ライフサイエンスコーパス: cistrome

1 ps with the estradiol (E2)-dependent ERalpha cistrome.

2 s: MARGE-potential, MARGE-express, and MARGE-cistrome.

3 ion factor binding sites has been termed the cistrome.

4 U.1 and did not contribute to the basal IRF8 cistrome.

5 ity dynamics are also predictive of the ESR1 cistrome.

6 AR-dependent gene expression profiles and AR cistromes.

7 de the first comparison of the ETS1 and ETS2 cistromes.

8 creases, but not reprograms, GATA2 and FOXA1 cistromes.

9 ceptor (AR) and glucocorticoid receptor (GR) cistromes.

10 l approach for predicting cell-type specific cistromes.

11 MARGE-cistrome adopts a novel semisupervised learning approach

12 cantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS b

13 AR cistrome analyses in CRPC cells have identified a large

14 Transcriptome and BRD4 cistrome analyses reveal enhanced expression of the GTPa

15 sulted in recruitment of EZH2 across the ERG-cistrome and a genome-wide loss of ERG-mediated transcri

16 Cistrome and chromatin analyses revealed that HNF4G is a

17 Comparison to cistrome and epicistrome datasets identifies association

18 Robust methods to construct comprehensive cistrome and epicistrome maps are critical for elucidati

19 able low-cost, high-throughput generation of cistrome and epicistrome maps for any organism, we devel

20 periments to provide information on both the cistrome and interactome for a given protein.

21 ativity and equilibrium with FOXA1 define AR cistrome and reveal a previously unknown function of FOX

22 cted lability within the adipocyte PPARgamma cistrome and show that, even in terminally differentiate

23 hanisms by which GATA2 and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 a

24 Exploring the AP-1 cistrome and the AP-1-regulated transcriptome, we obtain

25 variant 1 (ETV1) positively regulated the AR cistrome and transcriptional output in ETV1-translocated

26 We have determined the cistrome and transcriptome for the nuclear receptor live

27 e examine if the effect of bexarotene on RXR cistrome and transcriptomes depend on APOE isoform and A

28 teoblast progeny (OB), characterized the two cistromes and assessed their relationship to changes in

29 We find that AR and GR cistromes and transcription programs exhibit significant

30 matically catalog all of the genes bound by (cistromes) and transcriptionally activated by (regulomes

31 me to "ignite" an otherwise fully dissipated cistrome, and drive it to criticality; (iii) how couplin

32 substantial rewiring of human and mouse REST cistromes, and that REST may have human-specific roles i

33 Transcription factor cistromes are highly cell-type specific.

34 of the BMAL1, REV-ERB-alpha and REV-ERB-beta cistromes are highly enriched for both clock and metabol

35 the EGF-induced ERalpha genomic targets, its cistromes, are distinct from those induced by estrogen i

36 pied promoters and the subset of the ERalpha cistrome associated with coactivation.

37 chanism of LXR action in skin, we mapped its cistrome by identifying LXRbeta-RXRalpha binding sites u

38 aled that FOXA1 reprograms both AR and GATA2 cistrome by preferably recruiting them to FKHD-containin

39 Using DAP-seq, we defined the Arabidopsis cistrome by resolving motifs and peaks for 529 TFs.

40 MARGE-cistrome can predict the binding sites of silenced trans

41 roach to discover genome-wide changes in RXR cistrome (ChIP-Seq) and gene expression profile (RNA-Seq

42 ), CCCTC binding factor (CTCF), AR and FoxA1 cistrome data as well as androgen-regulated gene express

43 To overcome this challenge, we built the Cistrome database, a collection of ChIP-seq and chromati

44 Therefore, we constructed the CR Cistrome database, available online at http://compbio.to

45 The PR cistrome displayed a bimodal distribution.

46 Pdx1 and Slc2a2, and has a mature beta-cell cistrome distinct from that of pancreatic endocrine prog

47 e response in which repressive and inductive cistromes establish a dynamic balance between macrophage

48 Mechanistically, RB loss led to E2F1 cistrome expansion and different binding specificity, al

49 Human REST cistrome expansion involves additional peaks in genes ta

50 MARGE-cistrome exploits information from H3K27ac signal at DNa

51 Using ChIP-seq, we demonstrate that the cistrome for the AP-1 transcription factor c-Jun is comp

52 The macrophage RXR cistrome has 5200 genomic binding sites, which are not i

53 transcription factor's mutant phenotype and cistrome hence reveals the continued and distinct requir

54 How FOXA1 controls the AR cistrome, however, is incompletely understood.

55 Defining the GR-cistrome identified Gc regulation of motility genes.

56 AD heritability was enriched within the PU.1 cistrome, implicating a myeloid PU.1 target gene network

57 In this study, we examined the AR cistrome in a PCa cell line-derived CRPC model using int

58 onducted a genome-wide analysis of the RUNX2 cistrome in both pre-osteoblastic MC3T3-E1 cells (POB) a

59 , in the maintenance of the luminal-specific cistrome in breast cancer cells.

60 Unexpectedly, the REST cistrome in differentiated neurons exhibited unique feat

61 plied ChIP-seq analysis to identify the REST cistrome in human CD4+ T cells and compared it with publ

62 We defined the KN1 cistrome in maize inflorescences and found that KN1 bind

63 set of the estrogen receptor alpha (ERalpha) cistrome in MCF7 breast cancer cells provides specificit

64 Here we defined the BCL6 cistrome in primary human germinal center Tfh cells to a

65 s parameter, dependent on the details of the cistrome in question; (ii) the ability of an active cist

66 Through the analysis of the ER cistrome in tamoxifen-resistant breast cancer cells, we

67 e approach was used here to define the FOXA2 cistrome in the murine uterus.

68 To characterize the TRbeta1 cistrome in vivo, we expressed a biotinylated TRbeta1 in

69 ng (ChIP-seq), we demonstrate that PPARgamma cistromes in mouse adipocytes and macrophages are predom

70 y genome-wide mapping of the c-Fos and c-Jun cistromes in NHEKs, demonstrating that 77% of all the LX

71 dea was confirmed through discovery that VDR cistromes in POBs and OBs were also strikingly different

72 bution of genome-wide VDR-binding sites (VDR cistrome) in HSCs and facilitates VDR binding at SMAD3 p

73 lyses, we found that the Bcl-6 and NF-kappaB cistromes intersect, within nucleosomal distance, at nea

74 We believe CR Cistrome is a valuable resource for the epigenetics comm

75 ted transcriptome, and that 90% of the Bcl-6 cistrome is collapsed following Tlr4 activation.

76 Significantly, we found that the AR cistrome is largely retained in the CRPC stage.

77 The cistrome is the complete set of transcription factor (TF

78 y differentiated cells, PU.1 can remodel the cistrome of another master regulator.

79 cer risk-associated SNPs are enriched in the cistromes of FOXA1 and ESR1 and the epigenome of histone

80 3 and TP63 bind to overlapping, but distinct cistromes of sites through utilization of distinctive co

81 riptional role that dissects the overlapping cistromes of the two most common ETS gene fusions in PC:

82 such as ChIP-Seq have described the entire "cistrome" of transcription factors involved in specific

83 termined the genome-wide cis-acting targets (cistromes) of both REV-ERB isoforms in murine liver, whi

84 t http://compbio.tongji.edu.cn/cr and http://cistrome.org/cr/, to further elucidate CR functions and

85 e-specific transformation by altering the AR cistrome, priming the prostate epithelium to respond to

86 new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of

87 Analysis of the uterine FOXA2 cistrome provides novel insights into mechanisms governi

88 ionally linking these specific factors to AR cistrome reprogramming.

89 Thus, the hematopoietic stem/progenitor cell cistrome revealed a mediator of a signaling pathway that

90 Bioinformatics analysis of the cistrome revealed an enrichment of AP1 cis-regulatory mo

91 In addition, the MCF7 RNA polymerase II cistrome reveals preferential occupancy of E2-regulated

92 Bioinformatic analysis of the PLZF cistrome shows that PLZF negatively regulates multiple p

93 The EGF-induced ERalpha cistrome specifically regulates genes found overexpresse

94 ponsive transcription factors and define the cistrome that regulates vascular and hematopoietic devel

95 on of S305 by IKKbeta establishes an ERalpha cistrome that substantially overlaps with the estradiol

96 y on a global scale the components of the TF cistromes that function to orchestrate circadian gene ex

97 e in question; (ii) the ability of an active cistrome to "ignite" an otherwise fully dissipated cistr

98 lized prostate cell line reprogrammed the AR cistrome to resemble that of a prostate tumor, functiona

99 drive it to criticality; (iii) how coupling cistromes together can reduce their critical branching p

100 These approaches integrated cistrome, transcriptome and drug sensitivity relationshi

101 Here we show that the androgen receptor (AR) cistrome undergoes extensive reprogramming during prosta

102 The residual VDR cistrome was composed of 4617 sites, which was increased

103 The cistrome was integrated with transcription data to obtai

104 ion with dissecting enhancer features and TF cistromes, we implicated four key TFs regulating the fas

105 de scale, revealed that TRalpha1 and TRbeta1 cistromes were also different.

106 We found that REST cistromes were distinct among cell types, with REST bind

107 quencing (ChIP-seq), we define the NF-kappaB cistrome, which is comprised of 31,070 cis-acting bindin

108 fully annotated 12 SNPs present in the c-Myc cistrome with properties consistent with modulating c-My