ライフサイエンスコーパス: circular RNA

1 and ligates the processed ends to produce a circular RNA.

2 ets are a major source of miRNAs, YRNAs, and circular RNAs.

3 ously described cases of scrambled exons and circular RNAs.

4 ffect of doxorubicin via regulating a set of circular RNAs.

5 -state output of protein-coding genes toward circular RNAs.

6 native splicing can lead to the formation of circular RNAs.

7 able methods recently used to identify human circular RNAs.

8 genes are noncanonically spliced to produce circular RNAs.

9 uch as long non-coding RNAs, pseudogenes and circular RNAs.

10 g covalently modified RNAs, edited RNAs, and circular RNAs.

11 drug doxorubicin and their interaction with circular RNAs.

12 nerates an RNA pool consisting of lariat and circular RNAs.

13 t the first cell type-specific expression of circular RNAs-a neuron-specific and nuclear-enriched RNA

14 , including short microRNAs, long ncRNAs and circular RNAs, across various heart diseases indicates t

15 ogy, such as the functions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellu

16 e new strategy for the in vitro synthesis of circular RNAs and hairpin ribozymes is described.

17 mputational methods to discover and quantify circular RNA are essential.

18 Circular RNAs are found in a wide range of organisms and

19 In addition, the circular RNAs are found in complexes with proteins requi

20 but the underlying mechanisms by which these circular RNAs are generated are largely unknown.

21 Also, because circular RNAs are not primary substrates for exonuclease

22 eover, discovering biological contexts where circular RNAs are regulated will shed light on potential

23 verged eukaryotes, but the functions of most circular RNAs are still unknown.

24 irus (HDV) RNA, it is generally assumed that circular RNAs are the only templates.

25 y of minor spliceosome donors to splice into circular RNA at un-annotated, rather than annotated, exo

26 Our results uncover a mechanism for circular RNA biogenesis that may account for circulariza

27 in between the repeats can sometimes inhibit circular RNA biogenesis.

28 y eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown how the ratio o

29 Circular RNA (circR)-284 is a potential inhibitor of miR

30 entification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA

31 expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought

32 Circular RNA (circRNA) is a class of noncoding RNA whose

33 controls back-splicing reactions leading to circular RNA (circRNA) production.

34 2, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional

35 ing endogenous RNAs (ceRNA) including mRNAs, circular RNAs (circRNA) and long noncoding RNAs (lncRNA)

36 Circular RNAs (circRNAs) are a class of non-coding RNAs

37 Circular RNAs (circRNAs) are a newly appreciated class o

38 Recent studies have shown that circular RNAs (circRNAs) are abundant, widely expressed

39 Circular RNAs (circRNAs) are broadly expressed in eukary

40 Circular RNAs (circRNAs) are covalently closed RNA molec

41 Circular RNAs (circRNAs) are noncoding RNAs generated by

42 As circular RNAs (circRNAs) are resistant to degradation by

43 Circular RNAs (circRNAs) are single-stranded RNAs that a

44 -coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored.

45 Circular RNAs (circRNAs) have recently emerged as a larg

46 Blood, Alhasan et al report the existence of circular RNAs (circRNAs) in circulating human platelets,

47 The pervasive expression of circular RNAs (circRNAs) is a recently discovered featur

48 ecent evidence suggests that many endogenous circular RNAs (circRNAs) may play roles in biological pr

49 Circular RNAs (circRNAs) represent a class of endogenous

50 Circular RNAs (circRNAs) represent a new type of regulat

51 sized an important role for RBM20 in forming circular RNAs (circRNAs), a novel class of noncoding RNA

52 agues identify a new class of intron-derived circular RNAs (ciRNAs) and show that they have the poten

53 Particularly, the recently identified circular RNA, ciRS-7, which acts as a designated miR-7 i

54 Total RNA isolated from cells producing the circular RNA contained ribozyme activity.

55 A 48 nucleotide circular RNA containing the stem, bulge and loop of the

56 , and used a custom pipeline to characterize circular RNAs derived from coding exons.

57 We also detected approximately 250 circular RNAs derived from single or multiple exons.

58 identified regulated expression of specific circular RNAs derived from Ttn (Titin), Fhod3 (Formin ho

59 increases the sensitivity and specificity of circular RNA detection by discovering and quantifying ci

60 expression profiling revealed more than 476 circular RNAs differentially expressed in control brain

61 lic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second mes

62 for exploring the functional consequences of circular RNA expression across eukaryotes.

63 ogy to determine confidence in prediction of circular RNA expression, our algorithm uses a statistica

64 Circular RNAs generated by splicing are devoid of flanki

65 Both the small circular RNA genome and its complement, the antigenome,

66 capsid, which consists of a single-stranded, circular RNA genome complexed with delta antigen, the vi

67 Both the circular RNA genome of HDV and its complementary antigen

68 Both the circular RNA genome of HDV and its complementary antigen

69 The circular RNA genome of hepatitis delta virus (HDV) can f

70 Hepatitis delta virus (HDV) has a circular RNA genome that replicates by a double rolling-

71 Hepatitis delta virus (HDV) replicates its circular RNA genome via a rolling circle mechanism.

72 of HDV replication: (i) the 1,679-nucleotide circular RNA genome, (ii) its exact complement, the anti

73 e(s) to transcribe its 1,679-nucleotide (nt) circular RNA genome.

74 d suggests that ligation may be used to form circular RNA genomes.

75 uences, and (ii) thousands of novel intronic circular RNAs (IcircRNAs) are expressed in cells.

76 nucleotide from its helical complex with the circular RNA in an ATP-dependent reaction.

77 s suggest a potentially significant role for circular RNA in human development.

78 tion of splicing intermediates, we show that circular RNA in Schizosaccharomyces pombe is generated t

79 tudies have revealed thousands of endogenous circular RNAs in mammalian cells, some of which are high

80 le and useful strategy for the generation of circular RNAs in preparative amounts; and (iii) that sel

81 Seq), we compared the expression patterns of circular RNAs in proliferating (early-passage) and senes

82 s the branch sites confirmed lariat RNAs and circular RNAs in the pool generated by constitutive and

83 ing induction of general and tissue-specific circular RNAs, including in the heart and lung, during h

84 regulate the expression of other Drosophila circular RNAs, including Plexin A (PlexA), suggesting a

85 Moreover, inhibition of Ttn-derived circular RNA increased the susceptibility of cardiomyocy

86 harmacologically, the steady-state levels of circular RNAs increased while expression of their associ

87 Pervasive expression of circular RNA is a recently discovered feature of eukaryo

88 The pervasive expression of circular RNA is a recently discovered feature of gene ex

89 H and 2',3'-cyclic phosphate termini to form circular RNA is an essential step in the life cycle of t

90 s largely unknown how the ratio of linear to circular RNA is controlled or modulated.

91 rtex, with marked enrichment for genes where circular RNA isoforms are dominant.

92 places box C/D RNAs among the extremely few circular RNAs known to exist in nature.

93 n for its biogenesis, we found that Laccase2 circular RNA levels are not controlled by Mbl or the Lac

94 n of the cleavage/polyadenylation machinery, circular RNA levels were similarly increased.

95 ti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby expanding t

96 ingle-strand RNA to form a covalently closed circular RNA molecule through ligase-adenylylate and RNA

97 e data also demonstrate the utility of small circular RNA molecules as tools for biochemical studies.

98 CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic se

99 RNA and creates highly stable and functional circular RNA molecules.

100 epatitis delta virus (HDV), which contains a circular RNA of 1.7 kilobases, is nonetheless able to re

101 The HDV genome is a closed circular RNA of about 1,700 bases which is replicated th

102 containing minimal repeats (<40 nt) generate circular RNAs predominately after 3' end processing.

103 he first examples of developmentally induced circular RNAs processed by the minor spliceosome, and an

104 The vast majority of circular RNA production occurs at major spliceosome spli

105 ected into alternative pathways that lead to circular RNA production.

106 larization of an exon of the PVT1 gene, as a circular RNA showing markedly reduced levels in senescen

107 This was not due to an inability to cut any circular RNA, since Vhs cuts circular mRNAs containing a

108 g and long noncoding transcripts, as well as circular RNA species that were also experimentally valid

109 encing have allowed comprehensive studies of circular RNA species.

110 Mixtures of linear and circular RNAs synthesized in vitro and containing 225-11

111 Circular RNA templates were found to be at least several

112 ) is a 1,679-nucleotide (nt) single-stranded circular RNA that is predicted to fold into an unbranche

113 tis delta virus (HDV) contains a viroid-like circular RNA that is presumed to replicate via a rolling

114 tis delta virus (HDV) contains a viroid-like circular RNA that replicates via a double rolling circle

115 e non-translatable, autonomously replicating circular RNAs that infect only plants.

116 Circular RNA transcripts were first identified in the ea

117 oding species such as long noncoding RNA and circular RNA transcripts whose presence had not been pre

118 tion of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate

119 These circular RNAs were rare and stochastic, although a few b

120 Hepatitis delta virus (HDV) contains a circular RNA which encodes a single protein, hepatitis d

121 e previously characterized Muscleblind (Mbl) circular RNA, which requires the Mbl protein for its bio

122 This circular RNA with no noncoding sequences is a unique nat