ライフサイエンスコーパス: circuit

1 wed atypical functional connectivity in this circuit.

2 or modulation of neural variability in this circuit.

3 tools to identify generic properties of the circuit.

4 key components of a LC-noradrenergic arousal circuit.

5 mygdala (BLA) is a key structure of the fear circuit.

6 arborization, or functional diversity of the circuit.

7 de a molecular identifier of the CO2 arousal circuit.

8 link epigenetic organization to a metabolic circuit.

9 ce choices within the GABAergic motor neuron circuit.

10 m by allowing lithium the access to external circuit.

11 for the operation of the circadian pacemaker circuit.

12 adjustment in a brainstem sound localization circuit.

13 for processing emotion, may be part of this circuit.

14 of INO1 via the Opi1p/Ino2p-Ino4p regulatory circuit.

15 sis that tACS engages endogenous oscillatory circuits.

16 nput from the periphery to mesolimbic reward circuits.

17 in number, exert powerful control over brain circuits.

18 compensatory and independent action of these circuits.

19 can be applied to the study of other neural circuits.

20 cations of synaptic strength within neuronal circuits.

21 ide cloud that covers the receptor-expressed circuits.

22 nd construct complex DNA strand displacement circuits.

23 g the packing density of photonic integrated circuits.

24 y be the reconfiguration of functional brain circuits.

25 tion of fully functional photonic-integrated circuits.

26 emodeling of aberrant glutamatergic neuronal circuits.

27 r and molecular reorganization of its neural circuits.

28 cal layer, and became integrated in cortical circuits.

29 s populations of projection neurons in brain circuits.

30 nd predict the behaviours of engineered gene circuits.

31 naptic potentiation in prefrontal excitatory circuits.

32 molecule activation from two independent DNA circuits.

33 e recurrent excitatory connections of the L4 circuits.

34 itical to the formation of functional neural circuits.

35 he readout chains of superconducting quantum circuits.

36 sing, neuromorphic function, and specialized circuits.

37 ircumstances and serve to reconfigure neural circuits.

38 as Arduino-based optical and thermal control circuits.

39 ue to diversity in the underlying functional circuits.

40 ute to the developmental function of network circuits.

41 experience-dependent plasticity shapes such circuits.

42 sensitivity mediated by the intact cortical circuits.

43 vel of synaptic plasticity rules, cells, and circuits.

44 or similar exploration of other gap junction circuits.

45 L/min, n = 49; 250 mL/min, n = 47) using 462 circuits (245 run at 150 mL/min and 217 run at 250 mL/mi

46 to T1 --> S0 conversion dynamics that short-circuit a microseconds time scale triplet lifetime.

47 Mapping neural circuits across defined synapses is essential for unders

48 The sensorimotor circuits activated by twitching limbs, and the developme

49 the effect of PS and ES on mesocorticolimbic circuit activation, VTA gene expression, and morphine in

50 els, yet how these phenomena affect cortical circuit activity remains unclear.

51 nformation from the CSF to underlying neural circuits along the ventral midline.

52 Besides the rewiring of excitatory circuits, an abnormal depolarizing gamma-aminobutyric ac

53 Here, using optogenetic circuit analysis and cell type-specific deep-brain recor

54 Here we examined the circuit anatomy of zebra finch HVC, a cortical region th

55 ptions for gene delivery experiments to test circuit and behavioral hypotheses using a variety of man

56 Circuit and patient data were collected until each circu

57 r are abstracted as faults in the equivalent circuit and the Boolean circuit model is then used to de

58 f synapses to spike patterns in a neuron and circuit and which is vulnerable to impairments in neurop

59 ry and inhibitory inputs in healthy cortical circuits and discuss how shifts in excitation/inhibition

60 l for understanding the properties of neural circuits and how they generate behaviors.

61 avelength optical components in nano-optical circuits and metasurfaces.

62 CE STATEMENT The proper development of brain circuits and neural response properties depends on both

63 e a correspondence between biological neural circuits and optimization in structured architectures, a

64 Low modulus, compliant systems of sensors, circuits and radios designed to intimately interface wit

65 tribute to this process; however, the neural circuits and synaptic mechanisms by which distinct popul

66 cilitating the understanding of natural gene circuits and the design of cell-based therapeutic strate

67 The uncovered neural circuits and their molecular and cellular targets offer

68 rd Tessellation Language) format, electronic circuits and wiring diagrams as well as software code.

69 s comparable in complexity to their inspired circuits and yield information not easily obtainable wit

70 rge numbers of neurons across multiple local circuits and, importantly, allow stable tracking of the

71 understand GxEs on the molecular, cellular, circuit, and behavioral level and link this interaction

72 type that is critical for the brain's reward circuit, and how Delta(9)-tetrahydrocannabinol occludes

73 gations into the interactions between genes, circuits, and computation.

74 Here, we describe the circuit architecture of the visual system of Drosophila

75 tic input, its precise relationship to local circuit architecture remains unclear.

76 How cortical circuits are altered and contribute to the intense sensa

77 ns unknown whether brainstem pain-modulation circuits are altered in individuals with chronic pain.

78 ts requires identifying how neurons in those circuits are connected to one another.

79 During subsequent adolescence, mPFC-BLA circuits are further modified by excitatory synaptic str

80 Cortico-basal ganglia circuits are thought to mediate goal-directed learning b

81 rience-dependent changes in brain inhibitory circuits are thought to play a key role during the "crit

82 ns of our findings for engineering synthetic circuits are: (i) sRNAs can potentially bind nascent mRN

83 Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory, percepti

84 ximizes the contribution of spinal locomotor circuits as well as remnant supraspinal inputs.

85 nity that ensure the proper wiring of neural circuits, as well as windows of vulnerability when abnor

86 imulate the "gut-brain axis" to alter neural circuits, autonomic function, and higher-order brain fun

87 capacity that are distributed into different circuits based on birth timing.

88 re we use an integrated photonic chip with a circuit-based approach to simulate the dynamics of a spi

89 egulation and explore potential cellular and circuit-based mechanisms for brain region-dependent alte

90 nput-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired act

91 can activate and potentially sculpt subplate circuits before permanent thalamocortical circuits to la

92 ent Assay (eELISA), using a Lab-on-a-Printed Circuit Board (LoPCB) approach, for TB diagnosis based o

93 th a lab-built low-cost miniaturized printed circuit board (PCB) to provide an electrical connection

94 S4s' compatibility with the standard printed circuit board assembly processes, a variety of commercia

95 However, to date, circuits built with carbon nanotubes have overlooked key

96 g visually identified cells in intact neural circuits, but it requires skill to perform.

97 lls (engram cells) by a common set of neural circuits, but this hypothesis has not been established.

98 s to functional connectivity within premotor circuits, but whether the specificity of learning depend

99 that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensi

100 lysis of the plasticity of developing neural circuits by showing that sensory experience during devel

101 tem (GFS), a simple escape response neuronal circuit, by increasing targeting of the gap junctional p

102 A key insight is that high-performing circuits can be engineered in the absence of intensive p

103 e brain can remove one sensory signal from a circuit carrying multiple related signals.

104 t and patient data were collected until each circuit clotted or was ceased electively for nonclotting

105 were associated with a reduced likelihood of circuit clotting.

106 DA subpopulations to assess: (1) whether the circuit connecting amygdala, CEA, and DA cells follows C

107 We developed a computational model of spinal circuits consisting of four rhythm generators coupled by

108 Determining how complex neural circuits control behavior is a major challenge that is o

109 and within these two ends, specific neuronal circuits control the actual rhythmic pattern of movement

110 GLP-1)-mediated paraventricular hypothalamic circuit coordinating the global stress response.

111 nge between 450 and 800 nm, and a high short-circuit current density (J SC ) of 17.92 mA cm(-2) .

112 higher values in open-circuit voltage, short-circuit current density, fill factor, and thereby much h

113 al pressure increased 5-HT release and short-circuit current via submucosal 5-HT3 and 5-HT4 receptors

114 e that Hoxb8 mutants contain corticostriatal circuit defects.

115 the sky-compass pathway, a visual navigation circuit described in other insects.

116 characterized the core molecular circuitry, circuit design and spatiotemporal dynamics.

117 for III-nitride based waveguide and photonic circuit design applications.

118 ion is a key control parameter for synthetic circuit design.

119 ial constraints for future molecular control circuit designs.

120 h regulation is coordinated to ensure proper circuit development is not known.

121 n behavioral output, and that Lef1 regulates circuit development that is fundamentally important for

122 our study reveals the basic principles and a circuit diagram enabling speed modulation by mechanosens

123 ng this approach to yeast, we identified the circuit dominating cell cycle timing.

124 that neural correlations increase across the circuit driving song variability, in agreement with the

125 sterior putamen and other areas of the motor circuit during tapping in TD patients, but not in PIGD p

126 it is crucial for the refinement of neuronal circuits during development.

127 Excitation of left sensorimotor circuits, during an adaptive cognitive state, can unmask

128 These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making

129 the sample, and pave the way for an on-chip circuit element of practical the zero-field microwave ci

130 Synthetic circuits embedded in host cells compete with cellular pr

131 Neuroendocrine circuits encode environmental information via changes in

132 fferences are mediated by shifts in relative circuit excitability.

133 dia-bearing mossy fibers, finding that these circuit features uniquely contribute to enhancing GrC di

134 demonstrated that neuroadaptations in reward circuits following cocaine self-administration (SA) unde

135 tional planar nanofluidic systems with logic circuits for lab-on-a-chip applications.

136 e of multitissue interactions such as neural circuit formation and cell metastasis.

137 ing regulator, with critical roles in neural circuit formation and function.

138 ated axon plasticity contributes to neuronal circuit formation and function.

139 gene in MCs is sufficient to instruct their circuit formation from the PV MOB to the anterior MeA.

140 In the MC-specific Nrp2 knockout mice, circuit formation of Nrp2(+) MCs and odour-induced attra

141 Proper neural circuit formation requires the precise regulation of neu

142 in interneuronal connectivity and inhibitory circuit formation.

143 major projections to the mesolimbic dopamine circuit from the lateral hypothalamus and dorsal raphe n

144 r) model of social bonding, how a functional circuit from the medial prefrontal cortex to nucleus acc

145 tanding of the relationship between neuronal circuit function and symptoms of schizophrenia, and as a

146 ur results demonstrate how stress alters CA1 circuit function through the impairment of endogenous NP

147 Aergic interneurons are essential for neural circuit function, and their loss or dysfunction is impli

148 stating impact of Disc1 deficiency on neural circuit function, partly due to Kv1.1 dysregulation that

149 of RA biosynthesis by utilizing a biological circuit generated by a bifunctional retinoid oxidoreduct

150 Pairwise coupled VO2 oscillator circuits have been analyzed before for basic computing o

151 CRN designs for synchronous sequential logic circuits have been proposed and their implementation in

152 al transport in axons is critical for neural circuit health and function.

153 , there is mounting evidence of neuronal and circuit hyperexcitability in several brain regions, whic

154 E STATEMENT Engagement of neural regions and circuits important in executive cognitive function can b

155 A map of a neuronal circuit in a marine worm reveals how simple networks of

156 contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive

157 Seminal studies of the thalamocortical circuit in the visual system of the cat have been centra

158 r region, the latter through a disinhibitory circuit in V1.

159 hese data identify critical immunoregulatory circuits in B cells that may be targeted to promote long

160 istinct Rab-protein-orchestrated trafficking circuits in bladder epithelial cells (BECs) that expels

161 insights into the coordination of signaling circuits in intact cells and multicellular organisms.

162 to a disruption of cortico-thalamo-cortical circuits in schizophrenia (SZ) and bipolar disorder (BD)

163 rneurons are essential for functional neural circuits in the brain.

164 ization of the effects of oxytocin on neural circuits in the hypothalamus is needed to establish the

165 s a major role in the development of sensory circuits in the mammalian brain.

166 larity and visual acuity may engage distinct circuits in the mouse visual system.SIGNIFICANCE STATEME

167 f odorants.SIGNIFICANCE STATEMENT Inhibitory circuits in the olfactory bulb (OB) play a major role in

168 out an involvement of the cerebrocerebellar circuits in the pathophysiology of an increasing number

169 Circuits in the sensorimotor system (e.g., spinal cord)

170 Functional circuits in the visual cortex require the coordinated ac

171 sight into defects in the function of neural circuits in vivo and provide an approach for exploring t

172 disease pathology on the function of neural circuits in vivo This work describes early postnatal dev

173 manufactured organic electronic devices and circuits in vivo, leveraging the internal structure and

174 rain functions can emerge from simple neural circuits, in this case the honeybee mushroom body.

175 ighted graph networks were then converted to circuits, in which node voltages of the circuit reflecti

176 ches have been utilized to decipher neuronal circuits, including electron microscopy (EM) and light m

177 xus of a complex prolactin-responsive neural circuit, indicating that changing prolactin levels can a

178 ity-parameters that critically govern neural circuit information processing-suggesting that similar c

179 ingle-cell data analysis of a synthetic gene circuit integrated in human kidney cells.

180 A glucose-sensitive signal transduction circuit involving the mTOR complex 1 (mTORC1), HIF1alpha

181 The cerebrocerebellar circuit is a feedback circuit that bidirectionally conne

182 One such circuit is the posterior hypothalamic histamine (HA) sys

183 hus, impaired adaptation in cortical sensory circuits is a potential cause of tactile defensiveness i

184 We show that formation of these circuits is abnormal after early (postnatal day 5) remov

185 bpopulations of neurons and ultimately brain circuits is largely unknown.

186 e development and maintenance of cholinergic circuits is limited, as the factors regulating the expre

187 na (POA) array using a simple lumped coupled circuit (LCC) model.

188 t trigger abnormal sensory processing at the circuit level or abnormal behavioral responses in ASD mo

189 However, the physiological mechanisms and circuit-level alterations underlying this aberrant behav

190 an ideal brain region for investigating the circuit-level impact of temporal patterning within a lin

191 ate some aspects of excitability, as well as circuit-level mechanisms that adjust inhibition.

192 lecule-mediated inhibition as a regulator of circuit-level neuronal plasticity in the adult retina.

193 als global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of ne

194 etwork-wide, tunable, all-optical functional circuit mapping that captures supra- and subthreshold de

195 rotransmitters GABA or glutamate within this circuit markedly reduced the capacity for prolactin acti

196 ons to the excitatory/inhibitory balance and circuit maturation.

197 These studies reveal a crucial circuit mechanism by which animals adjust their dietary

198 The neural circuit mechanism underlying this selectivity is still u

199 ard, and addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic

200 networks during sleep would reveal important circuit mechanisms in memory consolidation and provide n

201 Therefore, understanding circuit mechanisms that drive behavioral dysfunction is

202 However, the neural circuit mechanisms underlying persistent neuronal encodi

203 netic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could

204 in a temporal pole-medial prefrontal cortex circuit might speak to the social-emotional functional a

205 t synaptic development of auditory brainstem circuits might be a major underlying cause of the audito

206 An electrical-circuit model is established and the graphene-sheet patt

207 ts in the equivalent circuit and the Boolean circuit model is then used to design therapies tailored

208 model, we can identify functionally relevant circuit motifs and generalize the framework to solve oth

209 In this highly modulated and oscillating circuit, neuronal structures appear to be governed by a

210 zation and refinement of spinal sensorimotor circuits occurs as supraspinal projections are integrate

211 etween neurons in the escape response neural circuit of adult flies.

212 We have identified the local circuits of a population of cells in V1 layer (L)4B that

213 ervous system (PNS) must signal to the motor circuits of the central nervous system (CNS) through a s

214 d enable powerful explorations of how neural circuits operate.

215 The discovery is that neuronal circuits operating reflexively regulate innate and adapt

216 Although some mechanisms are common across circuits, others play unconventional and circuit-specifi

217 y NCLX of calcium exchange can map to neural circuit patterning and axon guidance decisions during de

218 The mechanisms by which neural circuits perform the computations prescribed by model-ba

219 development alters nociceptive behavior and circuit physiology in Drosophila larvae.

220 ine alters the composition of functional OFC circuits, possibly indicating a broader role for neuromo

221 rochemical impedance analysis (EIS) and open-circuit potential decay transients (OCVD), which attribu

222 s adjusted by polarization to the known open-circuit potential of the solid contact in 0.1 M KCl.

223 EDX, XPS, UV-visible spectroscopy, and open-circuit potential versus time experiments to understand

224 d to circuits, in which node voltages of the circuit reflecting the vessel structures were used for n

225 In the main olfactory bulb (MOB), inhibitory circuits regulate the activity of principal cells precis

226 While central neural circuits regulating thirst have been well studied, it is

227 rugs can derail the experience-driven neural circuit remodeling process important for executive contr

228 in, is a key mechanism in synapse and neural circuit remodeling.

229 be especially important in organizing neural circuits required for developmental acquisition of meani

230 ng the computations that take place in brain circuits requires identifying how neurons in those circu

231 nding the role of this mechanism in specific circuits requires identifying the protein composition an

232 ation of complex but highly organized neural circuits requires interactions between neurons and glia.

233 uous ongoing development of dense integrated circuits requires significant advancements in nanoscale

234 ain of the PLR, changing how a simple reflex circuit responds to physically identical stimuli.

235 ration method based on network structure and circuit simulation is stable, fault tolerant and efficie

236 We discovered that the fruit fly olfactory circuit solves this problem with a variant of a computer

237 tics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermono

238 oss circuits, others play unconventional and circuit-specific roles.

239 These results show that circuit stability is controlled both through cell-autono

240 ioxetine modulates neural responses across a circuit subserving working memory in a direction opposit

241 ped with the known spatial cell types in the circuit, such as place cells and grid cells.

242 er reconsolidation can reorganize the neural circuit supporting an existing memory after that memory

243 a complete wiring diagram of a higher-order circuit supporting associative memory has not been previ

244 ained memory, so that it better reflects the circuit supporting delay fear.

245 ing process appears to reorganize the neural circuit supporting the trace-trained memory, so that it

246 ltiple lines of evidence suggest that neural circuits supporting model-based behavior are structurall

247 of oscillations in inhibitory interneuronal circuits, supporting the hypothesis that tACS engages en

248 mulating above the carrier frequency of this circuit suppressed movement.

249 LMAN, the output of a basal ganglia-related circuit that also contributes a corrective bias to the v

250 The cerebrocerebellar circuit is a feedback circuit that bidirectionally connects the neocortex and

251 ctive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropi

252 for this effect and identify a disinhibitory circuit that mediates it.

253 These findings reveal a distributed thirst circuit that motivates drinking by the common mechanism

254 ty depends on specific cortico-basal ganglia circuits that are affected by normal ageing.

255 some of the key characteristics of appetite circuits that are emerging from recent work and synthesi

256 Synthetic gene circuits that combine DNA, protein, and RNA components h

257 profound disruptions of activity in neuronal circuits that mediate awareness and cognition.

258 euronal fate specification, to produce brain circuits that mediate physiology and behavior according

259 e control of social behavior, but the neural circuits that mediate these effects remain unknown.

260 ation of deep brain stimulation (DBS) within circuits that modulate motor function.

261 Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity.

262 ed by coordinated interactions between brain circuits that regulate reinforcement and homeostatic sig

263 However, the engrams and circuits that support neocortical memory consolidation h

264 mpete with the excitonic interactions, short-circuiting the I --> II --> III sequence.

265 s functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD

266 r, unlike previous descriptions of local L4B circuits, these cells consistently projected outside CO

267 l tracer injections into various arms of the circuit through specific DA subpopulations to assess: (1

268 ults allowed each variable in the equivalent circuit to be estimated.

269 anode and go through an external electronic circuit to power devices, while ions simultaneously tran

270 vinced the US Court of Appeals for the Sixth Circuit to stay the rule, and the subsequently elected a

271 t may allow multiple, specialized processing circuits to emerge during a reversal task requiring beha

272 te circuits before permanent thalamocortical circuits to layer 4 are present, and disruption of this

273 neurons or on the connectivity within neural circuits to maintain the persistent activity.

274 metal-oxide-semiconductor (CMOS) integrated circuits to realize a high-fidelity all-electrical elect

275 pire the fabrication of these cascaded logic circuits to stimulate a transformative generation of ene

276 ndom kinetic models corresponding to a fixed circuit topology, and utilizes statistical tools to iden

277 Addressing how neural circuits underlie behavior is routinely done by measurin

278 ative behaviors, and the causal role for CeA circuits underlying appetitive behaviors is poorly under

279 Str) is an area of anatomical convergence in circuits underlying motivated behavior, but it remains u

280 ings add to a growing list of potential cell/circuit underpinnings that may underlie cognitive impair

281 ational design of strongly coupled excitonic circuits using spatially organized dye aggregates for us

282 mputational principles governing specialized circuits versus more general-purpose learning machines.

283 is proposed to involve alterations of neural circuits via synaptic dysfunction, the underlying molecu

284 er limit, but they suffer from a larger open circuit voltage (VOC ) deficit than narrower bandgap one

285 The devices exhibit a high open circuit voltage of 1.08 +/- 0.01 V, attributed to the hi

286 version-efficiency of 7.26% with a high open-circuit voltage of approximately 1 V and a striking fill

287 how the FEC condenses on the surface at open circuit voltage then is reduced to C-O containing polyme

288 IOIC2-based OSCs show higher values in open-circuit voltage, short-circuit current density, fill fac

289 s has a slightly negative impact on the open circuit voltage.

290 Net citrate uptake from the CVVH circuit was 60 +/- 2 mg/min and provided 218 +/- 8 kcal/

291 Thus prepared BioCapacitor based circuit was able to operate an ultra-low-power microcont

292 However, the performance of such logic circuits was rather poor due to the difficulty of contro

293 ker-Fuse (KF), a key area in the respiratory circuit, was examined.

294 icity in songbirds depend on a basal ganglia circuit, which actively generates vocal variability.

295 ve chronic multimodal interrogation of brain circuits with high fidelity.

296 f the LON paves the way to understanding how circuits with reduced numerical complexity control wide

297 od-based decisions are generated in a neural circuit within the orbitofrontal cortex (OFC).

298 These data suggest that D2 MSNs and specific circuits within the basal ganglia are preferentially vul

299 temporarily precise activation of deep-brain circuits without the need for surgical implantation of a

300 the components of this complex multisynaptic circuit would thus advance our understanding of the dete