ライフサイエンスコーパス: circumsporozoite

1 Circumsporozoite, a predominant surface protein, is invo

2 nete micronemal proteins chitinase (PgCHT1), circumsporozoite and TRAP-related protein (CTRP), and vo

3 the first microneme protein of the ookinete: circumsporozoite- and TRAP-related protein (CTRP).

4 01, 99.7% of children were positive for anti-circumsporozoite antibodies, with a geometric mean titer

5 ozoite antibody titres using a model of anti-circumsporozoite antibody dynamics and the natural acqui

6 An anti-circumsporozoite antibody titre of 121 EU/mL (98-153) wa

7 We assessed the association between anti-circumsporozoite antibody titres and the magnitude and d

8 Anti-circumsporozoite antibody titres are a surrogate of prot

9 Waning anti-circumsporozoite antibody titres predict the duration of

10 n the incidence of clinical malaria and anti-circumsporozoite antibody titres using a model of anti-c

11 RTS,S/AS01-induced anti-circumsporozoite antibody titres were greater in childre

12 s to P. falciparum schizonts and recombinant circumsporozoite antigen, MSP-1(19), MSP-2, AMA-1, and P

13 cles carrying a recombinant Plasmodium vivax circumsporozoite antigen, VMP001, both entrapped in the

14 After initial successful evaluation of the circumsporozoite-based vaccine RTS,S/SBAS2, developed by

15 isplay two epitopes (MAL1 and MAL2) from the circumsporozoite CS proteins of Plasmodium falciparum an

16 ubcutaneously injected Plasmodium falciparum circumsporozoite (CS) peptides elicited strong parasite-

17 denovirus expressing a major malaria Ag, the circumsporozoite (CS) protein (AdPyCS), was determined u

18 The Plasmodium falciparum circumsporozoite (CS) protein (CSP) is a major vaccine t

19 ell epitope derived from a Plasmodium yoelii circumsporozoite (CS) protein (referred to as the PyCS-B

20 ke particle containing Plasmodium falciparum circumsporozoite (CS) protein epitopes, was shown to eli

21 dium uses a PEXEL/VTS motif to introduce the circumsporozoite (CS) protein into the hepatocyte cytopl

22 Circumsporozoite (CS) protein is a predominant surface a

23 Circumsporozoite (CS) protein is the major surface compo

24 The circumsporozoite (CS) protein of malaria parasites (Plas

25 ective recombinant adenovirus expressing the circumsporozoite (CS) protein of Plasmodium yoelii (AdPy

26 viruses expressing selected sequences of the circumsporozoite (CS) protein of the human malaria paras

27 are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface.

28 rozoites of Plasmodium predominantly express circumsporozoite (CS) protein on their surface, which bi

29 Plasmodium sporozoites display circumsporozoite (CS) protein on their surface, which is

30 Two circumsporozoite (CS) protein T cell epitopes, previousl

31 response to the Plasmodium berghei malarial circumsporozoite (CS) protein was severely impaired in C

32 echanism and the specific interaction of the circumsporozoite (CS) protein with liver-specific hepara

33 Native Plasmodium circumsporozoite (CS) protein, translocated by sporozoit

34 arget for malaria vaccine development is the circumsporozoite (CS) protein, which is expressed on the

35 patitis B surface Ag (HBs) and P. falciparum circumsporozoite (CS) protein-among Tanzanian children i

36 The Plasmodium falciparum circumsporozoite (CS) protein-based pre-erythrocytic sta

37 e focus on improving the immunogenicity of a circumsporozoite (CS) protein-based vaccine.

38 t, we use an adoptive transfer strategy with circumsporozoite (CS) protein-specific transgenic T cell

39 inimal epitopes of the Plasmodium falciparum circumsporozoite (CS) protein.

40 pecific for the repeat region of the surface circumsporozoite (CS) protein.

41 e repeat sequence of the gene coding for the circumsporozoite (CSP) protein from the AF54087 gene.

42 anti-repeat Abs that reacted with the native circumsporozoite on P. falciparum sporozoites.

43 s had a striking resemblance to the malarial circumsporozoite precipitate (CSP) reaction.

44 ng monoclonal antibody 3E2 which elicits the circumsporozoite precipitate (CSP)-like reaction and pas

45 phocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [E

46 in life and subsequent levels of antibody to circumsporozoite protein (a marker of sporozoite-stage r

47 ) in BALB/c mice required Plasmodium berghei circumsporozoite protein (CS(252-260))-specific memory C

48 denovirus serotype 35 (Ad35) vector encoding circumsporozoite protein (CS) (Ad35.CS), followed by boo

49 The circumsporozoite protein (CS) and the sporozoite surface

50 Circumsporozoite protein (CS) is the antigenic target fo

51 T-cell responses directed against the circumsporozoite protein (CS) of Plasmodium falciparum c

52 multiple-epitope string ME (ME-TRAP) or the circumsporozoite protein (CS) of Plasmodium falciparum.

53 ed the H-2K(d)-restricted CTL epitope of the circumsporozoite protein (CS) of Plasmodium yoelii betwe

54 onkeys and humans by eliciting antibodies to circumsporozoite protein (CS) that inhibit sporozoite in

55 The sporozoite's surface is covered by the circumsporozoite protein (CS), and its region II-plus ha

56 The circumsporozoite protein (CS), one of the major proteins

57 Despite extensive genetic diversity of circumsporozoite protein (CS), the most successful malar

58 The malaria circumsporozoite protein (CS), thrombospondin (TSP), and

59 The circumsporozoite protein (CS), which covers the surface

60 on the major sporozoite surface protein, the circumsporozoite protein (CS).

61 related adhesion protein (TRAP) 130-138-, or circumsporozoite protein (CSP) 252-260-derived epitopes

62 against the repeat-region of the Plasmodium circumsporozoite protein (CSP) abrogate sporozoite infec

63 gh antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T c

64 rongly against the pre-erythrocytic antigens circumsporozoite protein (CSP) and liver stage antigen 1

65 obulin G (IgG) antibodies to preerythrocytic circumsporozoite protein (CSP) and liver-stage antigen 1

66 ne constructs based on the Plasmodium yoelii circumsporozoite protein (CSP) and P. yoelii merozoite s

67 rized sporozoite-specific genes encoding the circumsporozoite protein (CSP) and thrombospondin-relate

68 ncies and median levels of IgG antibodies to circumsporozoite protein (CSP) and thrombospondin-relate

69 g the carboxy- and the amino-terminal of the circumsporozoite protein (CSP) antigen without the centr

70 ns a top priority, and vaccines based on the circumsporozoite protein (CSP) are among the lead candid

71 The Plasmodium circumsporozoite protein (CSP) binds to salivary glands

72 nduced shedding of the major surface protein circumsporozoite protein (CSP) exposed the SSP3 ectodoma

73 a plasmid expressing Plasmodium yoelii (Py) circumsporozoite protein (CSP) induces H-2Kd-restricted

74 ral repeat of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) inhibit parasite activity

75 The circumsporozoite protein (CSP) is a target for effector

76 The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three pri

77 The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoit

78 The circumsporozoite protein (CSP) is the major surface prot

79 ic recombinant protein, VMP001, based on the circumsporozoite protein (CSP) of P. vivax.

80 t of the FLAG epitope with an epitope of the circumsporozoite protein (CSP) of Plasmodium falciparum

81 nant that displays a B-cell epitope from the circumsporozoite protein (CSP) of Plasmodium falciparum

82 IL-5 circumsporozoite protein (CSP) ratios, a helper T cell t

83 d vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Pla

84 Several epitopes in the circumsporozoite protein (CSP) were identified as target

85 The circumsporozoite protein (CSP), a major surface antigen

86 alaria is based on the Plasmodium falciparum circumsporozoite protein (CSP), a major surface protein

87 Circumsporozoite protein (CSP), a predominant surface an

88 mbospondin-related anonymous protein (TRAP), circumsporozoite protein (CSP), and export protein 1 (Ex

89 RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase

90 including apical membrane antigen 1 (AMA-1), circumsporozoite protein (CSP), erythrocyte binding anti

91 The sporozoite's major surface protein, circumsporozoite protein (CSP), is a multifunctional pro

92 ch that targets four P. falciparum antigens: circumsporozoite protein (CSP), liver stage antigen 1 (L

93 udy sought to determine if antibodies to the circumsporozoite protein (CSP), liver-stage antigen 1 (L

94 Levels of IgG antibodies to circumsporozoite protein (CSP), liver-stage antigen type

95 Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antige

96 n can be prevented by antibodies against the circumsporozoite protein (CSP), the major surface protei

97 Unlike CTL responses to the circumsporozoite protein (CSP), the population of L3-spe

98 e, RTS,S, based on the Plasmodium falciparum circumsporozoite protein (CSP), will likely be the first

99 eading malaria vaccine in development is the circumsporozoite protein (CSP)-based particle vaccine, R

100 t leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against Pla

101 Circumsporozoite protein (CSP)-specific antibody titers,

102 Tetramer staining for the immunodominant circumsporozoite protein (CSP)-specific CD8(+) T cell ep

103 challenge, the RTS,S/AS01B group had greater circumsporozoite protein (CSP)-specific immune responses

104 well-characterized vaccine candidate is the circumsporozoite protein (CSP).

105 ntly based on targeting antigens such as the circumsporozoite protein (CSP).

106 tibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP).

107 bearing the type I repeat region of P. vivax circumsporozoite protein (CSP).

108 ytic malaria antigen, the Plasmodium berghei circumsporozoite protein (CSP).

109 Ag (RESA), and the dominant B epitope of the circumsporozoite protein (CSP).

110 es and sulfatide-binding recombinant malaria circumsporozoite protein (MCSP) inhibit this adhesion.

111 humans, a recombinant Plasmodium falciparum circumsporozoite protein (PfCSP) candidate vaccine, RTS,

112 ding two preerythrocytic-stage antigens, the circumsporozoite protein (PkCSP) and sporozoite surface

113 The geometric mean anti-P. knowlesi circumsporozoite protein (PkCSP) titers ranged from 1,76

114 DNA plasmid expressing the Plasmodium yoelii circumsporozoite protein (pPyCSP) protects mice against

115 cine which simultaneously expresses P. vivax circumsporozoite protein (PvCSP) and P25 (Pvs25) protein

116 studies indicated that the Plasmodium yoelii circumsporozoite protein (PyCSP) 57-70 region elicits T

117 cine plasmids encoding the Plasmodium yoelii circumsporozoite protein (PyCSP) and murine granulocyte-

118 sly shown that a DNA plasmid encoding the Py circumsporozoite protein (PyCSP) can protect mice agains

119 s neonates (7 days) with a Plasmodium yoelii circumsporozoite protein (PyCSP) DNA vaccine mixed with

120 The circumsporozoite protein (PyCSP) of Plasmodium yoelii wa

121 CTL responses against the Plasmodium yoelii circumsporozoite protein (PyCSP), BALB/c mice were immun

122 gimen: one inducing high-titer antibodies to circumsporozoite protein (RTS,S/AS01B) and the other ind

123 antigen-175; liver-stage antigen-1 [LSA-1], circumsporozoite protein [CSP], merozoite surface protei

124 The responses to one antigen (P. falciparum circumsporozoite protein [PfCSP]) were similar among vol

125 y against malaria parasites with the matched circumsporozoite protein allele than against mismatched

126 s showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins incre

127 A recombinant vaccine based on fusion of the circumsporozoite protein and HBsAg plus a potent adjuvan

128 iparum antigens derived from the sporozoite (circumsporozoite protein and sporozoite surface protein

129 epitope overlaps a polymorphic region of the circumsporozoite protein and strain cross-reactivity of

130 cell epitopes and sequences derived from the circumsporozoite protein and the merozoite surface prote

131 parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as

132 g T3-T1 and a potent B-cell epitope from the circumsporozoite protein central repeat region were test

133 elieved to be responsible for binding to the circumsporozoite protein found on the surface of the Pla

134 he antigen consists of a hybrid in which the circumsporozoite protein fused to hepatitis B surface an

135 positions and haplotypic regions within the circumsporozoite protein had on vaccine efficacy against

136 induced production of IL-2, INF-gamma, anti-circumsporozoite protein IgG, and proliferative T cells.

137 ombinant adenovirus expressing the P. yoelii circumsporozoite protein in mice.

138 Humoral immunity to Plasmodium falciparum circumsporozoite protein is partly mediated by a polymor

139 pecific to certain parasite genotypes at the circumsporozoite protein locus.

140 A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces toler

141 sted with a DNA vaccine plasmid encoding the circumsporozoite protein of P. relictum exhibited a mode

142 The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and ha

143 We developed a vaccine based on the circumsporozoite protein of Plasmodium falciparum that i

144 -4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a

145 Similar results were obtained when the circumsporozoite protein of Plasmodium yoelii was delive

146 hown that a plasmid DNA vaccine encoding the circumsporozoite protein of the malaria parasite elicits

147 icted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influen

148 region (amino acids 27-117) of P. falciparum circumsporozoite protein plays a critical role in the in

149 rom samples from 4985 participants to survey circumsporozoite protein polymorphisms.

150 Mice challenged with exogenous circumsporozoite protein produced antibodies against a d

151 h plasmid DNA encoding the plasmodium yoelii circumsporozoite protein protected one of five strains o

152 linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental c

153 accines containing the Plasmodium falciparum Circumsporozoite protein repeat domain are undergoing hu

154 ine containing minimal Plasmodium falciparum circumsporozoite protein repeat epitopes was assessed fo

155 nt P. berghei parasite bearing P. falciparum Circumsporozoite protein repeats.

156 The circumsporozoite protein that covers the surface of Plas

157 B cell epitopes of the Plasmodium falciparum circumsporozoite protein to compare these with previousl

158 We conclude that the binding of the circumsporozoite protein to hepatic heparan sulfate prot

159 have analyzed the DNA sequences of the Csp (circumsporozoite protein) gene in 24 geographically repr

160 with epitopes from the Plasmodium falciparum circumsporozoite protein, also was localized in the tran

161 surface protein of malaria sporozoites, the circumsporozoite protein, binds to heparan sulfate prote

162 The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated

163 We measured IgG responses to P. falciparum circumsporozoite protein, liver-stage antigen 1, apical-

164 Humoral responses to the malarial antigens circumsporozoite protein, liver-stage antigen-1, apical

165 rasite chitinase, the 25 kDa protein and the circumsporozoite protein, respectively.

166 s against four of the P.falciparum antigens (circumsporozoite protein, sporozoite surface protein 2,

167 te isolated from the whole mosquito binds to circumsporozoite protein, suggesting a role within the m

168 s specific for a conserved sequence from the circumsporozoite protein, which binds to many human leuk

169 gammadelta T cells were not required for circumsporozoite protein-specific Ab responses, and gamm

170 zed protective plasmid encoding P. y. yoelii circumsporozoite protein.

171 T cell epitope of the Plasmodium falciparum circumsporozoite protein.

172 coding for the highly polymorphic antigenic circumsporozoite protein.

173 adenovirus 35 (Ad35) (ARR) vector expressing circumsporozoite protein.

174 l infected hepatocytes that were pulsed with circumsporozoite protein.

175 D of the malaria parasite Plasmodium berghei circumsporozoite protein.

176 of protective CD8(+) T-cell responses to the circumsporozoite protein.

177 rotein-1 (PfExp-1), also called antigen 5.1, circumsporozoite related antigen, or QF116.

178 Here, we describe a model of circumsporozoite-specific memory CD8 T cell generation t

179 We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent s

180 ell epitopes present in native P. falciparum circumsporozoite surface protein (PfCSP), were fused in

181 a truncated version of Plasmodium falciparum circumsporozoite surface protein (tCSP) fused to Salmone

182 Anti-circumsporozoite titres wane according to a biphasic exp

183 Pre-vaccination anti-circumsporozoite titres were associated with lower immun