichment of these GPCRs thus operates via dist

104 Using this benchmark, we examined the ciliary enrichment signals of two G protein-coupled rece

105 to determine the degree of membrane protein ciliary enrichment that quantitatively accounts for the

106 are the same, thus providing a benchmark for ciliary enrichment.

107 as-yet-unidentified mechanism that triggers ciliary entry of IFT complexes.

108 ganizing the first known mechanism directing ciliary entry of IFT complexes.

109 e-docked IFT-B complexes, and thus initiates ciliary entry of IFT.

110 ing components and transiting cargoes during ciliary entry.

111 lization, ciliary motor-based transport, and ciliary EV release in a living animal.

112 Disruption of ciliary flow can lead to respiratory infections.

113 drugs to disease can cause an alteration in ciliary flow.

114 gnaling in oviductal epithelial cells alters ciliary function and impairs embryo transport.

115 in the United Kingdom consists of assessing ciliary function by high-speed microscopy and ultrastruc

116 unravel the molecular mechanisms underlying ciliary function in vitro and in vivo.

117 lasia, cytokine hypersecretion and decreased ciliary function of asthmatics.

118 TTLL-11 and CCPP-1 are also required for the ciliary function of releasing bioactive EVs, and TTLL-11

119 activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding

120 into and out of cilia is required for proper ciliary function, and this process is disrupted in cilio

121 Because both DNAH5 and ADGRV1 contribute to ciliary function, this study suggests that ciliary dysfu

122 ins are required for proper ciliogenesis and ciliary function.

123 n is indispensable for both ciliogenesis and ciliary function.

124 ing a role for Katnal1 in the development of ciliary function.

125 cell motility, intracellular trafficking and ciliary function.

126 ole of this protein in both ciliogenesis and ciliary function.

127 ltrastructure, intraflagellar transport, and ciliary functions of extracellular vesicle (EV)-releasin

128 ing Rab34, Pdcl, and Tubd1, were involved in ciliary functions, confirming the central role for prima

129 rescued by either chemogenetic activation of ciliary G-protein-coupled receptor (GPCR) signaling or t

130 The vertebrate ciliary ganglion (CG) is a relay station in the parasymp

131 ur data indicate that the innervation of the ciliary ganglion is more complex than previously thought

132 Consistent with a critical role in ciliary gate function, CEP-290 prevents inappropriate en

133 tein composition; however, the mechanisms of ciliary gating and the dynamics of the gating components

134 tein-protein interactions that occur between ciliary gating components and transiting cargoes during

135 hus spatially map to the outer region of the ciliary gating zone.

136 hus spatially map to the inner region of the ciliary gating zone.

137 ponents along the inner-to-outer axis of the ciliary gating zone.

138 quired for TF formation, TZ organization and ciliary gating.

139 uplication of 79 internal exons of the large ciliary gene HYDIN from chromosome 16q22.2 to chromosome

140 Mutations in ciliary genes alter the functions of a broad range of ce

141 Considering that numerous ciliary genes are associated with a scoliosis phenotype,

142 to have an accumulation of rare variants in ciliary genes.

143 aling or the selective induction of Sstr3, a ciliary GPCR, in Arl13b-deficient cilia.

144 lia function following the selective loss of ciliary GTPase Arl13b in interneurons impairs interneuro

145 ARL13B is a ciliary GTPase with at least three missense mutations id

146 We conclude that ciliary Hh signaling by FAPs orchestrates the regenerati

147 finity cargo is released by Arl3 and its non-ciliary homologue Arl2.

148 Growth induction displaces ciliary Inpp5e and accumulates phosphatidylinositol 4,5-

149 , cell signaling and adhesion molecules, and ciliary intraflagellar transport particles.

150 or studies suggested that the heterotrimeric ciliary kinesin may be dispensable for certain aspects o

151 In this study, we show in mouse models that ciliary length and beat frequency of the oviductal epith

152 Our results suggest that CDK5 may regulate ciliary length by affecting tubulin dynamics via its sub

153 apbeta2) nuclear import system regulates Gli ciliary localization and Hh pathway activation.

154 hanism and cellular machinery regulating Gli ciliary localization and identifies Kapbeta2 as a critic

155 ized to cilia, and Wdr34 is required for the ciliary localization of dynein 2 light intermediate chai

156 ian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Shh pathway activity.

157 The ciliary localization of odorant receptors (ORs) is evolu

158 ing of INPP5E to cilia is dependent upon the ciliary localization of RPGR.

159 t of GIIalpha for maturation and surface and ciliary localization of the ADPKD proteins (PC1 and PC2)

160 pha is up-regulated during ciliogenesis, and ciliary localization of the receptor is required for its

161 Using minimal ciliary localization sequences from GPCRs and fibrocysti

162 ty, resulting in altered ICK subcellular and ciliary localization, increased cilia length, aberrant c

163 Gli or knockdown of Kapbeta2 diminished Gli ciliary localization.

164 affinity INPP5E mutant which loses exclusive ciliary localization.

165 production by ~50% during stimulation of the ciliary-localized T2R38 receptor.

166 oteins, whereas a peptide derived from a non-ciliary localizing protein (Src) has low affinity.

167 Peptides derived from ciliary localizing proteins (GNAT1, NPHP3, and Cystin1)

168 er system for the whole-body coordination of ciliary locomotion.

169 tially growing compartments: the retina, the ciliary margin (CM), and the retinal pigment epithelium

170 of differentiation, and stem cells from the ciliary marginal zone (CMZ) being responsible for late n

171 l behaviour and retinal morphology including ciliary marginal zone (CMZ) cell death and decreased pho

172 (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ).

173 This newly defined ciliary mechanism may find significance in cell prolifer

174 g of compartmentalization of proteins in the ciliary membrane and the dynamics of trafficking into an

175 Proteins that are concentrated in the ciliary membrane are also localized to other cellular si

176 order and localization of a raft-associated ciliary membrane calcium sensor.

177 Z, precluding sensory cilia assembly, and no ciliary membrane cap associated with sperm ciliogenesis

178 litated by the unique lipid environment of a ciliary membrane containing high concentrations of stero

179 ses determining the level of proteins in the ciliary membrane include entry into the compartment, rem

180 cked down proteins potentially important for ciliary membrane targeting and determined how this affec

181 at the cell surface and concentrated in the ciliary membrane, boosting cell sensitivity to the ligan

182 vironment through receptors localized in the ciliary membrane, but mechanisms directing specific prot

183 e appearance of cytosolic axonemes lacking a ciliary membrane.

184 subsequent release into PI(4,5)P2-deficient ciliary membrane.

185 in the diffusion barrier, we found that the ciliary-membrane translocation of the PKD proteins polyc

186 hich the centrosome is retained while apical/ciliary membranes are shed.

187 embered protein complex that is recruited to ciliary membranes by the G-protein Arl6.

188 including abnormal positioning and number of ciliary microtubule doublets.

189 Ciliary microtubules (MTs) are extensively decorated wit

190 ry cilia revealed region-specific changes in ciliary morphology accompanied by alteration of acetylat

191 ent, and defective TMEM107 function leads to ciliary morphology disruptions in a region-specific mann

192 5, DRC4/GAS8) have been linked to defects in ciliary motility in humans and lead to a ciliopathy know

193 utant mice with impaired ciliogenesis and/or ciliary motility of the node.

194 associated with the protofilament ribbon and ciliary motility, also positively regulates lifespan.

195 inducing gene product whose mutation impairs ciliary motility, and polycystin-2, whose ablation is as

196 Furthermore, our work suggests additional ciliary motility-signaling connections, since EFHC1 (EF-

197 Disruption of ciliary motion can lead to severe respiratory diseases a

198 Ciliary motion plays a critical role in the overall resp

199 bulin code, controls ciliary specialization, ciliary motor-based transport, and ciliary EV release in

200 TTLL-11 is transported by ciliary motors.

201 The mechanisms regulating the assembly of ciliary multiprotein complexes and the transport of thes

202 as decreased and structurally altered in the ciliary muscle (46 +/- 5.6%) and trabecular meshwork (37

203 Age-related changes in lens elasticity and ciliary muscle contractility can affect how ocular param

204 imics the design of the crystalline lens and ciliary muscle of the human eye.

205 ar refractive power; this is mediated by the ciliary muscle through the zonule.

206 ic pathway activating the iris sphincter and ciliary muscle to mediate pupillary constriction and len

207 annular electrode operating as an artificial ciliary muscle.

208 Exogenous ciliary neurotrophic factor (CNTF) administration promot

209 filtrating DCs, which were a major source of ciliary neurotrophic factor (CNTF) in the cornea.

210 prenatal to early postnatal treatment with a ciliary neurotrophic factor (CNTF) small-molecule peptid

211 l effects of hepatocyte growth factor (HGF), ciliary neurotrophic factor (CNTF), and Artemin through

212 in (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of

213 Ciliary neurotrophic factor receptor alpha subunit (CNTF

214 gs in mice, we were able to show loss of the ciliary ODAs in humans via TEM and immunofluorescence (I

215 thologous to transporters in microvillar and ciliary opsin trafficking.

216 t gene structures suggest that xenopsins and ciliary opsins are of independent origin, irrespective o

217 Most neurons have ciliary organelles, and many features lack structural sp

218 photoreceptor cell type of mixed microvillar/ciliary organization.

219 and disorganized primary cilia and that this ciliary phenotype is specifically associated with an abs

220 The ciliary phenotype of Smo inhibition is haploinsufficient

221 ncreased CEP290 protein levels and rescued a ciliary phenotype present in patient-derived fibroblast

222 ristics atypical of polychaete eyes, such as ciliary photoreceptors [3,4] that hyperpolarize in respo

223 to those commonly associated with vertebrate ciliary photoreceptors, as opposed to the rhabdomeric re

224 toreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanis

225 at disrupting the recycling endosome reduces ciliary polycystin-2 and causes its accumulation in the

226 een production of aqueous humour (AH) by the ciliary processes and hydrodynamic resistance to its out

227 oles of gating zone components in regulating ciliary protein composition.

228 localize to the gating zone and may regulate ciliary protein composition; however, the mechanisms of

229 in PKHD1, a gene encoding for fibrocystin, a ciliary protein expressed in cholangiocytes.

230 dentified a novel homozygous mutation in the ciliary protein IFT43 as the underlying cause of recessi

231 Mutations in the ciliary protein RPGR (retinitis pigmentosa GTPase regula

232 ent connections to signaling, and uncovers a ciliary protein that underlies development and human dis

233 r34 is required for ciliogenesis, retrograde ciliary protein trafficking, and the regulation of Gli2/

234 outer segment development through regulating ciliary protein trafficking.

235 eins and has been proposed to have a role in ciliary protein transport; however, its function remains

236 GTPase 13b (ARL13b) as a model palmitoylated ciliary protein.

237 ubcellular localization of Shh effectors and ciliary proteins are severely disturbed in Npc1-deficien

238 Fluorescent antibodies to ciliary proteins are used to validate research genetic s

239 ects affecting either SHH pathway members or ciliary proteins cause a spectrum of developmental disor

240 Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 prote

241 Several ciliary proteins examined abnormally accumulate in the c

242 iopathy caused by mutation of genes encoding ciliary proteins leading to multi-system phenotypes, inc

243 mechanisms that regulate the localization of ciliary proteins, including Crumbs proteins themselves,

244 een identified that trigger the transport of ciliary proteins.

245 sorting process are not understood for most ciliary proteins.

246 e involved in cell signaling and turnover of ciliary proteins.

247 from diverse eukaryotes defines a conserved ciliary proteome, reveals ancient connections to signali

248 Finally, ciliary receptors that lack retrieval determinants such

249 In particular, the ciliary root of the sensory cells is a likely cellular b

250 The sensory dendrite contains a ciliary root with a pronounced cross-banding of electron

251 bsence of C-NAP1, although components of the ciliary rootlet were aberrantly localized away from the

252 a novel functional paradigm for Nesprin1 at ciliary rootlets and suggest that the wide spectrum of h

253 ociation of Nesprin1alpha with photoreceptor ciliary rootlets and the functional interaction between

254 forms of Nesprin1 are integral components of ciliary rootlets of multiciliated ependymal and tracheal

255 that rootletin recruits Nesprin1alpha at the ciliary rootlets of photoreceptors and identify asymmetr

256 form an ion channel complex that may mediate ciliary sensory processes and regulate endoplasmic retic

257 (IFT) particle components accumulate in the ciliary shaft of ome;crb3a double mutants.

258 A key regulator of ciliary shape has now been identified that links the est

259 Several key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a

260 that signal-dependent ectocytosis regulates ciliary signaling in physiological and pathological cont

261 3, essential for intraflagellar transport of ciliary signaling receptors.

262 Ciliary specialization in form and function is observed

263 the role of PTMs and the tubulin code in the ciliary specialization of EV-releasing neurons using gen

264 ation, as part of the tubulin code, controls ciliary specialization, ciliary motor-based transport, a

265 re, we demonstrate that basal restriction of ciliary structure dynamics is established by the cilia-e

266 nal fate with the formation of cell-specific ciliary structures in Caenorhabditis elegans.

267 cket hearing organ may depend on the size of ciliary structures.

268 r initiation of ciliogenesis does not affect ciliary structures.

269 truction with the iris implant placed in the ciliary sulcus.

270 In ciliary swimmers, ciliary beating, arrests, and changes

271 small GTPase ARLs are proposed as prominent ciliary switches, which when disrupted result in dysfunc

272 ostatin receptor 3, where the dual Ax(S/A)xQ ciliary targeting motifs within the third intracellular

273 signal, but the mechanisms underlying their ciliary targeting remains largely unknown.

274 Short ciliary targeting sequences (CTS) have been identified t

275 However, mechanistic studies that relate ciliary targeting to BBSome binding are missing.

276 RP2 and Arl3 also interact with another ciliary tip kinesin, Kif7, which is a conserved regulato

277 Here we identified the ciliary tip kinesins Kif7 and Kif17 as novel interaction

278 124, were able to restore Kif7 levels at the ciliary tip of RP2 null cells.

279 to the traffic jam of multiple trains at the ciliary tip, how IFT trains are remodeled in these turna

280 Ciliary trafficking defects are the underlying cause of

281 Ciliary trafficking defects underlie the pathogenesis of

282 argeting and determined how this affects the ciliary trafficking of fibrocystin, polycystin-2, and sm

283 ein TULP3 functions as a general adapter for ciliary trafficking of structurally diverse integral mem

284 se a three-step model for TULP3/TUB-mediated ciliary trafficking, including the capture of diverse me

285 ermore, Rab8, the key regulator of rhodopsin ciliary trafficking, was mislocalized in photoreceptor c

286 ifs to be sufficient and TULP3 dependent for ciliary trafficking.

287 and post-transcriptional regulation through ciliary transcription factors and microRNAs, which activ

288 The ciliary transition zone (TZ) is a complex structure foun

289 ermediate affinity (RP2) is localized at the ciliary transition zone as a gate keeper.

290 of the periciliary diffusion barrier at the ciliary transition zone.

291 ffinity cargo is exclusively released by the ciliary transport regulator Arl3, while low-affinity car

292 st microglial activity, increased retrograde ciliary transport, and a decrease in inhibition.

293 e mutants, indicating that IFT proteins have ciliary transport-independent roles, which add to the se

294 cohort of 35 patients diagnosed with PCD by ciliary ultrastructure, and a diagnostic accuracy cohort

295 ell-specific alpha-tubulin isotype regulates ciliary ultrastructure, intraflagellar transport, and ci

296 gans cilia, the deglutamylase CCPP-1 affects ciliary ultrastructure, localization of the TRP channel

297 ferent kinds of photoreceptor cells, such as ciliary vertebrate rods and cones or protostome microvil

298 Our data implicate CP110 in SDA assembly and ciliary vesicle docking, two requisite early steps in ci

299 final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axo

300 required for cilia initiation and dock onto ciliary vesicles, but axonemal microtubules fail to elon