ライフサイエンスコーパス: circadian

1 multiple time scales (seconds-to-minutes to circadian).

2 In vivo assays revealed several circadian abnormalities including lengthened period and

3 ptional inhibitor with enhanced affinity for circadian activator proteins Clock and Bmal1.

4 Circadian amplitude and timing of activity at baseline,

5 velopmental changes in sleep homeostasis and circadian amplitude make adolescents particularly sensit

6 ate that insulin misregulation underlies the circadian and cognitive phenotypes displayed by the Dros

7 -arachidonoylglycerol are very significantly circadian and dysregulated when sleep is disrupted.

8 insulin pathway also led to amelioration of circadian and memory defects.

9 Circadian and seasonal rhythms are seen in many species,

10 leep and wakefulness, including homeostatic, circadian, and motivational processes.

11 The endogenous circadian ( approximately 24 h) system allows plants to

12 required at different time points to rescue circadian behavior and memory.

13 oughout the day, which may be related to the circadian biology of the human body, the microbial commu

14 ence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modif

15 ells and which project intraretinally and to circadian centers in the brain, are sufficient to mediat

16 The molecular clock drives circadian changes in the membrane properties of SCN neur

17 st that starch turnover is controlled by the circadian clock acting as a dynamic homeostat responding

18 ese findings provide evidence that the human circadian clock adapts to seasonal changes in the natura

19 Together, these results establish circadian clock and cell cycle as interdependent coupled

20 iated role for direct DA input to the master circadian clock and highlight the importance of an evolu

21 Thus CRYs link the circadian clock and JAK-STAT signaling through control o

22 at mediate light-dependent maturation of the circadian clock and light-independent refinement of reti

23 Here we discuss the interplay between the circadian clock and metabolism, the importance of the mi

24 sponses implicating distinct elements of the circadian clock and processes involved in neuronal plast

25 ly candidates for signal transduction to the circadian clock are the PHYTOCHROME INTERACTING FACTOR (

26 haliana) plants in which the oscillator gene CIRCADIAN CLOCK ASSOCIATED1 (CCA1) was overexpressed und

27 re, this study provides insight into how the circadian clock can regulate hippocampus-dependent learn

28 nto cells, regulate the activity of the core circadian clock complex.

29 INSIG2/SREBP as a molecular pathway by which circadian clock components anticipatorily regulate lipog

30 The circadian clock contributes to the regulation of photosy

31 The circadian clock directs many aspects of metabolism, to s

32 y of evidence supports the importance of the circadian clock for plant health.

33 we show that DNA replication is required for circadian clock function in Neurospora.

34 Genetic ablation of circadian clock function or environmental CRD in mice in

35 with a dominant coding variation in the core circadian clock gene CRY1, which creates a transcription

36 an rhythms of DVM, metabolism, and most core circadian clock genes (clock, period1, period2, timeless

37 hologs of Arabidopsis (Arabidopsis thaliana) circadian clock genes EARLY FLOWERING3 (ELF3), ELF4, and

38 A circadian clock governs most aspects of mammalian behavi

39 However, their photosensitive circadian clock had to adapt to extreme seasonal photope

40 s B-box domain gene BBX32 We showed that the circadian clock in Arabidopsis regulates BBX32 and expre

41 Our study highlights the importance of the circadian clock in maintaining vascular homeostasis and

42 thermo-opsin that ultimately feeds the local circadian clock in mouse melanocytes and melanoma cells.

43 e demonstrate a potential involvement of the circadian clock in rapid antidepressant responses.

44 ed for the first time the involvement of the circadian clock in the host response following Giardia i

45 a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways,

46 In Drosophila, the circadian clock is comprised of transcriptional feedback

47 The Drosophila circadian clock is extremely sensitive to light.

48 Circadian clock is known to adapt to environmental chang

49 The master circadian clock is located in the suprachiasmatic nuclei

50 The circadian clock is the endogenous timekeeper critical fo

51 influences mood by utilizing a comprehensive circadian clock model that accurately predicts the chang

52 Starch measurements in circadian clock mutants suggested that the clock influen

53 The master circadian clock of the suprachiasmatic nucleus synchroni

54 function related genes, indicating that the circadian clock oscillators have been reset, was indepen

55 ous ascomycete Neurospora crassa affects the circadian clock output, yielding a pattern of asexual co

56 Our results therefore show that basic circadian clock properties are governed by dynamic inter

57 The circadian clock provides a mechanism for plants to antic

58 ate accumulation, CAM productivity, and core circadian clock robustness.

59 part the influences of light, metabolic, and circadian clock signaling on rates of cellulose biosynth

60 ein is a Light-Oxygen-Voltage(LOV) domain in circadian clock system.

61 Circadian clock systems help establish the correct daily

62 demonstrate that parasites have an intrinsic circadian clock that is independent of the host, and whi

63 uman activity are controlled by an intrinsic circadian clock that promotes approximately 24 hr rhythm

64 Drosophila brain cooperate with the central circadian clock to help regulate body temperature.

65 ing light signaling, photosynthesis, and the circadian clock under both dark and light conditions.

66 adiance) to synchronize the SCN's endogenous circadian clock with local time and drive the diurnal va

67 ial molecular link among the microbiota, the circadian clock, and host metabolism.

68 he beneficial effects of TRF are mediated by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin a

69 f food intake affects various aspects of the circadian clock, but its effects on immune function are

70 ironmental cycles relative to the endogenous circadian clock, on specific performance metrics in Majo

71 erimental evidence suggests that the retinal circadian clock, or its output signals (e.g., dopamine a

72 gh light is a strong modulator of the neural circadian clock, time of food intake is emerging as a do

73 f-1 expression is regulated by CR and by the circadian clock, we found that rhythms in Igf-1 expressi

74 ns in early pregnancy are uncoupled from the circadian clock, whereas in late pregnancy, energy avail

75 ses of animals are governed by an endogenous circadian clock, which is dependent on transcriptional r

76 AM PPC is regulated posttranslationally by a circadian clock-controlled protein kinase called phospho

77 ucleus (SCN)-often referred to as the master circadian clock-is essential in generating physiologic r

78 n modification of CREBH are regulated by the circadian clock.

79 scriptional repressors and components of the circadian clock.

80 for elucidating molecular mechanisms of the circadian clock.

81 nt with the >24-h period length of the human circadian clock.

82 nificant metabolic control on the Neurospora circadian clock.

83 best-described role is as components of the circadian clock.

84 s also tightly controlled by cell-autonomous circadian clock.

85 tes a major transcriptional regulator of the circadian clock.

86 e gut microbiota regulates the expression of circadian-clock genes to impact host lipid metabolism an

87 Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h e

88 Circadian clocks are autonomous daily timekeeping mechan

89 Thus, circadian clocks are mechano-sensitive, providing a pote

90 The genomic targets of circadian clocks are pervasive and are intimately linked

91 Circadian clocks are ubiquitous timing systems that indu

92 is emerging as a dominant agent that affects circadian clocks in metabolic organs.

93 Circadian clocks must be able to entrain to time-varying

94 Circadian clocks normally operate in approximately 150 b

95 Circadian clocks play an important role in lipid homeost

96 Timings of human activities are marked by circadian clocks which in turn are entrained to differen

97 events in the environment, courtesy of their circadian clocks.

98 ic rhythms and orchestrating synchrony among circadian clocks.

99 nce suggests that some mood disorders have a circadian component, and disruptions in circadian rhythm

100 analysis method of separating ultradian from circadian components and applied it to a published gene

101 spite evidence that some PIF genes are under circadian control and bind promoter motifs present in ci

102 Circadian control occurs through cryptochromes (CRYs)-tr

103 links the clock to motor outputs to modulate circadian control of locomotor activity.

104 oductive development, root architecture, and circadian coordination.

105 that controls glucose homeostasis across the circadian cycle or under metabolic stress.

106 st the human brain is protected by the daily circadian cycles in regional ICPs, without which patholo

107 up to 43 individuals, we found personalized circadian differences in physiological parameters, repli

108 present a unique mouse model to study human circadian disorders with unstable circadian rhythm phase

109 ome evidence supports a relationship between circadian disruption (CD) and PD, whether this is second

110 To examine whether circadian disruption affects development by acting as an

111 Circadian disruption for mice in the DSS condition was s

112 Pregnant mice were subjected to chronic circadian disruption from the time of uterine implantati

113 ft work decreases glucose tolerance and that circadian disruption is linked to glucose tolerance in m

114 on Cancer declared shift work that involved circadian disruption to be a "probable" carcinogen (grou

115 Postnatal circadian disruption was associated with reduced adult b

116 erturbation, we hypothesized that early-life circadian disruption would negatively impact offspring d

117 Conversely, sleep and circadian disruptions are implicated in a variety of adv

118 lignment that could be avoided by using less circadian-disruptive wavelengths.

119 a diurnal vertebrate, zebrafish, we studied circadian distribution of immunohistochemical markers of

120 es non-image-forming visual reflexes such as circadian entrainment [1-6].

121 esses such as the pupillary light reflex and circadian entrainment but also contribute to visual perc

122 While circadian entrainment by light is well characterized at

123 (ipRGCs) mediate the pupillary light reflex, circadian entrainment, and may contribute to luminance a

124 Direct measurements of circadian enzyme activities in mouse skeletal muscle con

125 ydroxylase phosphorylation is regulated in a circadian fashion.

126 Sleep homeostasis and circadian function are important maintaining factors for

127 This circadian function is variable, and can be either light-

128 nes was dependent on HSF1, the regulation of circadian function related genes, indicating that the ci

129 ever, other studies concluded that canonical circadian genes are not essential for FEO timekeeping.

130 control and bind promoter motifs present in circadian genes, until now PIFs have not been shown to a

131 This is accompanied by distinct circadian hepatic signatures in NAD(+)-related metabolit

132 ism in the mouse mammary gland and develop a circadian in vitro model for investigating changes in Ba

133 and wake behaviors in a light-dependent but circadian-independent manner.

134 The immune system is under circadian influence; time-of-day may alter inflammatory

135 esults were significant, and the addition of circadian information (combined model) maximized perform

136 terized rhodopsin, Rh7, which contributes to circadian light entrainment by circadian pacemaker neuro

137 he early rest period induces phase delays of circadian locomotor activity rhythm.

138 ar clock and essential for the generation of circadian locomotor behavior.

139 Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl

140 The CLOCK (circadian locomotor output cycles protein kaput) gene en

141 within the suprachiasmatic nuclei (SCN), the circadian "master clock," which is DNA methylated in reg

142 DNA replication as a critical process in the circadian mechanism.

143 To understand the significance of circadian-mediated anticipation in stomatal opening, we

144 pation of daily dark-to-light changes and of circadian-mediated stomatal opening in constant light.

145 further evidence for the integration of the circadian, metabolic, and immune systems.

146 ht increases, leading to disrupted sleep and circadian misalignment (i.e., social jet lag).

147 ults reveal surprisingly specific effects of circadian misalignment on athletic performance under nat

148 Exposure to blue-light at night leads to circadian misalignment that could be avoided by using le

149 This study encourages further research into circadian modulation of reward and underscores the metho

150 iptional targets and lengthens the period of circadian molecular rhythms, providing a mechanistic lin

151 cells appear to be responsible for the fly's circadian neurons becoming active at different times of

152 n contrast, SCN astrocytes are active during circadian nighttime, when they suppress the activity of

153 lso show that Sik3 reduction interferes with circadian nucleocytoplasmic shuttling of Histone deacety

154 Here, we analyzed the circadian orchestration of metabolic pathways by direct

155 ette expansion and leaf movement exhibited a circadian oscillation, with superimposed transients afte

156 w that PIFs mediate metabolic signals to the circadian oscillator and that sucrose directly affects P

157 affects PIF binding to the promoters of key circadian oscillator genes in vivo that may entrain the

158 The mechanism by which Suc affects the circadian oscillator in a GI-dependent manner was unknow

159 lants, and insects and are components of the circadian oscillator in mammals.

160 r proposed sugar sensor, HEXOKINASE1, or the circadian oscillator.

161 otosynthesis also feeds back to regulate the circadian oscillator.

162 e to temporal desynchrony between autonomous circadian oscillators in different regions, with differe

163 A critical role of circadian oscillators in orchestrating insulin secretion

164 i (SCN) of the hypothalamus and it regulates circadian oscillators in tissues throughout the body to

165 Our observations highlight how a circadian output pathway controls and temporally coordin

166 The central circadian pacemaker (Suprachiasmatic Nuclei, SCN) mainta

167 A mathematical model of the circadian pacemaker and its response to light was used t

168 eractions important for the operation of the circadian pacemaker circuit.

169 The master circadian pacemaker in mammals is located in the suprach

170 ontributes to circadian light entrainment by circadian pacemaker neurons in the brain.

171 The demonstration that Rh7 functions in circadian pacemaker neurons represents, to our knowledge

172 The circadian pacemaker of the Madeira cockroach, Rhyparobia

173 polar cycles, by periodically entraining the circadian pacemaker to its 24.84-h rhythm and altering t

174 lectrophysiological dissection of the master circadian pacemaker, the suprachiasmatic nuclei (SCN).

175 ms in astrocytes within the mammalian master circadian pacemaker, the suprachiasmatic nucleus (SCN),

176 assessment of circadian phase of the brain's circadian pacemaker.

177 ate the function of the s-LNvs as the master circadian pacemaker.

178 ngs, severe cold results in dysregulation of circadian pattern of gene expression causing profound mo

179 d in constant darkness, suggesting intrinsic circadian patterns of cell cycle progression.

180 nd that amyloid deposition may impair normal circadian patterns.

181 circadian rhythm strength, and lengthen the circadian period by approximately 2.5 h.

182 odel that accurately predicts the changes in circadian period evident in knock-out phenotypes and ind

183 d, altered light-dark environment can change circadian period length through a mechanism requiring de

184 e and female Afterhours mice which carry the circadian period lengthening loss-of-function Fbxl3(Afh)

185 pecifically in SCN astrocytes lengthened the circadian period of clock gene expression in the SCN and

186 Optic nerve crush rescued the circadian period of Myk/+ behavior, highlighting that af

187 ly corresponding with stabilization of their circadian periods.

188 nscriptome-based model enables assessment of circadian phase from a few samples.

189 ep-wake disorders both require assessment of circadian phase of the brain's circadian pacemaker.

190 ial contrast did not significantly alter the circadian phase resetting efficiency of light.

191 data provide a molecular explanation for how circadian phases, such as wake-sleep onset times, can be

192 lation is necessary to temporally reorganize circadian phasing among SCN neurons, which in turn chang

193 gue 8-bromo-cyclic AMP partially rescued the circadian phenotype in vivo We therefore propose that RA

194 ns in people, such as pupil constriction and circadian photoentrainment.

195 ontribution of these indirect projections to circadian photoreception is currently poorly understood.

196 role of this geniculohypothalamic pathway in circadian photoreception is poorly understood.

197 ty lighting may have differential effects on circadian physiology in young and older individuals.

198 an behavior is undisputed, but its impact on circadian physiology remains mostly unexplored.

199 es of cell cycle, as well as other cyclic or circadian processes (e.g., in liver), on single-cell res

200 During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure,

201 dentified CDF5 LONG NONCODING RNA (FLORE), a circadian-regulated lncRNA that is a NAT of CDF5.

202 th clock-associated cis-elements, suggesting circadian regulation of CAM.

203 oreceptor signalling pathways underlying the circadian regulation of chloroplast transcription by SIG

204 al skipping impacts these risks by affecting circadian regulation of energy balance, glucose metaboli

205 cological approaches that human RBCs display circadian regulation of membrane conductance and cytopla

206 ptional feedback loop have revealed a global circadian regulation of processes such as transcription

207 ted derivation of the ideal responses of the circadian regulation of starch breakdown to maintain suc

208 ndependent mechanisms of vertebrate-like CRY circadian regulation on the BMAL1 C terminus and the CLK

209 echanisms whereby the redox state influences circadian regulation.

210 nd temporal reconstruction in bridging basic circadian research and clinical medicine.

211 By circadian response analysis of pathway motifs, we determ

212 , and developing a theoretical method called circadian response analysis.

213 Sleep and circadian rhythm disruption (SCRD) is a ubiquitous featu

214 ostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk fa

215 rix in vivo, which contributes to a dampened circadian rhythm during ageing.

216 Moreover, variables pertaining to circadian rhythm entrainment were activated more strongl

217 regulation of a network of genes involved in circadian rhythm in both tissues and downregulation of t

218 tional transcription cycles, RBCs maintain a circadian rhythm in membrane electrophysiology through d

219 through Dopamine 2 Receptors to entrain the circadian rhythm in PER2::LUC bioluminescence.

220 tion factor that regulates genes involved in circadian rhythm maintenance and metabolism, effectively

221 HRMs affects the major cellular processes of circadian rhythm maintenance and metabolism.

222 ot alter actigraphic sleep parameters before circadian rhythm measurement.

223 tudy human circadian disorders with unstable circadian rhythm phases.

224 1, which is involved in learning, memory and circadian rhythm regulation.

225 Diagnosis and treatment of circadian rhythm sleep-wake disorders both require asses

226 lex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengthen the circadian pe

227 Use of endpoints, such as sleep and circadian rhythm, that are homologous across species wil

228 % of genes in T. brucei are expressed with a circadian rhythm.

229 ith altered locomotor activity and distorted circadian rhythm.

230 induces a mismatch between sleep timing and circadian rhythmicity ('social jet-lag').

231 Artificial light delays circadian rhythmicity and preferred sleep timing and com

232 atical model incorporating effects of light, circadian rhythmicity and sleep homeostasis to provide a

233 ibitory action was not associated with overt circadian rhythmicity in GHT output, indicating modulati

234 S) and slow-wave sleep (SWS), as well as the circadian rhythmicity of body temperature and locomotor

235 The circadian rhythmicity of oxygen consumption rate (Vo2) w

236 produces persistent disruptions in sleep and circadian rhythmicity, mimicking attributes of stress-re

237 rdiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice a

238 prompt chlorophyll fluorescence, to measure circadian rhythms and demonstrated that the technique wo

239 SST expression in the amygdala and disrupted circadian rhythms and rhythmic peaks of anxiety in BD su

240 hat the gastrointestinal microbiota exhibits circadian rhythms and that the timing of food consumptio

241 non-image forming visual processes including circadian rhythms and the pupillary light reflex.

242 Circadian rhythms are 24-h rhythms in physiology and beh

243 Sleep and circadian rhythms are affected in many of these conditio

244 Circadian rhythms are biological oscillations that sched

245 Thus, interventions that improve circadian rhythms are prospective entry points to mitiga

246 n reward systems and the impact of sleep and circadian rhythms changes on addiction vulnerability in

247 Circadian rhythms govern multiple aspects of animal meta

248 Measurements of circadian rhythms in body temperature suggest a biologic

249 EA (GI) is required to sustain Suc-dependent circadian rhythms in darkness.

250 sex of animals is an important modulator of circadian rhythms in gene expression and their response

251 a neurohormone involved in the regulation of circadian rhythms in humans.

252 horylation, which provides the mechanism for circadian rhythms in IGF signaling in vivo.

253 In contrast, a few cells show noisy circadian rhythms in the isolated E14.5 SCN and most sho

254 ust synchronize to each other to drive these circadian rhythms in the rest of the body.

255 AL1 TAD-independent mechanism for generating circadian rhythms in vivo.

256 It has been suggested that modifying circadian rhythms may be a means to manipulate crops to

257 ve a circadian component, and disruptions in circadian rhythms may even trigger the development of th

258 meostatic sleep drive takes longer to build, circadian rhythms naturally become delayed, and sensitiv

259 ral light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biologic

260 In the laboratory, C. finmarchicus shows circadian rhythms of DVM, metabolism, and most core circ

261 Although circadian rhythms of Vo2 were conserved in young lean CT

262 se of this study was to define the impact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in

263 nucleus (SCN) of the hypothalamus to entrain circadian rhythms that are generated within the SCN.

264 roduces progressive alterations in sleep and circadian rhythms that resemble features of depression a

265 cal research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience.

266 SDS reduced stress effects on both sleep and circadian rhythms, or hastened their recovery, and atten

267 role for CT-1 in the regulation of metabolic circadian rhythms.

268 ulation and the role of miRNAs in Drosophila circadian rhythms.

269 nimals affects the CR induced changes in the circadian rhythms.

270 el in blood and IGF-1 signaling demonstrates circadian rhythms.

271 e human master clock and multiple peripheral circadian rhythms.

272 e provide a molecular basis for the distinct circadian roles of different animal cryptochromes, which

273 Evidence for circadian SST expression in the amygdala and disrupted c

274 on similar to a ras-1 mutant that is used in circadian studies in N. crassa.

275 indicating that multiple signals may mediate circadian synchrony during the ontogeny of the SCN.

276 gnaling or action potentials did not disrupt circadian synchrony in the E15.5 SCN.

277 le levels after birth and after the onset of circadian synchrony.

278 the fetal pituitary gland, before the fetal circadian system and autonomous melatonin production is

279 udying network communication in the extended circadian system and provide novel insight into the role

280 onarily significant relationship between the circadian system and the neuromodulatory circuits that g

281 In plants, the circadian system controls a plethora of processes, many

282 The circadian system is a master regulator of nearly all phy

283 To enquire how the circadian system protects aging organisms, here we compa

284 results suggest that, as organisms age, the circadian system shifts greater regulatory priority to t

285 l now PIFs have not been shown to affect the circadian system.

286 hat retains connectivity across the extended circadian system.

287 n patterns of light consumption on the human circadian system.

288 metabolic health; yet, how eating at a later circadian time influences body composition is unknown.

289 tamine's clinical antidepressant effects and circadian timekeeping.

290 ssociation of irregular sleep schedules with circadian timing and academic performance has not been s

291 or in Chlamydomonas that is involved in both circadian timing and life cycle progression.

292 Further, we demonstrate that earlier circadian timing can be rapidly achieved through natural

293 Disruptions in circadian timing impair spatial memory in humans and rod

294 to achieve approximately 69% of the shift in circadian timing we previously reported after a week's e

295 t Irregular vs. Regular group differences in circadian timing were likely primarily due to their diff

296 r results show that there is variability for circadian traits in the wild barley lines.

297 biota regulates body composition through the circadian transcription factor NFIL3.

298 protein 1) sits at the core of the mammalian circadian transcription/translation feedback loop.

299 em protects aging organisms, here we compare circadian transcriptomes in heads of young and old Droso

300 , a mood-independent decrease of the central circadian value (mesor) was present on D1 after ketamine