ライフサイエンスコーパス: circumvent

1 from the reversible formation of ketals are circumvented.

2 as an animal model, science has been able to circumvent a number of problems.

3 sphate pathway back into glycolysis, thereby circumventing a glycolysis block and ensuring adequate A

4 ce that may be targeted with a strategy that circumvents a requirement for systemic GR ablation.

5 ks may require acceptance of a paradigm that circumvents, accelerates, or reorders traditional phases

6 n in drug discovery as a validated method to circumvent acquired resistance in oncology.

7 this fundamental difference, acupuncture may circumvent adverse effects of the rapamycin treatment.

8 es recapitulate loss-of-function phenotypes, circumventing an entire generation of breeding.

9 order to achieve proper tissue regeneration, circumventing an impaired stem/progenitor compartment.

10 increase fitness, parasites are predicted to circumvent and overcome host immunity.

11 It was thus remarkable that a mechanism to circumvent Anderson localization relying on the presence

12 To circumvent antiandrogen resistance in prostate cancer, a

13 PI3K/Akt signaling as an effective means to circumvent apoptosis and maintain survival.

14 This program can be circumvented by a protein-based genetic element, the [GA

15 they show that this undesired pathway can be circumvented by changing from a CF3 to a CF2CF3 ligand.

16 ios can lead to aggregation, but this can be circumvented by coating instead with an oligolysine-PEG

17 zontal gene transfer, or because they can be circumvented by environmentally available compounds.

18 adaptation, such evolutionary traps could be circumvented by indirect paths through genotype space in

19 troublesome major elements (Fe(3+), Ti) are circumvented by masking with ascorbic acid and hydrofluo

20 unctions (1-3) , although this effect can be circumvented by specially designed interfaces (4) .

21 ckpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yield

22 These limitations can now be circumvented by using miniature, integrated microscopes

23 so been demonstrated: infinite chains can be circumvented by using steric bulk either at the metalloc

24 atory hierarchy governing alkaline tolerance circumvents calcineurin signalling.

25 n of Gbeta5 might represent a novel means to circumvent cardiotoxicity in cancer patients whose treat

26 to their use as immunotherapeutics that can circumvent central tolerance and limit graft-versus-host

27 an alternative approach to induce fat loss, circumventing central leptin resistance.

28 ons that are much better studied, while they circumvented certain adverse reactions associated with F

29 rial on nanostructuring can be attributed to circumventing challenges with charge transport from pola

30 shment of more effective treatments that can circumvent chemoresistance in Multiple Myeloma (MM) is a

31 lls as wild-type cells, signifying that they circumvent cisplatin resistance.

32 ising theranostic anticancer agents that can circumvent cisplatin resistance.

33 nsition metal catalyzed cross-couplings, and circumvents common issues associated with proto-demetala

34 Notably, the optimal reaction conditions circumvented concurrent reactions via O-imidoylation and

35 To circumvent confounding, Mendelian randomization was appl

36 This non-specificity at the target circumvents conventional mechanisms of resistance and in

37 Factor Decoys (TFDs), have the potential to circumvent current resistance mechanisms by acting on no

38 inducible Drd2 null-allele mouse strain that circumvented developmental compensations found in consti

39 ts in cells and cell suspensions by MS while circumventing dialysis and centrifugation.

40 herapeutic agents, and other proteins, while circumventing difficulties associated with in vivo heter

41 Synthetic approaches that circumvent diffusion in solid-state reactions are rare a

42 sed to form an electronic 'neural bypass' to circumvent disconnected pathways in the nervous system.

43 aces each component in a precise location to circumvent disorder.

44 eal devices are analyzed, and strategies for circumventing dissolution are suggested.

45 cancer apoptosis is a promising strategy to circumvent drug resistance and present a target for brea

46 ation of potentially harmful UV light can be circumvented due to the fast thermal ring-opening except

47 changer NHE9 limits luminal acidification to circumvent EGFR turnover and prolong downstream signalli

48 on, while a cGMP-phosphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisat

49 itch with the engineered mutant CPK10(M141G) circumvents embryo lethality and enables conditional ana

50 g a single injection of AAV9-sgRNAs, thereby circumventing embryonic lethality.

51 c health due to the potential of variants to circumvent established treatment and/or preventative reg

52 To circumvent experimental confounds associated with LRRK2

53 alts the growth of damaged cells and must be circumvented for cancer to arise.

54 To circumvent functional compensation by the closely relate

55 lactic acid caused yeast cells to heritably circumvent glucose repression.

56 titutive PAF1 tether allowing MLL fusions to circumvent H3 competition.

57 ion in response to EGFR antagonists, thereby circumventing HER3-associated drug resistance.

58 lent locus identity, reanimating the gene to circumvent hisn6a lethality and hybrid incompatibility.

59 nisms by which beneficial organisms adapt to circumvent host defenses, we experimentally evolved ecol

60 te a proteolytic surface that GAS employs to circumvent host innate immunity.

61 exogenous TEs into Arabidopsis thaliana, we circumvented identity-based silencing, allowing us to is

62 ighlighting the need for novel approaches to circumvent immunoregulatory mechanisms that limit the in

63 -kappaB signaling, and how this mechanism is circumvented in glioblastoma through KLF6 loss.

64 e; thus, the Woodward-Hoffmann rules are not circumvented in this reaction via involvement of orthogo

65 gulation pathways, eIF2alphaP and mTORC1, to circumvent ineffective erythropoiesis, highlighting heme

66 ed with a p110alpha-specific inhibitor often circumvent inhibition and resume growth.

67 and implementation of new technologies that circumvent insecticide resistance.

68 witch within an ultra-stable SCI promises to circumvent insulin's complex global cold chain.

69 ed a variety of clinical E. coli isolates to circumvent intracellular colonization resistance and cau

70 To circumvent intrinsic variations between cell lines with

71 However, there is an ongoing need to circumvent islet loss posttransplant.

72 forming lobar lung transplantation (LLT) can circumvent issues with donor-recipient size mismatch; ho

73 tion of a cis-acyltransferase (AT) domain to circumvent its native extender unit preference leads con

74 pneumoniae has enhanced capacity to circumvent killing by human neutrophils, the primary cel

75 released substrate molecules enables them to circumvent kinetic traps in their conformational free en

76 this highlights how new drugs, introduced to circumvent known resistance mechanisms, can be rendered

77 activate androgen receptor signaling, which circumvents ligand-deprivation therapy.

78 ion of an acetone insecticide formulation to circumvent lipid-based uptake barriers decreased the res

79 omparable step-wise traditional approach and circumvents loading of the gel precursors with the hydro

80 thods could facilitate earlier diagnosis and circumvent loss to follow-up but remain logistically and

81 resides in early endosome-like vacuoles and circumvents lysosomal fusion through an unknown mechanis

82 SEEL can circumvent many of the possible issues associated with m

83 maging system described in the current study circumvents many of the inherent limitations of current

84 signed, synthesized, and characterized, that circumvents many of the limitations of the molecular pro

85 The procedure circumvents many sources of bias or false-positives inhe

86 With the goal of circumventing marrow toxicity, marrow was collected and

87 bited tubulin polymerization and effectively circumvented MDR.

88 n investigated in clinical trials in hope of circumventing MDR, with only limited success.

89 Alternative sugars, such as fructose, circumvent metabolic control systems and exacerbate this

90 al replacement therapies or techniques (MRT) circumventing mother-to-child mtDNA disease transmission

91 es compared to their parent compounds (e.g., circumventing multidrug resistance), making the dimeriza

92 ovides a fundamentally different strategy to circumvent multiple mechanisms of kinase inhibitor resis

93 ked difference in reactivity is leveraged to circumvent multistep functionalization by directly coupl

94 tion, a feedback that in the long term could circumvent N limitation of the CO2 response while mitiga

95 tion of EGR-MASP1 signaling may be useful to circumvent negative growth regulation limiting plant pro

96 This indicates that while photovoltage circumvents non-geminate losses, geminate recombination

97 able to alter cellular function in ways that circumvent normal signaling pathways.

98 apabilities of the herbivore for tolerating, circumventing, or disarming the defenses.

99 network and suggest novel interventions for circumventing oxidative stress in cardiac cells.

100 in mediating effector-triggered immunity to circumvent pathogen inhibition of immune signaling.

101 hows potential as a long-term treatment that circumvents patient compliance barriers compared to curr

102 To circumvent perinatal lethality, we have developed a nove

103 To circumvent PET studies' methodological variation, we gen

104 Compounds 3, 4, and 6-9 circumvented Pgp and betaIII-tubulin mediated drug resis

105 et genes repressed in tumors with Pten loss, circumventing PI3K-mediated repression of the androgen a

106 et validation has emerged as a concept which circumvents possible limitations of knockdown experiment

107 within in situ melanoma by using methods to circumvent potential limitations in prior study designs.

108 To circumvent potential neurohumoral reflexes, cardiac effi

109 lacement of Li metal with graphite anode can circumvent potential safety issues.

110 t such reversible thioester reactivity would circumvent potential soluble inhibitors, such as histami

111 ecombination in lineage tracing, effectively circumventing potential uncertainty of the cell-type spe

112 housands of gel compartments in series while circumventing power dissipation before contact.

113 Importantly, this "green" CCR protocol circumvents prefunctionalization, isolation of organomet

114 The adjustable side chains allow for circumventing problems associated with the isolation of

115 ely to increase long-term N accumulation and circumvent progressive N limitation without additional N

116 ses continuously drift, which allows them to circumvent protective immunity, but conserved epitopes p

117 s raised increasing interest for potentially circumventing receptor cross-talk and c-MET-mediated acq

118 Current strategies to circumvent resistance target the same or parallel pathwa

119 may yield stronger anti-tumour efficacy and circumvent resistance to EGFR-directed therapies.

120 Targeting Olig2 may circumvent resistance to EGFR-targeted drugs.

121 redict drug response or to design tactics to circumvent resistance.

122 er, we show that the Imry-Ma argument can be circumvented, resulting in the formation of stable order

123 vel chemotype as one strategy to potentially circumvent safety concerns from earlier derivatives such

124 opening provides a means for the bacteria to circumvent self-induced genotoxicity.

125 ials instead, which facilitated sampling and circumvented several confounding loss processes for some

126 The liquid-solid two-phase reaction pathway circumvents solid-state Mg(2+) diffusion and ensures a l

127 el-catalyzed C(sp(2) )-C(sp(3) ) coupling by circumventing solubility issues associated with potassiu

128 article electron cryomicroscopy (cryoEM) can circumvent some of the problems of x-ray crystallography

129 vention or treatment of bacterial infections circumventing some of the hurdles of protein IgG deliver

130 adband, from visible to short-infrared, thus circumventing some technical limitations of negative-ind

131 A misregulated form of the protease that circumvents specific genetic requirements for proteolysi

132 s or implement fast dissipationless driving, circumventing standard adiabatic limitations requiring i

133 Here, we use solvent viscosity to circumvent strand inhibition, demonstrating information

134 otein quality control machinery essential to circumvent stress-induced degradation and aggregation of

135 neration sequencing may offer the ability to circumvent such limitations, but a method has not been p

136 To circumvent systemic side effects, targeting peripheral o

137 rstellar medium, was established in order to circumvent tedious steps from previous methods.

138 To circumvent that photoisomerization problem, we explored

139 To circumvent the antiproliferative effects of G4 ligands,

140 al energy states of fluorescent molecules to circumvent the diffraction limit, preventing superresolv

141 ant enzymatic methodologies and nanozymes to circumvent the drawbacks associated with natural enzymes

142 Enteric bacteria circumvent the gastric acid barrier by activating extrem

143 nently correct disease-causing mutations and circumvent the hurdles of traditional gene- and cell-bas

144 n is critical to the ability of pathogens to circumvent the immune response and cause disease.

145 latory axis that cancer cells can exploit to circumvent the immune system.

146 ate and adaptive suppressive populations, to circumvent the impairment in antigen presentation, and t

147 Finally, an approach to circumvent the inability of post-mitotic cells to suppor

148 igning a monovalent targeting strategy could circumvent the inflammatory response.

149 infection downregulated EFTUD2 expression to circumvent the innate immune response.

150 in contractile speed allow certain birds to circumvent the intrinsic trade-off between muscular spee

151 To circumvent the intrinsic uncertainties of random mutatio

152 istacking approach was developed in order to circumvent the issues for stacking in nonaqueous MCE.

153 To circumvent the limitations of diffusion during static in

154 To circumvent the limitations of scenario-based life cycle

155 To circumvent the low level of precursor frequency in patie

156 at will favor graft acceptance and (ideally) circumvent the necessity of lifelong immunosuppression.

157 a mutant gamma ATP synthase allele (MGA) to circumvent the normal essentiality of the editing endonu

158 The metabolic rewiring of glycolysis can circumvent the normally lethal effects of oxygen depriva

159 that the L-T4 oral liquid formulation could circumvent the pH alteration resulting from atrophic gas

160 sisting of phased array antennas are able to circumvent the phase-matching requirement in on-chip non

161 roach is independent of, and can effectively circumvent the physical and material limitations of, the

162 Movement could potentially circumvent the physiological stress response associated

163 midine supplementation of the medium did not circumvent the polyamine auxotrophy of the Deltaarg line

164 Selectable markers derived from plant genes circumvent the potential risk of antibiotic/herbicide-re

165 To circumvent the problem, we performed single-nucleus tran

166 veloping new therapeutic treatments that can circumvent the problems seen in traditional hydroxamate-

167 bility to bypass some DNA lesions, which can circumvent the process leading to replication fork arres

168 As a way to circumvent the quantum no-cloning theorem, approximate q

169 so show that mismatch bubble templates could circumvent the requirement of TFB2M, but TFAM was still

170 To circumvent the surface oxide, a novel approach is discov

171 serving ASFV replication and infectivity can circumvent the time and labor-intensive steps associated

172 To circumvent the time scale disparity between the fast IMS

173 ical properties, providing an opportunity to circumvent the use of a complex set-up that involves mul

174 To circumvent the use of expensive and inefficient Pt catal

175 Immune isolation using encapsulation may circumvent the use of immunosuppressants and prolong the

176 ction at two selected wavelengths, which has circumvented the critical limitation of strong wavelengt

177 tibody-dependent murine ITP and successfully circumvented the inflammatory response as assessed by ch

178 ntity of aggregates in small tissue samples, circumventing the above problem.

179 of xenograft tumor development, effectively circumventing the challenge of targeting a cell-specific

180 pare interacting chiral quantum states, thus circumventing the challenges of a top-down approach that

181 the free energetic barriers to dewetting by circumventing the classical dewetting pathways.

182 n be harnessed to enhance Cas9 applications, circumventing the cleavage and ligation cycle and biasin

183 4 binding site, bnAb effectiveness relies on circumventing the defenses of a critical functional regi

184 ters in an extremely fast and automated way, circumventing the difficulties that are faced by maximum

185 asis of this disorder, and they suggest that circumventing the diseased BBB to deliver active TH to t

186 xistence of numerous degenerate pathways for circumventing the effects of potentially lethal mutation

187 decrease DA synthesis and availability, thus circumventing the efficacy of standard pharmacotherapies

188 p(2))-H activation/cross-coupling reactions, circumventing the extra steps of installation and subseq

189 uld therefore represent a novel approach for circumventing the IRDS produced in response to cancer th

190 rce under microscopic visualization, thereby circumventing the issue of tissue heterogeneity.

191 OR-PFL shunt" to reduce CO2 to formate while circumventing the lack of Fdh.

192 accelerates the fibrillation rate of CsgA by circumventing the lag phase during nucleation.

193 ses the size of a biological sample, thereby circumventing the limits of optical resolution.

194 e secondary hydroxyl group at C3 in glucose, circumventing the more readily accessible hydroxyl at C6

195 ata in real-time via a Web service protocol, circumventing the need for bulk data processing.

196 cell sources (for example, fibroblasts) and circumventing the need for ex vivo pre-processing.

197 reference data and images from other years, circumventing the need to finish reference data collecti

198 es for a population to reach a fitness peak, circumventing the need to have full knowledge about the

199 ng edge brain-specific therapies, capable of circumventing the physical and biochemical blockage of t

200 hetero)arenes with active C-H bonds, thereby circumventing the preparation of organometallic derivati

201 -aminoimidazoles with broad substrate scope, circumventing the problematic regiospecific acylation of

202 n enables binding to interaction partners by circumventing the restriction of orientation and conform

203 K2 have been already discovered that allowed circumventing the selectivity issue.

204 atics production much simpler and renewable, circumventing the use of ethylene at high pressure.

205 This new activity circumvents the 3-enzyme pathway that produces beta-MeTr

206 ates the need for transcript annotations and circumvents the challenges in estimating relative isofor

207 Furthermore our graphene wrapped approach circumvents the direct interaction between Ag array and

208 By selectively inhibiting BCL-2, venetoclax circumvents the dose-limiting, BCL-XL-mediated thrombocy

209 e phosphorescence lifetime-based measurement circumvents the drawbacks of intensity-based measurement

210 SSM circumvents the drawbacks of transposon-mediated transge

211 idates a photovoltaic window technology that circumvents the fundamental tradeoff between efficient s

212 YAMAT-seq circumvents the issue of inefficient adapter ligation, a

213 By allowing the client to fold itself, Spy circumvents the need for client-specific folding instruc

214 This method circumvents the need for electron microscopy reconstruct

215 caused by spontaneous Env activation, which circumvents the need for original cell receptor.

216 careful alignment and complex analysis, but circumvents the need of a terahertz transparent substrat

217 its ability to evoke a metabolic state that circumvents the negative effects of reactive nitrogen sp

218 noprobes with excellent biocompatibility and circumvents the problem of particle agglomeration.

219 on single-electron-mediated alkyl transfer, circumvents the restriction of using reactive alkylmetal

220 n electron transfer shunt from the electrode circumvents the slow dissociation of a ferric hydroxide

221 e potential for off-target side effects, and circumvents the substantial systemic delivery barriers.

222 s against predation and ways in which phages circumvent them, and provide a rationale for the prevale

223 nisms for how their organotrophic catabolism circumvents thermodynamic restrictions remain unclear.

224 One way to potentially circumvent these challenges is to adopt the concept of d

225 to regenerate injured or diseased tissue may circumvent these challenges.

226 iscuss potential pharmacologic approaches to circumvent these deleterious effects by reducing exogeno

227 Here, we demonstrate a new method to circumvent these difficulties and to greatly simplify th

228 ture uses iron-sulfur complexes ([Fe-S]), to circumvent these issues in vivo.

229 To circumvent these issues, this study describes a new way

230 ery system integrated with image guidance to circumvent these issues.

231 In this study, we aimed to circumvent these limitations by the use of a chimeric ad

232 ple Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiolo

233 To circumvent these limitations, ASCIIGenome runs exclusive

234 To circumvent these limitations, here we embrace instabilit

235 To circumvent these limitations, we adopted a strategy to r

236 To circumvent these limitations, we conjugated the chemothe

237 To circumvent these limitations, we suggest a novel approac

238 se discovery rate and exon-level analysis to circumvent these limitations.

239 proteins exploited by pathogens in order to circumvent these limitations.

240 To circumvent these potentially harmful events, we replaced

241 many cases ratiometric analysis can help to circumvent these problems and enable the quantitative st

242 To circumvent these problems, a program of clinical standar

243 To circumvent these problems, we designed a system where th

244 To circumvent these problems, we developed a cyclic RGD pep

245 To circumvent these problems, we developed Fixed and Recove

246 To potentially circumvent these problems, we have developed a single-mo

247 Circumventing these bioengineering limitations is critic

248 Ultrasonography circumvents these demerits and has emerged as the prefer

249 for a strontium optical lattice clock which circumvents these limitations.

250 In this study, we circumvent this by introducing a novel treatment protoco

251 Plasmonics is providing new opportunities to circumvent this challenge.

252 ochlear sensory epithelia of newborn mice to circumvent this challenge.

253 The maquette approach can circumvent this complexity by combining a robust de novo

254 To circumvent this confounding factor, we have generated a

255 To circumvent this constraint, STAG-CNS that can simultaneo

256 Here, we circumvent this difficulty by utilizing covalent dimers

257 tive substance from probiotic bacteria could circumvent this difficulty.

258 pired by cuticles of marine mussel byssi, we circumvent this inherent trade-off by incorporating sacr

259 To circumvent this issue and test the sensitivity of the hu

260 ribe a general approach that we developed to circumvent this issue that combines two technologies: ye

261 tion-alternating least-squares (MCR-ALS), to circumvent this issue while retaining the advantages of

262 To circumvent this issue, yolk-shell structured MPHNs compr

263 an innovative approach has been proposed to circumvent this issue: the use as phylogenetic markers o

264 We propose to circumvent this large sample size requirement by evaluat

265 To circumvent this limitation and detect strata even if onl

266 Here, we circumvent this limitation by analyzing genomes from mut

267 Here, we circumvent this limitation by exploiting cultured intest

268 Here we circumvent this limitation by fusing an extra phluorin-t

269 To circumvent this limitation, we developed a simple, fast,

270 To circumvent this limitation, we utilized the unique struc

271 se medicine with anti-cancer potential might circumvent this obstacle.

272 ittle is known about how enteropathogens may circumvent this physiologic barrier.

273 ere, we introduce an alternative approach to circumvent this problem by substituting the oxide ions i

274 To circumvent this problem we have applied a method of coll

275 To circumvent this problem, we developed a novel approach t

276 To circumvent this problem, we introduce a novel likelihood

277 To circumvent this problem, we now report the synthesis and

278 Masking groups are often employed to circumvent this problem, which is in opposition to the i

279 ble of representing invariant features could circumvent this problem.

280 use of antibiotics and create strategies to circumvent this problem.

281 Modern plant breeders increasingly seek to circumvent this process to produce doubled haploid indiv

282 hancers, including certain "superenhancers," circumvent this trade-off in specificity and activity.

283 Here, in an effort to circumvent this upper limit, we explore the potential of

284 To circumvent this waste of precious metal and follow a rat

285 Here, we circumvented this difficulty by studying for the very fi

286 Here, we circumvented this fundamental limitation by designing te

287 We have circumvented this problem by an innovative use of imagin

288 sposon and transposase from separate vectors circumvented this.

289 Here, we present a technique for circumventing this limitation.

290 Circumventing this problem, here we observed focal intra

291 Ribosome profiling circumvents this challenge by measuring global protein p

292 ata to identify a combinatorial therapy that circumvents this resistance through a two-step process o

293 null phenotype, but the loss of Sall1 can be circumvented through direct recruitment of the NANOG tra

294 quency variants, which together cooperate to circumvent tissue-specific challenges.

295 isms use chemical inactivation strategies to circumvent toxicity caused by many types of antibiotics.

296 NA vector expressing mature miR-122-5p could circumvent toxicity, despite the exogenous shRNA account

297 ngth about iron, odd-electron reactivity was circumvented via increased covalency.

298 ely on RNA interference (RNAi) mechanisms to circumvent viral infections.

299 uggest how this lethal relationship might be circumvented, which could help design better therapies f

300 tly, this mechanism of immune evasion can be circumvented with small-molecule CD4 mimetics (CD4mc) th