ライフサイエンスコーパス: class

1 (cephalosporin and macrolide vs neither drug class).

2 pical steroid from the corresponding potency class.

3 rved biosynthetic reaction in this molecular class.

4 t of individual neurons within each neuronal class.

5 tional features associated with each disease class.

6 articular disease etiologies related to that class.

7 allosteric inhibition mode of this compound class.

8 onsistent with any of these main topological classes.

9 nsitivity differed among tests across enzyme classes.

10 her compounds belonging to the different ATC classes.

11 cells and to all four subtypes of both cell classes.

12 aluated survival experience between the risk classes.

13 at produce proteins to block the function of class 1 CRISPR-Cas systems.

14 Gene expression profile status was class 1 in 247 tumors (70%) and class 2 in 106 tumors (3

15 e status was class 1 in 247 tumors (70%) and class 2 in 106 tumors (30%).

16 and relapse rates were observed between CTP class A and CTP class B/C patients (94% versus 78%, and

17 ently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation f

18 in the concentration of several berry aroma classes (about twice the total aroma: from around 3 to 6

19 Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pa

20 ocation problem and present a covariate free class allocation approach based on the distribution of l

21 We treat heterogeneity as a latent class allocation problem and present a covariate free cl

22 be >93% using Soft Independent Modelling of Class Analogy approach.

23 The latent class analysis model with the best fit to PASTURE data s

24 In the latent-class analysis, the highest-order maternal weight trajec

25 on this dataset, we developed and compared 2-class and 3-class DILI prediction models using the machi

26 pecies (all belonging to the triacylglycerol class and containing palmitate at the first position) we

27 prehensive urine screening of different drug classes and might be a promising alternative to conventi

28 l centric, and spans the breadth of AMR drug classes and resistance mechanisms, including intrinsic,

29 tion networks related to several therapeutic classes and tumor types, and in a genome-scale metabolic

30 notation of several domain-relevant semantic classes, and connection to complete syntactic annotation

31 In my writings, classes, and public speeches, I've tried to convey one i

32 erase reporter assays, spanning all major TE classes, and showed that 95.6% of tested TEs can functio

33 y dependencies fall into a limited number of classes, and unexpectedly, in 82% of models, the top bio

34 in grading legislation were divided into 13 classes, and were imaged with a multispectral imaging in

35 Rovalpituzumab tesirine is a first-in-class antibody-drug conjugate directed against delta-lik

36 However, individual drug classes appear to occupy a narrow and unique space in th

37 er of antifungal agents from only a few drug classes are available to treat patients with these serio

38 The classes are defined as follows: experimentally evaluated

39 difications, we determine that both enhancer classes are enriched for RNA Polymerase II, CBP, and arc

40 present a new test for selection in the same class as Fay and Wu's H and discuss its interpretation a

41 ected that a typical hydrocelectomy would be classed as highly cost-effective if the surgery cost les

42 Baseline clinical data and GEP class assignments were obtained.

43 reduction in PVR severity of at least 1 PVR class at 1 year.

44 lass) was ascertained in childhood (father's class at 10/11 y) and adulthood (42/43 years), and BMI r

45 e is little information describing this drug class at the alpha1-adrenergic receptors.

46 rom 10X Genomics, we document seven major SV classes at 5 kb SV resolution.

47 ension in communities that had all four drug classes available were more likely to use at least one b

48 ns using a multivalent immunogen, rare VRC01-class B cells successfully competed in germinal centers

49 ptor (GCGR) are members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) an

50 Class B G protein-coupled receptors (GPCRs) respond to p

51 es were observed between CTP class A and CTP class B/C patients (94% versus 78%, and 4% versus 14%, r

52 Harmonized social class-based SEP data (Registrar General's Social Class)

53 ., 70%) probability of remaining in the same class between visits 1 and 2 and between visits 2 and 3.

54 t detailed mechanistic investigations of the class C rSAM methyltransferase TbtI involved in the bios

55 In contrast, the TLR9 ligand class C, ODN2395, increased angiogenesis.

56 Sharks, rays, and chimaeras (Class Chondrichthyes; herein 'sharks') are the earliest

57 cerLocator outperforms two established multi-class classification methods on simulations and real dat

58 The all-classes comparison (R(2) = 0.86 and Q(2) = 0.83) indicat

59 The anatomically defined neuron classes connecting the AOTU, BU, and EB represent discre

60 ecting carbapenemase-producing P. aeruginosa Class D carbapenemases were the most prevalent carbapene

61 he distribution of tree cover and vegetation classes (defined by the modes of tree cover density), bu

62 set, we developed and compared 2-class and 3-class DILI prediction models using the machine learning

63 The CR-FS algorithm improves class discrimination and indicates that 113 variables in

64 for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor.

65 s generate a hump for intermediate abundance classes earlier than the distributions of high dispersal

66 orphological intermediate between two extant classes further confirms siliceous sponge monophyly and

67 reconstructed the genome of a Chromatiales (class Gammaproteobacteria) bacterium from a metagenomic

68 Latent class growth analysis was applied to longitudinal data o

69 hroughout childhood, identified using latent class growth modeling.

70 Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved for use in

71 t lower respiratory infection, manual social class, home overcrowding, and pollution exposure) and FE

72 NHERF-binding region contains both putative Class I (-(592)SAV-) and Class II (-(595)CLDM-) PDZ-bind

73 of peptide-major histocompatibility complex class I (p-MHC I) proteins displayed by antigen-presenti

74 AP5040-48 epitope in mice expressing the MHC class I allele H-2D(b).

75 s I antibodies alone, 4% Class II, and 14.4% class I and class II at mean fluorescent intensity great

76 ed CD4 and CD8 genes in mice with intact MHC class I and class II molecules with the hypothesis that

77 Forty patients presenting Miller Class I and II GRs were previously treated by CTG (contr

78 30% of subjects had circulating class I antibodies alone, 4% Class II, and 14.4% class I

79 ctational transfer of immunity can cross MHC class I barriers and that Th1 immunity can be imparted t

80 field is in its infancy as compared to their class I counterparts.

81 rge TPS family, including the monofunctional class I diTPS PxaTPS8, which converts geranylgeranyl dip

82 Class I KNOTTED-LIKE HOMEOBOX (KNOX) proteins regulate d

83 ed transgenic FVB mice that express the D(b) class I molecule.

84 Major histocompatibility complex class I molecules (MHC I) help protect jawed vertebrates

85 ribution of major histocompatibility complex class I molecules to brain atrophy in Theiler's murine e

86 M) gene eliminates surface expression of all class I molecules, but leaves the cells vulnerable to ly

87 eptides presented on the cell surface by MHC class I molecules.

88 entin intermediate filaments, SH3-containing class I myosins, the dual-GEF Trio, and other adaptors a

89 focused on the contribution of acquired MHC-class I on recipient DCs during the life span of a skin

90 ady state levels, thus indirectly increasing Class I promoter activity.

91 on by major histocompatibility complex (MHC) class I proteins initiates CD8(+) T cell-mediated immuni

92 Current guidelines give a class I recommendation to use of embolic protection devi

93 standing of the specificity of the bacterial class I release factors (RFs) in decoding stop codons ha

94 NRG3 class I was increased in bipolar and major depressive di

95 dnDSA with a significant higher frequency of class I, a higher frequency and a higher mean fluorescen

96 ting NK receptors or upregulated that of HLA class I, B7-H3, PD-L1, and PD-L2, molecules that might l

97 Accordingly, like class I, DP(84Gly) constitutively presents endogenous pe

98 To achieve this, we predicted HLA class I- and class II-restricted peptides from rDEN2Delt

99 apillary miRNA signature associated with HLA class I-DSA could improve our understanding of ABMR and

100 pecificity depends on the recognition of MHC class I-epitope complexes at the cell surface.

101 ased vaccine vectors expressing a single MHC class I-restricted high-avidity epitope provided strong,

102 esent cell corpse-associated antigens to MHC class I-restricted T cells, a property that was associat

103 us comorbidities and patients without use of class I/III anti-arrhythmic drugs or digoxin.

104 Silencing of the HLA class-I APM is due to histone deacetylation as inhibitio

105 In contrast to re-induction of HLA class-I by interferons, HDAC inhibitors did not interfer

106 Indeed, a reduced HLA class-I expression was observed in MCC tumor tissues and

107 t's immuno-surveillance, e.g. by loss of HLA class-I expression.

108 Thus, HDAC inhibition restored HLA class-I surface expression in vitro and in a mouse xenot

109 Classically Class IB phosphoinositide 3-kinase (PI3Kgamma) plays a r

110 tains both putative Class I (-(592)SAV-) and Class II (-(595)CLDM-) PDZ-binding motifs (PBMs).

111 alyses showed a primary association with HLA class II alleles encoding for the HLA DQ2.5 molecule.

112 ed contaminated (Centers for Disease Control class II and III) ventral hernia (CVH) repair over 24 mo

113 es alone, 4% Class II, and 14.4% class I and class II at mean fluorescent intensity greater than 1000

114 We hypothesized that HLA class II de novo donor-specific antibody (dnDSA) develop

115 Ablation of endothelial cell class II major histocompatibility complex molecules by s

116 with Ag receptors specific for a foreign MHC class II molecule type loaded with peptides from leukocy

117 D8 genes in mice with intact MHC class I and class II molecules with the hypothesis that this would e

118 onto major histocompatibility complex (MHC) class II molecules.

119 ealed periodontal access surgical needs when Class II or III furcation involvements and/or Grade II o

120 hich the cell downwardly tunes CRP-dependent Class II promoter activity, whilst elevating CRP steady

121 long-read sequence assembly of the horse MHC class II region with rigorous manual gene annotation, an

122 Unlike effector CD4(+) T cells, an MHC class II tetramer reagent specific for T. gondii did not

123 esults highlight the advantage of the use of class II tetramers in evaluating HIV-specific CD4(+) T c

124 e screened using M.tuberculosis-specific MHC class II tetramers.

125 action </=35% and New York Heart Association class II to III were randomly assigned to HIIT at 90% to

126 with chronic HF, New York Heart Association class II to IV symptoms, and a left ventricular EF of 40

127 ecules by small interfering RNA targeting of class II transactivator can reduce the capacity of human

128 had circulating class I antibodies alone, 4% Class II, and 14.4% class I and class II at mean fluores

129 visions from C57BL/6 donors but not from MHC class II- or CD40-deficient donors.

130 or subsets, including ThCTL that mediate MHC class II-restricted cytotoxicity.

131 achieve this, we predicted HLA class I- and class II-restricted peptides from rDEN2Delta30 and used

132 adoptive CD4(+) T-cell therapy using an MHC class II-restricted, HLA-DPB1*0401-restricted TCR that r

133 ranulation increases surface delivery of HLA class II/peptide, further enhancing stimulation of T-cel

134 telet therapy, findings that support the new Class IIb recommendation ("may be considered") to extend

135 ow that untreated subjects develop different Class III craniofacial growth patterns as compared to pa

136 onform to the canonical pairing expected for class III enzymes.

137 ring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients [CHAMPION]; NCT00531661

138 heart failure of New York Heart Association class III or IV, confirmed by a cardiologist, and a sign

139 ables (New York Heart Association Functional Class III or IV, previous admission for heart failure, a

140 The class III PI3K Vacuolar protein sorting 34 (Vps34) plays

141 ariable analysis, New York Heart Association class III/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-

142 representations of change in major land use classes impact modelled future distribution patterns.

143 t detectors identifying 20 different objects classes in scenes from a standard computer vision data s

144 ll viability and resistance to specific drug classes in the BM stroma-derived conditions was a result

145 deling of phenotypes for multilocus genotype classes in the epistatic networks is often improved by a

146 and pricing for 1302 drugs in 78 therapeutic classes in the United States, before and after implement

147 We show that all three classes independently acquired aerobic respiratory compl

148 rganization is the diversification of neuron classes into subclasses that share large sets of feature

149 bespoke conditions for challenging substrate classes is described.

150 considered among New York Heart Association class IV (NYHA IV) heart failure patients.

151 , Decapentaplegic (Dpp), specifically in the Class IV multidendritic nociceptive neuron, significantl

152 Three risk classes (low, moderate, and high) were created and logis

153 its, there was general stability across risk classes; MSM had on average a 0.70 (i.e., 70%) probabili

154 that in addition to these well-characterized classes, nearly all of the remaining two-thirds of mEC c

155 ReS2 represents a different class of 2D materials, which is characterized by low sym

156 ino acids, among the shortest known for this class of Abs, and achieved breadth with only 10% nucleot

157 study suggests that 12f is a new structural class of amphiphilic peptide with rapid fungicidal activ

158 phylogenetic analyses we identified a novel class of Arabidopsis thaliana pollen-borne CRPs, the PCP

159 of pyrazolo[4,3-c]quinolines acting as a new class of bacterial betaG-specific inhibitors in a pH-dep

160 scaffold is known to be the forefather of a class of biological active molecules.

161 turn complicates the biomedical use of this class of biomolecules.

162 vy chain (Hc) heterodimers represent a major class of bispecific drug candidates.

163 The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide anti

164 e Gas6-TAM interaction inhibitors as a novel class of cancer therapeutics.

165 As one of the latter class of compounds tetrahydropyrans (THPs) constitute a

166 lation, a novel mechanism of action for this class of compounds.

167 use in vivo functional imaging to identify a class of cutaneous sensory neurons that are selectively

168 th to access this previously largely obscure class of cyclooctatetraenyl radicals, which have been im

169 eloped for the rapid construction of a novel class of densely functionalized picolinates.

170 This new class of descriptors affords multivariate correlations f

171 We reasoned that a new class of direct inhibitors that offer better efficacy, s

172 first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been establi

173 denylase complex, restored mRNA levels for a class of downregulated, H3K36me3-rich genes.

174 ght structure-function relationship for each class of drugs with a specific target.

175 An exceptionally hindered class of enantiopure NHC ligands has been developed.

176 findings will require rethinking of how this class of endosomal proteins regulates trafficking of muc

177 Lactamase (BL) enzyme family is an important class of enzymes that plays a key role in bacterial resi

178 yltransferases (KMTs) represent an important class of epigenetic enzymes that play essential roles in

179 logical functions for this large and complex class of genes.

180 The recent discovery of a second class of high-Tc materials, Fe-based superconductors, ma

181 e estimated ITRIs were shorter with each new class of HIV tests, ranging from 5.9 to 24.8 days.

182 SPCH represents a class of hybrid supramolecular composites, opening a win

183 Host cell proteins (HCP) are a major class of impurities derived from recombinant protein pro

184 troduce a facile route for fabricating a new class of instrumented cardiac microphysiological devices

185 intrinsic particle properties from the whole class of interacting magnetic fine particle systems is a

186 As such, PHEn represents a unique class of isoenergetic wires where hole delocalization ma

187 use nanohoops and their derivatives as a new class of ligands.

188 for strategies to avoid racemization, a new class of light-driven molecular motors was designed, syn

189 Resolvins, a class of lipid mediators, counteract this effect, repres

190 hese findings provide a foundation for a new class of low-loss, magnetoelastic thin film materials th

191 ILs) have recently been developed as a novel class of lubricant anti-wear (AW) additives, but the for

192 Topological insulators are a new class of materials with an insulating bulk and topologic

193 approach to understand and classify this new class of materials, we also present three {P8W48}-based

194 approaches fail in describing this important class of materials.

195 ancies in the merochlorin and napyradiomycin class of meroterpenoid antibiotics, and we demonstrate t

196 Spore-forming bacteria are a class of microorganisms that possess the ability to surv

197 natural product-based agents as an important class of modulators.

198 an field theory calculations to design a new class of Mott multiferroics-double perovskite oxides A 2

199 Low-density lipoproteins (LDLs) are a class of nanocarriers for the targeted delivery of thera

200 ha4 and beta2 subunits are the most abundant class of nicotinic acetylcholine receptor in the brain.

201 The development of a unique class of NIR dyes via modifying the rhodol scaffold with

202 ization conversion coefficients of a general class of non-magnetic passive ultrathin metasurfaces.

203 of noncovalent complexes drawn from a broad class of nucleic acids and transient protein complexes f

204 The polypyrroloindolines are an interesting class of oligomeric natural products that consist of mul

205 The latter is a class of organisms developed exclusively for pharmaceuti

206 Here, we introduce a class of particle absorbers called transferable hyperbol

207 This paper describes the development of a class of peptide-based inhibitors as novel antitrypanoso

208 Here, we disclose a class of phosphines that enable the Ni-catalysed Csp(3)

209 city interaction between SN-38, and a unique class of photonic nanoporphyrin micelles (NPM), the extr

210 cal reactions are applicable only to a small class of photosensitive biomolecules because of strong a

211 enabled the identification of a distinctive class of Pnmt-expressing neuroendocrine cells and their

212 r cell-based interventions represent a novel class of potential therapies for retinal diseases, such

213 clinical studies, to determine whether this class of potential therapies will be safe and effective

214 Mn2/3 )O2 is designed as an example of a new class of promising cathode materials, Na(Li1/3 M2/3 )O2

215 more, we show that Annexin B9, a member of a class of proteins associated with the membrane resealing

216 of ligands by exponential enrichment of this class of proteins illustrates the recognition of unbranc

217 A new class of push-pull fluorophores featuring the pentafluor

218 tA), which belongs to the uncharacterized 3B class of PutAs.

219 hension of tautomeric equilibria of this new class of quinoid compounds is strongly required in order

220 Riboswitches are a widely distributed class of regulatory RNAs in bacteria that modulate gene

221 h the stationary-state statistics of a broad class of resource-limited community dynamics models, reg

222 , is the long-lost ligand sensed by the ykkC class of riboswitches, and identified that members of it

223 richia coli has become the paradigm for this class of secondary active transporters.

224 Here we show evidence of a new class of serpentinite diapirs within the external subduc

225 ificance and physicochemical origins of this class of sigma-hole interaction.

226 This new class of site-specifically metal-modified DNA films was

227 xes are druggable targets and identify a new class of small molecules that may be further optimized f

228 Monoterpene indole alkaloids, a class of specialized metabolites that includes the antic

229 is unit as a monomer, results with the first class of stimuli-responsive self-immolative polymers wit

230 norganic thiometallate ATTM represents a new class of sulfide-releasing drugs.

231 Quantum defects are an emerging class of synthetic single-photon emitters that hold vast

232 ing interfacial electron transfer in a broad class of systems, including other transition metal oxide

233 distant relative of receptors for a distinct class of the TGF-beta superfamily ligands.

234 (or more formally thiazolyl peptides) are a class of thiazole-containing, highly modified, macrocycl

235 ds on heat shock proteins 70 kDa (Hsp70s), a class of ubiquitous and highly conserved molecular chape

236 e can improve inference if only a particular class of variants confers disease risk and can suggest p

237 ts suggest the general-purpose nature of the class of vdW-DF functionals, with particular consequence

238 es revealed that the enzyme represents a new class of zinc-binding flavin-dependent halogenases and p

239 of acquired bacterial resistance to existing classes of antibiotics and with the emergence of vancomy

240 Among other classes of biomolecules, carbohydrates and glycoconjugat

241 n technique can be used for determination of classes of compounds in cases where deuterated counterpa

242 r solvents is presented to compare these two classes of compounds.

243 ts at uniting the analysis of four different classes of contaminants for both liquid and solid tea sa

244 prising finding is substantiated using three classes of cyclic game models through stability analysis

245 ive description and expression of both major classes of drug transporters, SLC and ABC, in resting hu

246 Several classes of enantioselective silylations of C-H bonds hav

247 ments of enzyme activity for three different classes of enzymes (amylase, lipase, and sulfatase), rel

248 tual screening, we recently identified novel classes of EPIs that interact with the membrane fusion p

249 ty in order for cells to perform the various classes of experimentally-observed motions.

250 operties of the glycopeptides with different classes of glycan structural variants, including high ma

251 or simultaneous determination of 120 various classes of herbicides in oilseed samples.

252 e approach may have applications for certain classes of high-throughput experiments and the analysis

253 In this paper, we focus on two common classes of integration algorithms, graph-based that depi

254 rigin of liver tumorigenesis and clarify the classes of liver cancer based on molecular features and

255 acquired through recombination with specific classes of long terminal repeat (LTR) retrotransposons a

256 ) hematopoietic progenitor cells, we defined classes of low to moderately expressed genes that are di

257 is of the juvenimicin, M-4365, and rosamicin classes of macrolide antibiotics via late-stage diversif

258 Different classes of MGE show a broad range of fitness effects, fr

259 x as the two most relevant features, and new classes of models featuring functions of Eg and omegamax

260 meworks (MOFs) are one of the most appealing classes of MOFs reported to date.

261 Maglev measures density, and certain classes of monomers show a large change in density when

262 ultipotential progenitors that generate both classes of myelinating cells.

263 containing X-X bonds are found in all major classes of natural products and often impart significant

264 Numerous classes of natural products have been subjected to these

265 ent with the effects of SUMOylation on other classes of nuclear receptors, dexamethasone (Dex)-induce

266 vones, three carotenoids, six FAs, and seven classes of PhytoPs.

267 ese reactions led to the construction of new classes of pyrrolidone-ring annulated thiophene/furan-ba

268 nces of both previously and newly discovered classes of riboswitches might reveal subgroups of RNAs t

269 key computational signatures of two distinct classes of RL models-namely, "actor/critic" models and a

270 Receiving more classes of RW-funded services is associated with improve

271 horylation at critical residues of different classes of specific transport proteins.

272 Several classes of sRNAs, which are distinguished by their origi

273 nd superadditive interactions among specific classes of TFs, with both spatially constrained and flex

274 t NMR and X-ray characterization for the two classes of these inhibitors.

275 ent a conceptual framework for how different classes of transcription factors interact to select and

276 osomal RNA NGS revealed that of 15 different classes of transcripts detected, 4 circulating exosomal

277 Here we identified two classes of unmyelinated sensory neurons (nonpeptidergic

278 rison of these results with those from other classes of vertebrates shows numerous common traits shar

279 ugh the replication modules of at least some classes of viruses might descend from primordial selfish

280 c secretin PulD, the founding member of this class, prevents pore formation by destabilizing the prep

281 Here, pioneers of this new drug class provide a bench-to-bedside review on preclinical v

282 benes (NHCs), a promising alternative ligand class regarding stability and variable design strategies

283 The prevalence of triple-class resistance was relatively low at 12%.

284 Differences by antibiotic class should be further explored, as this knowledge coul

285 The first-in-class soluble guanylate cyclase (sGC) stimulator riocigu

286 dual modulatory neurons can integrate neuron class-specific input from their target network, which is

287 Our results show that the major insect opsin class (SW) that typically confers sensitivity to "blue"

288 In B cells, Ig class switch recombination (CSR) is initiated by activat

289 ine, and the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline.

290 ated in NP, and there was evidence for local class switch recombination in NP.

291 ealthy controls revealed that frequencies of class-switched memory B cells were increased in the pati

292 CRPs, the PCP-Bs (for pollen coat protein B-class) that are related to embryo surrounding factor (ES

293 ulin sensitivity and glucose tolerance; as a class, these lipids are referred to as 'lipokines'.

294 Two (2%) class-waivered drugs were considered not relevant and 16

295 s-based SEP data (Registrar General's Social Class) was ascertained in childhood (father's class at 1

296 processing) rather than on specific material classes, we outline key cross-disciplinary concepts that

297 Cells within each class were located in different sublaminae.

298 individual HOCs from 32 different structural classes were detected in the blubber of 4 adult male T.

299 Six latent classes were identified, representing subphenotypes of A

300 of orangutan movement among all age and sex classes, with orangutans more likely to move in directio