ライフサイエンスコーパス: cisternae

1 tructural organization and function of Golgi cisternae.

2 arity, being most abundant on cis and medial cisternae.

3 endent membrane tethering of analogous Golgi cisternae.

4 hat consists of both tubules and fenestrated cisternae.

5 uclear envelope primarily originates from ER cisternae.

6 s translocation of Sig-1R from the MAM to ER cisternae.

7 GRASP proteins work together to stack Golgi cisternae.

8 rix within large rough endoplasmic reticulum cisternae.

9 ombined with relatively rapid exchange among cisternae.

10 olgi apparatus must be guided to the correct cisternae.

11 ere recruited to the region of nascent Golgi cisternae.

12 ct early (cis, medial) and late (trans, TGN) cisternae.

13 asma membrane from the underlying subsurface cisternae.

14 r enzymes and accumulate abnormal Golgi-like cisternae.

15 There is debate about the nature of these cisternae.

16 transport of Golgi resident proteins between cisternae.

17 e the Golgi by remaining within the maturing cisternae.

18 re confined to the space around these latter cisternae.

19 a membrane, cortical lattice, and subsurface cisternae.

20 secretory vesicles derived from trans-Golgi cisternae.

21 ive compartment with the structure of the SR cisternae.

22 zed with Sec7-DsRed, a marker of trans-Golgi cisternae.

23 etween a maturing tapetosome and numerous ER cisternae.

24 proximity to ER exit sites and to cis Golgi cisternae.

25 ent with a primary trans-Golgi origin of the cisternae.

26 than a direct role in the stacking of Golgi cisternae.

27 um (ER)-derived membranes nucleate new Golgi cisternae.

28 the buds that lack ER also lack early Golgi cisternae.

29 the inheritance of both early and late Golgi cisternae.

30 These connections all "bypass" interceding cisternae.

31 ing Golgi compartments to generate new Golgi cisternae.

32 ASP65 is directly involved in stacking Golgi cisternae.

33 l unstack Golgi membranes, generating single cisternae.

34 ernae, but are present in medial through TGN cisternae.

35 mbrane, the cortical lattice, and subsurface cisternae.

36 f small vesicles and bulk retrieval of large cisternae.

37 totic Golgi vesicles and tubules into mature cisternae.

38 ator of RyR1 channels within the SR terminal cisternae.

39 ate assembly of COPI coat complexes on Golgi cisternae.

40 arge bulging domains on the three trans-most cisternae.

41 s and alignment with the other stacked Golgi cisternae.

42 ation, and in marked disruption of the Golgi cisternae.

43 e, was not sufficient to maintain enveloping cisternae.

44 ich appear to pinch off from the rims of the cisternae.

45 of the pericentriolarly organized stacks of cisternae.

46 iral and cellular proteins in enveloping TGN cisternae.

47 GIC), and ERGIC elements then generate Golgi cisternae.

48 e receptor (RyR) channels in the SR terminal cisternae.

49 NARE proteins, Sed5p, present in early Golgi cisternae.

50 n indicate that it is present in early Golgi cisternae.

51 actor and the accumulation of abnormal Golgi cisternae.

52 ith its receptors, in stacking p97 generated cisternae.

53 xtend from the margins of both cis and trans cisternae.

54 th subjunctional dense bodies and subsurface cisternae.

55 egions of the plasma membrane and subsurface cisternae.

56 ulum before being transported into the Golgi cisternae.

57 calcium homeostasis in the CGN and cis-Golgi cisternae.

58 s it specifically to trans-Golgi dictyosomal cisternae.

59 of tethered stacks of cis, medial, and trans cisternae.

60 2 accumulates on cell bodies atop subsurface cisternae.

61 ) from both the centrosome and the cis-Golgi cisternae.

62 understanding tubules that connect the Golgi cisternae.

63 (ts1) animals converted these pits into bulk cisternae.

64 t retained polymerized ATZ within dilated ER cisternae.

65 d Golgi membranes with a single GRASP on all cisternae.

66 um (ER), an elaborate network of tubules and cisternae [1], establishes contact sites with the plasma

67 p115-mediated docking of vesicles with Golgi cisternae [12].

68 n expanded rough endoplasmic reticulum (rER) cisternae, a hallmark of PSACH.

69 tional increase in the number of trans-Golgi cisternae, a switch to larger-sized secretory vesicles t

70 collapse in the central domain of the trans-cisternae accompanying polysaccharide synthesis with a m

71 Margins of trans-Golgi cisternae accumulate the LM8 xylogalacturonan (XGA) epit

72 r in ARCL2 cells resulted in distended Golgi cisternae, accumulation of abnormal lysosomes and multiv

73 ith microbodies, mitochondria and a membrane cisternae, an arrangement characteristic of the microbod

74 f the golgin GMAP-210 causes a loss of Golgi cisternae and accumulation of numerous vesicles.

75 racellularly with concomitant dilation of ER cisternae and activation of the ER stress response marke

76 bud exclusively from medial- and trans-Golgi cisternae and are confined to the space around these lat

77 ture was comprised of a complex of segmented cisternae and branching canaliculi with clustered mitoch

78 of which are unique to IHCs, implicated the cisternae and complexes in the genesis of the vesicles.

79 o understand the relationship between fusome cisternae and cystoblast differentiation, we have begun

80 etory pathway, causing an accumulation of ER cisternae and dilation of the Golgi complex.

81 , and the mutant has Golgi bodies with fewer cisternae and enlarged vesicles.

82 s cisternae and occupy the space between cis cisternae and ER export sites, whereas the COPIb vesicle

83 ergo, that induces reversible loss of the ER cisternae and extensive ER tubulation, including formati

84 we observed dense granular aggregates within cisternae and intracisternal filament bundles associated

85 ts, which took the form of complex stackable cisternae and labyrinthine structures adjoining the PM a

86 t protein I (COPI) vesicles arise from Golgi cisternae and mediate the recycling of proteins from the

87 at adding artificial adhesive energy between cisternae and mitochondria by dimerizing rapamycin-bindi

88 COPIa vesicles bud exclusively from cis cisternae and occupy the space between cis cisternae and

89 segregated from each other within the Golgi cisternae and packaged into separate vesicles.

90 ocytosis and retrograde transport into Golgi cisternae and perhaps ER.

91 ed cells, F13L-GFP was associated with Golgi cisternae and post-Golgi vesicles containing the LAMP 2

92 scent vesicles bud from randomly distributed cisternae and surface membrane infoldings and enter vesi

93 cal features, such as proliferation of trans cisternae and swelling of the trans cisternae and trans-

94 -I (PGA/RG-I) are detected in the trans-most cisternae and TGN compartments.

95 m the Golgi occurs directly from three trans-cisternae and that specialized ER plays a significant ro

96 s revealed that Cdc42 is active at all Golgi cisternae and that this activity is controlled by Tuba a

97 microscopy, CALNUC is localized to cis-Golgi cisternae and the cis-Golgi network (CGN).

98 n cargo-laden carriers hopping across stable cisternae and the other on "maturing" cisternae that car

99 ented Golgi elements reformed into flattened cisternae and the re-assembled Golgi supported vesicle r

100 has been implicated in the stacking of Golgi cisternae and the regulation of Golgi disassembly/reasse

101 st that they form at the edges of the medial cisternae and then migrate inward.

102 to locate to ER tubules and the edges of ER cisternae and to induce constrictions in ER tubules when

103 of trans cisternae and swelling of the trans cisternae and trans-Golgi network (TGN) compartments.

104 ontinuous membrane network of interconnected cisternae and tubules spread out throughout the cytosol

105 artmentalized organization of interconnected cisternae and tubules while supporting a continuous flow

106 h the plasma membrane and occasionally Golgi cisternae and tubulovesicles.

107 continuously concentrated over stacked Golgi cisternae and tubulovesicular Golgi structures similar t

108 oteins disperses the Golgi stack into single cisternae and tubulovesicular structures, accelerates pr

109 Golgi fragments showed swollen distal Golgi cisternae and vesicular structures.

110 gous to early (RER and ERGIC), middle (Golgi cisternae), and late (TGN) secretory pathway compartment

111 2) intracellular matrix formation in the rER cisternae, and (3) increased chondrocyte apoptosis.

112 etory vesicles that bud from the trans-Golgi cisternae, and an increase in osmium staining of the sec

113 acts with mitochondria, multiple trans Golgi cisternae, and compartments of the endo-lysosomal system

114 n I)-coated vesicles and buds, but not Golgi cisternae, and it specifically activates Rab1.

115 ressed in HeLa cells was restricted to Golgi cisternae, and its membrane association was sensitive to

116 3) Late endosomes, cisternae, and multivesicular bodies accumulate in the p

117 OPIb vesicles is limited to medial and trans cisternae, and that diffusion of periGolgi vesicles is r

118 Third, intact TGN cisternae apparently peel off from the Golgi stacks and

119 Cisternae appear to be disk-shaped structures that do no

120 Cisternae appear to contain considerable lipidic and oth

121 abundant in cell bodies, with large, flat ER cisternae apposed to the PM, sometimes with a notably na

122 All cisternae are fenestrated and display coated buds.

123 iffraction limit of light microscopy, as the cisternae are only 10-20 nm thick and closely stacked in

124 The stacks of cisternae are positioned between two types of ER, cis an

125 During telophase, Golgi cisternae are regenerated and stacked from a heterogeneo

126 ransport continue-even when individual Golgi cisternae are separated and "land-locked" between mitoch

127 re entering mitosis, the stacks of the Golgi cisternae are separated from each other, and inhibiting

128 This suggests that while the cisternae are static on the time scale of protein traffi

129 In mammalian cells, these cisternae are stitched together as a perinuclear Golgi r

130 and function of these intranuclear membrane cisternae are unknown.

131 zes with RabE(RAB11), arriving at late Golgi cisternae as they dissipate into exocytic carriers.

132 o stacking and lateral interactions of Golgi cisternae as well as help it function as a vesicle tethe

133 places within individual cisternae when two cisternae at different levels in the Golgi have fused, m

134 act region across which bridges connect some cisternae at equivalent levels, but none at nonequivalen

135 since its removal allows recovery of the ER cisternae at the expense of the densely packed tubular E

136 We suggest that the cisternae attached to ribbons represent synaptic vesicle

137 mmunicate via vesicles and another one where cisternae biochemically mature to ensure anterograde tra

138 l maturation model postulates that transient cisternae biochemically mature to ensure anterograde tra

139 Second, fenestrae are absent from cis cisternae, but are present in medial through TGN cistern

140 RyR1 of TC; 3) release of FKBP from terminal cisternae by drug (FK590) treatment leads to a significa

141 ses in Golgi reassembly: formation of single cisternae by membrane fusion, and restacking.

142 type II cells occurred opposite subsynaptic cisternae (C synapses); all other synapses were asymmetr

143 The codistribution of parallel cisternae, canalicular-mitochondrial complexes, and syna

144 In mammalian cells, flat Golgi cisternae closely arrange together to form stacks.

145 compartments model postulates that permanent cisternae communicate through bi-directional vesicles, w

146 ls for intra-Golgi traffic: one where stable cisternae communicate via vesicles and another one where

147 With urine exposure, cisternae communicate with salts in the external solutio

148 At the ministack level, cisternae constrain the size of nanostructures ("quanta"

149 mic reticulum fractions enriched in terminal cisternae containing both isoforms 1 (>95%) and 3 (<5% o

150 is is because it enables the dilated rims of cisternae (containing the aggregates) to move across the

151 lular mature vaccinia virions are wrapped by cisternae, derived from virus-modified trans-Golgi or en

152 t the total amount of adhesive energy gluing cisternae dictates Golgi cisternal stacking, irrespectiv

153 esis and is primarily localized to the Golgi cisternae distinct from the trans-Golgi network (TGN) in

154 ate both formation and stacking of the Golgi cisternae during post-mitotic reassembly.

155 Some parallel cisternae ended with segmentation where they contacted m

156 The heterotypic fusion of cisternae, even transiently, raises important questions

157 nuclear envelope assembles directly from ER cisternae followed by membrane-dependent insertion of nu

158 This juxtaposition may indicate that Golgi cisternae form at tER sites.

159 ost readily explained by assuming that Golgi cisternae form at the cis face of the stack, progressive

160 ently reassembled in a process that involves cisternae formation and stacking.

161 lated processes including vesicle transport, cisternae formation, and cisternal stacking.

162 from virus-modified trans-Golgi or endosomal cisternae, forms a loose coat around some intracellular

163 function during cell-free assembly of Golgi cisternae from mitotic Golgi fragments revealed that NSF

164 ntial for the p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments, a process restri

165 of matrix organization was found in multiple cisternae from single chondrocytes and in chondrocytes w

166 ian cells.The different composition of Golgi cisternae gave rise to two different models for intra-Go

167 cubation demonstrated that the stacked Golgi cisternae generated a heterogeneous population of vesicl

168 e presence of TER94 suggests that the fusome cisternae grow by vesicle fusion and are a germ cell mod

169 trafficking between the cis and medial Golgi cisternae has been used previously to identify several p

170 ctions between stacked endoplasmic reticulum cisternae have a shape well known in classical different

171 ructure, leading to dramatically vesiculated cisternae in a variety of cell types.

172 CS2 antiserum stains medial and trans-Golgi cisternae in all cell types investigated.

173 r endoplasmic/sarcoplasmic reticulum (ER/SR) cisternae in cardiomyocytes remain obscure.

174 ll, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting tha

175 graphs of atrial myocytes show peripheral SR cisternae in close proximity to clusters of caveolae.

176 Although the dilation of some Golgi cisternae in Cog5-deficient cells resembled that observe

177 pressed, but was largely restricted to Golgi cisternae in the absence of F13L-GFP or when the F13L mo

178 esult from the unique arrangement of the two cisternae in the baso-lateral region of the OHC.

179 microscopy revealed the presence of swollen cisternae in the dorsal spinal cord after SNL.

180 Direct continuity between the membranes of cisternae in the Golgi complex in mammalian cells rarely

181 is composed of collapsed stacks and bloated cisternae in these cells.

182 hown to play a role in stacking of the Golgi cisternae in vitro.

183 cked structure of closely aligned, flattened cisternae in which Golgi enzymes reside; in mammalian ce

184 aused the buildup of huge membrane-connected cisternae, in contrast to the invaginated pits that accu

185 erved dilation of endoplasmic reticulum (ER) cisternae, increased phosphorylation of eukaryotic initi

186 ab family, Ypt1 and Ypt31, to specific Golgi cisternae interferes with addressing this question in ye

187 that affecting SM homeostasis converted flat cisternae into highly curled membranes with a concomitan

188 In addition, the resolution of endocytic cisternae into synaptic vesicles in response to strong s

189 The stacking of Golgi cisternae involves GRASP65 and GRASP55.

190 This behavior of late Golgi cisternae is consistent with the cisternal maturation mo

191 ory station composed of stacks of membranous cisternae, is a central yet unsettled issue in membrane

192 er of GC elements, small polarized stacks of cisternae, is quite similar in all fibers, but their int

193 has been explained by the movement of Golgi cisternae, known as cisternal maturation.

194 eosins and TAGs, and relatively high-density cisternae-like vesicles, which possessed calreticulin an

195 the familiar reticular network of convolved cisternae linked to tubules.

196 he Golgi apparatus is a network of polarized cisternae localized to the perinuclear region in mammali

197 ance of retrieval-based targeting, few Golgi cisternae-localized proteins have been demonstrated to b

198 Injection of KIR4.1 serum IgG into the cisternae magnae of mice led to a profound loss of KIR4.

199 ubular network capable of morphing into flat cisternae, mainly at three-way junctions, and back to tu

200 ells, the peripheral ER contains cytoplasmic cisternae, many tubules, and a large plasma membrane (PM

201 This approach reveals that individual cisternae mature, and do so at a consistent rate.

202 sanoid products, while the location in Golgi cisternae may also reflect its action as a secreted enzy

203 rough the stack along with cargo, but stable cisternae models do not.

204 Under stable cisternae models, Golgi residents remain in the same cis

205 to vesicular tubular complexes and cis-Golgi cisternae, mostly in brain, atlastin-2 and -3 are locali

206 TGN cisternae of cells infected with VZV mutants lacking gI

207 extending tubules associated with the trans-cisternae of control cells.

208 he usual organelles, including mitochondria, cisternae of endoplasmic reticulum and Golgi complexes.

209 trilin-3 (MATN3), also accumulate in the rER cisternae of PSACH chondrocytes, but it is unknown how m

210 s of six or eight and sets of three parallel cisternae of rough endoplasmic reticulum spanning betwee

211 invagination of plasma membrane and terminal cisternae of sarcoplasmic reticulum (SR) by reduction of

212 les, as well as highly disorganized terminal cisternae of sarcoplasmic reticulum, were common.

213 Interestingly, we observed subsurface cisternae of smooth endoplasmic reticulum at the close a

214 unicate to the nervous system via subsurface cisternae of smooth endoplasmic reticulum in lieu of con

215 Thus, we identified cisternae of the GA in distal perisynaptic and subependy

216 ted on the surface of the middle (or medial) cisternae of the Golgi complex.

217 re selectively deposited within the cis-most cisternae of the Golgi stack following a 15 degrees C bl

218 C2GnT was localized mainly in cis to medial-cisternae of the Golgi.

219 n the hippocampus identified numerous paired cisternae of the rough endoplasmic reticulum (RER) and o

220 is apparently in alignment with the terminal cisternae of the sarcoplasmic reticulum.

221 ithin nanometer-sized stores (the junctional cisternae of the SR) during elementary Ca(2+) release ev

222 cles could be traced in adjacent sections to cisternae open to the medium.

223 increases the number of cis- and trans-Golgi cisternae per cell, and Ena overexpression also redistri

224 cells had altered Golgi morphology and fewer cisternae per Golgi apparatus relative to wild-type cell

225 In the absence of GRASP65, the number of cisternae per Golgi stack is reduced without affecting t

226 55 or GRASP65 by siRNA reduces the number of cisternae per Golgi stack, whereas simultaneous knockdow

227 ne Kv2.1 clusters are adjacent to subsurface cisternae, placing Kv2.1 in close proximity to sites of

228 APM1 localizes at the margins of Golgi cisternae, plasma membrane, select multivesicular bodies

229 all and large intercellular pools of water ("cisternae") present throughout the stratum corneum, and

230 0 to 60 nm in diameter) in large cytoplasmic cisternae, presumably derived from the endoplasmic retic

231 n the cytosol, and these "free-floating" TGN cisternae produce clathrin-coated vesicles.

232 ke organelle composed of stacks of flattened cisternae punctuated by openings of various sizes.

233 Restacking of the newly formed Golgi cisternae requires dephosphorylation of Golgi stacking p

234 ecifically localized to cis and medial/trans cisternae, respectively, it is unknown whether each GRAS

235 , which localize to the cis and medial-trans cisternae, respectively.

236 rinsed) delivers vesicles via infoldings and cisternae selectively to a reserve pool with a halftime

237 1 x 4 microm3) contains two stacks of seven cisternae separated by a noncompact region across which

238 ities in adult, mainly acting on reducing ER cisternae size and favoring collagen secretion.

239 Thus each GRASP appears to play a direct and cisternae-specific role in linking ministacks into a con

240 y, it is unknown whether each GRASP mediates cisternae-specific tethering and whether such specificit

241 To test the consequence of loss of cisternae-specific tethering, we generated Golgi membran

242 l's lateral membrane and adjacent subsurface cisternae (SSC) could further limit the influence of rec

243 he cortical lattice (CL), and the subsurface cisternae (SSC).

244 We are prone to thinking by analogy-Golgi cisternae stack like pancakes, red blood cells look like

245 tes C1P steady-state levels and alters Golgi cisternae stack morphology.

246 Within 0.2 microm of the cisternae studied, there are 394 vesicles (8 clathrin co

247 ghout the stratum corneum, and at 24 h these cisternae substantially increase in size.

248 They pass beyond neighboring cisternae, suggesting that these tubules contribute to t

249 ticulum from rabbit skeletal muscle terminal cisternae (TC) contains four tightly associated FK506-bi

250 muscle triad junctions (triads) and terminal cisternae (TC) vesicles derived from sarcoplasmic reticu

251 is composed of a stack of cis, medial, trans cisternae that are biochemically distinct.

252 a membrane and presence in the subsurface ER cisternae that are juxtaposed to the plasma membrane in

253 ammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous

254 ee types of direct connections between Golgi cisternae that are normally distinct from one another.

255 y-state Golgi resident enzymes among stacked cisternae that are stationary.

256 stable cisternae and the other on "maturing" cisternae that carry cargo forward while progressing thr

257 s a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylati

258 nected network of narrow tubules and dilated cisternae that enclose a single lumen.

259 mograms revealed structures within the Golgi cisternae that have not been seen before.

260 that secretory proteins transit the Golgi in cisternae that mature by the continuous retrograde trans

261 the initial alignment and docking of single cisternae that may be an important prerequisite for stac

262 narily high density of endoplasmic reticulum cisternae that shadow neuronal, astrocytic, vascular, an

263 end-foot compartment showed high-density ER cisternae that shadow retinal ganglion cell (RGC) somata

264 ted recycling to the ER occurs only from cis cisternae, that retrograde transport of Golgi resident p

265 Within cisternae the lipid structure is disrupted by lamellar d

266 he flattened, stacked central regions of the cisternae, the soluble aggregates are in the dilated rim

267 s and soluble aggregates placed in cis-Golgi cisternae therefore have different fates.

268 forms close contacts with the two trans-most cisternae; this apposition may permit direct transfer of

269 he narrow central spacing of the trans-Golgi cisternae through zipper-like interactions, thereby forc

270 bind to giantin on vesicles and to GM130 on cisternae, thus acting as a tether holding the two toget

271 ave been implicated in the adhesion of Golgi cisternae to each other to form their characteristic sta

272 e GRASP isoforms specifically link analogous cisternae to ensure Golgi compartmentalization and prope

273 ain and mediate homotypic tethering of Golgi cisternae to form extended Golgi ribbons.

274 virions by modified trans-Golgi or endosomal cisternae to form intracellular enveloped virions is dep

275 ne could be used by trans-Golgi or endosomal cisternae to form new viral envelopes.

276 ng of Golgi by the ectopic adhesion of Golgi cisternae to mitochondria.

277 lus nidulans hyphae, we show that late Golgi cisternae undergo changes in composition to gradually lo

278 The pericentriolar stacks of Golgi cisternae undergo extensive reorganization during mitosi

279 ave been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, b

280 at GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism.

281 GRASP65 links cis-Golgi cisternae via a homotypic, N-terminal PDZ interaction, a

282 gi residents recycle from distal to proximal cisternae via retrograde carriers in synchrony with cist

283 With the increased spatial separation of cisternae, we show using three-dimensional live imaging

284 Enveloping membranous TGN cisternae were microscopically identified in cells infec

285 ibbons to become fragmented and dilated, but cisternae were still stacked and located in a juxtanucle

286 enzymes at specific places within individual cisternae when two cisternae at different levels in the

287 rotein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Go

288 protein localizes to the junctional SR (jSR) cisternae, where it is responsible for the storage of la

289 both Rab11a and Rab8a in collapsed membrane cisternae, whereas dominant-negative Rab11-FIP2(129-512)

290 "matrix." Each stack contains three to four cisternae, which can be classified as cis, medial, trans

291 ture vaccinia virus particles are wrapped by cisternae, which may arise from trans-Golgi or early end

292 he Golgi stack into cis-, medial-, and trans-cisternae, which separate early from late processing ste

293 nging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content

294 The three cisternae with bulging domains can be identified as tran

295 lls, most of the ER is organized as extended cisternae, with a very small fraction remaining organize

296 rmediate production and consumption by Golgi cisternae, with only a minor contribution of pre-existin

297 se was mapped to the medial- and trans-Golgi cisternae, with some being present in the TGN.

298 a to invade the stack and even replace Golgi cisternae within a few hours.

299 rastructurally, the antigen was localized to cisternae within horizontal cell somata, along tubuloves

300 bles gene disrupt the assembly of membranous cisternae within the fusome and block cystoblast differe