ライフサイエンスコーパス: class I gene

1 recisely and definitively mapped to the L(d) class I gene.

2 geneic donor-derived swine leukocyte antigen class I gene.

3 element and downstream core promoter of the class I gene.

4 allogeneic major histocompatibility complex class-I gene.

5 ilies, M1 and M10, distinct from other mouse class I genes.

6 species-specific expansion of paralogous Mhc class I genes.

7 iple of a primordial class I region with few class I genes.

8 The 6p21.3 minimal deletion spans HLA class I genes.

9 itive/retroviral elements not flanking other class I genes.

10 ducts differ considerably from classical HLA class I genes.

11 l block or may express only nonclassical MHC class I genes.

12 othelial cells stably transfected with human class I genes.

13 nscription of major histocompatibility (MHC) class I genes.

14 TR) and 131 different alleles encoded by HLA class I genes.

15 equences of major histocompatibility complex class I genes.

16 ved in the promoters of human and murine MHC class I genes.

17 ], is a key transcription coactivator of MHC class I genes.

18 eam of the betaGAP sequence are nonclassical class I genes.

19 LA-E gene is distinct from that of other MHC class I genes.

20 highlights three independent associations to class I genes.

21 ologs of the six fixed, functional human MHC class I genes.

22 eles from 57 major lineages of classical HLA class I genes.

23 identified transcriptional regulator of MHC class I genes.

24 NLRC5, as a transcriptional regulator of MHC class I genes.

25 ates with and activates the promoters of MHC class I genes.

26 ng the overall sequence similarity among the Class I genes.

27 lular major histocompatibility complex (MHC) class I genes.

28 , this cis-element is found 5' of 20 primate class I genes (15 human genes), seven of which are known

29 There were 453 class I genes, 258 class II genes, and 83 class III gene

30 Nineteen gene mutations, including 8 class I genes, 4 class II genes, WT1 and TP53 (class III

31 X1 box, to be involved in NLRC5-mediated MHC class I gene activation.

32 differences in the mechanisms repressing RSL class I gene activity between members of the Poaceae and

33 Strikingly, nearby tap2 and MHC class I genes also retain ancient sequence lineages, ind

34 transactivates the proximal promoters of MHC class I genes, although the molecular mechanism of trans

35 e last 50 kb of the H2-T region, including 2 class I genes and 3 class I pseudogenes, and includes th

36 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two sub

37 nstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of

38 Recent work has shown that MHC class I genes and CD3zeta, an obligate component of T ce

39 athogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial.

40 the first direct evidence incriminating MHC class I genes and CD8(+) T cells in the pathogenesis of

41 ined by combinations of variable KIR and HLA class I genes and conserved CD94:NKG2 genes.

42 pression of major-histocompatibility-complex class I genes and nuclear factor-kappaB target genes.

43 In addition to Class I genes and pseudogenes, we describe over 63 genes

44 Partial loss of several HLA class I genes and subsequent reduced presentation of min

45 essential element for the expression of HLA class I genes and that its transcriptional activity depe

46 take into account both the HLA class II and class I genes and use even larger samples.

47 c determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this re

48 Furthermore, we discovered that RSL class I genes are also required for the development of m

49 Class I genes are constitutively expressed and include t

50 at HLA class I-recognizing receptors and HLA class I genes are genetic risk determinants that modulat

51 The major histocompatibility complex (MHC) class I genes are induced synergistically by interferons

52 Class I genes are maximally expressed in the subjective

53 the expanded CMZ phenotype, suggesting that Class I genes are more likely to affect the stem cells a

54 However, given that RSL class I genes are not sufficient for root hair developme

55 ne coevolving with TAP transporters, whereas class I genes are poorly expressed.

56 ough understanding of the mechanism by which Class I genes are regulated.

57 The prevailing model stipulates that Class I genes are repressed and Class II genes are activ

58 Major histocompatibility complex class I genes are ubiquitously expressed and governed by

59 e genomic regions containing the KIR and HLA class I genes are unlinked, structurally complex, and hi

60 These findings identify MHC class I genes as direct targets of Foxp3 whose expressio

61 n, 4 Mb telomeric of human leukocyte antigen class I genes, at 6p22.1.

62 bidopsis thaliana homeodomain-leucine zipper class I genes; ATHB7 and ATHB12, both strongly induced b

63 Mutations in class I genes (AtTPS1-AtTPS4) indicate a role in regulat

64 unique to MHCII genes, because previous MHC class I gene-based therapies failed to produce Tregs.

65 products of certain nonclassical MHC-linked class I genes bind peptides in a similar way.

66 ed to the expressed cotton-top tamarin's MHC class I genes, but does show some similarity to So-N1, a

67 ss II odorant receptor (OR) genes to that of class I genes, but not in other vertebrate gene families

68 ates of ASFV increased the expression of MHC class I genes, but there was no parallel increase in MHC

69 ducks predominantly use UAA, one of five MHC class I genes, but whether biased expression is also tru

70 eric H2-T and the telomeric H2-M4, -5 and -6 class I genes by "nonclass I genes".

71 anscriptional mechanism of regulation of MHC class I genes by IFN-gamma.

72 IFNs regulate most MHC class I genes by stimulating transcription initiation.

73 The major histocompatibility complex (MHC) class I gene cAMP response element (CRE)-like site, -107

74 rphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent ste

75 Patr-AL is an expressed, non-polymorphic MHC class I gene carried by approximately 50% of chimpanzee

76 This M1/M10 class I gene-cluster is separated from the centromeric H

77 Class I genes code for structural proteins that effect c

78 biased expression of a single classical MHC class I gene coevolving with TAP transporters, whereas c

79 The cloning of shark class I genes completes the identification of molecules

80 The HLA-A*24 class I gene confers significant risk of disease and ear

81 The promoters of MHC class I genes contain a well-conserved core module, the

82 The data argue that class I gene conversion mutations dramatically affect bo

83 e key substrate for the natural selection of class I gene conversion variants is the diversity in imm

84 In contrast, a nonclassical MHC class I gene discovered in the chimpanzee is not present

85 These findings demonstrate that the self MHC class I gene dosage may regulate the extent of CD8(+) T

86 ional major histocompatibility complex (MHC) class I genes encode molecules that present intracellula

87 The major histocompatibility complex class I gene enhancer binding proteins MBP1 and MBP2 are

88 infection, the human leukocyte antigen (HLA) class I genes exhibit the strongest and most consistent

89 ombinatorial fine-tuning of the level of MHC class I gene expression in response to intrinsic and ext

90 could explain the repression of IFN-beta and class I gene expression in virus-infected cells.

91 CIITA also up-regulates MHC class I gene expression in vitro.

92 Tight regulation of MHC class I gene expression is critical for CD8 T cell activ

93 In this report, we demonstrate that MHC class I gene expression is enhanced by the T cell enhanc

94 Locus-specific down-regulation of MHC class I gene expression is frequently observed in human

95 Therefore, characterization of MHC class I gene expression of Papio subspecies is a prerequ

96 while higher levels restrict the domains of Class I gene expression to intermediate positions of the

97 Major histocompatibility complex class I gene expression, which also is regulated by TTF-

98 er involved in tissue-specific regulation of class I gene expression.

99 s, shuttles to the nucleus and activates MHC class I gene expression.

100 family transcription factors, to promote MHC class I gene expression.

101 to explain lung phenotype variation; (2) HLA class I genes, extending previous GWAS findings in the H

102 scribe two highly divergent nonclassical MHC class I genes found in the chicken (Gallus gallus) that

103 Class I gene fragments are amplified by the polymerase c

104 Amplified class I gene fragments can then be subcloned into the ex

105 CTL epitopes, we sequenced and expressed MHC class I genes from three ELA-A1 horses.

106 ne marrow transduced with the allogeneic MHC class I gene H-2K(b) led to long-term expression of K(b)

107 recombinant murine genes composed of the MHC class I gene H-2L(d) and the Fc portion of immunoglobuli

108 cination is performed with an allogeneic MHC class I gene (H-2 Kd)-modified tumor, the T cells obtain

109 duced major histocompatibility complex (MHC) class I gene (H-2K(b)) in bone marrow (BM)-derived cells

110 human major histocompatibility complex (MHC) class I genes has been shown previously to increase at t

111 Therefore RSL class I genes have been conserved since O. sativa and A.

112 These findings suggest that KIR and MHC class I genes have coevolved as an interacting system.

113 Suprisingly, however, class I genes have not been identified unambiguously in

114 sm of IFN-gamma stimulation of the human MHC class I gene HLA-A2, several human tumor cell lines were

115 Rats transgenic for the human MHC class I gene HLA-B27 are susceptible to a spontaneous mu

116 genotyped, combining anonymous loci with the class I genes HLA-B and -C distributed across a genetic

117 o pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; P(combi

118 All expressed human MHC class I genes (HLA-A, -B, -C, -E, -F, and -G) have funct

119 uding major histocompatibility complex (MHC) class I genes (HLA-A, HLA-B and B2M with p = 0.0001, p =

120 DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA).

121 The human MHC class I gene, HLA-B27, is a strong risk factor for susce

122 gamma-induced transcription of the human MHC class I gene, HLA-E.

123 ass II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1

124 The HLA class I genes, HLA-A, -B, and -C, contain an inverted CC

125 ar run-on assays revealed that, unlike other class I genes, IFN-gamma stimulation of HLA-A mRNA accum

126 ion of a retrovirally encoded allogeneic MHC class I gene in bone marrow-derived cells can be used to

127 of a retrovirally transduced allogeneic MHC class I gene in bone marrow-derived cells from recombina

128 -CCAAT, TATAA-like, Sp1BS, and Inr-of an MHC class I gene in primary B-cells during both basal and ac

129 ion of the RUNX1-containing complex with the class I gene in vivo.

130 e three codominantly expressed classical MHC class I genes in humans and mice.

131 A major expansion of from six class I genes in humans to as many as 22 active MHC clas

132 We show that there are three RSL class I genes in O. sativa and that each is expressed in

133 We characterized the function of class I genes in Oryza sativa root development.

134 One of the hallmarks of MHC class I genes in outbred populations is their extraordin

135 to all other classical and nonclassical MHC class I genes in primates, the rate of synonymous nucleo

136 genes in humans to as many as 22 active MHC class I genes in rhesus and levels of sequence divergenc

137 The limited variability of MHC class I genes in the Callitrichinae is likely the result

138 HC class I, UAA, although they have five MHC class I genes in the complex, arranged TAP1-TAP2-UAA-UBA

139 he human HC locus and implicate nonclassical class I genes in the control of iron absorption.

140 es, and a translocation and expansion of the class I genes in the mammalian lineage.

141 he role of the human leukocyte antigen (HLA) class I genes in this biological process.

142 ovine major histocompatibility complex (MHC) class I genes in transfected mouse Ltk- cells.

143 allogeneic major histocompatibility complex class-I genes in the absence of host T-cell depletion an

144 Tight linkage of proteasome and class I genes, in comparison with gene organizations of

145 era exhibit limited variability of their MHC class I genes, in contrast to the high variability displ

146 The rhesus monkey's complement of MHC class I genes includes the products of at least one expr

147 LCL 721.221 cells transfected with certain class I genes, including HLA-G, were also sufficient to

148 Cytokine induction of the MHC class I genes increases the nascent molecules available

149 his article, we show that NLRC5-mediated MHC class I gene induction requires the W/S and X1, X2 cis-r

150 y that is necessary for transcription of MHC class I genes: inhibition of the AT activity represses t

151 ate that a single mutational event in an HLA class I gene is sufficient for loss of the corresponding

152 ork on the Xenopus MHC, the single classical class I gene is tightly linked to immunoproteasome and t

153 pression of major histocompatibility complex class I genes is determined by a series of upstream regu

154 We show that expression of the MHC class I genes is downregulated in HPV-positive keratinoc

155 on of major histocompatibility complex (MHC) class I genes is regulated by both tissue-specific (basa

156 The expression of several MHC class I genes is up-regulated at the transcriptional lev

157 essed major histocompatibility complex (MHC) class I genes isolated from a range of equid species and

158 s-infected, major histocompatibility complex class I gene knockout mice compared with no deaths for w

159 MHC class I gene knockout mice were the most susceptible, mo

160 MHC class I gene loss and dramatic reduction in functional d

161 Biased expression of one MHC class I gene may make viral escape within an individual

162 s, but with the non-conventional MHC encoded class I gene, MICA (MHC class I chain-related gene A).

163 Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter

164 ence of class I loci or a failure to express class I genes might explain some of the relatively "weak

165 cal in the 5'-regulatory region of 12 rodent class I genes, nine of which have been shown to be funct

166 In addition to MHC class I genes, NLRC5 also induced the expression of beta

167 have cloned and characterized classical MHC class I genes of pig-tailed macaques and have identified

168 ily, termed H2-Mv, representing nonclassical class I genes of the major histocompatibility complex.

169 The MHC class I genes of the New World primate, the cotton-top t

170 ese findings reveal a novel influence of MHC class I genes on CD4(+) T-cell responses to viral infect

171 DAF-16 directly regulates class I genes only, through the DAF-16-binding element (

172 may be transfer of gene segments among shark class I genes over evolutionary time.

173 r than repressing, the expression of several Class I genes (Pax6, Dbx1, Dbx2).

174 The MHC class I gene, PD1, has neither functional TATAA nor Init

175 lanoma cell line expressed a mutated HLA-A11 class I gene product that was recognized by the bulk tum

176 Thus, HLA class I gene products not only mediate HIV-1 pathogenesi

177 e the major histocompatibility complex (MHC) class I gene products, interferon-induced genes, and the

178 d that mice which have altered expression of class I gene products, the beta2-microglobulin knockout

179 ) with self-major histocompatibility complex class I gene products.

180 ported to express distinct but undefined MHC class I gene products.

181 redominantly at the level of the TCR and MHC class I gene products.

182 Although CIITA also transactivates MHC class I gene promoters, loss of CIITA in humans and mice

183 At least one of these nonclassical class I genes, Q2, is expressed in the gastrointestinal

184 roles of NLRC5/class I transactivator in MHC class I gene regulation and host defense by CD8(+) T cel

185 ion of the products of this nonclassical MHC class I gene remains unknown.

186 echanism to ensure that the transcription of class I genes remains tightly repressed under various ph

187 y polymorphic, but co-evolution with TAP and class I genes remains unclear.

188 An in-depth analysis of the MHC class I gene repertoire in the two orangutan species, Po

189 omoter of a major histocompatibility complex class I gene requires TAF(II)250.

190 In gene trees of primate MHC class I genes, sequences from the Callitrichinae cluster

191 Class I genes, such as those encoding the v-cyclin, late

192 nus, therefore, expresses its own set of MHC class I genes, suggesting that an unusually high rate of

193 CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more global

194 basal and activated transcriptions of an MHC class I gene target distinct core promoter domains, nucl

195 may represent a remnant of a once active MHC class I gene that is no longer functional in the cotton-

196 lso well conserved in Xenopus, excluding the class I genes themselves.

197 The ability of MHC class I genes to facilitate CD4(+) Th1 development could

198 e sequenced introns 2, 3, and 8 of all three Class I genes (total>15.0 kb) for five non-human primate

199 example of a locus-specific repressor of MHC class I gene transcription in human tumor cells.

200 lls were treated with TNF-alpha or IL-1beta, class I gene transcription substantially increased when

201 whereby low levels of Shh signaling initiate Class I gene transcription, while higher levels restrict

202 ng that FlhG acts as a negative regulator of class I gene transcription.

203 I and class I-like genes, only two classical class I genes, two CD1 genes and some non-classical Rfp-

204 Another nonclassical class I gene (UAA-NC1) was detected that is linked neith

205 Three duck MHC class I genes (UBA, UCA, and UEA) are predicted to be pa

206 The Shh dependent activation of Class I genes was mediated, in part, by Gli2.

207 se data demonstrate that the function of RSL class I genes was to control the development of structur

208 n 6p21.32-p21.33, which included several HLA class I genes, was detected.

209 f the major histocompatibility complex (MHC) class I gene, we determined nucleosome occupancy and pos

210 three putative nonclassical full-length MHC class I genes were found.

211 s were presented by different molecules, MHC class I genes were identified in cDNA clones from Arabia

212 smid clones bearing the MHC-linked classical class I genes were isolated and shown to contain proteas

213 Class I genes were regulated primarily by unliganded ERb

214 "Class I" genes were uniformly induced by p53 in all cell

215 AP1 binding sites were more enriched in class I genes, whereas ERE, NFkappaB1, and SP1 sites wer

216 est a dual role for Shh in the regulation of Class I genes, whereby low levels of Shh signaling initi

217 e mammals have a third family of NKG2DL-like class I genes which we named MILL (MHC class I-like loca

218 DH classes I-V, the human cluster contains 3 class I genes while the mouse cluster has two class V ge

219 es, are transcribed from PEP promoters only (Class I genes), while in some instances (e.g. accD) gene