ライフサイエンスコーパス: cinnamyl

1 Cinnamyl 1-3,4-dihydroxy-alpha-cyanocinnamate (CDC), act

2 -7-chloro-8-hydroxy-3-[4'-(N,N-dimethylamino)cinnamyl]-1-phenyl-2,3,4 ,5 -tetrahydro-1H-3-benzazepine

3 pecific lipoxygenase (LO) pathway inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (1 mumol/L)

4 ith 12/15-lipoxygenase (12/15-LOX) inhibitor cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC), ERK1/

5 The 12-lipoxygenase inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC, 10 mic

6 ECs for 48 h with AdRZ or 4 h with 10 microm cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate significantl

7 12/15LO (AdRZ) or with the 12/15LO inhibitor cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate.

8 ose (HG) with or without the 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) or with 5.5

9 Pretreatment of the R15L cells with cinnamyl-3,4-dihydroxycyanocinnamate significantly inhib

10 mGSTP1 indicates that the haloenol lactone 3-cinnamyl-5(E)-bromomethylidenetetrahydro-2-furanone is c

11 d relies on the Pd-catalyzed dimerization of cinnamyl acetate and provides efficient access to DPH in

12 Both (E)-cinnamyl acetate and vinyl oxirane were efficiently used

13 alool oxide (furanoid), geranyl acetone, and cinnamyl acetate were identified as other potent odorant

14 e, we synthesized a series of 8-(substituted cinnamyl)-adenosine analogues, 5-17, and established a r

15 id (1-5), three coumaric acid (6-8), and two cinnamyl alcohol (9-10) derivatives, eight flavonol glyc

16 he enzymes cinnamoyl-CoA reductase (CCR) and cinnamyl alcohol dehydrogenase (CAD) catalyze the two ke

17 Cinnamyl alcohol dehydrogenase (CAD) catalyzes the conve

18 Cinnamyl alcohol dehydrogenase (CAD) catalyzes the final

19 y the thioacidolysis degradative method, for cinnamyl alcohol dehydrogenase (CAD) deficiency in angio

20 Silencing two CINNAMYL ALCOHOL DEHYDROGENASE (CAD) genes in Nicotiana

21 otated in the Arabidopsis genome database as cinnamyl alcohol dehydrogenase (CAD) homologues, an in s

22 alcohol precursors synthesized by the enzyme cinnamyl alcohol dehydrogenase (CAD).

23 Cinnamyl alcohol dehydrogenase (CAD; EC 1.1.1.195) has b

24 L.) in which expression of the gene encoding cinnamyl alcohol dehydrogenase (CAD; EC 1.1.1.195) is se

25 y pine (Pinus taeda L.) severely depleted in cinnamyl alcohol dehydrogenase (E.C. 1.1.1.195), which c

26 ntly, bmr6 plants were shown to have limited cinnamyl alcohol dehydrogenase activity (CAD; EC 1.1.1.1

27 QTL) analysis, identified and cloned a novel cinnamyl alcohol dehydrogenase allele (SbCAD2) that has

28 mer biosynthetic cinnamoyl CoA reductase and cinnamyl alcohol dehydrogenase in not only the lignifyin

29 thyltransferase, cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase in the presence of increa

30 hyltransferase, cinnamoyl-CoA reductase, and cinnamyl alcohol dehydrogenase were coordinately up-regu

31 ransposons into a gene annotated as encoding cinnamyl alcohol dehydrogenase, here designated M. trunc

32 opulus alba) by specifically down-regulating CINNAMYL ALCOHOL DEHYDROGENASE1 (CAD1) by a hairpin-RNA-

33 n of FaEOBII was silenced, the expression of cinnamyl alcohol dehydrogenase1 and FaEGS2, two structur

34 caffeic acid O-methyltransferase [COMT], and cinnamyl alcohol dehydrogenase6 [CAD6], two mutant allel

35 Although SAD and classical cinnamyl alcohol dehydrogenases (CADs) catalyze the same

36 identification and characterization of four cinnamyl alcohol dehydrogenases (CADs) from cucumber (Cu

37 cluding a protease, a ribosomal protein, two cinnamyl alcohol dehydrogenases, a nitrilase and glyoxal

38 a-beta), biphenyl/dibenzodioxocin (5-5), and cinnamyl alcohol end-group structures.

39 Cinnamyl alcohol is a strong attractant for Diabrotica b

40 In contrast, selectivity to the desired cinnamyl alcohol product is highly structure sensitive,

41 ustrated by the Pd/Pt-catalysed oxidation of cinnamyl alcohol to cinnamic acid.

42 ed with hydrogenation to the desired product cinnamyl alcohol.

43 onstructs were used to down-regulate tobacco cinnamyl-alcohol dehydrogenase (CAD; EC 1.1.1.195) and c

44 ay as storage and/or transportation forms of cinnamyl alcohols between the cytosol and the lignifying

45 dehydes; cinnamaldehydes are then reduced to cinnamyl alcohols by CAD.

46 uential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxi

47 onding SF5- or CF3-acetates of p-substituted cinnamyl alcohols with triethylamine followed by trimeth

48 nes could be alkylated with diarylmethanols, cinnamyl alcohols, and phenyl propargyl alcohols having

49 The products of CAD, cinnamyl alcohols, are the precursors of lignin, a major

50 ycinnamoyl CoA esters to their corresponding cinnamyl aldehydes in monolignol biosynthesis.

51 ]GTP-gamma-S binding, we show that the trans-cinnamyl analogues of (+)-(3R, 4R)-dimethyl-4-(3-hydroxy

52 Aromatic, cinnamyl, and aliphatic aldehydes are competent dipolaro

53 Aryl, cinnamyl, and aliphatic aldehydes are competent dipolaro

54 -stabilizing N substituents, such as benzyl, cinnamyl, and diarylmethyl, undergo facile homolytic C-N

55 of the 7-borylindole products to 7-aryl-, 7-cinnamyl-, and 7-haloindoles are demonstrated.

56 , a series of (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs was designed and prepared,

57 his series of (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepines also appears to be identifying an

58 xcellent diastereoselectivity when employing cinnamyl bromide (>95/5 anti/syn).

59 The use of cinnamyl bromide which led to the formation of a 1,6-eny

60 is of various thieno-fused heterocycles were cinnamyl bromide, 2-bromobenzyl chloride, bromocrotonate

61 bstituted allyl bromides, such as crotyl and cinnamyl bromide, can be used providing moderate enantio

62 tric allylic alkylation of ortho-substituted cinnamyl bromides with Grignard reagents is reported.

63 amenable to intermolecular coupling between cinnamyl bromochlorides and a diverse set of commerciall

64 ccur with electron-neutral, -rich, and -poor cinnamyl carbonates, alkyl and trityloxy-substituted all

65 The use of commercially available (SIPr)Pd(cinnamyl)Cl (SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-d

66 Pd(IPr)(eta(3)-crotyl)Cl and Pd(IPr)(eta(3)-cinnamyl)Cl precatalysts results in a larger kinetic bar

67 Suzuki-Miyaura reaction using Pd(IPr)(eta(3)-cinnamyl)Cl which are compatible with mild bases.

68 within 2-(4-aminophenyl)ethylamine with [Pd(cinnamyl)Cl](2)/L1 and 4-chlorotoluene (affording 5a); t

69 of the reactivity trends established for [Pd(cinnamyl)Cl](2)/L1 toward the chemoselective synthesis o

70 tion employing a single catalyst system ([Pd(cinnamyl)Cl](2)/L1; L1 = N-(2-(di(1-adamantyl)phosphino)

71 crystallographically characterized; the [Pd(cinnamyl)Cl](2)/L2 catalyst system exhibited divergent r

72 egioisomer (5a') was obtained when using [Pd(cinnamyl)Cl](2)/L2.

73 tonation of the oxyanion of the para-hydroxy-cinnamyl cysteine chromophore as a secondary result of a

74 avage of the ester side chain of pentacyclic cinnamyl ester 15.

75 oligomerization of the intermediately formed cinnamyl esters.

76 Either aldehyde or cinnamyl ether products can be selectively extracted fro

77 of photocycloaddition between silyl-tethered cinnamyl groups.

78 th LAQ824 (Novartis Pharmaceutical, Inc.), a cinnamyl hydroxamic acid analogue inhibitor of histone d

79 lyl)(mu-Cl)Pd2(IPr)2 (allyl = allyl, crotyl, cinnamyl; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2

80 a(p) and sigma(m)) of the substituent on the cinnamyl moiety.

81 showed that compounds 7-9 bearing the trans-cinnamyl N-substituent most closely reproduced the poten

82 H-indenes via metalloradical activation of o-cinnamyl N-tosyl hydrazones is presented, taking advanta

83 Neither the N-substituted cis-cinnamyl nor the cis-phenylcyclopropylmethyl compounds 1

84 Synthesis of cinnamyl- or coumarinyl-substituted ethanolamide derivat

85 The air-stable palladium complex (eta3-cinnamyl)PdCl.(3a) (5) was also employed successfully in

86 ntramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and b

87 s in heterocyclic rings corresponding to the cinnamyl phenyl ring displayed equal or higher biologica

88 made by introducing nitrogen atoms into the cinnamyl ring and replacing its E-double bond with XCH(2

89 OTf then Et3N) led to oligomerization of the cinnamyl SF5- and CF3-acetates.

90 d with protic acid in anhydrous solvent, the cinnamyl unit migrates from the oxygen of tyrosine to di