ライフサイエンスコーパス: circulating level of

1 Circulating levels of 111 biomarkers were analyzed for a

2 Higher circulating levels of 22:1 and 24:1, with apparently div

3 t of Cyp2r1 and Cyp27a1 maintained a similar circulating level of 25-hydroxyvitamin D3 and 1alpha,25-

4 We evaluated the relationship between the circulating levels of 25(OH)D and acute cellular rejecti

5 Circulating levels of 25(OH)D in children and adolescent

6 Type 1 diabetic patients have lower circulating levels of 25(OH)D than similarly aged subjec

7 Vitamin D deficiency (circulating levels of 25[OH]D </=20 ng/mL, defined using

8 oxygen-sensing pathways, are associated with circulating levels of 4 fatty acids in the de novo lipog

9 We found differences in circulating levels of 43 proteins involved in the acute-

10 We determined the circulating levels of 7 selected candidate miRNAs in 14

11 of Strongyloides infection, we measured the circulating levels of a large panel of pro- and anti-inf

12 Circulating levels of a soluble type I IFNR are elevated

13 ainst hAAT (AAT-ASO) and found reductions in circulating levels of AAT and both soluble and aggregate

14 on studies and the peripheral measurement of circulating levels of acute phase proteins have focused

15 We studied circulating levels of acyl and desacyl ghrelin in rats a

16 m of this study is to evaluate the local and circulating levels of adipocytokines (resistin, adiponec

17 obese persons could be the result of altered circulating levels of adipokines, polypeptide hormones w

18 ty or gestational diabetes mellitus have low circulating levels of adiponectin (ADN) and frequently d

19 ers of adipose tissue macrophages, increased circulating levels of adiponectin and preserved glucose

20 Increased circulating levels of adiponectin are associated with im

21 oma risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals.

22 such as 19 might also be useful to increase circulating levels of adult stem cells, thereby exerting

23 In individuals with MS, the circulating levels of AHR agonists were decreased.

24 ase dUTP nick-end labeling (TUNEL) staining, circulating levels of alanine aminotransferase and lacta

25 p.Glu167Lys was also associated with higher circulating levels of alanine transaminase, a marker of

26 However, elevated circulating levels of amylin may also lead to amylin acc

27 es from our laboratory showing that elevated circulating levels of AngII during hypertension result i

28 ercise arm (N = 117), or control (N = 87) on circulating levels of angiogenic biomarkers.

29 termediates in the LNG, as well as unaltered circulating levels of APAP, APAP-GSH, APAP-glucuronide,

30 han levels in noncarriers (P<1x10(-20)), and circulating levels of APOC3 in carriers were 46% lower t

31 Circulating levels of arginine vasopressin (AVP) are ele

32 viable target for therapies aiming to reduce circulating levels of atherogenic apoB lipoproteins.

33 al FGF1 expression was associated with lower circulating levels of atrial and brain natriuretic pepti

34 the BA sequestrant colestipol, which lowered circulating levels of BAs, prevented exacerbated spontan

35 In humans, circulating levels of BDNF decline with advancing age, a

36 s evaluating the relation between dietary or circulating level of beta-carotene and risk of total mor

37 occurs on human fetal cardiomyocytes; and 2) circulating levels of beta(2)GPI influence injury in ant

38 rtrophy, augmented by direct effects of high circulating levels of bile acids.

39 ATX with disorders associated with increased circulating levels of bile salts.

40 A biomarker risk score (BRS) based on the circulating levels of biomarkers C-reactive protein, fib

41 Circulating levels of bone-derived fibroblast growth fac

42 release of miRNAs into the bloodstream: the circulating levels of both cardiac- and non-cardiac-spec

43 production of IL-1beta and IL-18 and higher circulating levels of both cytokines.

44 Circulating levels of both miRNAs were similar among hea

45 Circulating levels of both seasonal and pandemic influen

46 genesis were elicited using doses that yield circulating levels of BPA analogous to those reported in

47 e vervet monkeys for 4 weeks continuously to circulating levels of BPA that were in the range measure

48 PA from multiple sources and has significant circulating levels of BPA.

49 , reduced ejection fraction, and an elevated circulating level of brain natriuretic peptide or N-term

50 Genetically elevated circulating levels of C-reactive protein (CRP), interleu

51 g an apparent fold increase of >10(6) in the circulating levels of C24 bile acids and C27 bile alcoho

52 alcitriol (1,25-dihydroxyvitamin D) and high circulating levels of calcidiol (25-hydroxyvitamin D) ea

53 at a high-fat diet selectively increases the circulating levels of CD11b(+) monocytes in wild-type mi

54 hepatocytes reduced by approximately 50% the circulating levels of cleaved ANGPTL3, while the lack of

55 We found no difference in the circulating levels of Clusterin in late-stage prion dise

56 al metabolism of cocaine, rapidly decreasing circulating levels of cocaine and norcocaine while incre

57 netic loci and biomarker-coding genes affect circulating levels of COPD-related pneumoproteins.

58 iemann-Pick C1-like 1 protein decreased when circulating levels of CORT increased.

59 ization increased anxiety-like behaviors and circulating levels of corticosterone, a stress hormone,

60 we also evaluated survival by prediagnostic circulating levels of cotinine, a metabolite of nicotine

61 keletal muscle that could cause increases in circulating levels of cTnT.

62 Here, we show that circulating levels of CTRP1 are strikingly reduced in di

63 A modest rise in circulating levels of CTRP12 by recombinant protein admi

64 The mRNA and circulating levels of CTRP12 were decreased in a mouse m

65 We show that circulating levels of CTRP3 are inversely correlated wit

66 i-IFN-gamma antibody significantly decreased circulating levels of CXCL9, CXCL10, and downstream proi

67 se in cerebral malaria involves elevation of circulating levels of cytokines and chemokines associate

68 palmitoylethanolamide content and normalized circulating levels of cytokines and immunoglobulin E.

69 ancer Screening Trial to investigate whether circulating levels of cytokines and other immune markers

70 y arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients

71 y, we observed a significant increase in the circulating levels of dendritic cells (DCs; CD11c(+)CD11

72 Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inh

73 Circulating levels of docosahexaenoic acid (DHA) were al

74 Whether circulating levels of each are associated with cardiovas

75 may in part or wholly explain the increased circulating levels of endocannabinoids reported after co

76 Circulating levels of endothelin (ET)-1 and endogenous E

77 Circulating levels of endotoxin in plasma from patients

78 CAP exposure decreased circulating levels of EPCs independent of apoptosis whil

79 r/day) for 4-30 days progressively decreased circulating levels of EPCs positive for both Flk-1 and S

80 chanism by which PM(2.5) exposure suppresses circulating levels of EPCs.

81 Circulating levels of exosomes are associated with the o

82 p between myocardial expression of miR-1 and circulating levels of FABP3 was found both in vitro and

83 enzyme, and limited studies suggest that the circulating level of FAP correlates with the degree of t

84 We also demonstrated that circulating levels of FGF2 were associated with non-mela

85 Decreased hepatic and circulating levels of FGF21 in fasted SIRT1 LKO mice wer

86 es not support a causal relationship between circulating levels of fibrinogen and coronary artery dis

87 notypes available in FHS (Alzheimer disease, circulating levels of fibrinogen, high-density lipoprote

88 Most importantly, dysregulation of circulating levels of fibrinogen, protein C activity, an

89 An increased circulating level of fibroblast growth factor 23 (FGF23)

90 Circulating levels of fibroblast growth factor (FGF)21 i

91 ctivation also raised hepatic expression and circulating levels of fibroblast growth factor 21 (FGF21

92 Circulating levels of fibroblast growth factor 21, a nov

93 Circulating levels of fibroblast growth factor 23 (FGF23

94 -free period led to complete recovery of the circulating levels of Flk-1(+)/Sca-1(+) cells.

95 (+/+)-STZ mice, which encompass increased 1) circulating levels of free fatty acid, ketone bodies, an

96 ing in both HFD-FBX groups and decreased the circulating levels of free fatty acids and triglycerides

97 As expected from the enhanced fat oxidation, circulating levels of free fatty acids were reduced in t

98 recombinant myonectin administration reduced circulating levels of free fatty acids without altering

99 HIV-infected patients had increased circulating levels of functional CD8(+)CD28(-)CD127(lo)C

100 SR-AI-deficient mice, which exhibit reduced circulating levels of FX in vivo and loss of FX-macropha

101 These data suggest that circulating levels of gamma'-Fg modulate the susceptibil

102 sue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in c

103 We validated our previous finding that circulating levels of GDF11/8 decline with age in mice,

104 the Vasculature in Uppsala Seniors (PIVUS), circulating levels of ghrelin and leptin were measured a

105 glucose-lowering properties, and an elevated circulating level of GLP-1 is a known characteristic of

106 Given a normally basal circulating level of GLP-1, knowledge of mechanisms regu

107 Additionally, circulating levels of glucocorticoids equivalent to thos

108 ndent of changes in pancreatic hormones, and circulating levels of glucose and free fatty acids.

109 e set out to investigate the hypothesis that circulating levels of glucose, the primary fuel source f

110 ts with this condition show highly increased circulating levels of GM-CSF, which is also locally expr

111 These effects occurred without increases in circulating levels of growth hormone and insulin-like gr

112 olymorphisms in 7 novel loci associated with circulating levels of >/=1 of these fatty acids.

113 abetes in rats resulted in a decrease in the circulating level of H(2)S; replacement of H(2)S protect

114 appeared to modify the relationship between circulating levels of HDM-IgE and HR: a significant posi

115 sponse was associated with a 34% decrease in circulating levels of hepcidin within 24 hours of vitami

116 homozygosity, likely through an increase of circulating levels of hepcidin.

117 Circulating levels of high-mobility group box 1 (HMGB1)

118 n was measured (Illumina 450K BeadChip), and circulating levels of hs-CRP and IL-18 were assessed in

119 The epileptic rats showed circulating levels of Hsp60 higher than controls.

120 We also determined the circulating levels of Hsp60 in epileptic animals and TLE

121 Circulating levels of ICAM-1 may also be associated with

122 nation therapy was associated with increased circulating levels of IFN-gamma, monokine induced by IFN

123 ce and beta-cell dysfunction, whereas higher circulating levels of IL-1 receptor antagonist (IL-1RA),

124 ndotoxaemia which can contribute to elevated circulating levels of IL-10 and down-regulation of MHC c

125 hese protective SNPs translated into reduced circulating levels of IL-1beta, IL-1alpha, IL-6, granulo

126 healthy donors and SLE patients have similar circulating levels of IL-2, whereas SLE patients exhibit

127 tro-orbital bleed sampling, we show that the circulating levels of IL-6 after PH were not directly co

128 Higher circulating levels of immune activation markers among tr

129 INCB018424 markedly reduced splenomegaly and circulating levels of inflammatory cytokines, and prefer

130 ase response in adipocytes, leading to lower circulating levels of inflammatory cytokines.

131 iolipin composition in mitochondria; reduced circulating levels of inflammatory cytokines; and elicit

132 Diet-induced obesity promotes an increase in circulating levels of inflammatory monocytes and their i

133 tor expression in CSCs, together with a high circulating level of insulin-like growth factor-1, repre

134 ature, enhanced insulin sensitivity, and low circulating levels of insulin and insulin-like growth fa

135 In mammals, circulating levels of insulin and nutrients, which fluct

136 Low circulating levels of insulin-like growth factor binding

137 ronic health factors significantly influence circulating levels of insulin-like growth factor-1 and i

138 relationship between glycated hemoglobin and circulating levels of interleukin (IL)-6, IL-8, and C-X-

139 Also measured were circulating levels of interleukin-6 (IL-6), an inflammat

140 We assessed the association between baseline circulating levels of isoleucine, leucine, valine, tyros

141 JH in queens was suggested by the fact that circulating levels of JH were ca. 2 orders of magnitude

142 rter provides a new direction for modulating circulating levels of ketone bodies in metabolic disease

143 controls, patients with cirrhosis had higher circulating levels of LBP and IL-10, an expansion of per

144 DOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholesterol in humans.

145 PCSK9-based therapeutic approaches to reduce circulating levels of LDL-cholesterol.

146 urthermore, the treatment did not affect the circulating levels of leptin and adiponectin in any grou

147 oot planing (SRP) on clinical parameters and circulating levels of leptin and adiponectin in patients

148 Circulating levels of leptin are elevated in systemic lu

149 Obese populations have higher circulating levels of leptin in contrast to low concentr

150 both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation

151 We investigated whether circulating levels of leptin, total adiponectin, and hig

152 Circulating levels of leuko-endothelial (CD31(+)/41(-)),

153 Our 2 goals were to determine whether circulating levels of LG3 are increased in association w

154 y an absence of pubertal development and low circulating levels of LH and gonadal steroids.

155 Whether circulating levels of lipasin in humans are altered in a

156 Simvastatin therapy did not affect circulating levels of lipid mediators, suggesting that p

157 cal solutions enabling the quantification of circulating levels of liposoluble micronutrients such as

158 Mean +/- SE circulating level of lipoxin A(4) was 5.89 +/- 0.63 nM a

159 E and TMEM49 may reflect novel influences on circulating levels of Lp-PLA(2) activity.

160 Chd7(Gt/+) mice also have decreased circulating levels of luteinizing hormone and follicle-s

161 ients with colorectal cancer (CRC) have high circulating levels of macrophage inhibitory cytokine-1 (

162 Remarkably, circulating levels of macrophage migration inhibitory fa

163 ale and male mice associated with changes in circulating levels of many glycoproteins.

164 omics revealed that nephrocytes regulate the circulating levels of many secreted proteins, the most n

165 Nrf2 did not affect circulating levels of MDSC in tumor-bearing mice because

166 Increasing circulating levels of Metrnl stimulates energy expenditu

167 In addition, circulating levels of miR-134, -10a, -195, -133b were si

168 Low circulating levels of miR-150 are associated with LV rem

169 In addition, circulating levels of miR-22 in 154 patients with systol

170 Circulating levels of miRNA-122 were independent predict

171 levels were highest in HIV/HBV patients, and circulating levels of miRNA-34a correlated positively wi

172 We analyzed the circulating levels of miRNAs in HIV patients with regard

173 ma analysis indicates significant changes in circulating levels of miRNAs on antimiR-208a treatment.

174 Circulating levels of miRNAs were measured by sequencing

175 Circulating levels of mitochondrial DNA at ICU admission

176 GDM may modulate both local and circulating levels of MMP-8 especially when associated w

177 Although mRNA and circulating levels of myonectin were reduced in a diet-i

178 Circulating levels of myonectin were tightly regulated b

179 ed with reduced and increased expression and circulating levels of myonectin, respectively, suggestiv

180 overexpression of myostatin, which increased circulating levels of myostatin by 3- to 4-fold, caused

181 this double blind crossover study, shifts in circulating levels of n-3 and n-6 PUFA-derived bioactive

182 Circulating levels of n-3 PUFAs provide an objective mea

183 HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type n

184 nts predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and

185 ey roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical fo

186 rove these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age.

187 We investigated whether circulating levels of osteoprotegerin are related to fea

188 Fluctuations in circulating levels of ovarian hormones have been shown t

189 ever, so far, few studies reported increased circulating levels of oxidative stress markers in patien

190 restraint in controls, but greatly elevated circulating levels of oxytocin.

191 Additionally, circulating levels of P-selectin, E-selectin, monocyte c

192 ession of MUC3 were robustly associated with circulating levels of PAI-1.

193 In epidemiologic studies, circulating levels of palmitic acid (16:0) are associate

194 Although the circulating level of peptide hormone urotensin II (UII)

195 We have recently found higher circulating levels of pituitary adenylate cyclase-activa

196 The circulating levels of plasma PK activity were measured i

197 Circulating levels of PMPs (either CD31+/42b+ or CD31+/4

198 Alterations in circulating levels of pro- and antiangiogenic factors ha

199 adaptive immune systems, their impact on the circulating levels of pro-inflammatory cytokines, and th

200 These changes were accompanied by suppressed circulating levels of proangiogenic growth factors (EGF

201 olipid transfer protein (PLTP) increases the circulating levels of proatherogenic lipoproteins, accel

202 Transgenic mice that produce high circulating levels of progastrin (hGAS) have increased p

203 ate manifested by leukocytosis and increased circulating levels of proinflammatory cytochemokines.

204 ed individuals exhibited significantly lower circulating levels of proinflammatory cytokines (gamma i

205 T decreased microglial activation, decreased circulating levels of proinflammatory cytokines, and pre

206 istance, altered hormone signaling, and high circulating levels of proinflammatory mediators.

207 epsis, including melioidosis, have decreased circulating levels of protein C.

208 ive cART during infancy significantly limits circulating levels of proviral and replication-competent

209 es a mechanism for the distal actions of low circulating levels of relaxin.

210 Renal function and circulating levels of renin-angiotensin-aldosterone syst

211 vivo overexpression also results in elevated circulating level of Resistin and development of hepatic

212 Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas

213 t of cells, and its deletion in mice reduces circulating levels of S1P, alters immune cell traffickin

214 , however, resulted in contrasting effect in circulating levels of S1P.

215 Our data suggest that circulating levels of sCD40L and sCD40R are associated w

216 es in gene expression and partially restored circulating levels of secondary BAs.

217 t on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A(2) rece

218 This study investigated whether circulating levels of serum C-reactive protein (CRP) and

219 CRS is associated with elevated circulating levels of several cytokines including interl

220 Intriguingly, circulating levels of several miRNAs are lower in patien

221 udies looking at the influence of tissue and circulating levels of sex hormones more recently in conj

222 Circulating levels of sex hormones, cortisol, and insuli

223 at shows pronounced seasonal fluctuations in circulating levels of sex-steroid hormones, which are kn

224 unction, the extent of which correlates with circulating levels of sFLT1.

225 genome-wide association study suggested that circulating levels of shed human transferrin receptor 1

226 In particular, these studies suggest that circulating levels of short vascular endothelial growth

227 AN, which will treat patients stratified for circulating levels of short VEGF-A isoforms with bevaciz

228 Circulating levels of SLPI, monocyte cluster of differen

229 ts with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and s

230 Plasma exchange reduced circulating levels of soluble B7 in patients with ALF an

231 arin treatment was associated with increased circulating levels of soluble fms-like tyrosine kinase-1

232 Circulating levels of soluble forms of urokinase-type pl

233 Circulating levels of soluble receptor for advanced glyc

234 s with acute myocardial infarction show high circulating levels of SP and NK1-positive cells that coe

235 Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme act

236 Mertk(CR) mice also have increased circulating levels of SPMs and less lung injury after I/

237 Serial changes in circulating levels of sub-clonal private mutations corre

238 Circulating levels of sVCAM-1 and TNFalpha were signific

239 Flow cytometry was used to analyze circulating levels of T and B cells and bone marrow (BM)

240 AR drives prostate cancer growth despite low circulating levels of testicular androgen and normal lev

241 ker of insulin secretion and sensitivity and circulating levels of testosterone in humans, but the en

242 Circulating levels of TGFBIp were measured in patients a

243 Circulating levels of TGFBIp were significantly elevated

244 Circulating levels of Th17 and Th1 cells decreased in a

245 which are vulnerable to the effects of high circulating levels of THC, and 2) associated either with

246 nt resulted in a significant decrease of the circulating level of the predominant thyroid hormone fre

247 sistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, th

248 renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and

249 RAGE(-/-) mice is associated with increased circulating levels of the anti-inflammatory cytokine int

250 In response to calorie deficiency the circulating levels of the appetite-promoting hormone, ac

251 Circulating levels of the biomarkers surfactant protein

252 Higher circulating levels of the branched-chain amino acids (BC

253 e-3-carbonitrile 61 significantly raised the circulating levels of the branched-chain amino acids leu

254 Circulating levels of the chitinase-like protein YKL-40

255 ockade of cell proliferation also normalized circulating levels of the cytokines leptin and interleuk

256 oduced a significant increase in hepatic and circulating levels of the endocannabinoid anandamide, wh

257 Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, an

258 Here we report that circulating levels of the muscle-enriched miR486 is lowe

259 ciated with APOL1 is probably not related to circulating levels of the mutant protein.

260 Clinically, measurements of circulating levels of the natriuretic polypeptides are u

261 y-risk" rs9939609 A allele have dysregulated circulating levels of the orexigenic hormone acyl-ghreli

262 bject recognition and location but only when circulating levels of the ovarian steroids, estradiol an

263 negatively correlated with clinical pain and circulating levels of the proinflammatory citokine inter

264 Lipid- and protein-rich nutrition attenuated circulating levels of the proinflammatory cytokines tumo

265 e, fat pad weight, and tissue expression and circulating levels of the secreted glycoprotein, lipocal

266 insufficiently high in the case of cortisol) circulating levels of the target-organ hormones.

267 Longitudinal changes in circulating levels of the top metabolite, were examined

268 ed adeno-associated viral vectors to elevate circulating levels of the tumorkines IL6 and/or activin

269 Previously, we observed that circulating levels of these 2 DAMPs are increased in hyp

270 Circulating levels of these biomarkers have a heritable

271 onal cells, indicating that the elevation of circulating levels of these microRNAs after cardiac arre

272 ver, we found a negative correlation between circulating levels of these three lncRNAs and body mass

273 Finally, we tested the circulating levels of these three lncRNAs in 8 obese hum

274 Our results suggest that circulating levels of these TTR-binding compounds in Inu

275 Epidemiologic studies have associated low-circulating levels of this adipokine with multiple metab

276 therapeutic action of GLP-1 and suggest that circulating levels of this hormone directly stimulate in

277 hich may mobilize methylmercury and increase circulating levels of this neurotoxin.

278 We found a significant decrease in circulating levels of three lncRNAs (lncRNA-p5549, lncRN

279 or environmental phthalate exposure to alter circulating levels of thyroid hormones in pregnant women

280 In addition, circulating levels of thyroid hormones thyroxine (T4) an

281 lamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH)

282 onic anterior pituitary that resulted in low circulating levels of thyroxine and IGF-1.

283 Patients with melioidosis have elevated circulating levels of tissue-type plasminogen activator,

284 ested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults.

285 yperglycemia, hypercholesterolemia, and high circulating levels of triglycerides.

286 Breast tumors exposed to high circulating levels of TSLP were arrested at an early ade

287 ed obesity resulted in an 80-95% decrease in circulating levels of TTR and RBP4.

288 Here, high circulating levels of tumor necrosis factor (TNF)-alpha

289 abant was associated with suppression of the circulating level of tumour necrosis factor-alpha.

290 ent infection is characterized by diminished circulating levels of type 1 (interferon gamma, interleu

291 in osteoblasts in mice resulted in decreased circulating levels of undercarboxylated OCN, impaired gl

292 ects associated with CKD arise from elevated circulating levels of urea that increase islet protein O

293 r primary breast cancer and determined their circulating levels of various immune cells shortly befor

294 r insufficiency in PAD occurs despite higher circulating levels of vascular endothelial growth factor

295 Heparin had no effect on circulating levels of vascular endothelial growth factor

296 As increased circulating levels of VEGFs and Angs have been observed

297 tive androstane receptor, profoundly reduced circulating levels of vemurafenib in humanized mice.

298 Low circulating levels of vitamin D affect colorectal cancer

299 sed lower serum FGF23 levels, despite normal circulating levels of vitamin D metabolites.

300 Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overa