ライフサイエンスコーパス: circadian rhythm

1 liver resulted in a dysregulated pace of the circadian rhythm.

2 iasmatic nucleus excitability that underlies circadian rhythm.

3 lator that integrates energy metabolism with circadian rhythm.

4 d simplify the entrainment of cyanobacterial circadian rhythm.

5 increased, confirming that miR-433 regulates circadian rhythm.

6 % of genes in T. brucei are expressed with a circadian rhythm.

7 her the repair of 8-oxoG DNA damage follow a circadian rhythm.

8 ith altered locomotor activity and distorted circadian rhythm.

9 , the shikimate pathway, the cell cycle, and circadian rhythm.

10 role for CT-1 in the regulation of metabolic circadian rhythms.

11 ironmental parameters may exert selection on circadian rhythms.

12 (circadian locomotor output cycles kaput) in circadian rhythms.

13 e human master clock and multiple peripheral circadian rhythms.

14 yte entry and exit is governed by repetitive circadian rhythms.

15 ll RNAs, symbiosis, self-incompatibility and circadian rhythms.

16 es, including proliferation, metabolism, and circadian rhythms.

17 t is critical for the seasonal adjustment of circadian rhythms.

18 idate GPCRs, and (iii) analyse the impact on circadian rhythms.

19 provided by the day-night cycles imposed by circadian rhythms.

20 esity is associated with a disruption in GVA circadian rhythms.

21 fy a novel and conserved role for NPF/Npy in circadian rhythms.

22 r evenings is determined by the phase of our circadian rhythms.

23 m in biology, particularly in the context of circadian rhythms.

24 ulation and the role of miRNAs in Drosophila circadian rhythms.

25 onal network to generate precise system-wide circadian rhythms.

26 essive disorder is associated with disturbed circadian rhythms.

27 sticity, muscle contraction, cell cycle, and circadian rhythms.

28 horylate the period protein (PER) to produce circadian rhythms.

29 ly related paralog, Nmu, do not lose in vivo circadian rhythms.

30 uch as the cell cycle, insulin secretion and circadian rhythms.

31 antigen PASD1 fulfills this role to suppress circadian rhythms.

32 s it is not required to initiate or maintain circadian rhythms.

33 HP is necessary to coordinate metabolism and circadian rhythms.

34 vivo, capable of generating robust, tunable circadian rhythms.

35 el in blood and IGF-1 signaling demonstrates circadian rhythms.

36 nimals affects the CR induced changes in the circadian rhythms.

37 iated that insulin action is closely tied to circadian rhythms.

38 of death was used to test associations with circadian rhythms.

39 , which is involved in photic entrainment of circadian rhythms.

40 ges in photoreceptors regulated by light and circadian rhythms.

41 and school demands further impact sleep and circadian rhythms.

42 eries analyses showed that all birds exhibit circadian rhythms.

43 an ethological form of stress, on sleep and circadian rhythms.

44 ost all forms of life to generate 24-hour-or circadian-rhythms.

45 ial for the establishment and maintenance of circadian rhythms?

46 eceive either hydrocortisone or placebo in a circadian rhythm (10 mg/m(2)/d) during both dexamethason

47 We discuss sleep and circadian rhythm abnormalities that occur in ICU patient

48 knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating sever

49 lic, and behavioral processes are subject to circadian rhythms, adapting to changing light in the env

50 Cell-autonomous circadian rhythms allow organisms to temporally orchestr

51 oes not display overt symptoms of HD but has circadian rhythm alterations and molecular changes chara

52 ediator in the association between disturbed circadian rhythm and adiposity, and anticipate that acti

53 We assessed the effect of circadian rhythm and beta-blocker therapy over tradition

54 s provide insight into the interplay between circadian rhythm and cartilage in osteoarthritis.

55 lation in mouse chondrocytes abolished their circadian rhythm and caused progressive degeneration of

56 ock 2 relative to each other that followed a circadian rhythm and entrained with their expression.

57 es to regulate or modify central and hepatic circadian rhythm and host metabolic function, the latter

58 nal courtship vocalization is regulated by a circadian rhythm and potentiated by melatonin at multipl

59 wever, essential roles for regulation of the circadian rhythm and reproduction of the CNNM family hav

60 , innate immune system, sex hormones, aging, circadian rhythm and seasonal rhythms.

61 ial jetlag.The misalignment between internal circadian rhythm and the day-night cycle can be caused b

62 Melanopsin influences circadian rhythm and the pupil, but its contribution to

63 der, an illness associated with dysregulated circadian rhythms and a high incidence of suicidality.

64 rdiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice a

65 s by providing an indirect cue that entrains circadian rhythms and also by inducing a direct and rapi

66 prompt chlorophyll fluorescence, to measure circadian rhythms and demonstrated that the technique wo

67 traits and aspects of phenology, physiology, circadian rhythms and fitness.

68 college students are associated with delayed circadian rhythms and lower academic performance.

69 functions include maintaining neuroendocrine circadian rhythms and managing affective processes.

70 Myk/+ mice exhibit concomitant disruption in circadian rhythms and mood.

71 pathway plays important roles in regulating circadian rhythms and neuronal maintenance in the adult

72 verlapping and distinct roles in maintaining circadian rhythms and regulating diverse biological proc

73 SST expression in the amygdala and disrupted circadian rhythms and rhythmic peaks of anxiety in BD su

74 Disruptions of normal circadian rhythms and sleep cycles are consequences of a

75 Circadian rhythms and sleep patterns change as people ag

76 o common mechanisms underlying both YROs and circadian rhythms and suggest two interpretations: eithe

77 hat the gastrointestinal microbiota exhibits circadian rhythms and that the timing of food consumptio

78 non-image forming visual processes including circadian rhythms and the pupillary light reflex.

79 and behaviour, including the entrainment of circadian rhythms and the regulation of sleep.

80 to reduce the circadian misalignment between circadian rhythms and the times for sleep, work and meal

81 e due to a misalignment between the internal circadian rhythms and the times for sleep, work, school

82 t of activity changes significantly over the circadian rhythm, and hence the means, variances and aut

83 odor types according to age, feeding state, circadian rhythm, and mating status.

84 cal research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience.

85 regulation of hepatocellular proliferation, circadian rhythms, and lipid metabolism during liver reg

86 lar regulation, cognition, seizure activity, circadian rhythms, and neurogenesis.

87 cked negative feedback loops contributing to circadian rhythms, and three feedback loops among them d

88 Circadian rhythms are 24-h rhythms in physiology and beh

89 Circadian rhythms are a nearly universal feature of livi

90 za A virus infections are enhanced when host circadian rhythms are abolished by disrupting the key cl

91 a range of techniques, we have examined how circadian rhythms are affected in higher order pif mutan

92 Sleep and circadian rhythms are affected in many of these conditio

93 However, circadian rhythms are also observed in isolated mammalia

94 Circadian rhythms are based on endogenous clocks that al

95 Circadian rhythms are biological oscillations that sched

96 Abnormalities in sleep and circadian rhythms are central features of bipolar disord

97 Circadian rhythms are conserved across kingdoms and coor

98 Behavioral circadian rhythms are controlled by multioscillator netw

99 The neuronal populations that govern circadian rhythms are described in many animal models, a

100 Circadian rhythms are endogenously generated daily oscil

101 In mammals, circadian rhythms are essential for coordinating the tim

102 Circadian rhythms are essential for health and are frequ

103 The process of aging and circadian rhythms are intimately intertwined, but how pe

104 in circadian rhythms has been described, but circadian rhythms are measured in artificial continuous

105 not regulate qrfp expression, and entrained circadian rhythms are not required for QRFP-induced rest

106 Thus, interventions that improve circadian rhythms are prospective entry points to mitiga

107 Circadian rhythms are regulated by the suprachiasmatic n

108 Circadian rhythms are severely disrupted among the criti

109 nt for understanding and treating the modern circadian-rhythm-based disorders which are due to a misa

110 Synchrony of circadian rhythms between tissues/organs appears critica

111 Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this res

112 and brain lesions not only disrupt cellular circadian rhythms but also destroy cells and eliminate i

113 a subgroup of 16 we evaluated rest-activity circadian rhythm by actigraphy.

114 n reward systems and the impact of sleep and circadian rhythms changes on addiction vulnerability in

115 the interplay between central and peripheral circadian rhythms, circadian clock gene function, and sl

116 D), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the ba

117 Circadian rhythms control a variety of physiological pro

118 Circadian rhythms controlled by clock genes affect plasm

119 Circadian rhythms coordinate cardiovascular health via t

120 adian biology and explores how understanding circadian rhythms could lead to crop improvement.

121 Circadian rhythms date back to the origins of life, are

122 24-hour sleep-wake disorder (non-24), a rare circadian rhythm disorder caused by an inability of ligh

123 They support the novel hypothesis that circadian rhythm disorder is an environmental risk facto

124 Sleep and circadian rhythm disorders are recurrent among PD patien

125 eep Phase (FASP) and CK1epsilon(tau) genetic circadian rhythm disorders, metabolic control of PER2 st

126 have particular relevance for patients with circadian rhythm disorders, shift workers, and transmeri

127 In Arabidopsis, circadian rhythms display organ specificity but the unde

128 Circadian rhythm disruption (CRD) is suggested as a risk

129 Sleep and circadian rhythm disruption (SCRD) is a ubiquitous featu

130 Circadian rhythm disruption impairs tissue homeostasis a

131 d epidemiological data indicate that chronic circadian rhythm disruption increases the risk of metabo

132 nce and repair of cartilage and suggest that circadian rhythm disruption is a risk factor for joint d

133 ostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk fa

134 Circadian rhythms drive the temporal organization of a w

135 l processes, such as energy balance, memory, circadian rhythm, drug addiction, etc.

136 However, quantitative modulation of circadian rhythms due to artificial selection has not ye

137 rix in vivo, which contributes to a dampened circadian rhythm during ageing.

138 t that mRGC degeneration is a contributor to circadian rhythm dysfunction in AD.

139 Moreover, variables pertaining to circadian rhythm entrainment were activated more strongl

140 Plant cryptochromes regulate the circadian rhythm, flowering time, and photomorphogenesis

141 We find that the phase of the circadian rhythm follows a simple scaling law in light-d

142 Recent in vitro studies have recorded circadian rhythms from the whole embryonic SCN.

143 fferentiation, which regulates metabolic and circadian rhythm genes in peripheral tissues.

144 anthers undergoing meiosis revealed that 19 circadian rhythm genes were affected and 47 pollen-relat

145 Circadian rhythms govern multiple aspects of animal meta

146 of gene expression, and natural variation in circadian rhythms has been described, but circadian rhyt

147 Aging and circadian rhythms have been linked for decades, but thei

148 Environmental factors that upset circadian rhythms have been linked to various diseases.

149 In the skeleton, circadian rhythm helps coordinate bone formation and res

150 bolites change with host diet and may affect circadian rhythm, highlighting functional links between

151 tical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established.

152 st whether the diabetic condition alters the circadian rhythm in a mouse cornea and whether insulin c

153 studied (Clock, Bmal1, and Per2) displayed a circadian rhythm in adipose tissue of both wild-type (WT

154 How microRNAs regulate circadian rhythm in bone is unexplored.

155 regulation of a network of genes involved in circadian rhythm in both tissues and downregulation of t

156 d the challenges to measuring alterations in circadian rhythm in critical illness and review methods

157 lved in gluconeogenesis, immune response and circadian rhythm in eleuthero-embryos confirmed the obse

158 hroughout the genome that have a significant circadian rhythm in expression in the human prefrontal c

159 enone (DRS) interfere with regulation of the circadian rhythm in fish.

160 Subcutaneous AT shows an endogenous circadian rhythm in insulin sensitivity that could provi

161 Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.

162 tional transcription cycles, RBCs maintain a circadian rhythm in membrane electrophysiology through d

163 humans, CT-1 plasma profile exhibited a 24-h circadian rhythm in normal-weight but not in overweight

164 We hypothesize that miR-433 helps maintain circadian rhythm in osteoblasts by regulating sensitivit

165 nual cortex would be associated with altered circadian rhythm in patients with depression and depress

166 through Dopamine 2 Receptors to entrain the circadian rhythm in PER2::LUC bioluminescence.

167 icoids play a critical role in synchronizing circadian rhythm in peripheral tissues, and multiple mec

168 Mechanisms establishing the timing of circadian rhythms in Arabidopsis thaliana through temper

169 ter understanding of both local and systemic circadian rhythms in atherosclerosis will enhance clinic

170 Measurements of circadian rhythms in body temperature suggest a biologic

171 Here we report robust molecular circadian rhythms in C elegans recorded with a biolumine

172 EA (GI) is required to sustain Suc-dependent circadian rhythms in darkness.

173 sex of animals is an important modulator of circadian rhythms in gene expression and their response

174 fore play a role in synchronizing peripheral circadian rhythms in humans and may have particular rele

175 a neurohormone involved in the regulation of circadian rhythms in humans.

176 horylation, which provides the mechanism for circadian rhythms in IGF signaling in vivo.

177 uman adipose tissue (AT) expresses intrinsic circadian rhythms in insulin sensitivity that could cont

178 vealed that subcutaneous AT exhibited robust circadian rhythms in insulin signaling (P < 0.00001).

179 we observe reduced-amplitude oscillations of circadian rhythms in intestinal stem cells and progenito

180 we synthesize key findings from the study of circadian rhythms in later life, identify patterns of ch

181 and thereby identify features shared between circadian rhythms in mammalian cells and non-circadian t

182 Circadian rhythms in mammals are coordinated by the supr

183 rousing stimuli have the ability to regulate circadian rhythms in mammals.

184 e circadian system, can selectively uncouple circadian rhythms in metabolic physiology from the centr

185 e-wide measurements have revealed widespread circadian rhythms in metabolism governed by a cellular g

186 Circadian rhythms in metazoan eukaryotes are controlled

187 e cartilage, and environmental disruption of circadian rhythms in mice predisposes animals to OA-like

188 access successfully reestablished entrained circadian rhythms in mice with SCNX.

189 Circadian rhythms in nocturnal and diurnal mammals are p

190 tput rhythms of the s-LNvs, particularly the circadian rhythms in PDF accumulation and axonal arbor r

191 evealed by the ultrashort (<19 h) but robust circadian rhythms in Per2(Edo/Edo); Csnk1e(Tau/Tau) mice

192 Circadian rhythms in physiology and behavior are modulat

193 the SCN communicate to neurons to determine circadian rhythms in physiology and in rest activity.

194 se findings highlight an integrative role of circadian rhythms in physiology and offer a new perspect

195 tt0416/FIG1F1fig1This teaching tool explores circadian rhythms in plants.

196 Using fluorescence, we analyzed circadian rhythms in populations of wild barley (Hordeum

197 This review will focus upon the genetics of circadian rhythms in sleep and health.

198 functions including olfactory biogenesis and circadian rhythms in the CNS.

199 Here we report circadian rhythms in the intracellular concentration of

200 In contrast, a few cells show noisy circadian rhythms in the isolated E14.5 SCN and most sho

201 derstanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (n

202 ust synchronize to each other to drive these circadian rhythms in the rest of the body.

203 ink between neuronal imprinting of Ube3a and circadian rhythms in two mouse models of AS, including e

204 AL1 TAD-independent mechanism for generating circadian rhythms in vivo.

205 Defects in circadian rhythm influence physiology and behavior with

206 Remarkably, the mouse corneal circadian rhythm is also photoentrainable ex vivo, and t

207 Circadian rhythm is regulated through transcriptional an

208 In addition, natural variation in circadian rhythms is important for local adaptation.

209 Disrupting SCN circadian rhythms is sufficient to cause helplessness, b

210 tion factor that regulates genes involved in circadian rhythm maintenance and metabolism, effectively

211 HRMs affects the major cellular processes of circadian rhythm maintenance and metabolism.

212 beta in a manner consistent with its role in circadian rhythm maintenance.

213 It has been suggested that modifying circadian rhythms may be a means to manipulate crops to

214 ve a circadian component, and disruptions in circadian rhythms may even trigger the development of th

215 Such regulation suggests that circadian rhythms may have an effect on disease onset, p

216 ot alter actigraphic sleep parameters before circadian rhythm measurement.

217 Circadian rhythms mediated by both central and tissue-sp

218 Articles relevant to circadian rhythms, melatonin, and light in the criticall

219 Circadian rhythms, metabolism, and nutrition are intimat

220 Circadian rhythms modulate many aspects of physiology.

221 meostatic sleep drive takes longer to build, circadian rhythms naturally become delayed, and sensitiv

222 ral light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biologic

223 ere fully consistent with the well-described circadian rhythm negative/positive feedback loops.

224 Network dynamics regulate cell division, circadian rhythms, nerve impulses and chemotaxis, and gu

225 Dose-dependent alterations in the circadian rhythm network were also observed in F1 eleuth

226 Transcriptional alterations of the circadian rhythm network were correlated with those in t

227 Significant alterations of the circadian rhythm network were observed in the zebrafish

228 CLO also induced genes regulating the circadian rhythm, nr1d1 and per1a.

229 With aging, significant changes in circadian rhythms occur, including a shift in phase towa

230 ere cold stress had pronounced effect on the circadian rhythm of a substantial proportion of genes.

231 ution of these peripheral clock genes in the circadian rhythm of blood pressure remains uncertain.

232 Conversely, Npas2 controlled the circadian rhythm of Shp expression by binding rhythmical

233 The circadian rhythm of the liver maintains glucose homeosta

234 capture how an individual deviates from the circadian rhythm of the population, and generate the wid

235 e3a(m-/p+) mice maintained relatively normal circadian rhythms of behavior and light-resetting, these

236 lamus has an essential role in orchestrating circadian rhythms of behaviour and physiology.

237 In the laboratory, C. finmarchicus shows circadian rhythms of DVM, metabolism, and most core circ

238 set of 235 genes (q < 0.05) with significant circadian rhythms of expression.

239 Circadian rhythms of gene expression are generated by th

240 ted in the control of cell dimensions and of circadian rhythms of gene expression in the model cyanob

241 d both isoforms contribute to phase-shifting circadian rhythms of locomotor behavior and light-mediat

242 orophyll fluorescence techniques to describe circadian rhythms of PSII operating efficiency (Fq'/Fm')

243 hat the expression of PIF4 target genes show circadian rhythms of thermosensitivity, with minimum res

244 Although circadian rhythms of Vo2 were conserved in young lean CT

245 se of this study was to define the impact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in

246 Circadian rhythms optimize physiology and behavior to th

247 taract surgery does not adversely affect the circadian rhythm or sleep.

248 and candidate genes that might modulate core circadian rhythms or light-sensing pathways.

249 iting responses, such as the (re-)setting of circadian rhythms or magnetoreception; however, electron

250 SDS reduced stress effects on both sleep and circadian rhythms, or hastened their recovery, and atten

251 Circadian rhythms organize many aspects of cell biology

252 Here, we found that the amplitudes of circadian rhythm oscillation in kidneys significantly in

253 nvolving angiogenesis, extracellular-matrix, circadian-rhythm, oxidative stress, and hypoxia, whereas

254 t in mouse calvaria, miR-433 displays robust circadian rhythm, peaking just after dark.

255 tudy human circadian disorders with unstable circadian rhythm phases.

256 Circadian rhythms play an influential role in nearly all

257 Disrupted or misaligned circadian rhythms promote multiple pathologies including

258 Disruption of circadian rhythms, provoked by artificial lighting at ni

259 ing activities such as photic entrainment of circadian rhythms, pupillary light reflexes, etc.

260 bsence of FRQ A known mutation that disrupts circadian rhythms (R806H) resides in a positively charge

261 Circadian rhythms regulate key biological processes and

262 f biobehavioural markers: sleep and wake and circadian rhythm regulation and the behavioural activati

263 1, which is involved in learning, memory and circadian rhythm regulation.

264 titude of mechanisms, including through host circadian rhythm regulation.

265 CSDS also altered mRNA levels of the circadian rhythm-related gene mPer2 within brain areas t

266 The molecular clock underlying mammalian circadian rhythms relies on the rhythmic expression and

267 The differences in circadian rhythms remaining today are relevant for under

268 within distinct neural networks that control circadian rhythms, reproduction, and vocalization, which

269 ationships between behavioural and molecular circadian rhythms requires simultaneous longitudinal obs

270 Also numerous genes lacking circadian rhythm responded to the cold by undergoing up-

271 l and intervention studies of the effects of circadian-rhythm-restoring factors on medical outcomes,

272 eview of circadian arrhythmia and the use of circadian-rhythm-restoring interventions among the criti

273 rimitive, yet fundamental functions, such as circadian rhythms, reward, aggression, anxiety, and fear

274 Diagnosis and treatment of circadian rhythm sleep-wake disorders both require asses

275 ts express behavioural deficits including in circadian rhythms, sleep, anxiety and learning/memory.

276 ysiological functions and behaviors, such as circadian rhythms, sleep-wake activities, and developmen

277 design of interventions to prevent and treat circadian rhythm-sleep disorders and social jet-lag.

278 Together, our data suggest that circadian rhythm stability is pivotal for the maintenanc

279 lex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengthen the circadian pe

280 These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes required f

281 nucleus (SCN) of the hypothalamus to entrain circadian rhythms that are generated within the SCN.

282 atory behaviors from calcium oscillations to circadian rhythms that recur daily.

283 roduces progressive alterations in sleep and circadian rhythms that resemble features of depression a

284 Use of endpoints, such as sleep and circadian rhythm, that are homologous across species wil

285 nal key element involved in maintaining host circadian rhythms, the gut microbiome.

286 tion of its complex varied with time of day (circadian rhythm)-this regulation required NR1D1.

287 temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-

288 By measuring the response of the circadian rhythm to dark pulses of varying lengths, we c

289 iods, suggesting that humans selected slower circadian rhythms to adapt the cultivated species to the

290 Animals use circadian rhythms to anticipate daily environmental chan

291 y investigating a possible mechanism linking circadian rhythms to metabolism.

292 w whether the transcriptional alterations in circadian rhythm translate into physiological effects.

293 ourtship vocalization exhibits an endogenous circadian rhythm under constant dark conditions that is

294 The similar circadian rhythm was also observed in aged wild type mic

295 ficient in Per1 and Per2 genes (thus lacking circadian rhythms), we artificially generate PER2 rhythm

296 No circadian rhythms were detected in visceral AT (P = 0.64

297 pecific Bmal1-knockdown (SCN-Bmal1-KD) mice, circadian rhythms were greatly attenuated in the SCN, wh

298 After each meal schedule, participants' circadian rhythms were measured in a 37-hr constant rout

299 ange of metabolic pathways are controlled by circadian rhythms whose oscillation is affected by nutri

300 Circadian rhythms with an endogenous period close to or