ライフサイエンスコーパス: citrate lyase

1 a acetyl-CoA synthetase) or citrate (via ATP citrate lyase).

2 ibitors of the recombinant human form of ATP-citrate lyase.

3 observed with mammalian, yeast, and mold ATP-citrate lyase.

4 cytosolic enzyme of citrate metabolism, ATP citrate lyase.

5 the reductive tricarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase,

6 Lowering ATP citrate lyase 88% did not inhibit glucose-induced insuli

7 these biosynthetic genes, which include ATP citrate lyase, ACC, FAS, and stearoyl-CoA desaturase.

8 Acetylated citrate lyase, acetate:CoA ligase (AMP forming), and pho

9 s been previously shown to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase (AM

10 ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthe

11 ATP-citrate lyase (ACL) is an essential enzyme of the reduct

12 NIP-H/Caytaxin links kinesin-1 (KLC1) to ATP citrate lyase (ACL), a key enzyme for ACh synthesis, and

13 is dependent on adenosine triphosphate (ATP)-citrate lyase (ACL), the enzyme that converts glucose-de

14 A (acetyl-CoA) production by the enzyme ATP-citrate lyase (ACL).

15 concentration, and nuclear functions of ATP-citrate lyase (ACL).

16 ia-derived citrate through the action of ATP citrate lyase (ACL).

17 the amino and carboxy portions of human ATP-citrate lyase (ACL).

18 olic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate o

19 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyze

20 ATP-citrate lyase (Acly) is one of two cytosolic enzymes tha

21 In this study, we report that nuclear ATP-citrate lyase (ACLY) is phosphorylated at S455 downstrea

22 ATP-citrate lyase (ACLY) is upregulated or activated in seve

23 ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis,

24 g proteins in breast cancer, identifying ATP-citrate lyase (ACLY), an enzyme in the de novo lipogenes

25 leads to increased levels of endogenous ATP-citrate lyase (ACLY), and this is accompanied by increas

26 se (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].

27 idosis is associated with an increase in ATP citrate lyase activity and protein abundance, and is par

28 ocitraturia and increased renal cortical ATP citrate lyase activity by 28%.

29 ria in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d.

30 Thus, human ATP:citrate lyase activity is regulated in vitro allosterica

31 Citrate lyase activity was higher than ATP citrate synth

32 feeding was associated with no change in ATP citrate lyase activity.

33 ight loss, is a competitive inhibitor of ATP-citrate lyase, an extramitochondrial enzyme involved in

34 ngth HCV RNAs express elevated levels of ATP citrate lyase and acetyl-CoA synthetase genes, both of w

35 Because adenosine triphosphate-citrate lyase and adenosine monophosphate-activated prot

36 These data suggest that citrate lyase and AMP-forming acetate:CoA ligase, but no

37 elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6, as well as impa

38 lation of citrate and the stimulation of ATP citrate lyase and fatty-acid synthase leading to de novo

39 ession by RNAi inhibits up-regulation of ATP citrate lyase and fatty-acid synthase.

40 lly deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key en

41 its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.

42 to the inhibition of adenosine triphosphate-citrate lyase and the activation of adenosine monophosph

43 y-acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, and Glut-1 were significantly increased t

44 oteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

45 Induction of spot 14, ATP citrate-lyase, and fatty acid synthase polypeptides, but

46 the 3-D crystal structure of M. tuberculosis citrate lyase beta-subunit (CitE), which as annotated sh

47 biosynthesis that is analogous to bacterial citrate lyase but producing acetyl-CoA rather than a pro

48 The rates of phosphorylation of ATP-citrate lyase by nm23-H1(S120G) and nm23-H1(P96S) were s

49 esis of fatty acids from glucose include ATP-citrate lyase (CL) and fatty acid synthase (FAS).

50 Flux through ATP-citrate lyase, combined with malic enzyme activity, cont

51 encoding the alpha- and beta-subunits of ATP citrate lyase could be amplified from both organisms.

52 situation observed for other prokaryotic ATP-citrate lyase enzymes, the C. tepidum enzyme was not abl

53 io of ATP/ADP, phospholipid content, and ATP citrate lyase expression.

54 of FAS, acetyl-CoA carboxylase-alpha and ATP-citrate lyase, fails to activate caspase-8 or to elicit

55 coding for key lipogenic (malic enzyme, ATP citrate-lyase, fatty acid synthase), glycolytic (pyruvat

56 nduction of mRNAs encoding malic enzyme, ATP citrate-lyase, fatty acid synthase, liver-type pyruvate

57 Both forms of RuBisCO, together with ATP citrate lyase genes in the rTCA cycle, increase with dis

58 genes, including SCD1, FAS, ACC1, ACC2, ATP-citrate lyase, glycerol kinase, and HMG-CoA reductase.

59 hypothesis that compounds which inhibit ATP-citrate lyase have the potential to be a novel class of

60 se results suggest an important role for ATP citrate lyase in proximal tubular citrate metabolism.

61 pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol.

62 and fumarase and activate the cytosolic ATP-citrate lyase in vivo, acting as a direct regulator of c

63 icant differences from other prokaryotic ATP-citrate lyases, including the enzyme from the closely re

64 the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cel

65 ETC-1002 is an adenosine triphosphate-citrate lyase inhibitor/adenosine monophosphate-activate

66 While the bacterial citrate lyase is a complex with three subunits, the M. t

67 Interestingly, the expression of ATP-citrate lyase is increased in Nat8l-silenced adipocytes

68 e show that acetyl-CoA synthase, rather than citrate lyase, is essential for acetyl-CoA synthesis in

69 Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are s

70 fat diet (HFD) results in suppression of ATP citrate-lyase levels in tissues such as adipose and live

71 Phosphorylation of C. tepidum ATP-citrate lyase occurred, presumably on a histidine residu

72 er that transcribes genes having homology to citrate lyase operon genes, citC, citD and citE, of Kleb

73 acid synthase (FAS), and phosphorylated ATP-citrate lyase (pACL).

74 ATP citrate-lyase produces acetyl-CoA in the nucleus and cyt

75 Renal cortical ATP citrate lyase protein abundance increased by 29% after 3

76 ose bisphosphate carboxylase (Calvin cycle), citrate lyase (reverse citric acid cycle), and malyl coe

77 , the catalytic properties of C. tepidum ATP-citrate lyase showed marked similarities to the eukaryot

78 dies we show that the levels of mRNA for ATP citrate lyase, the enzyme that produces acetyl-CoA, are

79 Recombinantly expressed human ATP:citrate lyase was purified from E. coli, and its kinetic

80 One of the key enzymes, ATP-citrate lyase, was purified to apparent homogeneity from

81 Activity and protein of ATP citrate lyase, which uses anaplerotic products in the cy

82 Two cytosol ATP-citrate lyases, which take part in the cycle of citrate

83 Inhibition of ATP citrate lyase with the competitive inhibitor, 4S-hydroxy