ライフサイエンスコーパス: ciliated cell

1 t eventually differentiate into post-mitotic ciliated cells .

2 terfowl viruses (which preferentially infect ciliated cells).

3 o samples of live human bronchial epithelial ciliated cells.

4 h was previously thought to contain only non-ciliated cells.

5 y receptors Sstr5 and Htr7, respectively, in ciliated cells.

6 ifferentially in mucus-secreting cells or in ciliated cells.

7 consist of mucus-secreting goblet cells and ciliated cells.

8 ns protein DYF1 that was highly expressed in ciliated cells.

9 cluding superficial epidermal cells and deep ciliated cells.

10 an virus, which infected proportionally more ciliated cells.

11 d that the promoter drives expression in all ciliated cells.

12 d ciliary length and a reduced percentage of ciliated cells.

13 avian influenza viruses exclusively infected ciliated cells.

14 into the outer epithelial cell layer to form ciliated cells.

15 ytoskeleton originating from basal bodies of ciliated cells.

16 otubule-based transport, such as neurons and ciliated cells.

17 ing of ciliogenesis, and the accumulation of ciliated cells.

18 LR development are specifically required in ciliated cells.

19 ably caused by a defect at the basal body of ciliated cells.

20 signated rootletin, found in the rootlets of ciliated cells.

21 erated exposing their contents, but never to ciliated cells.

22 d metaplasia, which included the presence of ciliated cells.

23 d step to regulate the spacing of the mature ciliated cells.

24 e generation of the spacing pattern of these ciliated cells.

25 n of left-right asymmetry and development of ciliated cells.

26 r trafficking of molecules in unciliated and ciliated cells.

27 of B. pertussis to asialo-GM2 and to rabbit ciliated cells.

28 Epithelial in both groups were dominated by ciliated cells.

29 nal differentiation program and convert into ciliated cells.

30 d produce differentiated secretory cells and ciliated cells.

31 he other expresses c-myb and directly yields ciliated cells.

32 docking during the differentiation of airway ciliated cells.

33 ted view of planar polarization of the brain ciliated cells.

34 al body of primary cilia in human and murine ciliated cells.

35 e show that two PCP signals are operating in ciliated cells.

36 reas its ligand EGF is induced by smoking in ciliated cells.

37 process causes an increase in the number of ciliated cells.

38 t proteins B and C, without affecting airway ciliated cells.

39 t cell metaplasia, and the loss of Clara and ciliated cells.

40 ury, PNECs can contribute to Clara cells and ciliated cells.

41 ed with the expression of ttll3 and ttll6 in ciliated cells.

42 with generation of differentiated Clara and ciliated cells.

43 ith the normal AP asymmetric distribution of ciliated cells.

44 14ECs) function as progenitors for Clara and ciliated cells.

45 to DNA damage when compared with neighboring ciliated cells.

46 ntrosome/basal body in non-ciliated, but not ciliated, cells.

47 e adenosine to signal in a paracrine faction ciliated cell A(2b) receptors to activate ion/water secr

48 tion in both zebrafish embryos and mammalian ciliated cells, a defect phenocopied by the silencing of

49 2 localizes to the basal body and axoneme of ciliated cells, a pattern reminiscent of that of the BBS

50 tron microscopy demonstrates the presence of ciliated cells, a proximal cell type, in the most periph

51 almost exclusively expressed in a subset of ciliated cells, a strong indicator of cilia-related func

52 eER adult mice, we have followed the fate of ciliated cells after epithelial injury by naphthalene or

53 By contrast, Il-6 null mice regenerate fewer ciliated cells and an increased number of secretory cell

54 rootletin fibers connect the basal bodies in ciliated cells and are present both at the ends of and i

55 e airway epithelial cell types, Clara cells, ciliated cells and basal cells, and activated UCHL1, a m

56 RVs, RSV-B, and HCoV-OC43 infected ciliated cells and caused no major cell death, whereas H

57 summarize current knowledge regarding airway ciliated cells and cilia, how they function to maintain

58 tion of proximal epithelial cells, including ciliated cells and Clara cells, appears to be unaffected

59 Importantly, the combination of no ciliated cells and excess mucous cells can account for t

60 erentiating deep layer cell types, including ciliated cells and neurons.

61 on in both cultures was restricted to apical ciliated cells and occasional nonciliated cells but not

62 signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes tran

63 basal cell fate by driving the generation of ciliated cells and preventing the production of Clara-li

64 oid morphogenesis and the differentiation of ciliated cells and reduces the expression of both notch

65 e human influenza viruses primarily infected ciliated cells and replicated efficiently, whereas a hig

66 green fluorescent protein (GFP) to cilia of ciliated cells and targets GFP to lipid rafts if the cel

67 in the microtubule organization of mammalian ciliated cells and that anosmia might be a useful determ

68 e that WT CFTR is predominantly expressed in ciliated cells, and deltaF508 CFTR pathogenesis in nativ

69 KIAA0556 is expressed almost exclusively in ciliated cells, and the worm and human KIAA0556 proteins

70 lara and goblet cell populations but not the ciliated cells, and this infection pattern corresponds t

71 n of asymmetry-called Kupffer's vesicle (KV)-ciliated cells are asymmetrically positioned along the a

72 d further weight to recent observations that ciliated cells are capable of transdifferentiating to ot

73 uggest that ACh-induced [Ca2+]i decreases in ciliated cells are caused by stimulated Ca2+ uptake into

74 In the mutant, ciliated cells are devoid of rootlets.

75 In zebrafish, these ciliated cells are found in Kupffer's vesicle (KV) and a

76 n the nasal epithelium of E2f4-/- mice where ciliated cells are replaced by columnar secretory cells

77 In Drosophila, the only ciliated cells are sensory neurons and sperm.

78 rectional non-cell-autonomous cues to orient ciliated cells as they differentiate, thus playing a cri

79 O) receptor cells and may represent the same ciliated cells as those found in the non-sensory part of

80 e human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell su

81 it remained unclear how the distribution of ciliated cells becomes asymmetric during KV development.

82 a consists of two to three irregular rows of ciliated cells but arise from 1q and 2q daughters, simil

83 The majority of the staining was in ciliated cells but was also observed in basal cells and

84 rn that appeared to originate primarily with ciliated cells, but lateral spread from the base of the

85 the swine respiratory tract at the level of ciliated cells by attaching specifically to the cilium m

86 Infection of ciliated cells by rgPIV3 was sensitive to a neuraminidas

87 the apical surface and spread to neighboring ciliated cells by the motion of the cilial beat.

88 ear and unambiguous evidence to suggest that ciliated cells can become goblet cells using immunoelect

89 e higher in WD-PBECs, coincident with higher ciliated cell contents, cell sloughing, and slightly com

90 oV GFP also replicated to a lesser extent in ciliated cell cultures derived from hamster or rhesus mo

91 This glycopeptide reproduces the specific ciliated cell damage observed in the respiratory tract d

92 norrhoeae contribute to the inflammation and ciliated cell death associated with gonorrhea and pelvic

93 induce inflammatory cytokine production and ciliated cell death in human fallopian tubes.

94 , structural and functional abnormalities of ciliated cells, decreased number of secretoglobin (SCGB1

95 V is asymmetric along the AP axis, with more ciliated cells densely packed into the anterior region.

96 on after naphthalene-mediated Clara-like and ciliated cell depletion.

97 ion for LRD protein in both ciliated and non-ciliated cells, despite its sequence classification as a

98 tment, while it's expression correlated with ciliated cell development and decreased along with incre

99 ective ablation of CTNNB1 from the oviductal ciliated cells did not affect embryo transport, possibly

100 epithelial cell fate by inhibiting Clara and ciliated cell differentiation and activating Uchl1, a ma

101 tream of aPKC and is sufficient to stimulate ciliated cell differentiation and inhibit superficial ep

102 airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell di

103 ction studies demonstrate that aPKC inhibits ciliated cell differentiation in Xenopus ectoderm and pr

104 A time course analysis during ciliated cell differentiation of RTE cells in culture de

105 DNAH7 was induced during ciliated cell differentiation, and immunohistochemistry

106 further our understanding of the process of ciliated cell differentiation.

107 MMP-9, TIMP-1, and TIMP-2 were localized in ciliated cells, endothelial cells, pneumocytes, macropha

108 mponents associated with either secretory or ciliated cell fate commitment.

109 ch acts when commitment to a ciliated or non-ciliated cell fate occurs in proximal progenitors, silen

110 (Aqp5 and Sftpc), Clara cells (Scgb1a1) and ciliated cells (Foxj1) in E18.5 lungs.

111 that govern the scattering of flagellated or ciliated cells from solid surfaces.

112 that E2f4-deficiency leads to an absence of ciliated cells from the entire airway epithelium and the

113 Specialized groups of ciliated cells have been implicated in LR patterning in

114 ockade (using s-IL-13Ralpha2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell

115 Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet)

116 on, factors that regulate the development of ciliated cells in culture regulated the expression of ax

117 22G variants infected a higher proportion of ciliated cells in cultures of human airway epithelium th

118 Thus, motile ciliated cells in general might use a similar cellular c

119 Efficient SARS-CoV infection of ciliated cells in HAE provides a useful in vitro model o

120 ngth and with a reduction of the fraction of ciliated cells in Npc1-deficient mouse brains and the hu

121 m concentration ([Ca2+]i) of rabbit tracheal ciliated cells in response to 8-bromo-cGMP (Br-cGMP) wer

122 onic development and contribute to Clara and ciliated cells in the adult lung.

123 n increase in mucous cells and a decrease in ciliated cells in the airway.

124 or different functions: basal, secretory and ciliated cells in the conducting airways and type II and

125 al mechanisms that polarize cilia, using the ciliated cells in the developing Xenopus larval skin as

126 syncytial virus (RSV) naturally infects the ciliated cells in the human airway epithelium.

127 Scattered ciliated cells in this transition zone resembled neither

128 n protein is enriched in cytosolic puncta in ciliated cells in zebrafish embryos.

129 protein is enriched in the apical domain of ciliated cells, in close proximity to the apical actin c

130 ncentration ([Ca(2+)](i)) of rabbit tracheal ciliated cells, in response to ATP, were simultaneously

131 rate luminal cells, including differentiated ciliated cells, in the absence of stroma.

132 In ciliated cells, including bovine and Xenopus laevis rod

133 shape changes that mediate tight packing of ciliated cells into the anterior pole.

134 calation becomes limiting and the spacing of ciliated cells is maintained.

135 We propose that the differentiation of the ciliated cells is not only regulated by Notch-mediated l

136 monas reinhardtii, and other flagellated and ciliated cells, is a highly specific process that involv

137 addition to using this homology to attach to ciliated cells, it activates human neonatal regulatory B

138 ubsequently differentiate into secretory and ciliated cell lineages.

139 primary cilium and to the plasma membrane in ciliated cell-lines and primary cells.

140 We also show that wild-type ciliated cells located at a mutant clone border reorient

141 cell death, whereas H3N2 and EV-D68 induced ciliated cell loss and tissue integrity disruption.

142 and lineage differentiation (ss-tubulin IV+ ciliated cells, MUC5AC+ goblet cells, p63 + basal cells)

143 on by smoke and alcohol was only observed in ciliated cells, not basal bronchial epithelium.

144 increased mucous cell numbers and decreased ciliated cell numbers.

145 icates a strong pattern of expression by the ciliated cells of the efferent ducts and strong staining

146 a 1-kb FOXJ1 promoter to drive CreER in the ciliated cells of the embryonic and adult lung.

147 response leads to the death and sloughing of ciliated cells of the Fallopian tube.

148 ion and motility specifically in a subset of ciliated cells of the mouse COA (posterior notochord, PN

149 optotic death of photoreceptors, the primary ciliated cells of the retina.

150 optotic death of photoreceptors, the primary ciliated cells of the retina.

151 et tissues: Serotonergic cells innervate the ciliated cells of the velum, numerous muscle systems, po

152 Retinas and ciliated cells of these zebrafish morphants were analyze

153 n shown both to increase the beating rate of ciliated cells of Tritonia and to accelerate heart contr

154 To produce directed flow, ciliated cells orient along a common planar axis in a di

155 tube, gastrocoel roof plate, epidermal multi-ciliated cells, otic vesicles, and kidneys.

156 ce that loss-of-gene function exclusively in ciliated cells perturbs vertebrate LR patterning.

157 e grown to goblet or normally differentiated ciliated cell phenotype at air-liquid interface in the p

158 ption factor 4, a factor associated with the ciliated cell phenotype.

159 We conclude that ciliated cells play a prominent role in repair of distal

160 rtion of alpha-2,6-linked sialic acid, while ciliated cells possess both sialic acid linkages.

161 t CEP290 localizes to the transition zone in ciliated cells, precisely to the region of Y-linkers bet

162 f ectoderm are selected out by Notch to form ciliated cell precursors (CCPs) that then radially inter

163 Because nascent ciliated-cell precursors prevent neighboring cells from

164 Ciliated-cell precursors then intercalate into the outer

165 et of cells are chosen to differentiate into ciliated-cell precursors.

166 Gas8 knockdown in ciliated cells reduces Smo signaling activity and ciliar

167 the proximal region of cilia in dividing and ciliated cells, respectively.

168 , viral antigen is detected predominantly in ciliated cells, similar to wild-type virus.

169 re derived from mice expressing GFP from the ciliated-cell specific FOXJ1 promoter (FOXJ1:GFP).

170 Importantly, ciliated cell-specific cAMP production (estimated by FRE

171 tein kinase (PKA) subunits expressed under a ciliated cell-specific promoter) in response to increase

172 re significant strain-related differences in ciliated cell squamation, initiation and duration of pro

173 beta-Tubulin IV, a marker of ciliated cells, stained the atypical columnar cells prod

174 Sox17 expression was restricted primarily to ciliated cells, suggesting its potential role in airway

175 ike epithelium with basal cells and immature ciliated cells surrounded by smooth muscle and myofibrob

176 embryos contains a population of specialized ciliated cells that are distributed in an evenly spaced

177 +) probes show in cultured airway epithelial ciliated cells that ATP can trigger periodic oscillation

178 urprisingly, we also found a region of multi-ciliated cells that line the posterior dorsal pole of th

179 It has been proposed that ciliated cells that produce a leftward fluid flow mediat

180 only assembled in terminally differentiating ciliated cells through the acentriolar pathway to trigge

181 ls demonstrate that Lrdr1 functions in these ciliated cells to control LR patterning.

182 nds on secretory cells (club and goblet) and ciliated cells to produce and transport mucus.

183 ucted an RNAi-based screen in Drosophila non-ciliated cells to test for cilium-independent loss-of-fu

184 sis and confocal microscopy we conclude that ciliated cells transiently change their morphology in re

185 -specific gene expression, especially in the ciliated cell type.

186 eceptors and to the transition zone in other ciliated cell types and that cilia are present in these

187 theoretical framework to conduct a census of ciliated cell types, create structural maps, and resolve

188 lene-mediated depletion of the secretory and ciliated cell types, the two basal cell pools coordinate

189 In most ciliated cell types, tubulin is modified by glycylation,

190 hology and no spread of the virus beyond the ciliated cell types.

191 rt of a highly conserved complex in multiple ciliated cell types.

192 ss of club cells, with a concomitant gain in ciliated cells, under homeostatic conditions without inc

193 amphioxus frontal eye is composed of simple ciliated cells, unlike vertebrate rods and cones, which

194 In addition to infection of ciliated cells via the apical membrane, RSV was shed exc

195 The proportion of ciliated cells was lower in the CF group than in the nor

196 Focusing on genes expressed in ciliated cells, we have identified new candidate cilioge

197 In ciliated cells, we observe localization of recombinant C

198 ecrease in Clara cells and a 25% decrease in ciliated cells were completely compensated for by an inc

199 Infection was highly cytolytic, as infected ciliated cells were necrotic and shed over time onto the

200 Ciliated cells were negative for EGFR and MUC5AC both in

201 (alpha2,6-linked) receptors predominated on ciliated cells, whereas avian-like (alpha2,3-linked) rec

202 ylases ccp2, ccp5, and ccp6 are expressed in ciliated cells, whereas ccp1 expression is restricted to

203 fficked exclusively to the apical surface of ciliated cells, which also was the site of release of pr

204 gesting that non-exocytotic ATP release from ciliated cells, which dominate our cultures, mediated hy

205 vy chains correlated with the development of ciliated cells, while cytoplasmic dynein heavy chain exp

206 and showed airways populated essentially by ciliated cells, with an increase in neuroendocrine cells

207 study to show that HPIV1 selectively infects ciliated cells within the HAE and that progeny virus is

208 protein localized to the apical membrane of ciliated cells within the superficial epithelium and gla

209 rock2b knockdown altered the AP placement of ciliated cells without affecting cilia number or length.

210 nstrate a direct conversion of club cells to ciliated cells without proliferation, meeting a conserva