ライフサイエンスコーパス: cilium

1 Hh signaling is triggered at the primary cilium.

2 ting mechanisms localized at the base of the cilium.

3 ghts the complexity of pathways taken to the cilium.

4 on of the basal body (BB) that templates the cilium.

5 clinically diverse disorders of the primary cilium.

6 gh calcium-permeable ion channels within the cilium.

7 but not leave small compartments such as the cilium.

8 e Hh signaling pathway relies on the primary cilium.

9 tical progenitors and neurons have a primary cilium.

10 bule-dependent radial movement away from the cilium.

11 heir carriers PDE6delta and UNC119a/b to the cilium.

12 by the combined loss of Vhl and the primary cilium.

13 A hallmark of ccRCC is loss of the primary cilium.

14 ties, which drive disassembly of the primary cilium.

15 istone deacetylase 6 delivery to the primary cilium.

16 evident, indicating growth outward from the cilium.

17 bidirectional protein trafficking along the cilium.

18 tion by inhibiting ectosome release from the cilium.

19 taCLR), a Gli2 variant not localizing to the cilium.

20 ntermediate chain that also localised to the cilium.

21 of the transition zone between centriole and cilium.

22 d blocks accumulation of Rab8 at the primary cilium.

23 e also abundant in the lumen surrounding the cilium.

24 neural stem cells (NSCs) contains a primary cilium.

25 precursor results in the loss of the primary cilium.

26 and spindle poles, as well as to the primary cilium.

27 the centrioles at the base of the connecting cilium.

28 lved in vesicular trafficking to the primary cilium.

29 t with the developmental role of the primary cilium.

30 ors, Patched and Smoothened, and the primary cilium.

31 for the renewal of the photoreceptor sensory cilium.

32 tors patched-1 and Smoothened in the primary cilium.

33 rtly after the Hh effector, Gli3, leaves the cilium.

34 bilizes axonemal microtubules in the primary cilium.

35 logy of the oldest known cell organelle, the cilium.

36 munological synapse may represent a modified cilium.

37 encoding proteins localising to the primary cilium.

38 of AURKA is required to maintain the primary cilium.

39 e it acts to regulate protein content of the cilium.

40 d IFT-A and IFT-B, that carry cargo into the cilium.

41 dynamics of trafficking into and out of the cilium.

42 errantly localized away from the base of the cilium.

43 ional regulation and function of the primary cilium.

44 tivation and its localization to the primary cilium.

45 ograde intraflagellar (IFT) transport of the cilium.

46 for proteins destined for the centrosome and cilium.

47 or of cargo protein targeting to the primary cilium.

48 , we found that the formation of the primary cilium, a cellular organelle that is essential for the H

49 e show that NRP1 localization to the primary cilium, a key platform for HH signal transduction, does

50 d us to analyze the formation of the primary cilium, a non-motile organelle that is specialized for S

51 The primary cilium, a sensory appendage that is present in most mamm

52 The primary cilium, a sensory organelle, regulates cell proliferatio

53 We found that the primary cilium, a signaling structure that arises from the mothe

54 Cell surface/cilium accumulation of Smo is thought to play an importa

55 The primary cilium acts as a cellular antenna, transducing diverse s

56 e report for the first time that the primary cilium acts as a crucial sensor for electrical field sti

57 is required for the timely resorption of the cilium after serum stimulation.

58 Although the primary cilium also participates in each of these pathways, its

59 which encode proteins active at the primary cilium, an antenna-like organelle that acts as the cell'

60 acking showed correlated fluctuations of the cilium and basal body.

61 ption factors, signal transduction proteins, cilium and BBSome components, and lipid binding proteins

62 ated that ectosomes can be released from the cilium and can mediate the intercellular communication [

63 essary antecedent for removal of the primary cilium and cessation of Hh signaling during myogenic dif

64 we examined the role of USP9X in the primary cilium and found that endogenous USP9X localizes along t

65 mechanical and structural properties of the cilium and how these properties contribute to ciliary pe

66 h signaling by binding to Hh and Ptc1 at the cilium and increasing the interaction of the receptor an

67 in 107 (TMEM107) is localized in the primary cilium and is enriched at the transition zone where it a

68 hat ARMC9 localizes to the basal body of the cilium and is upregulated during ciliogenesis.

69 tions in genes that encode components of the cilium and its anchoring structure, the basal body, are

70 is essential for the function of the primary cilium and maintenance of phosphoinositide balance in no

71 ar transport, cell architecture, and primary cilium and mitotic spindle organization.

72 protein Smoothened (Smo) within the primary cilium and of the zinc finger transcription factor Gli2

73 exes initially accumulate at the base of the cilium and periodically enter the cilium, suggesting an

74 protein delivery at the base of the primary cilium and suggest the existence of a novel microtubule-

75 n-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function pharmacolo

76 d that MAPKBP1 is not present at the primary cilium and that fibroblasts from affected individuals di

77 of the microtubule-organizing centre of the cilium and the 'pillar' microtubules, and that this netw

78 KC), both of which distribute to the primary cilium and the apicolateral cell membrane in NP rosettes

79 a was sufficient to impair elongation of the cilium and the ciliary transport of polycystin-2, as wel

80 but is dispensable for Gpr161 exit from the cilium and the consequent suppression of Gli3 processing

81 mitotic spindle, the function of the primary cilium and the DNA damage response.

82 Being homologous organelles, the primary cilium and the OS share common building blocks and molec

83 are the structural properties of the primary cilium and the OS, and propose a hypothesis that the OS

84 rafficking of cargo destined for the sensory cilium and this balance requires molecular specializatio

85 ies, disorders of the cholangiocytes primary cilium and various degrees of bile duct paucity and dysp

86 these molecules are delivered to the sensory cilium and whether they rely on one another for specific

87 es, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH pathway

88 accumulation of Gli proteins in the primary cilium, and its ability to induce Gli-dependent transcri

89 PKA was recently detected within the cilium, and PKA activity specifically in cilia regulates

90 with PDGF-AA, c-Cbl becomes enriched in the cilium, and the receptor is subsequently ubiquitinated a

91 seases resulting from defects of the primary cilium, and these patients often have cleft lip and pala

92 membrane protein composition of the primary cilium are central to development and homeostasis, but w

93 ck inhibition of PDGFRalpha signaling at the cilium are unknown.

94 um, the immunological synapse is a surrogate cilium as it utilizes the same machinery as ciliogenesis

95 cells were capable of signaling through the cilium, as determined by gene expression analysis after

96 Our data also suggest that cilium assembly and disassembly are in dynamic equilibri

97 3 through poly-ubiquitylation and suppresses cilium assembly.

98 ophagy pathway near the basal body regulates cilium assembly.

99 or PCM1 and a group of satellite proteins in cilium assembly.

100 n of satellite proteins and perturbs primary cilium assembly.

101 of Dido proteins to determine the link with cilium-associated disorders.

102 ved growth factor-AA and sonic hedgehog, two cilium-associated stimuli.

103 tor EHD1 as a novel regulator of the primary cilium-associated trafficking of Smoothened and Hedgehog

104 tein Dishevelled and to position the primary cilium at the abneural edge of the apical surface.

105 Thus, we have identified a primary cilium-autophagy-Nrf2 (PAN) control axis coupled to cell

106 ng, with the linear spring constant k of the cilium base calculated to be (4.6 +/- 0.62) x 10(-12) N/

107 some compartment in proximity to the primary cilium base.

108 ightly regulated by gating mechanisms at the cilium base; however, the mechanistic details of ciliary

109 (posterior mesenchyme) and Shh-independent, cilium-based (anterior mesenchyme) Hedgehog pathway func

110 The life cycle of a primary cilium begins in quiescence and ends prior to mitosis.

111 The mechanisms by which cilium biogenesis and disassembly are coupled to the cel

112 ciliary structures thought to be crucial for cilium biogenesis and function by acting as a ciliary ga

113 Our results suggest that C2cd3 regulates cilium biogenesis by promoting the assembly of centriola

114 The pathways controlling cilium biogenesis in different cell types have not been

115 3 (C2cd3), an essential regulator of primary cilium biogenesis.

116 otein biosynthesis, and a number of genes in cilium biogenesis.

117 The cilium both releases and binds to extracellular vesicles

118 ls causes cilium structural defects, such as cilium branching, and up to a 3-fold increase in length

119 nrichment of Kif7 and Gli2 at the tip of the cilium but is dispensable for Gpr161 exit from the ciliu

120 served that GPC6 is localized outside of the cilium but moves into the cilium upon the addition of Hh

121 , rod and cone photoreceptors have a sensory cilium, but develop and function abnormally and then rap

122 gnaling, localizes to the tip of the primary cilium, but the importance of its ciliary localization r

123 a vast quantity of tubulin into the growing cilium, but the mechanisms that regulate the targeting,

124 n4 is not required to extend a single motile cilium by cells involved in left-right patterning.

125 or the transport of axonemal proteins to the cilium by means of peripheral association with vesicles.

126 asure the mechanical properties of a primary cilium by using an optical trap to induce resonant oscil

127 ous cavity in this case, which suggests that cilium can be well tolerated in vitreous cavity for as l

128 rimary cilium of cells and at the connecting cilium (CC) of photoreceptor cells, indicating that SPAT

129 ucleators of the mitotic spindle and primary cilium, centrosomes play crucial roles in equal segregat

130 e transition zone at the base of the primary cilium, CEP290 also localizes to the nucleus; however, t

131 ion zone (TZ) is a specialized region of the cilium characterized by Y-shaped connectors between the

132 the cAMP-sensing Gpr161:PKA complex acts as cilium-compartmentalized signalosome, a concept that now

133 ary localization at the distal region of the cilium, consistent with the role of Arl13b in modulating

134 of the rod photoreceptor is a light-sensing cilium containing ~1,000 membrane-bound discs.

135 As a cellular organelle, the cilium contains a unique protein composition.

136 ineage commitmentin vivoand that the primary cilium contributes to this process.

137 cs as a role of the IFT54 protein beyond the cilium, contributing to the development of NPH-related c

138 As the primary cilium coordinates several signaling pathways essential

139 traffic Hedgehog pathway proteins within the cilium correctly.

140 Although the primary cilium critically influences signaling in development an

141 We explain these cilium deformations by developing a torsional pendulum m

142 ciliary localization of Gli2 is crucial for cilium-dependent activation of Hedgehog signaling.

143 yte-like cells, may play a role in a primary cilium-dependent mechanism of osteocyte mechanotransduct

144 al-differentiation factor Neurog2, determine cilium disassembly and final abscission.

145 Here we identify a mechanism that favours cilium disassembly and maintains the disassembled state.

146 e mother centriole to the tip of the primary cilium during ciliogenesis.

147 e the fate and potential role of the primary cilium during myofibroblast formation.

148 ween the central microtubule pair harden the cilium during the power stroke; this stroke's end is a c

149 ous deletion of PI3K-C2alpha in mice induced cilium elongation defects in kidney tubules and predispo

150 ese changes in turn cause defects in primary cilium elongation, Smo ciliary translocation, and Sonic

151 ss of E-cadherin-dependent junctions induces cilium elongation, whereas both stimuli are needed for d

152 Similarly, VxPx inhibited primary cilium enrichment of a chimera of rhodopsin and somatost

153 ing eye injury is the most possible cause of cilium entrance in vitreous cavity in this case, which s

154 i is a single-celled eukaryote with a single cilium/flagellum.

155 s permit transposition of SMO to the primary cilium followed by enhanced expression of transcription

156 in the inner segment through the connecting cilium, followed by assembly of the highly ordered discs

157 o a ring surrounding the base of the primary cilium, followed by microtubule-dependent radial movemen

158 pothesis states that physical bending of the cilium (for example, due to fluid flow) initiates signal

159 for adaptation of an ancient organelle, the cilium, for an animal-specific signaling network.

160 ociated with significantly decreased primary cilium formation and attenuated hedgehog signaling.

161 ion of septin2, which is critical for normal cilium formation during early embryonic development.

162 at the center of the apical surface, enables cilium formation.

163 orphology and trafficking and normal primary cilium formation.

164 vestigations of genes that are essential for cilium formation.

165 th, while overexpression of Cdc20 suppresses cilium formation.

166 subdistal appendages (sDAPs) during primary cilium formation.

167 We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy fo

168 or the targeted transport of proteins to the cilium from their sites of synthesis within the cell [1-

169 ily conserved component necessary for motile cilium function and flagella assembly.

170 Defects in centrosome and cilium function are associated with phenotypically relat

171 e of DYNC2LI1 in dynein-2 complex stability, cilium function, Hedgehog regulation and skeletogenesis.

172 aspects that extend beyond hearing, such as cilium function, neuronal signal computation, and sensor

173 lagellum to regulate protein composition and cilium function.

174 osome and are associated with centrosome and cilium function.

175 os lacking Tgifs were a number with links to cilium function.

176 Recently, we showed that cilium-generated signaling in Chlamydomonas induced rapi

177 During EMyT, initial cilium growth is followed by complete deciliation.

178 The primary cilium has an important role in signaling; defects in st

179 We demonstrate that the photoreceptor cilium has an innate ability to release massive amounts

180 The primary cilium has been found to be associated with a number of

181 y cells possess a single, nonmotile, primary cilium highly enriched in receptors and sensory transduc

182 select membrane proteins at the base of the cilium, illuminating BBSome roles at a critical host-pat

183 of the mechanosensing organelle, the primary cilium in a progenitor population, significantly decreas

184 specialized gate located at the base of the cilium in a region known as the transition zone.

185 its encoded protein localizes to the primary cilium in an in vitro model of human neurogenesis.

186 mainly localizes at the base of the primary cilium in developing podocytes from human fetal tissue a

187 The role of the primary cilium in key signaling pathways depends on dynamic regu

188 we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by balancing

189 y was to investigate the role of the primary cilium in mechanosensing by osteoblasts.

190 enal epithelial cells to loss of the primary cilium in response to specific signals.

191 , this is the longest reported presence of a cilium in the vitreous cavity.

192 signaling, and the importance of the primary cilium in this neoplastic process.

193 e we report a role for the beta-cell primary cilium in type 2 diabetes susceptibility.

194 anelles-the midbody, the centrosome, and the cilium-in the same cellular process.

195 in Drosophila non-ciliated cells to test for cilium-independent loss-of-function phenotypes of ciliar

196 he crossbridge-microtubule attachment at the cilium inflection point where torsion is at its maximum.

197 In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane

198 Thus, the primary cilium integrates Hedgehog and Wnt signaling between den

199 with an ARL13B (JBTS8) orthologue to control cilium integrity.

200 biotinylation (BioID) to map the centrosome-cilium interface; with 58 bait proteins we generate a pr

201 The primary cilium is a highly conserved organelle housing specializ

202 The primary cilium is a membrane protrusion that is crucial for vert

203 The primary cilium is a microtubule-based organelle that functions i

204 The primary cilium is a paradigmatic organelle for studying compartm

205 The cilium is a signaling platform of the vertebrate cell.

206 Primary cilium is a solitary organelle that emanates from the su

207 The primary cilium is a solitary organelle that responds to mechanic

208 The cilium is a specialized extension of the cell in which m

209 irst time, that the formation of the primary cilium is altered in NPC1 disease.

210 The cilium is an evolutionarily conserved organelle projecti

211 The primary cilium is an outward projecting antenna-like organelle w

212 use photoreceptors in which the photosensory cilium is built exclusively by KIF3.

213 The primary cilium is essential for skin morphogenesis through regul

214 In most cells, the cilium is formed within a compartment separated from the

215 The distal end of the eukaryotic flagellum/cilium is important for axonemal growth and signaling an

216 Although the cilium is lost during EMyT, its initial presence contrib

217 Our data indicate 1) the primary cilium is not a simple cantilevered beam; 2) the base of

218 The primary cilium is nucleated by the mother centriole-derived basa

219 A primary cilium is present on most eukaryotic cells and represent

220 The photoreceptor sensory cilium is recognized for fast membrane renewal, for whic

221 photoreceptors, in which the apical sensory cilium is subdivided into an inner and outer segment, ea

222 The primary cilium is the site where a subset of the cell's membrane

223 very rare and the response of the eye to the cilium is variable.

224 The presence of an intraocular cilium is very rare and the response of the eye to the c

225 arkers and displays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time-lapse i

226 pical abscission also dismantles the primary cilium, known to transduce sonic-hedgehog signals, and i

227 associated with a shortening of the primary cilium length and with a reduction of the fraction of ci

228 3K-C2alpha rescues Rab11 activation, primary cilium length, and Shh pathway induction.

229 Thus myofibroblasts represent a unique cilium-less entity with profoundly reprogrammed cilium-r

230 scratch-wounded epithelium, TGFbeta provokes cilium loss exclusively along the wound edge.

231 Both EMyT and cilium loss require two-hit conditions: disassembly/abse

232 beta-Catenin deregulation directly disrupts cilium maintenance and signaling via Tulp3, essential fo

233 e, and disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenitor funct

234 products localize in and around the primary cilium, making JS a canonical ciliopathy.

235 suppresses renal cyst formation, loss of the cilium may be an initiating event in the formation of cc

236 simple cantilevered beam; 2) the base of the cilium may be modeled as a nonlinear rotatory spring, wi

237 that pharmaceutical targeting of the primary cilium may have therapeutic benefits in the treatment of

238 argeting of ciliary components necessary for cilium morphogenesis and signaling is largely unknown.

239 tool included genes/proteins associated with cilium morphogenesis, signal transduction proteins (part

240 in powers of the amplitude of the individual cilium movement.

241 gene products (NPHP) function at the primary cilium, NPH is classified as a ciliopathy.

242 g Tgifs resulted in a partial restoration of cilium numbers and in the transcriptional response to ac

243 thened (SMO), which localizes to the primary cilium of a cell on activation and is both positively an

244 we show that SPATA7 localizes at the primary cilium of cells and at the connecting cilium (CC) of pho

245 Galphas is highly enriched at the primary cilium of granule neuron precursors and suppresses Shh s

246 ring other signaling proteins to the sensory cilium of photoreceptor cells, the outer segment.

247 in the retinal ganglion cells and connecting cilium of photoreceptor cells.

248 Insulin receptor is recruited to the cilium of stimulated beta-cells and ciliary/basal body i

249 localize to Wdr35(-/-) cilia, but not to the cilium of the IFT retrograde motor mutant Dync2h1(-/-),

250 Our results suggest that the primary cilium or an associated structure influences the domain

251 alignment and cilium orientation, defects in cilium organization and reduced fluid flow in the trache

252 gether with loss of basal-body alignment and cilium orientation, defects in cilium organization and r

253 The primary cilium originates from the mother centriole and particip

254 The primary cilium plays critical roles in vertebrate development an

255 monitoring dynamic changes in the centrosome-cilium protein interaction landscape during ciliogenesis

256 acting protein 1 (RPGRIP1), a key connecting cilium protein that has also been linked to LCA.

257 Nearly all vertebrate cells have a single cilium protruding from their surface.

258 at its loss of function could indeed disrupt cilium-regulated processes.

259 Signaling from the primary cilium regulates kidney tubule development and cyst form

260 R, localised to the photoreceptor connecting cilium, regulates rhodopsin transport to the outer segme

261 ium-less entity with profoundly reprogrammed cilium-related signaling.

262 scades, yet the mechanical properties of the cilium remain incompletely measured, resulting in confus

263 ility and signaling functions of the primary cilium require a unique protein and lipid composition th

264 he ciliary base, is important for regulating cilium resorption.

265 The cilium's capacity to sense and transduce extracellular s

266 ransports membrane proteins into the primary cilium signaling organelle in eukaryotes and is implicat

267 (OS) is a unique modification of the primary cilium, specialized for light perception.

268 d, dynamic, and can be recapitulated without cilium-specific proteins or lipids.

269 on in hair cells and supporting cells causes cilium structural defects, such as cilium branching, and

270 uately methylate septin2, a key regulator of cilium structure and function.

271 quired for cohesion of basal bodies, but the cilium structure appears normal in Root mutant neurons.

272 Hedgehog signaling requires the primary cilium such that maintenance of this compartment is esse

273 ase of the cilium and periodically enter the cilium, suggesting an as-yet-unidentified mechanism that

274 Because the primary cilium suppresses renal cyst formation, loss of the cili

275 ssociated with the anatomy and physiology of cilium; terms associated with docking.

276 d-like undulating swimmer, and an artificial cilium that could mimic the complex beating patterns of

277 ate photoreceptor cell contains an elaborate cilium that includes a stack of phototransductive membra

278 brain possess an appendage called a primary cilium that projects from the soma into the extracellula

279 pse, even though immune cells lack a primary cilium that would be the typical setting for this machin

280 While immune cells lack a cilium, the immunological synapse is a surrogate cilium

281 Located near the base of the cilium, the TZ is in the prime location to act as a gate

282 y gate can migrate away from the base of the cilium, thereby functioning independently of the centrio

283 egulates actin disassembly in the connecting cilium, thus facilitating rhodopsin transport to photore

284 ng from protein sorting in the photoreceptor cilium to photoreceptor electrophysiology.

285 tebrate CK1gamma is localized at the primary cilium to promote Smo phosphorylation and Sonic hedgehog

286 r segment structure evolved from the primary cilium to provide photoreceptor cells with vast membrane

287 ructure called the ciliary rootlet links the cilium to the cell body.

288 Cilium trafficking of P/rds was sustained even when the

289 zed outside of the cilium but moves into the cilium upon the addition of Hh.

290 of Vhl together with ablation of the primary cilium via deletion of the kinesin family member 3A (Kif

291 One end of the cilium was embedded in the retina, whereas the other end

292 scleral indentation at 5-o'clock position, a cilium was found at far retinal periphery.

293 The cilium was removed through the pars plana sclerotomy wit

294 e cortex at the distal end of the connecting cilium, we propose that the evagination occurs via a pro

295 nknown function, localizes to the connecting cilium where it is thought to regulate cargo trafficking

296 GR localises to the photoreceptor connecting cilium where its function remains unknown.

297 compartment (PRE) at the base of the primary cilium, where it regulates production of a specific pool

298 of transduction over the full length of the cilium, which suggests an additional ATP source.

299 tering the centrosome, and beckoning forth a cilium-who would have guessed this is how polarized epit

300 e is known about ion channels in the primary cilium (with the exception of TRPP2).