ライフサイエンスコーパス: ciliary neurotrophic factor

1 noic acids, vitamin D, thyroid hormones, and ciliary neurotrophic factor.

2 genesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor.

3 the highest homology to cardiotrophin-1 and ciliary neurotrophic factor.

4 th its proposed function as a target-derived ciliary neurotrophic factor.

5 gainst brain-derived nerve growth factor and ciliary neurotrophic factor.

6 c factor, platelet-derived growth factor and ciliary neurotrophic factor.

7 fibroblast growth factor-2 (FGF2) but not by ciliary neurotrophic factor.

8 e glutamate receptor agonist, treatment with ciliary neurotrophic factor afforded marked protection a

9 Ciliary neurotrophic factor, along with other neuropoiet

10 The ciliary neurotrophic factor alpha-receptor (CNTFRalpha)

11 ions showed that the increased production of ciliary neurotrophic factor and brain-derived neurotroph

12 neration of astrocytes in collaboration with ciliary neurotrophic factor and growth factors.

13 Ciliary neurotrophic factor and leukemia inhibitory fact

14 rs of the same cytokine subfamily, including ciliary neurotrophic factor and leukemia inhibitory fact

15 Treatment of SN56 cells with the cytokines ciliary neurotrophic factor and leukemia inhibitory fact

16 uggest that astrocytes themselves respond to ciliary neurotrophic factor and that ciliary neurotrophi

17 Messenger RNA for both ciliary neurotrophic factor and the alpha-component of t

18 In contrast, ciliary neurotrophic factor and thyroid hormone T3 act i

19 Brain-derived neurotrophic factor, ciliary neurotrophic factor, and 8-(4-chlorophenylthio)-

20 (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1), many

21 regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (

22 IL-10, IL-4, ciliary neurotrophic factor, and IL-2, cytokines not kno

23 of this group of cytokines, oncostatin M and ciliary neurotrophic factor, and the LIF receptor beta a

24 ted by a neutralizing anti-LIF, but not anti-ciliary neurotrophic factor, antiserum.

25 hree other drugs, bupropion, topiramate, and ciliary neurotrophic factor, are undergoing clinical tri

26 The related cytokines Il-6, ciliary neurotrophic factor, as well as epidermal growth

27 actor, brain derived neurotrophic factor, or ciliary neurotrophic factor at the lesion site also show

28 e examined the effects of a modified form of ciliary neurotrophic factor [Axokine, which is hereafter

29 otrophin-3 (NT-3), neurotrophin-4/5 (NT4/5), ciliary neurotrophic factor, basic fibroblast growth fac

30 Ciliary neurotrophic factor (CNTF) acts as a potent neur

31 Ciliary neurotrophic factor (CNTF) acts instructively to

32 Ciliary neurotrophic factor (CNTF) administration mainta

33 Exogenous ciliary neurotrophic factor (CNTF) administration promot

34 riptional activity via the 5th intron of the ciliary neurotrophic factor (CNTF) alpha receptor gene (

35 lls provides a feed-forward loop, increasing ciliary neurotrophic factor (CNTF) and basic fibroblast

36 ed to determine the mRNA expression of bFGF, ciliary neurotrophic factor (CNTF) and brain-derived neu

37 Here, we examined ciliary neurotrophic factor (CNTF) and fibroblast growth

38 factor (FGF2) and in situ hybridization for ciliary neurotrophic factor (CNTF) and glial growth fact

39 Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL

40 Ciliary neurotrophic factor (CNTF) and leptin decrease f

41 n of retinal glia, and subsequent release of ciliary neurotrophic factor (CNTF) and leukaemia inhibit

42 Ciliary neurotrophic factor (CNTF) and leukemia inhibito

43 Neuropoietic cytokines, including ciliary neurotrophic factor (CNTF) and leukemia inhibito

44 etermine the intracellular pathways by which ciliary neurotrophic factor (CNTF) and leukemia inhibito

45 trophic factors, but the mechanisms by which ciliary neurotrophic factor (CNTF) and other neurotrophi

46 rtex coexpress surface receptor proteins for ciliary neurotrophic factor (CNTF) and platelet-derived

47 ic factor (BDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and their respective

48 The cytokine ciliary neurotrophic factor (CNTF) and transforming grow

49 he CDFs leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) bind to a LIFR.gp130

50 Neuropoletic cytokines such as ciliary neurotrophic factor (CNTF) can activate multiple

51 te that leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) cause sympathetic neu

52 normal adult canine retina and suggest that ciliary neurotrophic factor (CNTF) could have a direct p

53 was to evaluate the therapeutic efficacy of ciliary neurotrophic factor (CNTF) delivered through enc

54 proof of concept phase 2 study, we evaluated ciliary neurotrophic factor (CNTF) delivered via an intr

55 Ciliary neurotrophic factor (CNTF) exhibits multiple bio

56 A likely trigger of such sprouting is ciliary neurotrophic factor (CNTF) expressed in local sp

57 cellular pathways by which neurotrophins and ciliary neurotrophic factor (CNTF) function to regulate

58 Basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) gene expression were

59 Ciliary neurotrophic factor (CNTF) has been found to inc

60 Ciliary neurotrophic factor (CNTF) has been implicated i

61 Ciliary neurotrophic factor (CNTF) has been implicated i

62 Ciliary neurotrophic factor (CNTF) has been shown to be

63 Ciliary neurotrophic factor (CNTF) has been shown to pro

64 Ciliary neurotrophic factor (CNTF) has potent survival-p

65 c protein and neurotrophic factors including ciliary neurotrophic factor (CNTF) in astrocytes in a do

66 filtrating DCs, which were a major source of ciliary neurotrophic factor (CNTF) in the cornea.

67 r changes induced by sustained expression of ciliary neurotrophic factor (CNTF) in the rds mutant mou

68 Similar to leptin, the cytokine ciliary neurotrophic factor (CNTF) induces hypophagia an

69 Ciliary neurotrophic factor (CNTF) induces weight loss i

70 ome of these changes are mimicked by chronic ciliary neurotrophic factor (CNTF) infusions into the sa

71 dogenous GFAP gene was examined by injecting ciliary neurotrophic factor (CNTF) into the eye.

72 ugh lentiviral gene transfer of the cytokine ciliary neurotrophic factor (CNTF) into the rat striatum

73 Ciliary neurotrophic factor (CNTF) is a cytokine that ha

74 Ciliary neurotrophic factor (CNTF) is a neuropoietic cyt

75 Ciliary neurotrophic factor (CNTF) is a neurotrophic fac

76 Ciliary neurotrophic factor (CNTF) is a potent neural cy

77 Ciliary neurotrophic factor (CNTF) is a promyelinating t

78 Ciliary neurotrophic factor (CNTF) is a trophic factor f

79 Ciliary neurotrophic factor (CNTF) is important for the

80 Ciliary neurotrophic factor (CNTF) is pleiotrophic for c

81 Ciliary neurotrophic factor (CNTF) is primarily known fo

82 Here we report that the sprouting induced by ciliary neurotrophic factor (CNTF) is qualitatively diff

83 Ciliary neurotrophic factor (CNTF) is undergoing testing

84 Ciliary neurotrophic factor (CNTF) maintains survival of

85 ctor (BDNF), and a 24-h delayed induction of ciliary neurotrophic factor (CNTF) mRNA.

86 of basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) on axotomy-induced ce

87 fferentiation into GFAP+ cells is induced by ciliary neurotrophic factor (CNTF) or by leukemia inhibi

88 The neuropoietic cytokine ciliary neurotrophic factor (CNTF) potently induces tran

89 Ciliary neurotrophic factor (CNTF) potently reduces appe

90 Exogenous ciliary neurotrophic factor (CNTF) promotes motor neuron

91 Ciliary neurotrophic factor (CNTF) promotes photorecepto

92 Ciliary neurotrophic factor (CNTF) promotes the survival

93 inson's disease and animals reduces, whereas ciliary neurotrophic factor (CNTF) promotes, neurogenesi

94 Ciliary neurotrophic factor (CNTF) protects pancreatic i

95 Ciliary neurotrophic factor (CNTF) protein and bioactivi

96 and recruited to the gp130 component of the ciliary neurotrophic factor (CNTF) receptor complex upon

97 Indirect data suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling ma

98 prenatal to early postnatal treatment with a ciliary neurotrophic factor (CNTF) small-molecule peptid

99 Ciliary neurotrophic factor (CNTF) specifically induced

100 Ciliary neurotrophic factor (CNTF) sustains the viabilit

101 brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) to developing neuromu

102 Furthermore, GDNF synergizes with ciliary neurotrophic factor (CNTF) to enhance TRKA recep

103 In this Phase I safety trial, human ciliary neurotrophic factor (CNTF) was delivered by cell

104 Ciliary Neurotrophic Factor (CNTF) was first characteriz

105 Ciliary neurotrophic factor (CNTF) was found to have a r

106 Consistently, a transient upregulation of ciliary neurotrophic factor (CNTF) was observed within t

107 Ciliary neurotrophic factor (CNTF) was the most effectiv

108 his study was conducted to determine whether ciliary neurotrophic factor (CNTF), a combination of BDN

109 Ciliary neurotrophic factor (CNTF), a cytokine closely r

110 mulation of wild-type neural stem cells with ciliary neurotrophic factor (CNTF), a differentiation-in

111 Expression of apolipoprotein E (apoE) and ciliary neurotrophic factor (CNTF), a pleiotropic neuron

112 a (LIFbeta) heterodimeric receptors, such as ciliary neurotrophic factor (CNTF), activated signal tra

113 bitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), all involve the sign

114 l effects of hepatocyte growth factor (HGF), ciliary neurotrophic factor (CNTF), and Artemin through

115 inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1

116 lex consisting of gp130, LIF-R, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha recept

117 ne receptor (DRD3), apolipoprotein E (APOE), ciliary neurotrophic factor (CNTF), and the mu opioid re

118 licated gp130 receptor ligands, particularly ciliary neurotrophic factor (CNTF), as potential anti-ob

119 ctor (BDNF), neurotrophin-3, neurotrophin-4, ciliary neurotrophic factor (CNTF), Axokine (a mutein of

120 PCR demonstrated the presence of message for ciliary neurotrophic factor (CNTF), brain-derived neurot

121 (BDNF) and an unrelated neurotrophic factor, ciliary neurotrophic factor (CNTF), but not by NGF [7] [

122 t their response to the anorectic actions of ciliary neurotrophic factor (CNTF), corticotropin releas

123 udies using transgenic mice that overexpress ciliary neurotrophic factor (CNTF), direct injection of

124 ng brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), fibroblast growth fa

125 or brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-derived n

126 in (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of

127 Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Interleukin-11 (IL-1

128 ardiotrophin-1 (CT-1), a cytokine related to ciliary neurotrophic factor (CNTF), is expressed at high

129 of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast

130 cytokines: leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), or cardiotrophin-1 (

131 ssessed in normal and rcd1 dogs treated with ciliary neurotrophic factor (CNTF), to examine the effec

132 erived O-2A/OPCs to thyroid hormone (TH) and ciliary neurotrophic factor (CNTF), well-characterized i

133 Ciliary neurotrophic factor (CNTF), which acts parallel

134 astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the a

135 Ciliary neurotrophic factor (CNTF)-dependent induction o

136 Cytokines of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory f

137 A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory f

138 impact of exaggerated polyol pathway flux on ciliary neurotrophic factor (CNTF)-like bioactivity and

139 leukemia inhibitory factor (LIF) or LIF and ciliary neurotrophic factor (CNTF).

140 s: basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF).

141 e-derived neurotrophic factor (GDNF) and the ciliary neurotrophic factor (CNTF).

142 ue with respect to the neurotrophic molecule ciliary neurotrophic factor (CNTF).

143 uction of hypothalamic cell proliferation by ciliary neurotrophic factor (CNTF).

144 the signalling mediated by the neurotrophin ciliary neurotrophic factor (CNTF).

145 differentiate into astrocytes in response to ciliary neurotrophic factor (CNTF).

146 ated cell technology (ECT) devices releasing ciliary neurotrophic factor (CNTF).

147 mitter acetylcholine (ACh) is upregulated by ciliary neurotrophic factor (CNTF).

148 as well as a therapeutically useful protein [ciliary neurotrophic factor (CNTF)].

149 [Axokine, which is hereafter referred to as ciliary neurotrophic factor (CNTF)Ax15], which uses a le

150 ture media with the differentiating cytokine ciliary neurotrophic factor (CNTF; n = 9) or 2) allowed

151 ematopoietins (IL-6, oncostatin M [OSM], and ciliary neurotrophic factor [CNTF]), we found that while

152 iven the effects of a related family member (ciliary neurotrophic factor, CNTF) on neuronal cell surv

153 ion of the alpha subunit of the receptor for ciliary neurotrophic factor (CNTFR alpha), which is esse

154 tor, nerve growth factor, neurotrophin-3, or ciliary neurotrophic factor could protect striatal outpu

155 In untreated rats, ciliary neurotrophic factor cRNA labeling density was hi

156 s on removal of mitogens and the addition of ciliary neurotrophic factor (days >90).

157 ntiated from these cells by stimulation with ciliary neurotrophic factor express phosphorylated tau s

158 These results demonstrate that astroglial ciliary neurotrophic factor expression is increased in f

159 nitis pigmentosa study 3 (CNTF3; n = 65) and ciliary neurotrophic factor for early-stage retinitis pi

160 Ciliary neurotrophic factor for late-stage retinitis pig

161 c factors brain-derived neurotrophic factor, ciliary neurotrophic factor, forskolin, or insulin.

162 Brain-derived neurotrophic factor, ciliary neurotrophic factor, glial-derived neurotrophic

163 Ciliary neurotrophic factor has also been shown to have

164 based expression vector containing the human ciliary neurotrophic factor (hCNTF) was transfected into

165 t that astrocytes are a source of endogenous ciliary neurotrophic factor in the central nervous syste

166 Ciliary neurotrophic factor increases the expression of

167 esence of basic fibroblast growth factor and ciliary neurotrophic factor induces the generation of A2

168 Intravitreal injection of ciliary neurotrophic factor inhibited photoreceptor inju

169 ember of a family of cytokines that includes ciliary neurotrophic factor, interleukin-6, interleukin-

170 Ciliary neurotrophic factor is a cytokine that has effec

171 Long-term intraocular delivery of ciliary neurotrophic factor is achieved by the encapsula

172 for some myeloma cells include IL-6, IL-11, ciliary neurotrophic factor, leukemia inhibitory factor,

173 The gp130 family cytokines ciliary neurotrophic factor, leukemia inhibitory factor,

174 ce and inhibit neurotrophic factors, such as ciliary neurotrophic factor, leukemia inhibitory factor,

175 pond to ciliary neurotrophic factor and that ciliary neurotrophic factor may also be important in gli

176 Intraocular injection of ciliary neurotrophic factor mimics the effect of injury

177 contains sequences thought to confer direct ciliary neurotrophic factor modulation of glial fibrilla

178 ed in the present study to determine whether ciliary neurotrophic factor mRNA expression is increased

179 at, in both control and experimental tissue, ciliary neurotrophic factor mRNA was colocalized with gl

180 owth factor, basic fibroblast growth factor, ciliary neurotrophic factor, N-acetyl cysteine, vitamin

181 ), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor, nerve growth factor, basic

182 h brain-derived neurotrophic factor, but not ciliary neurotrophic factor, neurotrophin-4, or glial ce

183 bited elaborate processes immunoreactive for ciliary neurotrophic factor, neurotrophin-4/5, nerve gro

184 his study, we demonstrate in vivo effects of ciliary neurotrophic factor on astrocytes in both the in

185 taining and was attenuated by application of ciliary neurotrophic factor or insulin-like growth facto

186 ts suggest that TS acts in synergy with host ciliary neurotrophic factor or leukemia inhibitory facto

187 fferences were observed in the expression of ciliary neurotrophic factor or nerve growth factor.

188 TF3, there was no change in acuity in either ciliary neurotrophic factor- or sham-treated eyes at 1 y

189 Evidence that ciliary neurotrophic factor promotes axonal sprouting an

190 ites/cell) affinity receptors for [125I]-rat ciliary neurotrophic factor (rCNTF) on astrocytes.

191 d that the receptor for CLF-1/CLC signaling, ciliary neurotrophic factor receptor (CNTFR), was expres

192 CE ciliary neurotrophic factor receptor (CNTFRalpha) and CN

193 the 5th intron of the alpha component of the ciliary neurotrophic factor receptor (CNTFRalpha) gene f

194 Ciliary neurotrophic factor receptor alpha (CNTFR alpha)

195 Ciliary neurotrophic factor receptor alpha (CNTFRalpha)

196 Expression of CNTF and its receptors, ciliary neurotrophic factor receptor alpha (CNTFRalpha)

197 Ciliary neurotrophic factor receptor alpha subunit (CNTF

198 rophic factor and the alpha-component of the ciliary neurotrophic factor receptor is demonstrated in

199 t neurons express the alpha-component of the ciliary neurotrophic factor receptor, the results of the

200 the p40 subunit of interleukin-12 and to the ciliary neurotrophic factor receptor, whose expression i

201 was used to antagonize signaling through the ciliary neurotrophic factor receptor-alpha (CNTFRalpha).

202 t from its known role as a co-ligand for the ciliary neurotrophic factor receptor.

203 Over the short term, ciliary neurotrophic factor released continuously from a

204 estigations indicated that recombinant human ciliary neurotrophic factor (rhCNTF) may have potential

205 tically engineered recombinant human variant ciliary neurotrophic factor (rhvCNTF) that signals throu

206 ve previously purified and cloned a secreted ciliary neurotrophic factor that was called growth-promo

207 dministration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic h

208 Our studies revealed that neither CT-1 nor ciliary neurotrophic factor treatment affected adipocyte

209 In both studies, ciliary neurotrophic factor treatment resulted in a dose

210 Interleukin-6 and ciliary neurotrophic factor, two cytokines related struc

211 ia cell line-derived neurotrophic factor, or ciliary neurotrophic factor, was increased at the lesion

212 cortical progenitor cells were treated with ciliary neurotrophic factor, which induces precocious gl