ライフサイエンスコーパス: clan

1 rototypical zinc metallopeptidase (gluzincin clan).

2 an chooses a bride in a different lineage or clan).

3 rally differs from the other families in the clan.

4 that SpoIVB is a serine peptidase of the SA clan.

5 ts of the S107 family, a member of the VHIII clan.

6 e relevant to other transporters in the MtN3 clan.

7 ests that these proteins belong to the EsxAB clan.

8 ies and redefine relationships across the CE clan.

9 ion modules that together comprise the Tudor clan.

10 nabled the grouping of related families into clans.

11 s and the homologous families are grouped in clans.

12 (Pfam 29.0) includes 16 295 entries and 559 clans.

13 s and the homologous families are grouped in clans.

14 contains 758 peptidases, 153 families and 22 clans.

15 Cards describing the individual families and clans.

16 have similar tertiary folds are grouped into clans.

17 partitioning of sperm whales into sympatric clans.

18 nto families, which are in turn grouped into clans.

19 nto families, which are in turn grouped into clans.

20 ped into a family; families are grouped into clans.

21 nto families, which are in turn grouped into clans.

22 ouped into families and in turn grouped into clans.

23 ubtilisin-like and alpha/beta-hydrolase fold clans according to phylogenetic lineages, and indicate t

24 One group (the CYP71 clan) after an early trigger to diversification, has kep

25 e-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating factor, bel

26 include two cytochromes P450 from the CYP71 clan and an alcohol dehydrogenase (ADH).

27 The identification of GH-A clan and GH2 specific residues in the active site of BtM

28 identical to the howardite-eucrite-diogenite clan and, like them, are probably derived from the aster

29 beta3 integrin antibodies, however, induced CLANs and actually enhanced CLAN formation in cells spre

30 n of the microdissected tissue revealed that CLANs and CLAN-like structures were a common finding in

31 ased on the MEROPS nomenclature of peptidase clans and families, is incorporated into the Plant Prote

32 on of groupings of related RNA families into clans and new developments to the website.

33 was used to identify molecular components of CLANs and quantitate CLAN formation in HTM cells plated

34 tten, concise text annotations for peptidase clans and the small molecule inhibitors that are outside

35 copy was used to identify phalloidin-labeled CLANs and to ascertain the presence of alpha-actinin, PI

36 species (known as a 'holotype'), family and clan, and each protein species, family and clan has its

37 he cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms.

38 nized into so-called descent groups (tribes, clans, and lineages) and practice exogamous marriages (a

39 ng, thereby eliminating the possibility that CLANs are artifacts of culture conditions, and to determ

40 These clans are defined by sequence homologies primarily in hi

41 Pfam clans are described in detail, together with the new ass

42 in organized TM tissue, which indicates that CLANs are far more common than predicted (even from tiss

43 CLANs are unique actin-branched networks whose formation

44 by an 18-year empirical study, we show that clans are unlikely products of stochastic processes (gen

45 CLANs associated with either DEX treatment or beta3 inte

46 Identification and analysis of Clan CA (papain) cysteine proteases in primitive protozo

47 Cysteine proteases of the Clan CA (papain) family are the predominant protease gro

48 sources have the hallmarks of a papain-like, Clan CA Cys protease.

49 eal-time PCR, the expression of twenty-seven clan CA cysteine protease genes in the Giardia genome wa

50 asites like Leishmania predominantly express Clan CA cysteine proteases for key life cycle functions.

51 ve and do not show any cross reactivity with clan CA cysteine proteases such as papain, cathepsin B,

52 ine peptidases differ fundamentally from the clan CA enzymes and have been included together in clan

53 and separase, and their differences from the clan CA enzymes are described.

54 f papain-like cysteine proteases (family C1, clan CA) is determined by S2-P2 interactions.

55 e cysteine proteases cathepsin B and papain (clan CA), and legumain (clan CD).

56 Clan CA, family C1 cysteine peptidases (CPs) are importa

57 ificities of papain-like cysteine proteases (clan CA, family C1) papain, bromelain, and human catheps

58 entral domain homologous to the papain-like (clan CA, family C1) protease family.

59 to the group of papain-like enzymes known as clan CA.

60 Caspases are proteases of clan CD and were described for the first time more than

61 It shares core structural elements with clan CD cysteine peptidases but otherwise structurally d

62 Clan CD cysteine peptidases, a structurally related grou

63 le protease inhibitors, are specific for the clan CD cysteine proteases.

64 tors that are highly potent and specific for clan CD cysteine proteases.

65 le protease inhibitors, are specific for the clan CD cysteine proteases.

66 The main characteristics of clan CD enzymes are outlined here, in particular glycosy

67 They belong to clan CD of cysteine peptidases and contain a well-conser

68 r, unlike other well-characterized groups of clan CD peptidases, there are no high-resolution structu

69 hepsin B and papain (clan CA), and legumain (clan CD).

70 A enzymes and have been included together in clan CD.

71 K7L belongs to protease Clan CE, which includes distantly related cysteine prote

72 d SAM-binding riboswitches belong to the SAM clan, comprising three families that share a common SAM-

73 These results indicate that CLAN contributes to several biological processes central

74 To directly investigate the expression of clan-defined supraclonal sets, we exploited the evolutio

75 databases, summary alignments for peptidase clans, displays to show the distribution of peptidases a

76 coustic repertoires, mirroring the empirical clans, emerge when whales learn preferentially the most

77 This study showed for the first time that CLANs exist in cells of TM tissues from both normal and

78 rpose of this study was to determine whether CLANs exist within TM cells in situ in tissue unmanipula

79 on of glycoside hydrolase (GH) families into clans expands the utility of information on catalytic me

80 ested that family 26 was related to the GH-A clan (families 1, 2, 5, 10, 30, 35, 39, and 42) of (alph

81 Members of the alpha/beta-knot clan form deep trefoil knots in their native backbone st

82 CLANs form in glaucomatous and steroid-treated TM cells,

83 LY294002 decreased beta1 integrin-mediated CLAN formation by 42%, and PP2 completely blocked it.

84 3766, and Trio siRNA decreased beta3-induced CLAN formation by 72%, 45%, and 67%, respectively, where

85 however, induced CLANs and actually enhanced CLAN formation in cells spread on fibronectin, VCAM-1, t

86 molecular components of CLANs and quantitate CLAN formation in HTM cells plated on coverslips coated

87 Thus, glucocorticoid-induced CLAN formation may involve enhanced beta3 integrin signa

88 retreatment increased beta3 integrin-induced CLAN formation nearly sixfold and the level of alphavbet

89 n or CD47 activation significantly increased CLAN formation over beta1 integrin-induced levels, where

90 egrin overexpression in TM-1 cells increased CLAN formation twofold.

91 was PI-3K dependent, whereas beta3-mediated CLAN formation was CD47 and Rac1/Trio dependent and migh

92 CLAN formation was dependent on the ECM substrate and wa

93 beta1-Mediated CLAN formation was PI-3K dependent, whereas beta3-mediat

94 AP-5, LY294002 did not affect DEX-associated CLAN formation, whereas NSC23766 decreased the percentag

95 -5, both inhibitors decreased DEX-associated CLAN formation.

96 egrin signaling pathways converge to enhance CLAN formation.

97 d porcine VH genes belong to the VH3 family (clan), four of which, VHA, VHB, VHC, and VHE, alone comp

98 rare variations in disease and supports the clan genomics hypothesis.

99 e crystal structure of the beta-glycosidase (clan GH-1A, family 1) from the hyperthermophilic archaeo

100 structure, instead they are similar to other clan GH-A enzymes specific for manno-configured substrat

101 ing of glycoside hydrolase families known as clan GH-A, with the catalytic acid/base Glu 139 and nucl

102 s, confirming the mechanistic commonality of clan GH-D members.

103 confirms their predicted classification into clan GH-F together with GH43 alpha-L-arabinofuranosidase

104 Each peptidase, family and clan has a unique identifier.

105 gh the structure of the SAM-I member of this clan has been extensively studied, how the alternative p

106 w the relationship between families within a clan has been improved by the introduction of a new tool

107 d clan, and each protein species, family and clan has its own unique identifier.

108 ile the number of new peptidase families and clans has only grown slowly the number of complete genom

109 Enzymes of this clan have now been identified in parasitic protozoa.

110 CLANs have been observed in steroid-treated and glaucoma

111 y scored more remotely related Pfams in Pfam clans higher than closely related Pfams, thus, leading t

112 vely charged CDR2 sequences, whereas high IF clan I J558 CDR2 sequences are diverse.

113 election, that it may operate differently in clan I versus II/III V(H)s, and that it has a lasting in

114 se odors within the colony obscures separate clan identities.

115 VH3 clan IgG from S. aureus-infected or SpA-treated animals

116 High IF clan II/III V(H)s share more positively charged CDR2 seq

117 ncoded by variable region heavy chain (V(H)) clan III genes via a V region framework surface that has

118 phage display, to derive Abs diagnostic for clan III Ig.

119 t avian single chain Fv Abs specific for the clan III products, including those from the human VH3 fa

120 e with a model B cell superantigen induced a clan III-restricted clonal deletion.

121 nal set of susceptible B cells that includes clan III/V(H) S107 family-expressing lymphocytes.

122 itative analysis showed that there were more CLANs in glaucoma TM specimens than normal TM specimens,

123 cale redistributions of sperm whale cultural clans in the Pacific have likely changed mitochondrial g

124 t of which could be classified into a single clan, indicating a single evolutionary source for the ma

125 CLANs lacked Arp3 and cortactin.

126 ocus group discussions (FGDs) were held with clan leaders, traditional cutters, and their assistants

127 icrodissected tissue revealed that CLANs and CLAN-like structures were a common finding in the TM cel

128 tamate-specific metallocarboxypeptidase from clan MC to be identified and characterized.

129 idase with sequence similarity to enzymes of clan MC, but with a novel predicted specificity towards

130 sequence exhibits features characteristic of clan ME family M16 metallopeptidases, including an "inve

131 at mediates interactions between other Tudor clan members and their substrates.

132 a hydrophobic cavity that is common to Tudor clan members, disrupts chromatin binding and virus infec

133 ular basis regulating specificity among GH-J clan members, which represent an interesting target for

134 inal Phe or Lys) or methotrexate, cleaved by clan MH glutamate carboxypeptidases.

135 We expressed and assayed CYP3 clan midgut P450s and demonstrated that CYP9Q1, CYP9Q2,

136 pproaches, we demonstrate in this study that CLAN modulates endogenous caspase-1 activation and subse

137 The CYP71 clan now represents more than half of all CYPs in higher

138 Clan-O formed by families GH88 and GH105 was singular in

139 As for all the clan of GH-A enzymes, the two catalytic glutamate residu

140 teins, all of which belong to the pfam EsxAB clan of mycobacterial T7SS.

141 many proteins belonging to the Transthyretin clan of Pfam.

142 from families 7, 13 and 43, appear to form a clan of related structures with identical catalytic appa

143 The At3g26430 protein belongs to the SGNH clan of serine hydrolases, and more specifically to the

144 ers and reminiscent of the SA (chymotrypsin) clan of serine proteases.

145 evel society with an upper level composed of clans of individuals communicating using similar pattern

146 sin, aminopeptidase, and dipeptidylpeptidase clans of MPs.

147 A common theme among these three unrelated clans of serine proteases is the development or maintena

148 to fall into two evolutionarily independent clans of serine proteases, herpesvirus assemblin-like an

149 se, although it has little homology to other clans of serine proteases.

150 Evolution of the Ab system has yielded three clans of VH region genes that are represented in almost

151 ublished tertiary structures for a peptidase clan or family, and search for peptidase specificity dat

152 ding serine proteases of the subtilisin-like clan, or subtilases, have been identified.

153 whereas NSC23766 decreased the percentage of CLAN-positive cells by 80%.

154 It also provides quantitative data on CLAN prevalence in organized TM tissue, which indicates

155 CE clan proteases, specific hydrolases for ubiquitin-like m

156 The CARD of the CLAN proteins binds a number of other CARD-containing pr

157 e their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targe

158 tional adaptations observed among diverse CE clan proteins.

159 roteins represent an ancient metalloprotease clan regulating cellular communications across biologica

160 med that jellypin was an inhibitor of the S1 clan SA family of serine proteinases.

161 The subtilisin protease (SUB; Clan SB, family S8) of Leishmania donovani was cloned an

162 nounced PREP specificity within the group of Clan SC proteases was generally observed.

163 ectrometry identified oligopeptidase B (OPB; Clan SC, family S9A) as the responsible enzyme.

164 CLAN size and phenotype were variable, with the same var

165 type, LJ-26, was demonstrated to recognize a clan-specific surface expressed in diverse mammalian, an

166 ing enzyme (ICE)-like subfamily, and a large clan that does not cluster with any of the vertebrate ca

167 The mean number of CLANs/TM cell in our glaucoma tissue was estimated to be

168 CLAN vertices contained the actin-binding proteins alpha

169 Fcgamma binding activity, which retains the clan VHIII Fab binding specificity.

170 CLAN was also found to mediate a direct antibacterial ef

171 CLANs were induced by plating cells on fibronectin (a be

172 DEX-associated CLANs were structurally similar to those induced by mAb

173 hown to contain cross-linked actin networks (CLANs) when exposed to dexamethasone, as have TM culture

174 orbed beta1 integrin antibodies also induced CLANs, whereas adsorbed beta3 or alpha2beta1 integrin an

175 carbohydrate active enzyme) classes and Pfam clans, which attested its usefulness in the phylogenetic