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1 o resulted in Cyp19a1 suppression, decreased circulating 17beta-estradiol levels, abnormal fat accumu
3 Similarly, a possible role for the BCR or circulating Ab in mediating CTL responses to B cell-deri
5 ibited reduced fat mass, decreased levels of circulating adipokines, improved insulin sensitivity, an
7 d fatty acid synthesis-related genes and the circulating ADIPOQ protein level were lower in Brd4 hete
8 appa administration, but modest increases in circulating adrenocorticotropic hormone and cortisol wer
10 udinal associations of physical activity and circulating amino acids concentration in peripubertal gi
12 e found that the H7N8 LPAI virus most likely circulated among diving ducks in the Mississippi flyway
15 st that blood monocytes are distributed into circulating and marginating pools, but no direct evidenc
17 se cells constitute a distinct population of circulating and tissue-resident effector T cells with im
18 the development and functional maturation of circulating and tissue-resident human NK and CD8(+) T ce
19 enza season, when antigenic mismatch between circulating and vaccine influenza strains resulted in th
20 tigate the association between pre-diagnosis circulating androgens [testosterone, free testosterone,
21 lantation] 2013 grades), immunostaining, and circulating anti-HLA donor-specific antibodies at the ti
23 mal resting cell, and the mechanism by which circulating anti-PE antibodies access cellular PE remain
24 erans syndrome; however, the significance of circulating antibodies before transplant remains unclear
25 of this immunosensor, capable of identifying circulating antibodies in real time, can also be applied
26 posits in the tubular basement membrane, and circulating antibodies reactive with normal human kidney
28 It has been assumed that the majority of circulating ApoL1 is produced by the liver, but this has
29 pothesized that freely or wrapped FKRP might circulate as an extracellular glycosyltransferase, able
30 getic protons, electrons and other particles circulate at altitudes from about 500 to 40,000 kilometr
31 uran-3-carboxylic acid) is a metabolite that circulates at high concentrations in type 2 and gestatio
33 minant humoral immune responses that produce circulating autoantibodies that can be used clinically f
36 Mechanistically, CpG increased the number of circulating B cells, which produced elevated amounts of
39 pheral T cells have mostly been described to circulate between blood, secondary lymphoid organs (SLOs
41 teine treatment for paracetamol overdose had circulating biomarkers measured at hospital presentation
43 Quantification of cell-free DNA (cfDNA) in circulating blood derived from a transplanted organ is a
48 gs have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, t
49 s hypothesis shows that chronic elevation in circulating catecholamines in IUGR fetuses persistently
51 y BM fibrosis, extramedullary hematopoiesis, circulating CD34+ cells, splenomegaly, and a propensity
54 than 200 cells/muL; however, the numbers of circulating CD4+ cells in the HIV-negative (HIV-) brain-
55 ciated opportunistic infections increases as circulating CD4+ lymphocytes decrease to less than 200 c
57 er that, within heterogeneous populations of circulating CD66b(+) neutrophils present in inflammatory
59 ions could be found in an unbiased manner in circulating cell-free DNA (cfDNA) to predict treatment r
60 mor load and tissue-of-origin mapping in the circulating cell-free DNA of 59 patients with lung or co
63 naive wild-type (WT) mice, this persistently circulating CHIKV strain displayed a capacity for earlie
68 re, in addition to the direct effect of high circulating concentrations of 25-hydroxyvitamin D, local
70 and it is also unknown whether variation in circulating concentrations of PLP influences long-term o
71 ic avian influenza (HPAI) A(H5) viruses have circulated continuously in Vietnam since 2003, resulting
75 k genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweigh
76 er our data support that increased levels of circulating CXCL4 may contribute to immune dysregulation
78 -/-) mice, and transient reconstitution with circulating CXCR3-replete monocytes was sufficient to re
82 n is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and nat
84 g because of the absence of readily detected circulating disease or canonic chromosomal translocation
86 le at one location (e.g. under Indian Ocean) circulates down to the core-mantle boundary (CMB), but r
87 othalamic engagement in response to elevated circulating E2 Collectively, we will need to modify the
91 xifen and to aromatase inhibitors that lower circulating estradiol occurs in up to 50% of patients, g
94 different classes of transcripts detected, 4 circulating exosomal sequences within the miRNA category
96 ntal feature of the stress response and that circulating exosomes transporting immunomodulatory signa
97 besity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevate
101 e conclude that CD146/MCAM interactions with circulating galectin-3 may have an important influence o
103 g levels of GDF-15 and whether elevations in circulating GDF-15 are associated with decline in kidney
105 f FOXP3(+)CD39(+) Treg cell frequency within circulating gluten-specific CD4(+) T cells after oral gl
107 from the rapid spread of these mutations in circulating H1 influenza viruses that the previously sub
108 d breast cancer in animal models, and higher circulating hCG concentrations were associated with sign
110 that lipoproteins including brain (apoE) and circulating (high-density lipoprotein, HDL) synergize to
111 epublic of the Congo (DRC) is a reservoir of circulating HIV strains exhibiting high levels of divers
112 iological outcomes to be achieved with lower circulating hormone levels than pharmacological means du
116 obust map of immune-related gene networks in circulating human cells, their interactions with metabol
117 rom both these ancestral viruses and current circulating human seasonal H3N2 strains in terms of thei
118 cent research has identified the presence of circulating IFX-specific T cells in treated patients.
119 atus, and both correlated with birth weight, circulating IGF-I, and total and abdominal fat at age 2
120 the simultaneous binding of IgG, and reduces circulating IgG levels in preclinical animal models.
123 ld be used to predict relative abundances of circulating immune cell populations that matched traditi
126 have peripheral nerve involvement, an intact circulating immunoglobulin, and lower circulating dFLC.
127 aureus toxins and virulence proteases often circulate in host blood vessels leading to life-threaten
128 CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for
133 ting in Triaenops bats and 229E-like viruses circulating in Hipposideros bats, with the breakpoint lo
135 3 is a recombinant between NL63-like viruses circulating in Triaenops bats and 229E-like viruses circ
136 bda are immunoglobulin constituents but also circulate independently in blood as free light chains.
138 DSC), which expand during states of elevated circulating inflammatory cytokines, may link the systemi
139 uble mutation, 93/244) that are not found in circulating influenza virus strains or have not been pre
140 n and formed larger tumors in mice with high circulating LDL-C concentrations than in mice with lower
142 t mice showed impaired glucose tolerance and circulating leptin, GLP-1, and insulin levels were reduc
143 nscriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gra
144 ation as potential biomarkers inasmuch their circulating levels are increased in metabolic syndrome p
146 ase dUTP nick-end labeling (TUNEL) staining, circulating levels of alanine aminotransferase and lacta
149 alcitriol (1,25-dihydroxyvitamin D) and high circulating levels of calcidiol (25-hydroxyvitamin D) ea
150 i-IFN-gamma antibody significantly decreased circulating levels of CXCL9, CXCL10, and downstream proi
153 sue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in c
154 ature, enhanced insulin sensitivity, and low circulating levels of insulin and insulin-like growth fa
155 HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type n
156 rove these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age.
158 ts with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and s
162 diate and nonclassical monocytes have longer circulating lifespans ( approximately 4 and approximatel
163 two phases, and conclude that the currently circulating lineages are the result of evolution in diff
165 tify sortilin-1(Sort1), a known regulator of circulating low-density lipoprotein levels in humans, as
166 giectasia mutated (pATM), were quantified in circulating lymphocytes in operators during the peri-ope
168 dhesive interactions with E-selectin than do circulating lymphocytes, which exhibit variable E-select
169 hatic endothelial-specific manner, creates a circulating lymphopenia and a higher percentage of effec
170 es in concentration of C-reactive protein, a circulating marker of inflammation, have been reported t
173 Here we systematically examine the fluxes of circulating metabolites in mice, and find that lactate c
174 rum retinol concentration is associated with circulating metabolites in various metabolic pathways, p
175 .Sodium intake is associated with changes in circulating metabolites, including gut microbial, trypto
176 Suppression of Erdr1 depends on detection of circulating microbial products by Toll-like receptors on
177 ersely, Par4-deleted mice, which had reduced circulating microparticles (MPs), supported accelerated
178 hial artery flow-mediated dilation (FMD) and circulating microparticles before and after 20 minutes o
182 ablishes the possibility that the pattern of circulating miRNAs may identify recurrence prior to radi
183 sed CPB duration yielded in higher levels of circulating mitochondrial (mt)DNA, soluble thrombomoduli
185 ature, characterized by increased numbers of circulating monocytes and dendritic cells that produce m
186 acrophage apoptosis and decreased ingress of circulating monocytes into the joint are responsible for
188 d monocytopenia was observed; restoration of circulating monocytes was achieved by the early release
189 n 1beta, and tumor necrosis factor alpha) in circulating monocytes, pulmonary arterial endothelial ce
190 sed the origin, concentration and content of circulating MPs from 33 individuals: 11 with T2D and acu
191 1 ECs to MPs shed from senescent P3 cells or circulating MPs from ACS patients induced increased sene
194 rived from self-report of dietary intake and circulating n-3 (omega-3) polyunsaturated fatty acids] a
195 nt findings on biological characteristics of circulating ncRNAs and highlight their value as potentia
196 participants had a median absolute number of circulating neoplastic cells of 4.6 (IQR 2-12) cells per
197 ed systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b express
198 s post-myocardial infarction, with increased circulating neutrophils and platelets, consistent with i
200 vation at HA that was evidenced by increased circulating noradrenaline concentration had little effec
201 se wave velocity and augmentation index, (4) circulating NT-proBNP (N-terminal pro-B-type natriuretic
205 significantly attenuated nor were a host of circulating or intra-alveolar inflammatory cytokines.
207 that binds to both P. berghei and clinically circulating P. falciparum from malaria endemic areas in
209 understood, although it is established that circulating pathogenic natural IgM, which is primarily p
211 essed the relationship between the number of circulating PCs and the pathogenesis and severity of HF
213 rmacodynamic substudy from 4 phase 2 trials, circulating PCSK9 levels were measured at baseline and t
215 unctional CD8alphaalpha T cells are found to circulate peripherally, as well as reside within the lym
216 onclusion, this follow-up study demonstrated circulating plasma exosomal miR-125a-3p is readily acces
218 Systematic profiling of a larger portion of circulating plasma proteins (the plasma proteome) will p
219 APP-KO mice presented a higher number of circulating platelet-leukocyte aggregates, and neutrophi
221 m outcome.We compared vitamin B-6 intake and circulating PLP concentrations of RTRs with those of hea
223 ecreased regenerative capacity, both LTL and circulating progenitor cell levels are independent and a
228 (SE-iFISH), to detect a variety of aneuploid circulating rare cells (CRCs), including CTCs and circul
230 ipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP4
231 ed to a widely held hypothesis that elevated circulating RBP4 is a direct result of increased product
233 (43.02%), but 7 other subtypes (33.14%), 20 circulating recombinant forms (CRFs; 11.63%), and 20 unc
234 eatment gradually repopulated the numbers of circulating regulatory T cells within the first 7 days a
238 tood; however, chronic exposure to excessive circulating serotonin is considered one of the most impo
242 r study shows that the resulting increase in circulating sTie2 is unlikely to affect Angpt1 activity
243 Interestingly, CRF01_AE is the predominant circulating strain in Thailand, where the RV144 trial to
244 ctively capturing the diversity of currently circulating strains and addressing properties of variant
246 lation between H3N2 egg-adapted vaccines and circulating strains likely contributed to reduced vaccin
249 In contrast, activated ICOS(hi) PD-1(hi) circulating T follicular helper (Tfh) cells decreased af
250 used profiling of a mechanistically relevant circulating T-cell subpopulation calibrated to pretreatm
253 requency of CXCR5(+)PD-1(+)ICOS(+)-activated circulating Tfh cells is increased both in children with
254 h a missense variant in APOC3 causes reduced circulating TG levels and, hence, protects from CHD.
255 to TB disease could be related to a loss of circulating Th1* CD4(+) T cells rather than major change
256 maturation step to mature naive T cells that circulate through secondary lymphoid organs ready to be
258 gut, increases of the activated B cells and circulating tissue-like memory B cells, and expansion of
259 re summarized in a policy statement that was circulated to the steering committee and revised multipl
260 h groups improved dyslipidemia, with reduced circulating triglycerides, but showed differential respo
263 ored, using individual patient data, week 13 circulating tumor cell (CTC) and prostate-specific antig
264 linical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate m
265 hange in prostate-specific antigen level and circulating tumor cell count (r = 0.63 [95% CI: 0.27, 0.
268 arly detection of metastasis can be aided by circulating tumor cells (CTC), which also show potential
270 en receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells (CTCs) correlated with poor outc
272 e examined copy-number aberrations (CNAs) in circulating tumor cells (CTCs) from pretreatment SCLC bl
273 lterations in single primary tumor cells and circulating tumor cells (CTCs) from the same patient.
276 are often easily accessible in the blood as circulating tumor cells (CTCs), making them ideal target
279 rous devices developed to isolate individual circulating tumor cells from blood, these devices are in
280 n and on-chip phenotypic characterization of circulating tumor cells from peripheral venous blood in
281 In some applications (e.g., working with circulating tumor cells in blood), only a limited number
282 it of reducing tumor size, PTX increased the circulating tumor cells in the blood and enhanced the me
283 ug assays with patient-derived cells such as circulating tumor cells requires manipulating small samp
284 nd to move collectively, forming clusters of circulating tumor cells that are key tumor-initiating ag
285 s of tumor spread were measured serially and circulating tumor cells were detected via fluorescence m
288 nd noninvasive molecular detection relies on circulating tumor DNA (ctDNA) shed from tumor deposits i
291 a trial evaluating the role of pretreatment circulating tumor markers as predictors of prognosis in
296 amin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.This stud
297 ndance of vitamin D metabolic components and circulating vitamin D metabolites [i.e., LDL-related pro
298 tabolism and its role in modulating maternal circulating vitamin D metabolites during pregnancy.Neste
300 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL-40 levels at 4 years of age were tested
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