ライフサイエンスコーパス: ciliogenesis

1 find that centrioles degenerate early during ciliogenesis.

2 romises normal neural tube closure (NTC) and ciliogenesis.

3 ow that excess inactivated ARL-3 compromises ciliogenesis.

4 centrosome and coordinate the initiation of ciliogenesis.

5 form a tubulin-binding module important for ciliogenesis.

6 ciliary vesicle formation, an early event in ciliogenesis.

7 a subunit of the IFT-B complex required for ciliogenesis.

8 volutionary derivations of compartmentalized ciliogenesis.

9 small calcium-binding protein, centrin2, in ciliogenesis.

10 amically localized TZ proteins for cytosolic ciliogenesis.

11 ormed, cultured B and T cells caused primary ciliogenesis.

12 lagellar transport A complex assembly during ciliogenesis.

13 ll morphology, proliferation, migration, and ciliogenesis.

14 the cell cycle and without progression into ciliogenesis.

15 wed that its levels inversely correlate with ciliogenesis.

16 l (RPE1) cells resulted in severe defects in ciliogenesis.

17 body of the cilium and is upregulated during ciliogenesis.

18 d mechanism fundamental to the regulation of ciliogenesis.

19 iole to the tip of the primary cilium during ciliogenesis.

20 es IFT protein mislocalization and disrupted ciliogenesis.

21 ological events, including cell division and ciliogenesis.

22 ssion in the (ret)Arl13b(-/-) retina rescued ciliogenesis.

23 sms through which miR-34/449 regulate motile ciliogenesis.

24 protein 88, proteins that are essential for ciliogenesis.

25 basal body, two critical steps in initiating ciliogenesis.

26 e required for normal lung morphogenesis and ciliogenesis.

27 ting that centrosomal CK1delta has a role in ciliogenesis.

28 er centriole to the cellular membrane during ciliogenesis.

29 his process, at least in part, by modulating ciliogenesis.

30 lagellar transport protein 20 homologue, and ciliogenesis.

31 is required for both lung tubulogenesis and ciliogenesis.

32 Centrioles are essential for ciliogenesis.

33 down with short hairpin RNA interferes with ciliogenesis.

34 hat tubulin glutamylation is a key driver of ciliogenesis.

35 distal appendage during the early stages of ciliogenesis.

36 ithelia suggest a functional significance in ciliogenesis.

37 gellar compartment is, therefore, crucial to ciliogenesis.

38 ritical positive regulator of early steps in ciliogenesis.

39 atellite-associated proteins, is involved in ciliogenesis.

40 ate Hedgehog signaling through their role in ciliogenesis.

41 screen linked 30 novel protein kinases with ciliogenesis.

42 ke phenotypes, suggesting a role for Hap1 in ciliogenesis.

43 suggesting that cdc42 and sec10 cooperate in ciliogenesis.

44 ed for recruitment of proteins essential for ciliogenesis.

45 nd that knockdown in Xenopus interfered with ciliogenesis.

46 Golgi-localized membrane protein involved in ciliogenesis.

47 d centriole length and in the suppression of ciliogenesis.

48 rable rates of proliferation, apoptosis, and ciliogenesis.

49 ility of Spop independent of its function in ciliogenesis.

50 dent pathway, Sdc2 and Tbx16 also control KV ciliogenesis.

51 Second, DZIP1 is required for ciliogenesis.

52 n while restricting centriole elongation and ciliogenesis.

53 e found to play critical roles in regulating ciliogenesis.

54 attributed to a requirement for Dzip1 during ciliogenesis.

55 of the mother centriolar component Cep164 in ciliogenesis.

56 that it may have a unique role distinct from ciliogenesis.

57 tivity and localization are regulated during ciliogenesis.

58 ntrol left-right (LR) axis determination and ciliogenesis.

59 iation, is not active early in photoreceptor ciliogenesis.

60 ere it modifies specific targets to initiate ciliogenesis.

61 riole distal appendage protein important for ciliogenesis.

62 itin ligase cofactor, which was required for ciliogenesis.

63 nduce its separation from the mother abolish ciliogenesis.

64 ands induces Cyp1a1 but not Ccno and impeded ciliogenesis.

65 rbates TZ anomalies and completely abrogates ciliogenesis.

66 SR2) some of which have established links to ciliogenesis.

67 cp110 to produce optimal Cp110 levels during ciliogenesis.

68 tes with and cooperates with Pk3 to regulate ciliogenesis.

69 cting as both a suppressor and a promoter of ciliogenesis.

70 served role for Girdin in BB positioning and ciliogenesis.

71 ilia, a regulatory process indispensable for ciliogenesis.

72 sical removal of the remnant greatly impairs ciliogenesis.

73 at high levels, while optimal levels promote ciliogenesis.

74 together with the NPHP module to facilitate ciliogenesis.

75 heal epithelia, and its loss inhibits motile ciliogenesis.

76 t antagonistically with ARL-3, in regulating ciliogenesis.

77 act as a suppressor to control the timing of ciliogenesis.

78 Knockdown of FAM92A in RPE1 cells impairs ciliogenesis.

79 nate the end of mitosis and the beginning of ciliogenesis?

80 at the synapse and basal body docking during ciliogenesis [1, 4-8], suggesting that CTL centrosomes m

81 Cep83, required for membrane contact during ciliogenesis [11], impairs CTL secretion.

82 Mutations in AHI1 affect ciliogenesis, AHI1 protein localization, and AHI1-protei

83 part of the molecular machinery involved in ciliogenesis also participates in the early steps of the

84 gnaling pathways, cell cycle regulation, and ciliogenesis, among others.

85 deficiency resulted in a disruption of renal ciliogenesis and a polycystic kidney disease phenotype i

86 g and membrane supply during early stages of ciliogenesis and adherens junction remodeling.

87 e a mechanism by which Fuzzy participates in ciliogenesis and affects both canonical WNT and PCP sign

88 membrane adhesion glycoprotein in promoting ciliogenesis and barrier function as part of a network o

89 as a crucial role in the normal processes of ciliogenesis and basal body positioning.

90 ed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to e

91 sicular trafficking, a pathway important for ciliogenesis and cell signalling.

92 erapeutic approaches aimed at restoration of ciliogenesis and cellular differentiation as a promising

93 iliary components for assembly very early in ciliogenesis and chloride transport by ANO1/TMEM16A is r

94 tes the expression of many genes involved in ciliogenesis and cilia function.

95 ) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance.

96 CAs, its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK pla

97 we examined the role of this protein in both ciliogenesis and ciliary function.

98 nd that both domains are required for proper ciliogenesis and ciliary function.

99 This interaction is indispensable for both ciliogenesis and ciliary function.

100 Several key regulators of ciliogenesis and ciliary signaling are mutated in humans

101 ffector, was recently shown to regulate both ciliogenesis and collective cell movement, but the under

102 tract infections due to profound defects in ciliogenesis and complete loss of mucociliary clearance.

103 Together, our findings establish primary ciliogenesis and consequent Hh signaling as a key mechan

104 Ciliogenesis and cystogenesis require the exocyst, a con

105 mutations in two IFT-A genes, blocked normal ciliogenesis and decreased Shh signaling.

106 that loss of ttc26 function prevents normal ciliogenesis and differentiation in the photoreceptor ce

107 f ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation.

108 of the Xenopus laevis epidermis compromised ciliogenesis and directional fluid flow.

109 molecular trafficking machineries underlying ciliogenesis and Hh signaling can be segregated, thereby

110 Recently the PCP pathway was implicated in ciliogenesis and in ciliary function.

111 ese data suggest a novel role for SDCCAG3 in ciliogenesis and in localization of cargo to primary cil

112 compartmentalization plays pivotal roles in ciliogenesis and in various signaling pathways.

113 that are crucial for both lumenogenesis and ciliogenesis and indicate that these processes are genet

114 SCA11); these mutant proteins do not promote ciliogenesis and inhibit ciliogenesis in wild-type cells

115 t protein 88 (IFT88), a crucial component of ciliogenesis and intraciliary transport.

116 m1, Mlf1, and Dyx1c1, are upregulated during ciliogenesis and localize to centrioles and cilia.

117 Control of ciliogenesis and lumenogenesis is not yet fully understo

118 Tuba most likely plays a critical role in ciliogenesis and nephrogenesis by regulating Cdc42 activ

119 cific guanine nucleotide exchange factor, in ciliogenesis and nephrogenesis using Tuba knockdown Madi

120 a new genetic module, which we term CPLANE (ciliogenesis and planar polarity effector), and an exten

121 rmalities in this pathway result in deranged ciliogenesis and polycystic kidney disease.

122 d IFT88 in adult mice to study photoreceptor ciliogenesis and protein trafficking.

123 s identify a previously unknown regulator of ciliogenesis and provide insight into how ciliary factor

124 ia serves as a diffusion barrier to regulate ciliogenesis and receptor localization for key signaling

125 rotein trafficking complex, is essential for ciliogenesis and regulated by multiple Rho and Rab famil

126 Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dep

127 se data show that Nek2 is a switch balancing ciliogenesis and resorption in the development of LR asy

128 t the exocyst is necessary for photoreceptor ciliogenesis and retinal development, most likely by tra

129 an amino-terminal domain of PCM1 can restore ciliogenesis and satellite localization of certain prote

130 6 and Mkksko alleles in mice led to improved ciliogenesis and sensory functions compared with those o

131 These results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein trans

132 support the importance of Ttc26 function in ciliogenesis and suggest that screening for TTC26 mutati

133 summary, this work shows that Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least p

134 stnatal cardiomyocytes are unable to undergo ciliogenesis and the nuclear envelope adopts the functio

135 resembled that of mutant mice with impaired ciliogenesis and/or ciliary motility of the node.

136 ilia involves regulation of cilia formation (ciliogenesis) and formation of a luminal space (lumenoge

137 of protein modules in centriole duplication, ciliogenesis, and centriolar satellite biogenesis and hi

138 regulating genes that control cell movement, ciliogenesis, and cilia function.

139 PDGFRalpha is up-regulated during ciliogenesis, and ciliary localization of the receptor i

140 We show that 3M genes are involved in ciliogenesis, and that patient fibroblasts lack cilia.

141 transitions of the midbody, the beginning of ciliogenesis, and the accumulation of ciliated cells.

142 Wnt signaling and ciliogenesis are core features of embryonic development

143 at regulate BB positioning in the context of ciliogenesis are largely unknown.

144 nd disease, but the mechanisms that regulate ciliogenesis are not understood.

145 Unexpectedly, kif3a function precedes ciliogenesis as ciliary basal bodies are mispositioned i

146 asal bodies to the actin cytoskeleton during ciliogenesis as well as in mature multiciliated cells.

147 s suggest that IL-6/Stat3 signaling promotes ciliogenesis at multiple levels, including increases in

148 tive cilia loading, but not a global loss of ciliogenesis, basal body docking or PCP signaling leads

149 During ciliogenesis, BBS4 relocalizes from centriolar satellite

150 ARL-13 do not affect its established role in ciliogenesis, but fail to regulate the proper ciliary ta

151 Many proteins are known to promote ciliogenesis, but mechanisms that promote primary cilia

152 Cellular quiescence potentiates ciliogenesis, but the regulation of basal body formation

153 Loss of PCM1 blocks ciliogenesis by abrogating recruitment of ciliary vesicl

154 ody and ciliary axoneme and is essential for ciliogenesis by delivering Rab8 to the basal body and pr

155 sults point to an undiscovered regulation of ciliogenesis by Lys63 ubiquitination and provide new per

156 sults suggest that CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its c

157 demonstrating that ATMIN primarily promotes ciliogenesis by regulating Dynll1 expression.

158 at the centrosome/ciliary base, is vital for ciliogenesis by regulating the CEP164-dependent recruitm

159 ckdown in miR-34/449-deficient MCCs restored ciliogenesis by rescuing basal body maturation and docki

160 Thus, PCM1 promotes ciliogenesis by tethering a key E3 ligase to satellites

161 Remarkably, ciliogenesis can be restored in Cep164-depleted cells by

162 knowledge, that a PCP component required for ciliogenesis can directly modulate the actin cytoskeleto

163 Defects in ciliogenesis can lead to a group of genetic syndromes kn

164 During early stages of ciliogenesis, Cby1 is required for the efficient recruit

165 During ciliogenesis, ciliary membrane proteins, along with stru

166 perspectives for the understanding of normal ciliogenesis, ciliopathies and cancer.

167 transcription factor is a major regulator of ciliogenesis, controlling the expression of the many ess

168 Because of its dual role in ciliogenesis, Cp110 levels must be precisely controlled.

169 iding a possible molecular mechanism for the ciliogenesis defect in Cby1(-/-) cells.

170 Golgi trafficking contribute to the observed ciliogenesis defects and provide an unanticipated, highl

171 Fltp knock-out mice show BB docking and ciliogenesis defects in multiciliated lung cells.

172 ited in Xenopus embryos, MCCs show transient ciliogenesis defects similar to those seen in mutants of

173 ts from affected individuals did not display ciliogenesis defects, indicating that MAPKBP1 may repres

174 otein not yet ciliopathy-associated, display ciliogenesis defects.

175 a JBTS patient with a JBTS17 mutation showed ciliogenesis defects.

176 rom Csnk1d (CK1delta)-null mice also exhibit ciliogenesis defects.

177 elin loss, namely basal body positioning and ciliogenesis defects.

178 Such compartmentalized ciliogenesis depends on the core intraflagellar transpor

179 Ciliogenesis depends on the sphingolipid ceramide and it

180 ed degradation of HYLS-1 after initiation of ciliogenesis does not affect ciliary structures.

181 FAK down-regulation leads to aberrant ciliogenesis due to impaired association between the bas

182 ate-dependent methylation of septins governs ciliogenesis during neural tube closure.

183 efore hypothesize that Rfx2 broadly controls ciliogenesis during vertebrate development.

184 ful subcellular analyses as well as in vitro ciliogenesis experiments in CCNO-mutant cells showed def

185 Vertebrate cells can initiate ciliogenesis from centrioles at the cell center, near th

186 and reduces the expression of both notch and ciliogenesis genes (Mcidas, Rfx2, and Myb) with distinct

187 development, sensory placode specification, ciliogenesis, germ layer specification).

188 ng TTC25, which we show here is required for ciliogenesis, HH signaling, and left-right patterning.

189 , some of which also play essential roles in ciliogenesis, highlighting the long-standing question of

190 A Wnt inhibitor likewise restores ciliogenesis in 3D IMCD3 cultures, emphasizing the impor

191 s to demonstrate that BBs remodel to support ciliogenesis in a subset of sensory neurons.

192 Here, we show abrogated protein levels and ciliogenesis in affected fibroblasts.

193 e conclusion that kif3a is indispensable for ciliogenesis in all cells, including photoreceptors.

194 centrioles and regulates BB positioning and ciliogenesis in Caenorhabditis elegans sensory neurons a

195 tment with beta-catenin inhibitors to rescue ciliogenesis in ccRCC.

196 in mice, we found kidney cysts and decreased ciliogenesis in cells surrounding the cysts.

197 e-targeted Neurl-4 was sufficient to restore ciliogenesis in cells with manipulated daughter centriol

198 a downstream target of AurA, HDAC6, restores ciliogenesis in ceramide-depleted cells.

199 Efficient ciliogenesis in chicken DT40 B lymphocytes required cent

200 toceramide and ceramide that is critical for ciliogenesis in Chlamydomonas and murine ependymal cells

201 CCDC65 expression was up-regulated during ciliogenesis in cultured airway epithelial cells, as was

202 stal tubules and collecting ducts, decreased ciliogenesis in cyst cells, increased tubular cell proli

203 Specifically, disruption of normal ciliogenesis in developing neocortical neurons, either b

204 has been associated with cilia function and ciliogenesis in directing the orientation of cilia and b

205 um starvation led to a two-fold reduction in ciliogenesis in fibroblasts derived from pathogenic LRRK

206 these severe diseases and the mechanisms of ciliogenesis in general.

207 ein kinase 1 delta (CK1delta) blocks primary ciliogenesis in human telomerase reverse transcriptase i

208 exocyst trafficking complex is required for ciliogenesis in kidney tubule cells.

209 g in the regulation of foxj1a expression and ciliogenesis in KV.

210 es represents a general mechanism to promote ciliogenesis in mammalian cells.

211 To investigate whether Arl13b has a role in ciliogenesis in mammalian kidney and whether loss of fun

212 lizes to mature centrioles, is important for ciliogenesis in multiciliated airway epithelia in mice,

213 on kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells.

214 highly enriched in cilia and is required for ciliogenesis in multiple organs.

215 flagellar transport proteins and accelerated ciliogenesis in neonatal neocortex, the induction of whi

216 owever, the regulatory mechanisms of primary ciliogenesis in normal and cancer cells are incompletely

217 gated the uncharacterized process of primary ciliogenesis in polarized epithelial cells.

218 onsistent with growth impairment and altered ciliogenesis in the absence of CDK10.

219 s have been reported to degenerate following ciliogenesis in the C. elegans embryo, although neither

220 Loss of CCDC11 leads to defective ciliogenesis in the pronephros and within the Kupffer's

221 s indicate that Rfx2 is broadly required for ciliogenesis in vertebrates.

222 s a dedicated regulator of the initiation of ciliogenesis in vivo.

223 eins do not promote ciliogenesis and inhibit ciliogenesis in wild-type cells.

224 c transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle (KV).

225 Rfx2 is also required for ciliogenesis in zebrafish pronephric duct.

226 cilium as it utilizes the same machinery as ciliogenesis including the nucleation of microtubules at

227 TTBK2 then triggers key events required for ciliogenesis, including removal of CP110 and recruitment

228 e nimbus") enriched in proteins required for ciliogenesis, including the small GTPases Cdc42 and Arl1

229 ntrosome and catalytically active to promote ciliogenesis independently of NF-kappaB.

230 dominant-negative mutant of aPKC suppresses ciliogenesis, indicating that the association of ceramid

231 conversion, a complex process essential for ciliogenesis, involves the progressive addition of speci

232 Ciliogenesis is accomplished by the intraflagellar trans

233 ientation of cilia (rotational polarity) and ciliogenesis is established.

234 Our results indicate that ciliogenesis is initiated in late fetal stages after neu

235 Although the regulation of ciliogenesis is intensively studied, how it is initiated

236 o ciliary membrane cap associated with sperm ciliogenesis is made.

237 Ciliogenesis is rescued by the histone deacetylase (HDAC

238 that one of the major functions of Cep164 in ciliogenesis is to recruit active TTBK2 to centrioles.

239 iated cells, but its contribution to primary ciliogenesis is unclear.

240 report that kif17 is largely dispensable for ciliogenesis; kif17 homozygous mutant animals are viable

241 All five DAP components are essential for ciliogenesis; loss of CEP83 specifically blocks centriol

242 he centrosome is critical for cell division, ciliogenesis, membrane trafficking, and immunological sy

243 of human FBF1, in a whole-genome screen for ciliogenesis mutants.

244 Interestingly, early during ciliogenesis, Neurl-4 transiently associated with the mo

245 ng vertebrate evolution of genes involved in ciliogenesis, nonparalogous genes were arranged to a fun

246 criptome analyses implicate dysregulation of ciliogenesis, nuclear translocation, and an epigenetic m

247 t their regulation roles for tissue-specific ciliogenesis occur at a specific level of the TZ.

248 te that mammalian basal body replication and ciliogenesis occur independently of CETN2; however, mous

249 MCC differentiation and ciliogenesis occurs normally in embryos where bbof1 acti

250 use it acts as a signaling nexus, defects in ciliogenesis or cilial function cause multiple congenita

251 These diseases are caused by defects in ciliogenesis or ciliary function.

252 ontrast, overexpressing Intu did not promote ciliogenesis or Hh signaling.

253 been previously implicated in the control of ciliogenesis, our epistatic studies suggest a more downs

254 Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of a

255 xchange factors not known to be in the Cdc42/ciliogenesis pathway and a scrambled control morpholino

256 d(2) and talpid(3) mutations affect a common ciliogenesis pathway, they are caused by mutations in di

257 suggest that tuba and cdc42 act in the same ciliogenesis pathway.

258 Consideration of the different ciliogenesis pathways allows us to propose how three typ

259 in cultured cells recapitulated the in vivo ciliogenesis phenotypes and expression of DYNLL1 or the

260 These data further rationalize several ciliogenesis phenotypes of IFT mutant strains.

261 atient-derived fibroblasts displayed reduced ciliogenesis potential and abnormally elongated cilia.

262 PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific prote

263 In summary, we show that ciliogenesis programs are conserved in the kidneys and e

264 was caused by stabilization of the negative ciliogenesis regulator CP110 and was corrected by CP110

265 mass spectrometry revealed that the primary ciliogenesis regulator, RILPL1 specifically interacts wi

266 hosphorylation of Dishevelled (DVL), another ciliogenesis regulator.

267 composition, assembly, and exact function in ciliogenesis remain poorly understood.

268 d cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood.

269 Nek8 kinase activity, as well as its role in ciliogenesis, remains to be defined.

270 hat loss of Cep164 leads to early defects in ciliogenesis, reminiscent of the phenotypic consequences

271 ed mucociliary transport caused by defective ciliogenesis, resulting in chronic airway infection.

272 Disrupting ciliogenesis results in hair follicle morphogenesis defe

273 herefore, like Dnchc2, Wdr34 is required for ciliogenesis, retrograde ciliary protein trafficking, an

274 pes with down-regulation of genes related to ciliogenesis, secretory differentiation, and markedly re

275 Dzip1 to levels insufficient for perturbing ciliogenesis, sensitized Xenopus embryos to Hh signaling

276 ediating the network of interactions between ciliogenesis, signaling systems and tissue patterning.

277 , although neither BB architecture nor early ciliogenesis steps have been described in this organism.

278 urthermore, the study of mice with defective ciliogenesis suggested that failed elongation of cilia i

279 Before ciliogenesis, the channel becomes organized into a torus

280 TEM) tomography analysis to show that, as in ciliogenesis, the distal appendages of the CTL mother ce

281 Thus, centrin2 regulates primary ciliogenesis through controlling CP110 levels.

282 del in which the daughter centriole promotes ciliogenesis through Neurl-4-dependent regulation of CP1

283 mily of transcription factors is crucial for ciliogenesis throughout evolution.

284 , we show that FSTL1 is a novel regulator of ciliogenesis thus underscoring a regulatory loop between

285 s rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecule

286 We propose that spatial control of ciliogenesis uncouples or specifies sensory properties o

287 FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling proce

288 Ciliogenesis was also disrupted in the mutant cells, wit

289 Ciliogenesis was intact in Nek8-deficient embryos and ce

290 The effect of miR-34/449 on ciliogenesis was mediated, at least in part, by post-tra

291 -cilium protein interaction landscape during ciliogenesis, we also identify satellite proteins that s

292 ucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 prot

293 the activation of Hh signaling downstream of ciliogenesis, we examined the Hh signaling pathway in mo

294 To test their role in ciliogenesis, we investigated mutant phenotypes of zebra

295 with the recently described role of CSPP1 in ciliogenesis, we show that mutant fibroblasts from one a

296 th either the ciliary localization of Smo or ciliogenesis, we undertook a high-throughput, microscopy

297 s centrosome over-duplication and suppresses ciliogenesis, whereas its depletion inhibits centriole a

298 Knockdown of Dcdc2 in IMCD3 cells disrupts ciliogenesis, which is rescued by wild-type (WT) human D

299 e affected individual have severely impaired ciliogenesis with concomitant defects in sonic hedgehog

300 fferentiating multiciliated cells to promote ciliogenesis without mitotic progression.