ライフサイエンスコーパス: circadian oscillation

1 encephalitis by using the cosinor model for circadian oscillation.

2 elasticity and temporal structure of the SCN circadian oscillation.

3 while excluding most effects associated with circadian oscillation.

4 it reduced amplitude and shortened period of circadian oscillation.

5 enotypes, such as blood pressure, subject to circadian oscillation.

6 is subset of roughly 7000 genes screened for circadian oscillation.

7 tenuated and failed to exhibit a significant circadian oscillation.

8 oteins and more modern proteins required for circadian oscillation.

9 l activation by BMAL1/CLOCK and for in vitro circadian oscillation.

10 of KaiC phosphorylation, which is central to circadian oscillation.

11 transcriptional networks and the creation of circadian oscillations.

12 s in generating as well as modulating robust circadian oscillations.

13 phosphorylation dramatically dampened PAI-1 circadian oscillations.

14 rresponds to one circuit topology that shows circadian oscillations.

15 and increase the robustness and accuracy of circadian oscillations.

16 is, mPer RNAs exhibit prominent, synchronous circadian oscillations.

17 es, suppressing them or giving rise to novel circadian oscillations.

18 influences the circadian clock and undergoes circadian oscillations.

19 trol introduces delays that are critical for circadian oscillations.

20 olecular species, may bear the potential for circadian oscillations.

21 rtion of mammalian gene expression undergoes circadian oscillations.

22 cal co-stabilization is essential for robust circadian oscillations.

23 etabolic and physiological processes display circadian oscillations.

24 ry of their protein products is the basis of circadian oscillation [1, 2].

25 d liver X receptor alpha as well as with the circadian oscillation activator DBP and the repressor E4

26 uc/p75(NTR-/-) liver explants showed reduced circadian oscillation amplitude compared with those of P

27 essential features: the ability to generate circadian oscillations, an output signal, and the abilit

28 or contributors to determining the period of circadian oscillation and enhancing robustness.

29 nogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning on

30 iological processes, from the cell cycle, to circadian oscillations and developmental processes.

31 Robust circadian oscillations and entrainment to light pulses w

32 heral cellular activities by governing their circadian oscillations and pulmonary margination, which

33 express self-sustained, rather than damped, circadian oscillations and suggest the existence of orga

34 n SOV and seizures are primarily governed by circadian oscillations and the notion that hippocampal t

35 n trans) features, able to fine-tune its own circadian oscillation, and consequently, adjust the onse

36 ion, namely loss of plasmatic corticosterone circadian oscillation, and promotes reduction of GR hipp

37 Of these, five showed persistent, large circadian oscillations, and four had partial optic nerve

38 tic cells harbor an intact clock with robust circadian oscillations, and genetic knockout models reve

39 nous CHRONO occupancy around E-boxes shows a circadian oscillation antiphasic to BMAL1.

40 Circadian oscillations are generated by the purified cya

41 Circadian oscillations are markedly altered when mice ar

42 Circadian oscillations are predicated on transcriptional

43 Autonomous circadian oscillations arise from transcriptional-transl

44 ), revealed internal phase patterning to the circadian oscillation at these extreme periods and diffe

45 pecific gene activity that is independent of circadian oscillations but differs between reproductive

46 In contrast, xPer1 mRNA exhibits circadian oscillations but is relatively insensitive to

47 cted that GABA would affect the amplitude of circadian oscillations but not synchrony among individua

48 receptor occupancy at the Cxcl5 locus shows circadian oscillations, but this is disrupted in mice wi

49 ite leaf diel datasets identified genes with circadian oscillation, CAM-related functions, and source

50 A circadian oscillation can be reconstituted in vitro from

51 holog of this gene have similar fast-running circadian oscillations compared with WT.

52 l a/b binding protein gene CAB, in which the circadian oscillations damp to low steady state mRNA abu

53 entified over 1,000 transcripts that exhibit circadian oscillations, demonstrating that the cell-auto

54 Protein synthesis rates demonstrate circadian oscillations dependent on BMAL1.

55 REGULATOR7 (PRR7), and PRR9, although later circadian oscillations develop in mutants defective in e

56 ANCE STATEMENT We recorded the onset of PER2 circadian oscillations during embryonic development in t

57 pheral tissues are capable of self-sustained circadian oscillations for >20 cycles in isolation.

58 models of molecular processes essential for circadian oscillations have been developed, their comple

59 Circadian oscillations have been observed in animals, pl

60 ude that individual SCN neurons can generate circadian oscillations; however, there is no evidence fo

61 these proteins can reconstitute a remarkable circadian oscillation in a test tube.

62 achiasmatic nuclei (SCN) exhibit a prominent circadian oscillation in cAMP response element (CRE)-med

63 It exhibits a circadian oscillation in constant conditions.

64 iA protein abundance undergoes little if any circadian oscillation in constant light.

65 Although circadian oscillation in dynamics of intracellular Ca2+

66 ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, po

67 The circadian oscillation in markers of mRNA translation was

68 2 and Cryptochrome1, whose expression show a circadian oscillation in peripheral tissues, inhibit the

69 ramatically underestimated the prevalence of circadian oscillation in plant gene expression.

70 enylyl cyclase and MAPK activities undergo a circadian oscillation in the hippocampus and that inhibi

71 /2 MAPK phosphorylation and cAMP underwent a circadian oscillation in the hippocampus that was parall

72 /2 MAPK phosphorylation and cAMP underwent a circadian oscillation in the hippocampus that was parall

73 mage by nucleotide excision repair, exhibits circadian oscillation in the liver but not in testis.

74 erodimer is best known as a regulator of the circadian oscillation in the mammalian CLOCK system.

75 als, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of

76 The chick retina and pineal gland exhibit circadian oscillations in biochemical and physiological

77 We found evidence of large circadian oscillations in calcineurin-dependent activiti

78 Normal, opposing circadian oscillations in calcineurin-dependent activiti

79 Circadian oscillations in cAMP and MAPK activity were ab

80 Circadian oscillations in cAMP and MAPK activity were ab

81 of PER2, rather than CRY1, are critical for circadian oscillations in cells and in the intact organi

82 Circadian oscillations in clock components are central t

83 are sufficient to either entrain or restart circadian oscillations in cortical glia.

84 represses Fgf21 expression and disrupts its circadian oscillations in cultured hepatocytes.

85 e show that loss of PER2 expression silences circadian oscillations in decidualizing human endometria

86 ndicate that the SCN regulates expression of circadian oscillations in different peripheral organs by

87 The potential connections between circadian oscillations in gene expression and circadian

88 This loop in turn drives circadian oscillations in gene expression that direct SC

89 elongatus PCC 7942 exhibits global biphasic circadian oscillations in gene expression under constant

90 ty, in addition to providing the impetus for circadian oscillations in general.

91 the bone marrow microenvironment, directing circadian oscillations in hematopoiesis and HSC migratio

92 show that transcription is not required for circadian oscillations in humans, and that non-transcrip

93 is modulated by but does not require normal circadian oscillations in locomotor activity.

94 Circadian oscillations in mammalian physiology and behav

95 tion of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues.

96 ircadian oscillations in gene expression and circadian oscillations in metabolic activity are a major

97 y expressing viral oncogenes E6/E7) disrupts circadian oscillations in mouse embryonic fibroblasts, m

98 otein levels of GM129 exhibit high amplitude circadian oscillations in mouse liver, and Gm129 gene en

99 in roots (SHM4), and show that both exhibit circadian oscillations in mRNA abundance that are in pha

100 protein, the period protein PER, show robust circadian oscillations in mRNA and protein levels.

101 Interestingly, serum shock generated circadian oscillations in PAI-1 mRNA in NIH3T3 cells, su

102 In the fruitfly Drosophila, circadian oscillations in per expression occur in chemos

103 Circadian oscillations in period (per) mRNA and per prot

104 Circadian oscillations in peripheral tissues, such as th

105 There is also evidence for independent circadian oscillations in synaptic strength and morpholo

106 There are circadian oscillations in the abundance of many chloropl

107 Plants have circadian oscillations in the concentration of cytosolic

108 We have tested the hypothesis that circadian oscillations in the concentration of cytosolic

109 and leading to tissue-specific, differential circadian oscillations in the expression of endothelial

110 o two components, 12 h apart, with antiphase circadian oscillations in the left and right SCN.

111 Low amplitude circadian oscillations in the molecular circadian clock

112 onal regulation (PTR) circuit that generates circadian oscillations in the phosphorylation state of t

113 Recently, circadian oscillations in the redox state of peroxiredox

114 eria (KaiA, KaiB, and KaiC) can reconstitute circadian oscillations in vitro.

115 has been shown to play a fundamental role in circadian oscillations, influencing how groups of cells

116 on factor known to be essential for cellular circadian oscillation is also slowed.

117 l epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota th

118 The peak-to-trough circadian oscillation is paralleled by the sequential ac

119 y for high-amplitude (approximately 10-fold) circadian oscillation lie upstream of -317 and are remov

120 onfer a low-amplitude (approximately 2-fold) circadian oscillation lies within 317 base pairs of the

121 The model simulated circadian oscillations, light entrainment, and a phase-r

122 mammalian circadian system has revealed that circadian oscillations may be a fundamental property of

123 Circadian oscillation of body temperature is a basic, ev

124 cillation, since loss of p75(NTR) alters the circadian oscillation of clock genes in the SCN, liver,

125 In the liver, SIRT1 coordinates the circadian oscillation of clock-controlled genes, includi

126 udy shows for the first time region-specific circadian oscillation of dCREB2/NF-kappaB activity in th

127 All promoters seem to exhibit circadian oscillation of expression, but the phasing of

128 e Lhcb gene in plants, we tested whether the circadian oscillation of free calcium is responsible for

129 -protein-coupled receptor (GPCR), to augment circadian oscillation of glucocorticoid levels in a para

130 reover, deletion of p75(NTR) also alters the circadian oscillation of glucose and lipid homeostasis g

131 Circadian oscillation of mouse SCN organotypic slice cul

132 hese results suggest that CLIF regulates the circadian oscillation of PAI-1 gene expression in endoth

133 embryonic brain were not detected, a robust circadian oscillation of PER immunoreactivity is present

134 Immunohistochemical staining revealed a circadian oscillation of phospho-MAPK in the vicinity of

135 component of the circadian network, controls circadian oscillation of several clock genes, including

136 egulated in a cyclic manner in virtue of the circadian oscillation of the coenzyme NAD(+).

137 ng and quantitative MS analyses suggest that circadian oscillation of the FRQ phosphorylation profile

138 The circadian oscillation of the repair capacity is caused a

139 r capacity is caused at least in part by the circadian oscillation of the xeroderma pigmentosum A DNA

140 A key unanswered question is whether the circadian oscillation of this signaling pathway is intri

141 Furthermore, we find that the circadian oscillation of XPA is achieved both by regulat

142 of zCry1a and zPer2 genes and the subsequent circadian oscillation of zPer1.

143 We suggest that the circadian oscillations of [Ca(2+)](cyt) and CAB2 promote

144 Both red and blue light regulate circadian oscillations of [Ca(2+)](cyt).

145 e the temporal development of light/dark and circadian oscillations of AANAT activity in cultured ret

146 's transcriptional feedback loops and drives circadian oscillations of Ca2+ release.

147 tablished a mathematical model that predicts circadian oscillations of cell cycle components and circ

148 n dispersed culture can generate independent circadian oscillations of clock gene expression and neur

149 Circadian oscillations of clock gene products are though

150 At the molecular level, circadian oscillations of gene expression are regulated

151 We apply this method to analyze circadian oscillations of gene expression in individual

152 ucial factor in this issue is the endogenous circadian oscillations of genes during sampling.

153 Recently, circadian oscillations of hormone secretion, clock gene

154 loops determine the period and amplitude of circadian oscillations of individual cells.

155 escence imaging to visualize GCaMP3-reported circadian oscillations of intracellular calcium [Ca2+]i

156 hiasmatic nucleus (SCN) but exhibited normal circadian oscillations of mPer1 and mCry1 messenger RNA

157 n the phase and 2- to 4-fold in amplitude of circadian oscillations of Per2, Cry1, and Bmal1 between

158 lock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved

159 The remarkably stable circadian oscillations of single cyanobacteria enable a

160 Robust circadian oscillations of the proteins PERIOD (PER) and

161 lock elements is required to maintain strong circadian oscillations of these clock-controlled outputs

162 nonlinearity is essential to simulate robust circadian oscillations of transcription in our model and

163 ative feedback strength necessary for stable circadian oscillations over a range of component concent

164 Circadian oscillations persisted when the positive feedb

165 er, the molecular mechanisms regulating this circadian oscillation remain unknown.

166 In mice, this pathway undergoes a circadian oscillation required for memory persistence th

167 , includes enzymes whose transcripts exhibit circadian oscillations, such as ornithine decarboxylase

168 nsferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core cl

169 ns in CAT3 mRNA abundance and reveals strong circadian oscillations that persist for multiple cycles

170 Unexpectedly, we unveiled normal circadian oscillations that reflect the allelic state of

171 Both models displayed circadian oscillations that were robust to parameter var

172 to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock i

173 L influences the period and the amplitude of circadian oscillations through changing model parameters

174 topologies of a simple biochemical model of circadian oscillations to ask two questions: Do differen

175 nal and cytosolic rhythms, thereby promoting circadian oscillations to integral properties of cellula

176 nts and innate immune cells tunes epithelial circadian oscillations via Nfil3, modulating lipid uptak

177 quantify the pervasiveness and plasticity of circadian oscillations, we conduct the first large-scale

178 Circadian oscillations were only obtained if time delays

179 These circadian oscillations were preceded by a rapid and tran

180 PER2::luc bioluminescence demonstrated that circadian oscillations were significantly lower in ampli

181 were found to be essential for simulation of circadian oscillations with this model.

182 ette expansion and leaf movement exhibited a circadian oscillation, with superimposed transients afte

183 results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phe