ライフサイエンスコーパス: class II gene

1 on T1D that is distinct from that of any MHC class II gene.

2 ncing selection acting on MHC class I versus class II genes.

3 DR2(+) transgenic mice lacking all mouse MHC class II genes.

4 CIITA to transactivate transcription of MHC class II genes.

5 tion of the major histocompatibility complex class II genes.

6 t of proteins interact with the promoters of class II genes.

7 1, CIITA was unable to activate cellular MHC class II genes.

8 omplex are required for transcription of MHC class II genes.

9 Sjogren's syndrome are influenced by the HLA class II genes.

10 tive and IFN-gamma-induced expression of MHC class II genes.

11 on of major histocompatibility complex (MHC) class II genes.

12 ired for IFN-gamma-induced expression of MHC class II genes.

13 IITA) activates the transcription of all MHC class II genes.

14 constitutive and inducible expression of MHC class II genes.

15 rm of RNA polymerase activates expression of Class II genes.

16 for CIITA to function as an activator of MHC class II genes.

17 dependent diabetes mellitus is linked to MHC class II genes.

18 FIIB) play crucial roles in transcription of class II genes.

19 equired for the functional regulation of MHC class II genes.

20 mune response to insulin is regulated by MHC class II genes.

21 A splicing and transcriptional activation of class II genes.

22 ements and is required for expression of MHC class II genes.

23 in NF-Y-mediated transcriptional control of class II genes.

24 ys an important role in the transcription of class II genes.

25 f the major histocompatibility complex (MHC) class II genes.

26 re a common mechanism of regulation with the class II genes.

27 o not bind to the homologous sequence of all class II genes.

28 and CIITA are responsible for activation of class II genes.

29 ding proteins that functionally regulate MHC class II genes.

30 ory factors controlling transcription of MHC class II genes.

31 moters and is essential for transcription of class II genes.

32 synonymous substitution in the PBR of mouse class II genes.

33 romoters of major histocompatibility complex class II genes.

34 human major histocompatibility complex (MHC) class II genes.

35 quired for IFN-gamma-inducible expression of class II genes.

36 m a coordinated lack of transcription of all class II genes.

37 pression or major histocompatibility complex class II genes.

38 to be strongly associated with specific HLA class II genes.

39 ion complex genes, and were depleted for MHC class II genes.

40 histocompatibility complex region, near HLA class II genes.

41 nscriptional coactivator CIITA regulates MHC class II genes.

42 pression of major histocompatibility complex class II genes.

43 kappaB1, and SP1 sites were more enriched in class II genes.

44 n to the established associations of the MHC class II genes.

45 s the master integrator of expression of MHC class II genes.

46 in the reciprocal-suppressive effect between class II genes.

47 on factor required for the expression of MHC class II genes.

48 X1 box sequence located upstream of all MHC class II genes.

49 by sequencing TAP1, in conjunction with HLA class II genes.

50 nuclear translocation and expression of MHC class II genes.

51 r (CIITA) is the 'master coactivator' of MHC class II genes.

52 ater than that of mutation in the history of class II genes.

53 variation in the IL4RA gene (16p12), the HLA class II genes (6p21), and the interferon-alpha gene clu

54 M genes are regulated in a similar manner as class II genes, a series of in vivo and in vitro analyse

55 imum amount of IFN-gamma is required for MHC class II gene activation despite the fact that the level

56 s generated that lacked all endogenous mouse class II genes (AE(o)) and expressed the RA susceptibili

57 r map of chicken MHC genes (containing a MHC class II gene and two rRNA genes) to Rfp-Y validated the

58 ion of Major Histocompatibility Complex (MHC)class II genes and an effective immune response.

59 ations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin

60 1.DQ8 mice, activated CD4(+) T cells express class II genes and can present DR4- and DQ8-restricted p

61 e classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studi

62 cusing on potential interactions between HLA class II genes and enteroviral infections.

63 , including major histocompatibility complex class II genes and genes in human hepatitis B virus.

64 loenzyme is essential for expression of most class II genes and is a target of at least one transcrip

65 ential for transcriptional activation of MHC class II genes and mediates enhanced MHC class I transcr

66 itment to proximal promoter sequences in MHC class II genes and more distally involving the canonical

67 vator (CIITA) is a critical regulator of MHC class II genes and other genes involved in the Ag presen

68 , including major histocompatibility complex class II genes and other genes located within this regio

69 dently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induct

70 RFX complex to DNA, transcription of all MHC class II genes and the appearance of these determinants

71 f the highly polymorphic HLA class I and HLA class II genes and the complex structural diversity of c

72 Elucidation of functionally important dog class II genes and the identification of 23 microsatelli

73 volved in the immune response, including MHC class II genes and the interleukin-4 gene.

74 echanism for the uncoupled regulation of MHC class II genes and the processing enzyme GILT in human m

75 There were 453 class I genes, 258 class II genes, and 83 class III genes.

76 y flagellar basal body structure, encoded by class II genes, and is activated by the transcription fa

77 hown to transactivate MHC class I as well as class II genes, and this investigation shows that CIITA

78 . aeruginosa infection were enriched for HLA class II genes, and those associated with MI were relate

79 of the HLA-DRA gene, the canonical human MHC class II gene; and with increased Rb binding to the YY1

80 pulates that Class I genes are repressed and Class II genes are activated by high levels of Shh signa

81 The human MHC class II genes are associated with genetic susceptibilit

82 eneic major histocompatibility complex (MHC) class II genes are cell-based vaccines for the treatment

83 The MHC class II genes are coordinately regulated by conserved p

84 have suggested that the expression of DM and class II genes are coordinately regulated.

85 Class I and class II genes are genetically linked in tetrapods but a

86 cies showed that classical class I (UAA) and class II genes are genetically linked.

87 ly expressed in the subjective dusk, whereas class II genes are maximally expressed in the subjective

88 ss, there is substantial evidence that human class II genes are not always coordinately regulated, ra

89 Because small numbers of MHC class I and class II genes are present in both B: and Rfp-Y, the two

90 Class II genes are primarily clustered in nonconserved r

91 Major histocompatibility complex (MHC) class II genes are regulated at the transcriptional leve

92 Class II genes are the earliest to be expressed and are

93 Class II genes are transcribed without TPA treatment but

94 Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and g

95 enetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on

96 enes can clearly be divided into class I and class II genes, as was previously noted.

97 und to be required for expression of all MHC class II genes associated with antigen presentation.

98 ll combined with subtle variation in the HLA class II gene associations and autoreactivity.

99 Class II genes (AtTPS5-AtTPS11) encode multifunctional e

100 role in development, we demonstrate that the class II gene AtTPS6 is important for controlling cellul

101 ma was required for strong overexpression of class II genes but not for CD4(+) T cell activation, oli

102 , CIITA not only activates the expression of class II genes but recruits another B cell-specific coac

103 Induction of class II genes by DAIs was accompanied by activation of

104 IIB (TFIIB) is required for transcription of class II genes by RNA polymerase II.

105 ctivator that directly controls development (class II) genes by binding to the DAF-16-associated elem

106 ial proximity between PML bodies and the MHC class II gene cluster in different human cell types.

107 Major histocompatibility complex class II genes contain a common complex enhancer that al

108 The proximal promoters of all MHC class II genes contain a sequence element, the 19-bp X b

109 vaccines is preserved in both CD4-/- and MHC class II-/- gene-deficient animals.

110 l sex workers had individual alleles for HLA class II genes determined by using labeled sequence-spec

111 The clinical importance of HLA class II gene disparity in unrelated stem cell transplan

112 Moreover, in contrast to other class II genes, DO beta expression remains high in the a

113 tides corresponding to the X2 box of the MHC class II genes DPA and DQB were used to screen B cell an

114 The HLA class II gene DQB1*0301 has been linked to several cance

115 ells of these patients do not transcribe MHC class II genes due to a defect in the trans-acting facto

116 expression of IFN-gamma-inducible genes-MHC class II gene E beta; MHC class II transactivator; IFN r

117 llitus in humans is linked with specific HLA class II genes, e.g., HLA-DQA1*0301/ DQB1*0302 (DQ8).

118 g the major histocompatibility complex (MHC) class II genes (eg, HLA-DRA) which correlated with bette

119 The major histocompatibility complex (MHC) class II genes encode a series of heterodimeric cell sur

120 s code for regulatory components of closure: Class II genes encode Drosophila Jun amino (N)-terminal

121 s suggests several additional members of the class II genes exist in the Arabidopsis genome.

122 activity can repress IFN-gamma-inducible HLA class II gene expression and also demonstrate that HDAC

123 ontrol of CIITA is necessary to regulate MHC class II gene expression and induction of an immune resp

124 )-inducible major histocompatibility complex class II gene expression and transcriptionally productiv

125 CIITA, a master regulator of MHC class II gene expression and truncated in B-cell lymphom

126 gulation of major histocompatibility complex class II gene expression as well as in exocrine gland an

127 Finally, the inhibition of class II gene expression by the glucocorticoid hormone c

128 or (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells.

129 and may function to selectively enhance MHC class II gene expression in dendritic cells.

130 equences of Shh misexpression on Class I and Class II gene expression in the hindbrain of ShhP1 embry

131 ritical for major histocompatibility complex class II gene expression in vivo contribute to both the

132 Activation of eukaryotic class II gene expression involves the formation of a tra

133 Precise regulation of MHC class II gene expression is crucial for development and

134 activator (CIITA), is a key regulator of MHC class II gene expression that associates and cooperates

135 DQ8 transgenic mice lacking endogenous mouse class II gene expression were actively immunized and lat

136 is domain contributes to MHC class I and MHC class II gene expression with a bias for activation of M

137 ss of major histocompatibility complex (MHC) class II gene expression, is caused by inherited mutatio

138 nism involved in regulation of CIITA and MHC class II gene expression.

139 ells induces CIITA expression as well as MHC class II gene expression.

140 urface of C3-/- macrophages, without loss of class II gene expression.

141 the macromolecular assemblies that drive MHC class II gene expression.

142 highly conserved WXY motifs, and, like other class II genes, expression of both DN alpha and DO beta

143 III anti-sigma28 gene, flgM, flanked by the class II genes, flgA, flgBCD and flhBA, and a novel puta

144 We examined intron phase I-containing HLA class II genes for the presence of intergenic mRNAs and

145 suggest that the conserved X and Y boxes of class II genes function similarly and define a single mu

146 de from a few common human leukocyte antigen class II genes--had been identified that clearly associa

147 Class II genes have more diverse expression patterns.

148 the 5' proximal promoter region of the human class II gene HLA-DQA1 have been shown to influence its

149 5 kb centromeric of the disease-predisposing class II gene HLA-DQB1.

150 ity determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1, but these genes ca

151 dependently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1.

152 GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostl

153 Additionally, unlike the classical MHC class II genes, HLA-DOB expression was present in the ab

154 s the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP.

155 rols the expression of the three major human class II genes, HLA-DR, HLA-DQ, and HLA-DP.

156 The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I g

157 et autoantibodies localizing to the same HLA class II genes, HLA-DRB1 and HLA-DQB1, the effects of th

158 X. maculatus and found to be orthologous to class II genes identified in other fishes.

159 h regard to the coordinate regulation of the class II genes if the factors though to regulate the HLA

160 current study we studied the HLA class I and class II genes in 231 Chinese voluntary blood donors who

161 n histocompatibility leukocyte antigen (HLA) class II genes in 54 cases of tuberculoid leprosy (TL) a

162 consistent and strong associations with MHC class II genes in Caucasian patients with inflammatory b

163 mice has helped to elucidate the role of HLA class II genes in chronic inflammatory and demyelinating

164 To investigate the role of individual HLA class II genes in immune responses to human Ro60 (hRo60)

165 s Ciita and major histocompatibility complex class II genes in murine macrophages, thereby inhibiting

166 nic trophoblast cells from up-regulating MHC class II genes in response to IFN-gamma.

167 Furthermore, IFN-gamma induction of the MHC class II genes in solid human tumor lines requires retin

168 ins encoded by the classical HLA class I and class II genes in the major histocompatibility complex (

169 ces the activator-dependent transcription of class II genes in vitro, but it was later shown that PC4

170 is generally required for activation of all class II genes in vivo, we have constructed substitution

171 clear whether any are general repressors of class II genes in vivo.

172 s are independent of human leukocyte antigen class II genes in whites but may interact antagonistical

173 gulatory proteins initiates transcription of class II genes in yeast cells.

174 Class II genes including fleSR, encoding a two-component

175 tivator (CIITA) is a master regulator of MHC class II genes, including DR, DP, and DQ, and MHC class

176 investigating the transfer of allogeneic MHC class II genes into recipient bone marrow cells (BMC), u

177 In an attempt to define the MHC class II genes involved in disease, we previously studie

178 al human leukocyte antigen (HLA) Class I and Class II genes is among the most polymorphic and diverse

179 IFN-gamma stimulation of class II genes is further enhanced by inhibiting the nuc

180 o inherit putative protective alleles of HLA class II genes is linked to the development of breast ca

181 The expression of major histocompatibility class II genes is necessary for proper antigen presentat

182 ences present in the promoters of eukaryotic class II genes is the first step in the sequential assem

183 of the reciprocal-suppressive effect between class II genes is unclear, although the involvement of r

184 The transcription of nonconventional MHC class II genes is, however not affected by CIITA deficie

185 of C57BL/6 major histocompatibility complex class II gene knockout mice and CD4 cell-depleted C3H mi

186 ( P = 7.5 x 10(-35)), which included the HLA class II genes, known to be the primary determinants of

187 In the present study, we characterize an MHC class II gene-linked butyrophilin family member, butyrop

188 ns in major histocompatibility complex (MHC) class II genes may be of pathogenetic importance in infl

189 ith type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MICB P

190 n histocompatibility leukocyte antigen (HLA) class II gene most commonly associated with human type 1

191 latory sequences are conserved among all MHC class II genes, multiple base pair changes are found, ev

192 Coordinate regulation of MHC class II genes occurs in a tissue-specific and cytokine-

193 The class II genes of the major histocompatibility complex e

194 The Class II genes of the MHC represent a major locus with q

195 e TAP1 gene to human leukocyte antigen (HLA) class II genes on chromosome 6, we postulated that a lin

196 ce to eliminate any effect of endogenous MHC class II genes on the development of autoimmune diseases

197 The major histocompatibility complex class II genes play an important role in the genetic pre

198 2 Ags in the context of the HLA-DRbeta1*1502 class II gene product.

199 major histocompatibility complex class I and class II gene products and certain chemokine genes are t

200 These findings demonstrate that class II gene products are required for virus clearance

201 s (Abo) were used to investigate the role of class II gene products in resistance or susceptibility t

202 histocompatibility complex (MHC) class I and class II gene products in the development of functional

203 One of the class II gene products, the FIIA protein, is an alternat

204 ce CIITA-induced gene expression from an MHC class II gene promoter.

205 ion and transcription from sigma73-dependent class II gene promoters.

206 atory factors required for expression of MHC class II genes, rather than the genes themselves, are re

207 transactivation of major histocompatibility class II genes remains unclear.

208 Expression of MHC class II genes requires CIITA.

209 lar and extracellular pathogens (class I and class II genes, respectively) in vertebrates.

210 , encompassing two MHC class I and three MHC class II genes, separated from the B system by a region

211 ed by polymerase II and can be classified as class II genes similar to protein-coding genes.

212 Another locus contains HLA class II genes studied in relation to elevated squamous

213 ential for transcription initiation from all class II genes studied.

214 ciation of type 1 diabetes with specific MHC class II genes, such as I-A(g7) in nonobese diabetic mic

215 ptionally a more potent activator of the MHC class II gene than the form expressed in B cells.

216 Our findings demonstrate that BAD1 is a TCP class II gene that functions to promote cell proliferati

217 s III regions, including the MHC class I and class II genes that play a primary role in the immune re

218 Some Class II genes that we found, such as SLC19A1 and ATAD3B

219 Like the class II genes, the HLA-DM genes contain upstream regula

220 ecent data from the author's laboratory on a class II gene therapy induction of tolerance to allogene

221 In addition to the MHC class II genes, there are at least two MHC-linked diabet

222 Thus, hTRFP may regulate transcription of class II genes through association with the RNA polymera

223 response (class I) and downregulating other (class II) genes through a mechanism that depends on the

224 Transfer of MHC class II genes, through allogeneic bone marrow (BM) tran

225 on also reduces transcription of seven other class II genes, thus indicating a broad role for this yT

226 Previous studies have shown cattle MHC class II genes to be subdivided into two distinct subreg

227 Class II gene transcription commences with the assembly

228 likely responsible for this higher level of class II gene transcription, as purified Tax was found t

229 or of major histocompatibility complex (MHC) class II gene transcription.

230 coordinate with phosphorylation to regulate class II gene transcription.

231 ue-specific major histocompatibility complex class II gene transcription.

232 master regulator of major histocompatibility class II gene transcription.

233 transactivator, the master regulator of MHC class II gene transcription.

234 n that transplantation tolerance, induced by class II gene transfer into syngeneic BMC, results in pa

235 ese results demonstrate the potential of MHC class II gene transfer to permit tolerance to solid orga

236 nism of tolerance induction achieved through class II gene transfer, BMC from C57BL/10 mice, which la

237 e mice were generated by introduction of HLA class II genes, various human cytokines, and human B cel

238 nkage of ring3 and beta2M to MHC class I and class II genes was determined by single-strand conformat

239 Transcription of class II genes was elevated in an nsrR mutant during ana

240 as NO insensitive in vitro, transcription of class II genes was moderately induced by NO, which invol

241 Other MHC class II genes were found to predict survival similarly.

242 Class II genes were regulated only with E(2), whereas cl

243 uniformly induced by p53 in all cell lines; "class II" genes were induced in a subset of the lines; a

244 n levels of major histocompatibility complex class II genes, whereas a differential ubiquitin signatu

245 ator of the major histocompatibility complex class II genes, which are involved in antigen presentati

246 s the expression of major histocompatibility class II genes, which encode antigen-presenting molecule

247 c, the stretches that encode the class I and class II genes, which epitomize the Mhc, are the least c

248 ern of dyscoordinate regulation of their MHC class II genes, which is reflected in a new phenotype of

249 a CIITA-inducible gene, and DO beta as a MHC class II gene whose expression is independent of CIITA.

250 port in live APCs, we replaced the mouse MHC class II gene with a version that codes for a class II m

251 Experiments with class II genes with truncated cytoplasmic tails indicate

252 gene mutations, including 8 class I genes, 4 class II genes, WT1 and TP53 (class III), and 5 epigenet

253 , binds to the promoter regions of flagellar class II genes, yet, despite extensive analysis of the F