ライフサイエンスコーパス: class switch

1 feration of viable B cells, but not with IgE class switch.

2 uced circulating B cells and impaired B cell class-switch.

3 eir B cells could not undergo immunoglobulin class switching.

4 nd CD8 T cells, or to undergo immunoglobulin class switching.

5 otein P6, with impaired IgG1, IgG2a, and IgA class switching.

6 a GC-like phenotype or the rate of antibody class switching.

7 ifferentiation, B cell proliferation, and Ig class switching.

8 ecific human CD8 T cells, and immunoglobulin class switching.

9 d with progressive B-cell maturation and IgE class-switching.

10 elp in germinal centers and is necessary for class-switched Ab responses.

11 sociated with a rapid decline in Ag-specific class-switched Ab.

12 High-affinity class-switched Abs and memory B cells are products of th

13 ciated Ab formation, decreases production of class-switched Abs targeting nonnuclear Ags, and limits

14 Twenty percent of the clones consisted of class switched and IgM(+)(IgD(+)) members, a feature tha

15 Evidence for IgG-expressing B cells, class switching and antibody maturation in normal and ma

16 ells, significantly reduced CD40-mediated Ig class switching and plasma cell differentiation ex vivo.

17 hibition, together with the rescue of B cell class switching and plasma cell survival by enforced NF-

18 a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combinat

19 4 derived from Tfh cells is required for IgE class switching and plasmablast formation.

20 n, and in this study we mechanistically link class switching and proliferation via c-Myc.

21 T-dependent mechanisms orchestrate Ig alpha class switching and SIgA responses against commensal and

22 germinal center B-cell responses, including class switching and somatic hypermutation.

23 gene knockout or Rab7 activity inhibition in class switching and survival, respectively, whereas prol

24 Blimp-1), are critical for the generation of class-switched and hypermutated (mature) Ab and autoanti

25 In addition, it decreased class-switched and hypermutated autoantibodies, ameliora

26 epigenetic mechanisms, valproic acid blunted class-switched and hypermutated T-dependent and T-indepe

27 Greater apoptotic depletion of class-switched and IgM memory cells was associated with

28 vidual t1/2 of pre-established Ag-induced Ig class-switched and IgM-positive memory B cells over 402

29 nt infections due to impaired immunoglobulin class-switching and somatic hypermutation.

30 B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through

31 ils and mast cells, promoting immunoglobulin class switching, and preventing excessive activation.

32 3 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA r

33 s high-affinity antibodies, promote antibody class switching, and yield B cell memory.

34 s impaired, with fewer memory cells, reduced class-switching, and lower frequency and complexity of s

35 and hemagglutinin leads to the production of class-switched anti-MOG antibodies, dependent on the pre

36 velop systemic autoimmunity characterized by class-switched anti-nuclear Abs.

37 The production of high affinity, class switched antibodies produced by B cells hinges on

38 GC response that increases the generation of class-switched antibodies and the frequency of somatic h

39 KIs might be useful to enhance production of class-switched antibodies following vaccination.

40 Expression of class-switched antibodies from Ara h 2-positive cells co

41 al center reaction and for the production of class-switched antibodies in response to thymus-independ

42 In contrast, class-switched antibodies specific to S. aureus are comm

43 ologous naive B cells, higher frequencies of class-switched antibodies were detected in cocultures of

44 essential in the induction of high-affinity, class-switched antibodies.

45 tial for B cell production of high-affinity, class-switched antibodies.

46 tigen-specific GC B cells, and high-affinity class-switched antibody production.

47 , supporting the induction of high-affinity, class-switched antibody responses, long-lived plasma cel

48 s, follicular CD4 T cells, and production of class-switched antibody, together with expansion of B1 B

49 hogenic infections through the generation of class-switched antibody-secreting cells (ASCs) in germin

50 mune responses, especially the generation of class-switched, antigen-specific antibody responses.

51 NP, local IgE level and key markers of local class switching are increased compared with AR and norma

52 the cellular interactions necessary for IgA class switching are poorly defined.

53 rogressive introduction of hypermutation and class-switching as animals age.

54 SceI DSB frequency, undergo I-SceI-dependent class switching at almost normal levels.

55 High titer, class-switched autoantibodies are a hallmark of systemic

56 m BAFF-transgenic mice spontaneously produce class-switched autoantibodies ex vivo.

57 ion must be exquisitely controlled because a class-switched B cell cannot revert back to the parent i

58 5(+)), proliferation markers (Ki-67(+)), and class-switched B cells (IgG(+)); and (5) both TNFRSF17 m

59 est that Sox2 may regulate AID expression in class-switched B cells to suppress genomic instability a

60 Complete absence of class-switched B cells was a sensitive predictor of AID

61 clone assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma cells,

62 otential mechanism through which appropriate class-switching can be coupled to plasmablast proliferat

63 s of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in

64 splenic B1a cells, which differentiated into class-switched CD138(+) IgG-secreting B1a cells.

65 (TD) Ags are considered to largely reside in class-switched CD27(+) cells.

66 reduced numbers of marginal zone B cells and class-switched cells, and were associated with decreased

67 n induces terminal maturation and Ig isotype class switch (class switch recombination [CSR]).

68 Class switch-competent anti-insulin B cells fail to prod

69 These data demonstrate that class switch-competent anti-insulin B cells remain funct

70 , B cell maturation, and immunoglobulin (Ig) class switching critical for adaptive immunity.

71 tone variant H2AX are required for efficient class switch (CSR) and V(D)J recombination in part becau

72 e deficit, possibly due to an immunoglobulin class switch defect, in obesity and T2D during exacerbat

73 Notably, early IgE class switching did not require germinal center formatio

74 uman basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of

75 Class-switch DNA recombination (CSR) and somatic hypermu

76 Antibody class-switch DNA recombination (CSR) is initiated by AID

77 Elevated chemokines and IgE class switching events were observed in IMT samples, con

78 These processes, including class switching, evolved with and appear inseparable fro

79 eaminase (AID), DNA repair enzymes, and post-class-switch expression of IgA and IgG, was successfully

80 Immunoglobulin class switching from IgM to IgG in response to peptides

81 in place of Sgamma1 undergo I-SceI-dependent class switching from IgM to IgG1 at 5-10% of normal leve

82 vaccination through their effect on the IgA class-switching function of LDCs.

83 erns and lineage characteristics of antibody class switching have remained uncharacterized in living

84 TOR-KI compound AZD8055 increased titers of class-switched high-affinity antibodies to a hapten-prot

85 , as well as increased levels of Ag-specific class-switched Ig production following immunization with

86 3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular poly

87 In this study, we showed that the class-switched IgG autoantibody response in MRL/Fas(lpr/

88 CD19(+) B cells, including IgM(+) naive and class-switched IgG memory B cells, with a concomitant in

89 o associated with a significant reduction in class-switched IgG, and anti-nucleosomal IgG-secreting B

90 in vitro and produced high concentrations of class-switched IgG2b and IgG2c, including anti-RNA antib

91 We hypothesized that clonally expanded, class-switched IgG4-positive B cells and plasma cells co

92 ly related cells exist when purified B cells class switch in vitro, suggesting that class switch reco

93 ferentiation and showed that TOR-KIs enhance class switching in a manner dependent on forkhead box, s

94 te as it is central to the initiation of IgE class switching in B cells.

95 ect activation-induced deaminase to initiate class switching in B cells.

96 f autoantigen specificities and autoantibody class switching in BXD2 and control (C57BL/6) mice and h

97 IgG responses, suggesting defective isotype class switching in CD73-deficient mice.

98 HEJ is insufficient to impact immunoglobulin class switching in DEK knockout mice.

99 hensively measured the landscape of antibody class switching in human adult twins using antibody repe

100 salivary prostaglandin E2 triggers antibody class switching in mature B cells, increasing the levels

101 use line that completely failed to induce Ig class switching in vitro and in vivo.

102 increase the fraction of B cells undergoing class switching in vitro.

103 We further demonstrate that AhR suppresses class switching in vivo after influenza virus infection

104 -21-induced proliferation and immunoglobulin class-switching in B cells, cytokine production in T cel

105 B cells undergo maturation and class-switching in response to antigen exposure and T-ce

106 , nonspecific B cell activation, nonspecific class switching, increased cell turnover, breakage of to

107 globulinemia, nonspecific B cell activation, class switching, increased cell turnover, breakage of to

108 arable somatic hypermutation frequencies and class-switching indicated affinity-matured antibodies in

109 Antibody class switching is a feature of the adaptive immune syst

110 ability of A2 mice to undergo immunoglobulin class switching is due to deficient CD4 helper T cell fu

111 Even though class switching is essential for mounting a protective r

112 atible with the idea that division-linked Ig class switching is in part due to CDK2-regulated AID nuc

113 ngraftment, but also significantly increased class switched memory B cells and serum immunoglobulin G

114 Frequencies of AF DENV(+) class-switched memory B cells (IgD(-)CD27(+) CD19(+) cel

115 Numbers of total memory (CD27(+)) and class-switched memory B cells (IgM(-)) were significantl

116 cted to those patients with severely reduced class-switched memory B cells and an elevated level of C

117 B-cell lymphopenia, decreased frequencies of class-switched memory B cells and hypogammaglobulinemia

118 reased (healthy donors) MHC-II expression as class-switched memory B cells and intermediate costimula

119 e number of iNKT cells and the percentage of class-switched memory B cells and propensity to lymphopr

120 Class-switched memory B cells showed: accumulation of FA

121 Deep sequencing of the BCR from E2-specific class-switched memory B cells sorted from two independen

122 HCV-specific class-switched memory B cells were detected in 3 out of

123 ealthy controls revealed that frequencies of class-switched memory B cells were increased in the pati

124 latory molecule expression between naive and class-switched memory B cells, indicating their potentia

125 n thymic failure and the severe reduction in class-switched memory B cells, while gathering longitudi

126 of naive, mature CD5(+), IgM(+) memory, and class-switched memory B cells.

127 ly diverse compartment of IgM(+)(IgD(+)) and class-switched memory B cells.

128 ny large B-cell clones, especially among non-class-switched memory B cells.

129 germinal center and ensure replenishment of class-switched memory CD27(+) B cells from Ag-experience

130 Class switching occurs by a deletional recombination bet

131 IgH class switching occurs rapidly after activation of matur

132 C T cell frequency, GC B cell frequency, and class switching of GC B cells to IgG1.

133 ar differentiation, GC B cell frequency, and class switching of GC B cells to IgG1.

134 protein (CD40-muIg) binding, and rescued IgG class switching of naive B cells in vitro.

135 nograft recipients, anti-CD154mAb may reduce class-switching of anti-pig antibodies by binding both T

136 found significant expansion, retention, and class-switching of autoreactive B cells in GCs under con

137 e lupus-associated, somatically mutated, and class-switched pathogenic autoantibodies are generated i

138 Lyn-deficient mice by blocking production of class-switched pathogenic IgG autoantibodies.

139 ted and delineates a two-tiered hierarchy of class switch pathways.

140 -cell subsets to generate IgE(+) PCs and the class switching pathways involved.

141 cells to promote B cell differentiation into class-switched plasmablasts and led to downregulation of

142 ycle time of approximately 11 h, and that Ig class switching preferentially occurred in the late G1 o

143 s and supports a controllable immunoglobulin class-switching reaction.

144 ve mice without memory T cells recapitulated class-switched recall alloantibody responses.

145 ls, including DSBs generated during antibody class switch recombination (CSR) and DSBs generated by i

146 We find that both class switch recombination (CSR) and R-loop formation de

147 n-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutati

148 mphocytes use two DNA alteration mechanisms, class switch recombination (CSR) and somatic hypermutati

149 uced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutati

150 ing (V(D)J) recombination and immunoglobulin class switch recombination (CSR) are key processes in ad

151 d the mechanisms underlying abnormalities in class switch recombination (CSR) associated with the hum

152 D) initiates somatic hypermutation (SHM) and class switch recombination (CSR) by deaminating cytidine

153 Class switch recombination (CSR) diversifies antibodies

154 hypermutation (SHM) and immunoglobulin (Ig) class switch recombination (CSR) enable B cells to produ

155 In mature B cells, class switch recombination (CSR) generates different ant

156 Class switch recombination (CSR) generates isotype-switc

157 recombination in developing lymphocytes and class switch recombination (CSR) in antigen-stimulated B

158 on-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiatin

159 Antibody class switch recombination (CSR) in B lymphocytes joins

160 In B lymphocytes, Ig class switch recombination (CSR) is induced by activatio

161 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activat

162 In B cells, Ig class switch recombination (CSR) is initiated by activat

163 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the tra

164 Class switch recombination (CSR) is instigated by activa

165 IgH class switch recombination (CSR) occurs through the deli

166 to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes.

167 ine, and the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline.

168 Class switch recombination (CSR) plays an important role

169 Immunoglobulin heavy chain class switch recombination (CSR) requires targeted forma

170 gE(+) cells in vivo and the low frequency of class switch recombination (CSR) to IgE ex vivo.

171 Immunoglobulin class switch recombination (CSR) to IgE is a tightly reg

172 ity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-depen

173 uch as those occurring during immunoglobulin class switch recombination (CSR), are repaired by non-ho

174 globulin switch (S) regions is essential for class switch recombination (CSR), but no molecular funct

175 ions has been implicated in regulation of Ig class switch recombination (CSR).

176 ate antibody somatic hypermutation (SHM) and class switch recombination (CSR).

177 duced cytidine deaminase (AID)-dependent IgH class switch recombination (CSR).

178 cytes hypersecrete IgM and do not undergo Ig class switch recombination (CSR).

179 atory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

180 inal maturation and Ig isotype class switch (class switch recombination [CSR]).

181 of cytokines, including IL-21, and inhibited class switch recombination and B cell activation.

182 l center (GC) reaction where B cells undergo class switch recombination and clonal selection to gener

183 GC reaction in primary B cells by impairing class switch recombination and memory B and plasma cell

184 tidine deaminase (AID) is a key regulator of class switch recombination and somatic hypermutation of

185 ) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of

186 lack the ability to undergo normal levels of class switch recombination and somatic hypermutation, tw

187 hat targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation.

188 uced cytidine deaminase (AID), the enzyme of class switch recombination and somatic hypermutation; th

189 of B cells involves the sequential events of class switch recombination and somatic hypermutations ch

190 ts or (ii) deletion of enhancer elements for class switch recombination and transcription, or (iii) a

191 dergone the affinity-maturation processes of class switch recombination and, possibly, somatic hyperm

192 ich accumulates in the nucleus and increases class switch recombination as well as chromosomal transl

193 nzymatic function of host UNG in an in vitro class switch recombination assay.

194 me is required for somatic hypermutation and class switch recombination at the immunoglobulin locus.

195 region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline

196 tant role in repairing DSBs generated during class switch recombination by promoting the classical NH

197 region super-enhancer and leads to decreased class switch recombination efficiency.

198 The dramatic reduction in class switch recombination for all H chain genes and the

199 e functionality of AID by evaluating in vivo class switch recombination in 52 MCL cases; and sought f

200 d break repair protein that is essential for class switch recombination in B lymphocytes and for sens

201 S phases of the cell cycle, interferes with class switch recombination in B lymphocytes, and leads t

202 c stability in mouse fibroblasts, and in IgH class switch recombination in mature B cells.

203 ated in NP, and there was evidence for local class switch recombination in NP.

204 cells class switch in vitro, suggesting that class switch recombination is directed toward specific i

205 Germinal center somatic hypermutation and class switch recombination machineries were activated, a

206 was previously found to be unable to support class switch recombination or to promote radial chromoso

207 in the normal G+C-rich context of mammalian class switch recombination regions, R-loops are obligato

208 In B cells, STAT6 is required for class switch recombination to IgE and for germinal cente

209 remodeling (global somatic hypermutation and class switch recombination to major isotypes) in activat

210 Class switch recombination to several isotypes was also

211 genes associated with B cell activation and class switch recombination was measured by qRT-PCR.

212 Class switch recombination was partly lost due to a fail

213 in switch (S) regions during immunoglobulin class switch recombination, a physiological, deletion/re

214 o B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiat

215 pair, V(D)J recombination and immunoglobulin class switch recombination, as well as innate immune and

216 ase (AID) involved in somatic hypermutations/class switch recombination, in primary human B cells.

217 xpression, germ-line transcription preceding class switch recombination, interactions between targete

218 sured the expression of two miRs crucial for class switch recombination, miR-155 and miR-16, in human

219 ting Ab production, affinity maturation, and class switch recombination.

220 G1 Abs, demonstrating a functional effect on class switch recombination.

221 deletion of intervening DNA sequences during class switch recombination.

222 ution and impedes B cell differentiation and class switch recombination.

223 tation but defective affinity maturation and class switch recombination.

224 homologous end-joining during immunoglobulin class switch recombination.

225 erate double-strand DNA breaks for efficient class switch recombination.

226 ects VDJ recombination with minor effects on class switch recombination.

227 plex human B cell phenotypes during antibody class switch recombination.

228 )J recombination, somatic hypermutation, and class switch recombination.

229 ate somatic hypermutation and immunoglobulin class switch recombination.

230 , Id3-depleted B cells displayed a defect in class switch recombination.

231 induced cytidine deaminase gene required for class switch recombination/somatic hypermutation inducti

232 Classical class-switch recombination (cCSR) substitutes the Cmu ge

233 Class-switch recombination (CSR) alters the Ig isotype t

234 Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into

235 eviously unappreciated role for Flt3 in IgG1 class-switch recombination (CSR) and production.

236 tidine deaminase (AID), the enzyme-mediating class-switch recombination (CSR) and somatic hypermutati

237 ed cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutati

238 6, must process the deoxyuridine to initiate class-switch recombination (CSR) and somatic hypermutati

239 AID mediates class-switch recombination (CSR) and somatic hypermutati

240 CD103(+) and CD24(+)CD11b(+) DCs induced IgA class-switch recombination (CSR) by activating B cells t

241 y initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of

242 nduced cytidine deaminase (AID) initiates Ab class-switch recombination (CSR) in activated B cells re

243 Somatic hypermutation (SHM) and class-switch recombination (CSR) increase the affinity a

244 M(+) mouse B cells and hybridomas, we induce class-switch recombination (CSR) of the IgH chain to the

245 enes through somatic hypermutation (SHM) and class-switch recombination (CSR) processes.

246 atory functions that control IgH expression, class-switch recombination (CSR), and somatic hypermutat

247 lity to perform somatic hypermutation (SHM), class-switch recombination (CSR), or both.

248 IgH switch (S) region DNA breaks (DSBs) for class-switch recombination (CSR).

249 insights into the process of immunoglobulin class-switch recombination (CSR).

250 ctivation-induced deaminase during IgH (Igh) class-switch recombination (CSR).

251 Because BAFF promotes B cell class-switch recombination and humoral autoimmunity, we

252 together with previously reported defects in class-switch recombination and memory immune response, u

253 s B-cell differentiation leading to antibody class-switch recombination and secretion.

254 bility, confirming that these AHAs underwent class-switch recombination and somatic hypermutation.

255 ncy patients into subgroups and identified a class-switch recombination defect caused by an UNG mutat

256 Immunoglobulin class-switch recombination defects (CSR-D) are rare prim

257 We find that AhR negatively regulates class-switch recombination ex vivo by altering activatio

258 n history, somatic hypermutation status, and class-switch recombination in 17 children with Down synd

259 receptor participates in the control of IgE class-switch recombination in B cells.

260 e authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells withou

261 ic gene expression, antigen presentation and class-switch recombination in plasmablasts.

262 Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) ge

263 ty of the double-strand break repairs in the class-switch recombination process in vivo.

264 immunoglobulin M (IgM) BCR despite an active class-switch recombination process, and by the introduct

265 ls, IRF4 controls germinal center formation, class-switch recombination, and the generation of plasma

266 s recruitment to switch (S) regions leads to class-switch recombination.

267 y diversification: somatic hypermutation and class-switch recombination.

268 delayed-type hypersensitivity responses, and class-switch recombination.

269 and Toll receptor stimuli and undergo normal class-switch recombination.

270 ription 3 phosphorylation and immunoglobulin class-switch recombination.

271 were detectable in plasma, demonstrating IgG class-switch recombination.

272 tion of B lymphocytes and T cell-independent class-switch recombination.

273 over extended regions during immunoglobulin class-switch recombination.

274 ired B cell proliferation and immunoglobulin class-switch, reduced T cell effector functions, and var

275 Ig class switching requires cell proliferation and is divis

276 PP IgA class switching requires innate lymphoid cells, which pr

277 prevented the age-dependent accumulation of class-switched resting memory B cells.

278 lp in germinal center reactions that support class switching, somatic hypermutation, and the generati

279 induce B cell maturation and immunoglobulin class switching than cells from HIV progressors.IMPORTAN

280 production is thought to involve sequential class-switching that requires input from T cells.

281 and is involved in modulating immunoglobulin class switch through regulating the expression of activa

282 ipid C34 as an adjuvant designed to induce a class switch to form the vaccine candidates.

283 n B cells enhanced GC output by augmenting a class switch to IgG2a, affinity maturation, and the memo

284 n in response to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood

285 B cells determines their capacity to undergo class switching to IgE ex vivo, with the GC-derived B ce

286 0 signaling, cell proliferation, and de novo class switching to IgE were analyzed by RT-PCR and FACS.

287 -driven activation of the Cepsilon locus and class switching to IgE.

288 ve macrophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3(-/-) mic

289 gM(+)IgD(+)CD27(+) B cells into PCs, induced class switching to IgG2, and was reproducible in cocultu

290 germline transcripts and inhibited efficient class switching to the immunoglobulin G1 isotype.

291 increased B cell death, low impairs antibody class switching to the pro-inflammatory IgG2c antibody i

292 Cytokines direct IgH class-switching to a particular isotype by initiation of

293 (H)2 responses in T cells and immunoglobulin class-switching to IgE in B cells.

294 We found that class-switching to IgG1 biased the fate choice made by B

295 class switch was analyzed by quantitation of class switch transcripts.

296 activity of IgG1 and IgG2a anti-erythrocyte class-switch variants of 34-3C monoclonal autoantibody.

297 IgE class switch was analyzed by quantitation of class switc

298 Ig class switching was completely reconstituted by expressi

299 numbers with Stat3-deficient TFH cells, IgG1 class switching was greatly increased.

300 atic hypermutation (SHM), and immunoglobulin class-switching was performed.