ライフサイエンスコーパス: citric acid cycle

1 diauxic shift (including glycolysis and the citric acid cycle).

2 f the tricarboxylic acid branch of the Krebs citric acid cycle.

3 a-ketoglutarate, another intermediate in the citric acid cycle.

4 mer of cis-aconitate and an inhibitor of the citric acid cycle.

5 labeled because of isotopic exchanges in the citric acid cycle.

6 actate and other precursors derived from the citric acid cycle.

7 that contain all 11 members of the reductive citric acid cycle.

8 which can supply alpha-ketoglutarate to the citric acid cycle.

9 intermediary metabolism in autotrophs is the citric acid cycle.

10 imulated growth, we suspected a block in the citric acid cycle.

11 d PDH activity and maintain flux through the citric acid cycle.

12 a substantial fraction to anaplerosis of the citric acid cycle.

13 e transfer between two of the enzymes of the citric acid cycle.

14 ondria as they lack DNA, cytochromes and the citric acid cycle.

15 substrate between two of the enzymes of the citric acid cycle.

16 yl-CoA, and 2-ketoglutaric acid entering the citric acid cycle.

17 cludes the ability to oxidize acetate in the citric acid cycle.

18 relative abundance of metabolites within the citric acid cycle.

19 provide a ready feedstock for entry into the citric acid cycle.

20 ccurred after glucose had passed through the citric acid cycle.

21 ic pathway for providing constituents of the citric acid cycle.

22 of ATP, phosphate, and intermediates of the citric acid cycle.

23 bles "anaplerotic" influx of carbon into the citric acid cycle.

24 moiety of heptanoate into anaplerosis of the citric acid cycle.

25 of isocitrate to alpha-ketoglutarate in the citric acid cycle.

26 of two distinct pathways after it enters the citric acid cycle.

27 glycolysis and through intermediates of the citric acid cycle.

28 opomer analysis of liver gluconeogenesis and citric acid cycle.

29 thways: glycolysis, gluconeogenesis, and the citric acid cycle.

30 or example, 7 of the 10 intermediates in the citric acid cycle.

31 control the direction of carbon flow in the citric acid cycle.

32 or NAD biosynthesis or to acetyl-CoA for the citric acid cycle.

33 OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle.

34 In addition to being the major citric acid cycle aconitase in Escherichia coli the acon

35 adenine dinucleotide metabolism and altered citric acid cycle activity, but not with disease-specifi

36 dition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and pr

37 Pathways such as glycolysis/gluconeogenesis, citric acid cycle, amino acid metabolism, and fatty acid

38 proliferation, especially in the context of citric acid cycle anaplerosis.

39 e bifunctional proteins that function in the citric acid cycle and act as posttranscriptional regulat

40 unctional in 12 processes: photorespiration, citric acid cycle and associated reactions, lipid metabo

41 an increase in matrix Ca(2+) stimulates the citric acid cycle and ATP synthase.

42 xes, resulting in diminished capacity of the citric acid cycle and disruption of energy metabolism.

43 wo different ways: for detoxification in the citric acid cycle and for a possibly novel biosynthetic

44 orm of Trypanosoma brucei lacks a functional citric acid cycle and is dependent solely on glycolysis

45 ellular metabolism linking glycolysis to the citric acid cycle and lipogenesis.

46 ntly used to provide carbon flux through the citric acid cycle and maintain adequate amounts of the a

47 ically block key steps of glycolysis and the citric acid cycle and monitor the effect on RpoS degrada

48 (13)C MFA studies have identified increased citric acid cycle and pentose phosphate pathway fluxes a

49 We apply the method to the Citric Acid Cycle and the Glycolysis pathways of differe

50 increases SMC glucose metabolism through the citric acid cycle and the pentose phosphate pathway by 2

51 The root of this tree combines the reductive citric acid cycle and the Wood-Ljungdahl pathway into a

52 ylase (Calvin cycle), citrate lyase (reverse citric acid cycle), and malyl coenzyme A lyase (3-hydrox

53 owever, glycerol may also be oxidized in the citric acid cycle, and glycogen synthesis from glycerol

54 ycolysis, gluconeogenesis, lipid metabolism, citric acid cycle, and neurodevelopment.

55 ular, the balance between glycolysis and the citric acid cycle appears as a determinant/indicator of

56 The intermediates of the citric acid cycle are present at micromolar concentratio

57 flux through lactate dehydrogenase, and the citric acid cycle (as inferred by flux through pyruvate

58 Although analysis of the citric acid cycle by NMR is simpler (and more intuitive)

59 succinyl analogs ties its metabolism to the citric acid cycle by reduction of the fumarate pool.

60 actate dehydrogenase fluxes while activating citric acid cycle (CAC) flux and glutamine uptake.

61 The citric acid cycle (CAC) is linked to acetic acid resista

62 Yet some tumours harbour mutations in the citric acid cycle (CAC) or electron transport chain (ETC

63 A high rate of cardiac work increases citric acid cycle (CAC) turnover and flux through pyruva

64 systems of reactions like glycolysis and the citric acid cycle can also be considered at specified co

65 that glutamate formed from the amination of citric acid cycle-derived alpha-ketoglutarate is a messe

66 at glycogen production from the level of the citric acid cycle did not occur and that the glycerol co

67 e enzyme catalyzing the only reaction of the citric acid cycle directly producing energy; succinyl-Co

68 ical model of the mitochondria including the citric acid cycle, electron transport chain and ROS prod

69 le of mitochondrial processes, including the citric acid cycle, electron transport, and oxidative pho

70 f NO. exposure inactivated the NO.-sensitive citric acid cycle enzyme aconitase, and inactivation was

71 untranslated region of the transcript of the citric acid cycle enzyme mitochondrial aconitase from fo

72 In addition, the nearly ubiquitous citric acid cycle enzyme, aconitase, plays a role in tra

73 r work thus reveals a novel subunit of a key citric acid-cycle enzyme and shows how this large comple

74 ts suggest that the novel cross-talk between citric acid cycle enzymes and electron transfer chain co

75 lase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.

76 In contrast, several citric-acid cycle enzymes, the peptide transporter CstA,

77 lls, including the electron transport chain, citric acid cycle, fatty acid oxidation, amino acid synt

78 ose and glycerol that had passed through the citric acid cycle first increased in fasted animals from

79 For the group infused with both tracers, citric acid cycle flux estimates from the analysis of gl

80 ed PPARalpha(-/-) mice suggested compromised citric acid cycle flux, enhanced urea cycle activity, an

81 rated analysis of hepatic glucose output and citric acid cycle fluxes from plasma glucose isotopomers

82 asurements of hepatic glucose production and citric acid cycle fluxes from the NMR analysis of a sing

83 Citric acid cycle fluxes, pyruvate cycling, anaplerosis,

84 boxylation pathway travels in reverse of the citric acid cycle from alpha-ketoglutarate to citrate.

85 d reaction chemistry with the portion of the citric acid cycle from oxaloacetate to alpha-ketoglutara

86 ansporter gene in the order Lactobacillales, citric acid cycle genes in Burkholderiales or molybdenum

87 azolidinedione treatment, beta-oxidation and citric acid cycle genes were upregulated.

88 processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neuro

89 alpha-ketoglutaric acid (all members of the citric acid cycle) have not been identified in extraterr

90 tance factor (AarC) with a role in a variant citric acid cycle in Acetobacter aceti.

91 utants, these results suggest a role for the citric acid cycle in the infection and colonization stag

92 The citric acid cycle in the microaerophilic pathogen Campyl

93 lic archaeon Pyrobaculum islandicum uses the citric acid cycle in the oxidative and reductive directi

94 hetases catalyze the reverse reaction in the citric acid cycle in which the ADP-forming enzyme augmen

95 roduce several (nonenzymatic) members of the citric acid cycle including oxaloacetic acid.

96 e phosphate pathway (PPP), metabolism in the citric acid cycle, incomplete equilibration by triose ph

97 e cells but forms spontaneously from the key citric acid cycle intermediate cis-aconitate, we suggest

98 esized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid.

99 se tissue, suggesting that signaling by this citric acid cycle intermediate may regulate energy homeo

100 esis of 12 amino acids, of ornithine, and of citric acid cycle intermediate products.

101 By highlighting three receptor families-(a) citric acid cycle intermediate receptors, (b) purinergic

102 Creatine and the citric acid cycle intermediate succinate followed a simi

103 We show that selective accumulation of the citric acid cycle intermediate succinate is a universal

104 ptor (GPCR), functions as a receptor for the citric acid cycle intermediate succinate.

105 n was obtained from the labeling patterns of citric acid cycle intermediates and related compounds.

106 verall, our data show that gluconeogenic and citric acid cycle intermediates cannot be considered as

107 The higher levels of citric acid cycle intermediates found in the mitochondri

108 ter (NaDC1) is involved in the absorption of citric acid cycle intermediates from the lumen of the re

109 +)/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the sm

110 Oscillations in citric acid cycle intermediates have never been previous

111 oxyacetone phosphate); and (iii) labeling of citric acid cycle intermediates in tissue versus effluen

112 Other citric acid cycle intermediates measured either did not

113 In addition to citric acid cycle intermediates such as alpha-ketoglutar

114 boxylate cotransporter transports Na(+) with citric acid cycle intermediates such as succinate and ci

115 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and ci

116 pendent mechanism for transporting Krebs and citric acid cycle intermediates through the epithelium o

117 e pathway involves synthesis of PEP from the citric acid cycle intermediates via PEP carboxykinase, w

118 Citric acid cycle intermediates were lower in salt-treat

119 erosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their

120 Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell

121 of gluconeogenic carbon leaves the liver as citric acid cycle intermediates, mostly alpha-ketoglutar

122 Sodium-coupled transport of citric acid cycle intermediates, such as succinate and c

123 ism for feedback inhibition of glycolysis by citric acid cycle intermediates.

124 six enzymes that convert protocatechuate to citric acid cycle intermediates.

125 The mitochondrial citric acid cycle is a central hub of cellular metabolis

126 tain group of chemoautotrophs, the reductive citric acid cycle is an engine of synthesis, taking in C

127 The citric acid cycle is central to the regulation of energy

128 Specifically, we will focus on how the citric acid cycle is involved in cardioprotection.

129 omplex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA.

130 at mitochondrial aconitase, an enzyme in the citric acid cycle, is a specific target during aging of

131 1-(11)C-Labeled acetate, a substrate for the citric acid cycle, is superior.

132 direct homologue of 3-isopropylmalate in the citric acid cycle, isocitrate, is also a very poor subst

133 oxygen, but it also plays a key role in the citric acid cycle, ketone metabolism, and heme synthesis

134 of metabolites of liver gluconeogenesis and citric acid cycle labeled from NaH(13)CO(3) or dimethyl

135 mitochondrial aconitase and function of the citric acid cycle may be regulated by iron levels in cel

136 we report that glutamine-dependent oxidative citric acid cycle metabolism is required to generate fum

137 , and [U-13C]propionate, a tracer of hepatic citric acid cycle metabolism.

138 The lesion can be prevented or reversed by citric acid cycle metabolites that anaerobically generat

139 to enhance aerobic glycolysis coupled to the citric acid cycle, mitochondrial respiration and ATP gen

140 Combined with the results of other citric acid cycle mutants, these results suggest a role

141 anism for the order Corynebacteriales, whose citric acid cycle occupies a central position in energy

142 ecule metabolic cycles such as the reductive citric acid cycle on mineral surfaces make unreasonable

143 s demonstrated by chemical inhibitors of the citric acid cycle or mitochondrial respiration.

144 t evidence for metabolism of glycerol in the citric acid cycle or the PPP but not an influence of eit

145 to support the hypothesis that the reductive citric acid cycle originated as a self-organized cycle c

146 s the main catalyst for this reaction in the citric acid cycle outside the retina, and that the retin

147 of several metabolic pathways, including the citric acid cycle, polyamine, and fatty acid metabolism.

148 regulation of in vivo glucose-producing and citric acid cycle-related fluxes during an acute bout of

149 ations in enzymes that catalyse steps in the citric acid cycle result in human diseases with various

150 that altered redox status down-regulates the citric-acid cycle, sparing fatty acids for triglyceride

151 ory effect on aconitase, a key enzyme of the citric acid cycle, suggesting that these methyltransfera

152 Ni deficiency also disrupted the citric acid cycle, the second stage of respiration, wher

153 ted that one third of glutamine entering the citric acid cycle travels to citrate via reductive carbo

154 glycerol, or substrates passing through the citric acid cycle via glyceroneogenesis.

155 letion of the catalytic intermediates of the citric acid cycle via leakage through cell membranes (ca

156 A derivatives involved in anaplerosis of the citric acid cycle via precursors of propionyl-CoA, i.e.,

157 he glycerol contribution to oxidation in the citric acid cycle was negligible in the presence of alte

158 In general, genes involved in the citric acid cycle were not differentially expressed; how

159 ast, genes related to beta-oxidation and the citric acid cycle were relatively overexpressed in adipo

160 The glutaminolysis pathway follows the citric acid cycle, whereas the reductive carboxylation p

161 s encodes aconitase, the enzyme of the Krebs citric acid cycle, which is responsible for the intercon

162 there is robust oxidation of glucose in the citric acid cycle, yet glucose contributes less than 50%