ライフサイエンスコーパス: class II transactivator

1 f interferon regulatory factor 1 and the MHC class II transactivator.

2 hal reporter construct and subsequently, the class II transactivator.

3 his in turn was caused by lack of functional class II transactivator.

4 nvestigated in cells stably transfected with class II transactivator.

5 used CRISPR/Cas9 to disrupt the gene for the class II transactivator.

6 is associated with up-regulation of the MHC class II transactivator, a key transcription factor with

7 t ovariectomy up-regulates IFN-gamma-induced class II transactivator, a multitarget immune modulator,

8 prevented transcription of the gene encoding class II transactivator, a transactivator protein requir

9 also induced by HPIV3 in cells defective in class II transactivator, an important intermediate of th

10 These transacting factors are the class II transactivator and 3 subunits of regulatory fac

11 nsfection of small interfering RNA targeting class II transactivator attenuates major histocompatibil

12 ecules by small interfering RNA targeting of class II transactivator can reduce the capacity of human

13 We previously established that the class II transactivator CIITA binds GTP and disruption o

14 Coexpression of the class II transactivator CIITA in these cells, which stim

15 The class II transactivator CIITA is required for transcript

16 factor RFX (RFX-B, RFX5, and RFXAP) and the class II transactivator CIITA.

17 The MHC class II transactivator (CIITA) activates the expression

18 Class II transactivator (CIITA) activates the expression

19 The presence of the class II transactivator (CIITA) activates the transcript

20 The major histocompatibility complex (MHC) class II transactivator (CIITA) acts as a master switch

21 The class II transactivator (CIITA) and B cell octamer-bindi

22 une evasion strategies such as inhibition of class II transactivator (CIITA) and MHC-II expression, t

23 ractions of chromatin-modifying enzymes with class II transactivator (CIITA) and relevant DNA-binding

24 ty complex (MHC)-II and its master regulator class II transactivator (CIITA) are downregulated in CML

25 a signal transduction (Jak/Stat pathway) and class II transactivator (CIITA) are required components

26 igation has defined major histocompatibility class II transactivator (CIITA) as a key factor in media

27 lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expre

28 Here, we show that the MHC class II transactivator (CIITA) can suppress this pathwa

29 ells and in a cell line that is defective in class II transactivator (CIITA) demonstrates that NK cel

30 feron-gamma treatment or transduction of the class II transactivator (CIITA) gene induces class II ex

31 Class II transactivator (CIITA) has a distinct function

32 anges in cancer immunity mediated by the MHC class II transactivator (CIITA) have not been extensivel

33 The role of the MHC class II transactivator (CIITA) in Ag presentation by as

34 scriptional regulation, which is governed by class II transactivator (CIITA) in all cells, microbial

35 P-deficient cells, transfection of exogenous class II transactivator (CIITA) into these RFX-B-deficie

36 The MHC class II transactivator (CIITA) is a critical regulator

37 The MHC class II transactivator (CIITA) is a critical transcript

38 Class II transactivator (CIITA) is a global transcriptio

39 The class II transactivator (CIITA) is a highly specific tra

40 Although complex, the co-activator class II transactivator (CIITA) is a key regulator of MH

41 The class II transactivator (CIITA) is a master regulator of

42 Class II transactivator (CIITA) is a master regulator re

43 The class II transactivator (CIITA) is a master transcriptio

44 The class II transactivator (CIITA) is a master transcriptio

45 The class II transactivator (CIITA) is a transcriptional co-

46 Class II transactivator (CIITA) is an unusual transcript

47 The class II transactivator (CIITA) is essential for the exp

48 The class II transactivator (CIITA) is induced by gamma inte

49 complex along with major histocompatibility class II transactivator (CIITA) is induced by interferon

50 Class II transactivator (CIITA) is known as a coactivato

51 Class II transactivator (CIITA) is necessary for express

52 Class II transactivator (CIITA) is required for both con

53 The major histocompatibility complex (MHC) class II transactivator (CIITA) is the 'master coactivat

54 The class II transactivator (CIITA) is the key regulator of

55 The class II transactivator (CIITA) is the master integrator

56 Class II transactivator (CIITA) is the master regulator

57 Class II transactivator (CIITA) is the master regulator

58 The class II transactivator (CIITA) is the master regulator

59 The major histocompatibility complex (MHC) class II transactivator (CIITA) is the master regulatory

60 Class II transactivator (CIITA) is the unique mediator o

61 amma-inducible transcription at multiple MHC class II transactivator (CIITA) promoters and suppressed

62 s II MHC genes requires the induction of the class II transactivator (CIITA) protein, a master regula

63 ctivation of class II MHC genes requires the class II transactivator (CIITA) protein, a regulator tha

64 The major histocompatibility complex (MHC) class II transactivator (CIITA) regulates the expression

65 s strictly dependent upon the binding of the class II transactivator (CIITA) to the highly conserved

66 The discovery of the class II transactivator (CIITA) transcription factor, an

67 negative trans-acting factors that suppress class II transactivator (CIITA) transcription.

68 Expression of class II transactivator (CIITA) types I and III, but not

69 Depending on whether MHC-II genes and the class II transactivator (CIITA) were being expressed, tw

70 Class II transactivator (CIITA), a coactivator required

71 have now transduced tumor cells with the MHC class II transactivator (CIITA), a regulatory gene that

72 The transcriptional coactivator class II transactivator (CIITA), although predominantly

73 tion analysis demonstrated that induction of class II transactivator (CIITA), and consequently, HLA-D

74 Recently, a non-DNA binding protein, class II transactivator (CIITA), has been shown to be re

75 ter regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and

76 re, inhibition of promoter activities of MHC class II transactivator (CIITA), IFN-gamma-activated sit

77 ated inhibition of MNV replication in vitro, class II transactivator (CIITA), interferon regulatory f

78 mary and immortalized astrocytes up-regulate class II transactivator (CIITA), invariant chain (Ii) (p

79 An NLR protein, class II transactivator (CIITA), is a key regulator of M

80 We show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of

81 anism involved interactions between CTCF and class II transactivator (CIITA), the master regulator of

82 uires recruitment of a master regulator, the class II transactivator (CIITA), to the MHC class II pro

83 orrelating to a decrease in the mRNA for the class II transactivator (CIITA), whereas CIITA expressio

84 nodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately cont

85 non-DNA-binding master regulator of MHC-II, class II transactivator (CIITA), which is crucial for en

86 t the major histocompatibility complex (MHC) class II transactivator (CIITA), which is required for e

87 of several immune function genes, including class II transactivator (CIITA), which regulates class I

88 Therefore, MHC class II transactivator (CIITA)-deficient mice that do n

89 in line with the role of CREBBP in promoting class II transactivator (CIITA)-dependent transcriptiona

90 ion of this family of genes requires the MHC class II transactivator (CIITA).

91 I BLS patient is a 24 aa deletion in the MHC class II transactivator (CIITA).

92 ators, such as regulatory factor X (RFX) and class II transactivator (CIITA).

93 tch for the expression of these genes is the class II transactivator (CIITA).

94 gene transcription through regulation of the class II transactivator (CIITA).

95 atory factor for X-box 5 (RFX5) complex with class II transactivator (CIITA).

96 xpression is negatively regulated by the MHC class II transactivator (CIITA).

97 factor for X-box 5 (RFX5) complex as well as class II transactivator (CIITA).

98 o involve a defect in IFN-gamma induction of class II transactivator (CIITA).

99 due to differences in the expression of the class II transactivator (CIITA).

100 led by the master transcriptional regulator, class II transactivator (CIITA).

101 a specific transcriptional coactivator, the class II transactivator (CIITA).

102 ications and gene expression mediated by the class II transactivator (CIITA).

103 One of these is the class II transactivator (CIITA).

104 of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in

105 y the major histocompatibility complex (MHC) class II transactivator, CIITA, which binds to myogenin

106 g the major histocompatibility complex (MHC) class II transactivator, CIITA.

107 This expression is initiated by the class II transactivator, CIITA.

108 3 that inhibits promoter function of the HLA class II transactivator, decreasing expression of genes

109 However, class II transactivator-deficient mice can prime a subop

110 tion and targeted IFN response factor 1- and class II transactivator-dependent and independent promot

111 pathways including Stat-3, beta-catenin, and class II transactivator-dependent antigen presentation.

112 Up-regulation of class II transactivator derives from increased productio

113 Thus, increased IFN-gamma-induced class II transactivator expression and the resulting enh

114 henotype can be rescued by reintroduction of class II transactivator expression.

115 STAT1 is an activator of CIITA, the class II transactivator for MHC II expression; CIITA exp

116 The MHC class II transactivator gene (CIITA) coordinately contro

117 The MHC class II transactivator gene (CIITA) is an important tra

118 was accompanied by activation of a repressed class II transactivator gene in a plasma cell tumor but,

119 t from a pig transgenic for a mutant (human) class II transactivator gene, resulting in down-regulati

120 in reaction analysis for gene transcripts of class II transactivator, HLA-DRagr;, and HLA-DRbeta1 sho

121 nducible genes-MHC class II gene E beta; MHC class II transactivator; IFN regulatory factor-1; and Mg

122 Re-expressing the class II transactivator in the PELs increased expression

123 Mounting evidence suggests that the class II transactivator modulates promoter accessibility

124 demonstrate that NOD mice lacking the CIITA (class II transactivator) molecule, and hence deficient i

125 tion of the IFN gamma-responsive chromosomal class II transactivator promoter revealed that MCMV infe

126 Because the class II transactivator protein (CIITA) induces Ia and I

127 by either IFN-alpha/beta (Mx1) or IFN-gamma (class II transactivator protein [CIITA] and inducible ni

128 gen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory fa

129 ion arises from biallelic gene disruption in class II transactivator that leaves other essential prop

130 One such NLR protein is the MHC class II transactivator, the master regulator of MHC cla

131 ested that NLRC5 acts in a manner similar to class II transactivator to drive MHC expression and reve

132 ss II was induced in the apparent absence of class II transactivator transcripts.

133 e selective: while transcription of CD64 and class II transactivator were decreased, certain other IF

134 C57BL/6 (B6) mice deficient for the class II transactivator, which have defects in MHC class

135 d proteins form a platform that attracts the class II transactivator, which initiates and elongates M