ライフサイエンスコーパス: circadian clock

1 he internal environment (hormones, diet, and circadian clock).

2 n modification of CREBH are regulated by the circadian clock.

3 t is defective for central properties of the circadian clock.

4 isms by which PIFs regulate signaling to the circadian clock.

5 ritical link between light signaling and the circadian clock.

6 a factor SIG5 are regulated by light and the circadian clock.

7 of transcription 3), and the epithelial cell circadian clock.

8 dian physiology in the absence of the master circadian clock.

9 e-advancing light entrainment pathway to the circadian clock.

10 character of the cold-response of the maize circadian clock.

11 tes to period determination of the mammalian circadian clock.

12 ges in cell wall extensibility driven by the circadian clock.

13 scriptional repressors and components of the circadian clock.

14 s critical for this arousal resetting of the circadian clock.

15 ry connection between abiotic stress and the circadian clock.

16 tes a major transcriptional regulator of the circadian clock.

17 t and stress hormone, abscisic acid, and the circadian clock.

18 eripheral cells together, set our biological circadian clock.

19 for elucidating molecular mechanisms of the circadian clock.

20 nt with the >24-h period length of the human circadian clock.

21 nificant metabolic control on the Neurospora circadian clock.

22 best-described role is as components of the circadian clock.

23 s also tightly controlled by cell-autonomous circadian clock.

24 box protein ZEITLUPE, a key regulator of the circadian clock.

25 behavior that is normally controlled by the circadian clock.

26 interplay between sleep homeostasis and the circadian clock.

27 euromodulation, and proteins involved in the circadian clock.

28 sent within the eye are under the control of circadian clocks.

29 llator (WICO) are generated by non-canonical circadian clocks.

30 chimeric circuits form robust and resilient circadian clocks.

31 s (TTFLs) are a conserved molecular motif of circadian clocks.

32 uman conditions caused by disruptions of the circadian clocks.

33 events in the environment, courtesy of their circadian clocks.

34 ic rhythms and orchestrating synchrony among circadian clocks.

35 In the Neurospora crassa circadian clock, a protein complex of frequency (FRQ), c

36 Circadian clock abnormalities are related to mood disord

37 st that starch turnover is controlled by the circadian clock acting as a dynamic homeostat responding

38 both produce arousal and reset the phase of circadian clock activate (i.e., induce Fos expression in

39 ese findings provide evidence that the human circadian clock adapts to seasonal changes in the natura

40 Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h e

41 The principles that determine how circadian clocks align to these external cycles are not

42 The circadian clock allows plants to anticipate and respond

43 The circadian clock, an endogenous and cell-autonomous biolo

44 conditions are typically orchestrated by the circadian clock, an intrinsic time-keeping system that a

45 nt knowledge about the interplay between the circadian clock and antimicrobial responses.

46 Together, these results establish circadian clock and cell cycle as interdependent coupled

47 intercellular coupling component linking the circadian clock and cell cycle in enteroids.

48 a focus on the molecular events linking the circadian clock and defense.

49 nted role for light in the maturation of the circadian clock and discovered that intrinsically photos

50 nstrate a crucial link between the molecular circadian clock and electrical activity, providing examp

51 under intricate temporal control by both the circadian clock and feeding.

52 e demonstrate that CREBH is regulated by the circadian clock and functions as a circadian regulator o

53 iated role for direct DA input to the master circadian clock and highlight the importance of an evolu

54 t understanding of the interplay between the circadian clock and hormone signaling pathways.

55 Thus CRYs link the circadian clock and JAK-STAT signaling through control o

56 at mediate light-dependent maturation of the circadian clock and light-independent refinement of reti

57 Here we discuss the interplay between the circadian clock and metabolism, the importance of the mi

58 ochastic versions of published models of the circadian clock and NF-kappaB system are used to illustr

59 rize a new protein that associates with both circadian clock and photoreceptor components, named PHOT

60 sponses implicating distinct elements of the circadian clock and processes involved in neuronal plast

61 statistical predictions, which indicate that circadian clock and sleep are complementary processes in

62 ) neurons contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key tran

63 For many years, a connection between circadian clocks and cancer has been postulated.

64 d by examples, including the architecture of circadian clocks and the connections between the oscilla

65 d, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well kn

66 how natural environmental conditions affect circadian clocks and their physiological outputs.

67 fixation, stomatal movement, heat tolerance, circadian clock, and carbohydrate metabolism in K. fedts

68 ial molecular link among the microbiota, the circadian clock, and host metabolism.

69 ly candidates for signal transduction to the circadian clock are the PHYTOCHROME INTERACTING FACTOR (

70 Circadian clocks are autonomous daily timekeeping mechan

71 Circadian clocks are cell-autonomous timing mechanisms t

72 Circadian clocks are disabled in Period1/2/3 triple muta

73 Circadian clocks are endogenous oscillators that control

74 Circadian clocks are fundamental to the biology of most

75 Feeding behavior, metabolism and circadian clocks are interlinked.

76 Thus, circadian clocks are mechano-sensitive, providing a pote

77 The genomic targets of circadian clocks are pervasive and are intimately linked

78 Circadian clocks are ubiquitous timing systems that indu

79 Although terrestrial circadian clocks are well understood, knowledge of clock

80 pars intercerebralis and lack an autonomous circadian clock, are functionally connected to the centr

81 ial functions that include regulation of the circadian clock, arousal state, and hormone levels.

82 light exposure rapidly disrupts the central circadian clock as well as reduces motor performance and

83 the COLD SHOCK DOMAIN PROTEIN 3 (MdCSP3) and CIRCADIAN CLOCK ASSOCIATED 1 (MdCCA1) genes.

84 indicate that ketamine alters expression of circadian clock-associated molecules, and clinical studi

85 treatment strongly reduced the expression of CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HY

86 ccumulate LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) splice variants, amon

87 haliana) plants in which the oscillator gene CIRCADIAN CLOCK ASSOCIATED1 (CCA1) was overexpressed und

88 consisting of CCA1 HIKING EXPEDITION (CHE), CIRCADIAN CLOCK ASSOCIATED1 (CCA1), and TIMING OF CAB EX

89 ve feedback loop formed by the morning genes CIRCADIAN CLOCK ASSOCIATED1 (CCA1)/LATE ELONGATED HYPOCO

90 ors (TF) PHYTOCHROME INTERACTING FACTOR3 and CIRCADIAN CLOCK ASSOCIATED1.

91 he beneficial effects of TRF are mediated by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin a

92 tal platforms for driving the cyanobacterial circadian clock both in vivo and in vitro.

93 f food intake affects various aspects of the circadian clock, but its effects on immune function are

94 lant-specific GIGANTEA protein regulates the circadian clock by stabilizing the F-box protein ZEITLUP

95 , genetic or environmental disruption of the circadian clock can cause metabolic diseases or exacerba

96 re, this study provides insight into how the circadian clock can regulate hippocampus-dependent learn

97 on (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit.

98 k, are functionally connected to the central circadian clock circuit via DN1 neurons.

99 Acquiring circadian clock cis-regulatory elements in CAM-related g

100 nto cells, regulate the activity of the core circadian clock complex.

101 e also found that the acrophase of molecular circadian clock component REV-ERBalpha mRNA expression i

102 INSIG2/SREBP as a molecular pathway by which circadian clock components anticipatorily regulate lipog

103 Importantly, deletion of circadian clock components did not reproduce the hallmar

104 The circadian clock contributes to the regulation of photosy

105 ively, these results indicate that the renal circadian clocks control a variety of metabolic/homeosta

106 Circadian clocks control rhythmic behaviors of most life

107 In animals, molecular circadian clocks control the timing of behavioral activi

108 AM PPC is regulated posttranslationally by a circadian clock-controlled protein kinase called phospho

109 ntially affect the expression of hundreds of circadian-clock-controlled genes, many of which are invo

110 suprachiasmatic nucleus (SCN) is the master circadian clock controlling daily behavior in mammals.

111 The circadian clock controls a wide variety of metabolic and

112 The circadian clock controls metabolic and physiological pro

113 s responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a

114 Furthermore, we found that the circadian clock coordinates the phase relation between t

115 red energy metabolism and disruptions in the circadian clock create a downward spiral that can lead t

116 ncy before the onset of the night reflects a circadian clock-dependent response.

117 arising from differentiated cells governing circadian clock-dependent synchronized cell division cyc

118 The circadian clock directs many aspects of metabolism, to s

119 Outside the laboratory, circadian clocks do not generally free-run but are drive

120 triction of these phenotypes to the day, the circadian clock does not regulate qrfp expression, and e

121 Circadian clocks drive approximately 24 h rhythms in tis

122 Circadian clocks drive rhythmic physiology and metabolis

123 Circadian clock dysregulation promotes cancer growth.

124 Circadian clocks enable organisms to anticipate and adap

125 nthetic products which are controlled by the circadian clock feedback to affect the circadian oscilla

126 ng homoeologous transcription factors in the circadian-clock feedback loop, consisting of CCA1 HIKING

127 bing the only known link between CAM and the circadian clock feeds back to perturb the central circad

128 y of evidence supports the importance of the circadian clock for plant health.

129 was very early in ICCV 96029, an analysis of circadian clock function failed to show any clear loss o

130 he genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanism

131 we show that DNA replication is required for circadian clock function in Neurospora.

132 Genetic ablation of circadian clock function or environmental CRD in mice in

133 rimarily through the AHK3 receptor, supports circadian clock function to guard against the detrimenta

134 The circadian clock gates a population of cells with heterog

135 Whole-body knockout of the circadian clock gene Bmal1 in mice affects several aspec

136 with a dominant coding variation in the core circadian clock gene CRY1, which creates a transcription

137 Because astrocytes have persistent circadian clock gene expression and ATP release in vitro

138 en central and peripheral circadian rhythms, circadian clock gene function, and sleep in maintaining

139 In Neurospora crassa, the circadian clock generates daily rhythms in the activatio

140 an rhythms of DVM, metabolism, and most core circadian clock genes (clock, period1, period2, timeless

141 The rhythms in the expression of circadian clock genes are affected by calorie restrictio

142 other tissues - the rapid induction of these circadian clock genes drives the resetting process.

143 hologs of Arabidopsis (Arabidopsis thaliana) circadian clock genes EARLY FLOWERING3 (ELF3), ELF4, and

144 ly affected the rhythms in the expression of circadian clock genes in mice on the mRNA and protein le

145 we found that DA-induced expression of core circadian clock genes Period1 and Period2 accompanied bo

146 The liver expression of some circadian clock genes such as Bmal1 and three Periods (P

147 w-amplitude or arrhythmic expression of core circadian clock genes under cool ambient temperature cyc

148 in the liver and highlight the functions of circadian clock genes under physiological and pathologic

149 Circadian clock genes were overrepresented among the top

150 ons in the transcript abundance of many core circadian clock genes, suggesting that perturbing the on

151 h reflect GABA circuit maturation, BDNF, and circadian Clock genes.

152 ing pre-mRNA splicing of light signaling and circadian clock genes.

153 le NBs did not affect the expression of core circadian clock genes.

154 e gut microbiota regulates the expression of circadian-clock genes to impact host lipid metabolism an

155 A circadian clock governs most aspects of mammalian behavi

156 nomic regulatory mechanism through which the circadian clock governs skeletal muscle bioenergetics.

157 However, their photosensitive circadian clock had to adapt to extreme seasonal photope

158 llate rhythmically with the time of day, the circadian clock has emerged as an important gatekeeper f

159 The circadian clock has remarkable stability of period and p

160 Alterations of the circadian clock have been linked to cancer development.

161 Monarch circadian clocks have a distinct molecular mechanism, an

162 Autonomous circadian clocks have been identified in mouse cartilage

163 We showed that the shoot and root circadian clocks have different rhythmic properties (per

164 In animals, circadian clocks have evolved to orchestrate the timing

165 The circadian clock helps plants measure daylength and adapt

166 cellular coupling between the cell cycle and circadian clock in 3D murine intestinal organoids (enter

167 nata of the basal forebrain phase shifts the circadian clock in a manner similar to that of our arous

168 s B-box domain gene BBX32 We showed that the circadian clock in Arabidopsis regulates BBX32 and expre

169 n data and protein reporter data in the core circadian clock in Arabidopsis thaliana, and how such re

170 ION1 (TOC1) contributes to regulation of the circadian clock in Arabidopsis.

171 od potentiates light resetting of the master circadian clock in diurnal rodents, and activation of ca

172 hms in metabolic physiology from the central circadian clock in humans.

173 Our study highlights the importance of the circadian clock in maintaining vascular homeostasis and

174 Neurons in the central circadian clock in mammals provide a model system to inv

175 suprachiasmatic nucleus (SCN) is the central circadian clock in mammals.

176 thermo-opsin that ultimately feeds the local circadian clock in mouse melanocytes and melanoma cells.

177 e demonstrate a potential involvement of the circadian clock in rapid antidepressant responses.

178 ed for the first time the involvement of the circadian clock in the host response following Giardia i

179 ntal signals.SIGNIFICANCE STATEMENT A master circadian clock in the suprachiasmatic nuclei (SCN) of t

180 nally, the cell cycle generically influences circadian clocks in a nonspecific fashion: The regular,

181 However, the complexity of circadian clocks in higher organisms has prevented a cle

182 is emerging as a dominant agent that affects circadian clocks in metabolic organs.

183 us, a definitive causal role for functioning circadian clocks in mood regulation has not been establi

184 We thus suggest that circadian clocks increase zooplankton fitness by optimiz

185 portant entraining signal for the endogenous circadian clock, independent of light, is food intake.

186 a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways,

187 Cell-autonomous circadian clocks interact with daily light-dark and feed

188 The circadian clock interacts with other regulatory pathways

189 The plant circadian clock is a complex network of genes crucial fo

190 The circadian clock is a complex regulatory network that enh

191 The circadian clock is a critical regulator of plant physiol

192 The circadian clock is an endogenous biological timekeeping

193 The mammalian circadian clock is based on a transcription-translation

194 The mammalian circadian clock is built on a feedback loop in which PER

195 egrating light perception and the endogenous circadian clock is central to a plant's capacity to coor

196 In Drosophila, the circadian clock is comprised of transcriptional feedback

197 Visual input to the suprachiasmatic nucleus circadian clock is critical for animals to adapt their p

198 The Drosophila circadian clock is extremely sensitive to light.

199 Circadian clock is known to adapt to environmental chang

200 The master circadian clock is located in the suprachiasmatic nuclei

201 This model predicts that the circadian clock is only advantageous in highly regular c

202 Further, we find that the human circadian clock is sensitive to seasonal changes in the

203 The circadian clock is the endogenous timekeeper critical fo

204 ucleus (SCN)-often referred to as the master circadian clock-is essential in generating physiologic r

205 dian clock feeds back to perturb the central circadian clock itself.

206 The Drosophila circadian clock keeps time via transcriptional feedback

207 and Per2 modulates aging gene expression and circadian-clock maintenance.

208 ogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression

209 ver, such a dispersed network of dissociable circadian clocks may provide greater flexibility when fa

210 e dynamics of starch turnover arise from the circadian clock measuring and responding to the rate of

211 xpected that SIC is directly involved in the circadian clock mechanism; instead, SIC likely contribut

212 ny biological processes, such as cell cycle, circadian clock, menstrual cycles, are governed by oscil

213 influences mood by utilizing a comprehensive circadian clock model that accurately predicts the chang

214 votal implications for understanding how the circadian clock modulates sleep and behavior.

215 Circadian clocks must be able to entrain to time-varying

216 Starch measurements in circadian clock mutants suggested that the clock influen

217 centers that are indirectly connected to the circadian clock network.

218 m these photorecptors is integrated into the circadian clock neuron network to support entrainment is

219 new and unexpected network motifs within the circadian clock neuron network.

220 Circadian clocks normally operate in approximately 150 b

221 ever, the general principles that govern the circadian clock of Caenorhabditis elegans have remained

222 Here we show that the circadian clock of cultivated tomato (Solanum lycopersic

223 period 2 (PER2) (I324N) that accelerates the circadian clock of Per2(Edo/Edo) mice by 1.5 h.

224 The principal pacemaker of the circadian clock of the cyanobacterium S. elongatus is a

225 The master circadian clock of the suprachiasmatic nucleus (SCN) enc

226 The master circadian clock of the suprachiasmatic nucleus synchroni

227 ion of H2A.Z uncoupled the dependence of the circadian clock on DNA replication.

228 A growing understanding of the impact of circadian clocks on mammalian transcription has sparked

229 ironmental cycles relative to the endogenous circadian clock, on specific performance metrics in Majo

230 status of the plant and independently of the circadian clock or light signaling.

231 aints, particularly in individuals with slow circadian clocks or when imposed wake-times occur after

232 erimental evidence suggests that the retinal circadian clock, or its output signals (e.g., dopamine a

233 The circadian clock orchestrates diverse physiological proce

234 function related genes, indicating that the circadian clock oscillators have been reset, was indepen

235 iously unrecognized mechanism whereby a core circadian clock output signal converges immediately with

236 ous ascomycete Neurospora crassa affects the circadian clock output, yielding a pattern of asexual co

237 nd CCA1 splice variants are needed for sic-3 circadian clock phenotypes.

238 eds of key regulators of photosynthesis, the circadian clock, phytohormone signalling, growth and res

239 Circadian clocks play an important role in lipid homeost

240 we show that the evening complex (EC) of the circadian clock plays a major role in directly coordinat

241 The circadian clock plays a role in many biologic processes,

242 Our results therefore show that basic circadian clock properties are governed by dynamic inter

243 Thus, circadian clock properties depend in part upon a genetic

244 Bioluminescent recording of circadian clock protein (PERIOD2) output from ex vivo SC

245 The circadian clock provides a mechanism for plants to antic

246 Endogenous circadian clocks regulate 24-h rhythms of physiology and

247 Circadian clocks regulate much of behavior and physiolog

248 electrophysiology reveals that IPCs display circadian clock-regulated daily rhythms in firing event

249 Second, we measured the expression of two circadian clock-regulated genes-Per3 and Nr1d2-from peri

250 The circadian clock regulates inflammatory arthritis.

251 The circadian clock regulates phytohormone biosynthesis and

252 tuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two

253 Polymorphisms in a circadian clock-related gene, PER3, are associated with

254 However, the role of the renal circadian clocks remains largely unknown.

255 accumulate in sic mutants likely affect the circadian clock response to cool ambient temperature.

256 ynchrony between the external time and their circadian clock, resulting in a constant state of social

257 ate accumulation, CAM productivity, and core circadian clock robustness.

258 er, little is known about how cell-intrinsic circadian clocks sense and respond to their microenviron

259 ispanic European-Americans in how much their circadian clocks shifted after a 9 hour phase delay of t

260 part the influences of light, metabolic, and circadian clock signaling on rates of cellulose biosynth

261 y measuring their growth, division rate, and circadian clock state over many days.

262 sis, increased ROS production, and disturbed circadian clock synchronization of glucose and lipid met

263 The circadian clock synchronizes a wide range of biological

264 The endogenous circadian clock synchronizes with environmental time by

265 ein is a Light-Oxygen-Voltage(LOV) domain in circadian clock system.

266 Circadian clock systems help establish the correct daily

267 demonstrate that parasites have an intrinsic circadian clock that is independent of the host, and whi

268 uman activity are controlled by an intrinsic circadian clock that promotes approximately 24 hr rhythm

269 of human sleeping sickness, has an intrinsic circadian clock that regulates its metabolism in two dif

270 TRACT: Sensory input to the master mammalian circadian clock, the suprachiasmatic nucleus (SCN), is v

271 DAC3 in skeletal muscle is controlled by the circadian clock, these results delineate an epigenomic r

272 gh light is a strong modulator of the neural circadian clock, time of food intake is emerging as a do

273 cell cycle to control DNA replication and a circadian clock to anticipate changes between day and ni

274 2 acts downstream of light signaling and the circadian clock to control expression of the main photop

275 sm where a plastid signal converges with the circadian clock to fine-tune the regulation of nuclear g

276 Drosophila brain cooperate with the central circadian clock to help regulate body temperature.

277 aptation would require the internal, master, circadian clock to make large phase shifts to reduce the

278 r 20 min light-dark cycle entrains the human circadian clock to solar time, such that the internal bi

279 ing between circadian and cell cycles allows circadian clocks to gate cell division and DNA replicati

280 ing light signaling, photosynthesis, and the circadian clock under both dark and light conditions.

281 nd RORgamma, key components of the molecular circadian clock, up-regulate expression of lipogenic gen

282 ium (RPE)-choroid preparation to monitor the circadian clock using PERIOD2 (PER2)::LUC knock-in mouse

283 ystems are linked; forced desynchrony of the circadian clock via nighttime light exposure or genetic

284 ke in the WT, in Deltaras2, operation of the circadian clock was affected by glucose; compared with s

285 The circadian clock was proposed as a potential mediator of

286 f-1 expression is regulated by CR and by the circadian clock, we found that rhythms in Igf-1 expressi

287 ision and DNA replication in many organisms, circadian clocks were thought to function independently

288 ns in early pregnancy are uncoupled from the circadian clock, whereas in late pregnancy, energy avail

289 Timings of human activities are marked by circadian clocks which in turn are entrained to differen

290 ted both in response to nutrients and by the circadian clock, which allows anticipatory Pol III trans

291 e cell cycle cause a periodic driving of the circadian clock, which can dramatically alter its behavi

292 Disruption of the circadian clock, which directs rhythmic expression of nu

293 Cyanobacteria evolved a robust circadian clock, which has a profound influence on fitne

294 ses of animals are governed by an endogenous circadian clock, which is dependent on transcriptional r

295 One such important system is the circadian clock, which provides temporal structure to sl

296 aily activity rhythms through their internal circadian clocks, which are synchronized by oscillating

297 ge of organisms features molecular machines, circadian clocks, which generate endogenous oscillations

298 established as an essential component of the circadian clock with conserved functions in regulating p

299 adiance) to synchronize the SCN's endogenous circadian clock with local time and drive the diurnal va

300 ircadian pacemaker to synchronize endogenous circadian clocks with the solar day.