ライフサイエンスコーパス: classical complement pathway

1 lement factor 1q (C1q) and activation of the classical complement pathway.

2 ts C1r and C1s of the first component of the classical complement pathway.

3 n through C1q fixation and activation of the classical complement pathway.

4 ace that recruit natural IgM to initiate the classical complement pathway.

5 so can bind C1q and act as inhibitors of the classical complement pathway.

6 lity of FX to protect Ad5 from attack by the classical complement pathway.

7 lization was mediated by natural IgM and the classical complement pathway.

8 ollate injection, suggesting a defect in the classical complement pathway.

9 s to apoptotic cells, thereby activating the classical complement pathway.

10 ling of the lptA mutant occurred through the classical complement pathway.

11 s, which triggered activation of C1q and the classical complement pathway.

12 f C5 but not of downstream components of the classical complement pathway.

13 h FcgammaRI and FcgammaRII and activates the classical complement pathway.

14 rarely with IgM indicating activation of the classical complement pathway.

15 great extent on its ability to activate the classical complement pathway.

16 mplement components C1q, C1r, and C1s of the classical complement pathway.

17 dothelium of the graft and activation of the classical complement pathway.

18 to GBS was associated with activation of the classical complement pathway.

19 h immune complex dependent activation of the classical complement pathway.

20 that sialylation may indirectly regulate the classical complement pathway.

21 min) mediated through the antibody-dependent classical complement pathway.

22 in diseases accompanied by the activation of classical complement pathway.

23 ins, indicating a role for components of the classical complement pathway.

24 iphery by the activation and fixation of the classical complement pathway.

25 Classical complement pathway activation did not promote

26 This protein blocked classical complement pathway activation in a comparable

27 gG3-triggered CML and to force a switch from classical complement pathway activation to C1q-dependent

28 via its most N-terminal SCR, which leads to classical complement pathway activation.

29 totoxic IgM anti-mouse antibodies and strong classical complement pathway activity with minimal alter

30 teps of complement and effectively depressed classical complement pathway activity, alternative compl

31 C1q is the target recognition protein of the classical complement pathway and a major connecting link

32 imannan immunoglobulin G (IgG) activates the classical complement pathway and accelerates initiation

33 s open a connection between the inflammatory classical complement pathway and connective tissue homeo

34 plement C1q protein, thereby attenuating the classical complement pathway and facilitating pneumococc

35 C1q is the initiator of the classical complement pathway and opsonizes apoptotic cel

36 was protective in mice lacking a functional classical complement pathway and show that alternative c

37 C1q is the initiator of the classical complement pathway and, as such, is essential

38 and C1s, proteases required to activate the classical complement pathway, and C3 showed a significan

39 h C1q, leading to a strong activation of the classical complement pathway, and results in consumption

40 for exploring CRP-mediated activation of the classical complement pathway, and that the characteristi

41 s rapid and is mediated by components of the classical complement pathway; and that gC mainly protect

42 addition to AMR-triggered activation of the classical complement pathway, antibody-dependent cellula

43 vation but have fully active alternative and classical complement pathways, are protected from cardia

44 nonoverlapping epitopes, which activates the classical complement pathway as well as inhibits fH bind

45 The classical complement pathway associated proteins were ac

46 We hypothesized that activation of the classical complement pathway at the endothelial cell sur

47 that elicits serum antibodies that activate classical complement pathway bacteriolysis and also inhi

48 expressed in eukaryotic cells activated the classical complement pathway but not the alternative or

49 Modified forms of LDL activate the classical complement pathway, but no lectin pathway acti

50 The first step in the activation of the classical complement pathway, by immune complexes, invol

51 Deficiency of an early component of the classical complement pathway, C1q, C1r/C1s, C4, or C2, r

52 The results indicated that activation of the classical complement pathway (CCP) was a primary mechani

53 in and C1q, the recognition component of the classical complement pathway (CCP), which results in the

54 ndicated that genetic variation within early classical complement pathway components (C1q, C1r, and C

55 cheal model of type 8 infection in mice with classical complement pathway deficiency.

56 cantly more resistant to antibody-dependent, classical complement pathway-directed bacteriolysis than

57 etic deficiencies of early components of the classical complement pathway (e.g., C1q, C4, and C2) are

58 ulted in normal functional properties of the classical complement pathway followed by reduced severit

59 at the characteristic of CRP to activate the classical complement pathway has no role in protecting m

60 ave been previously reported to activate the classical complement pathway in an antibody-independent

61 Thus, to investigate the role of the classical complement pathway in contusion-induced SCI, m

62 Inactivation of the classical complement pathway in normal human serum with

63 de the first direct genetic evidence for the classical complement pathway in the induction of EAMG in

64 cteria can activate both the alternative and classical complement pathways in the absence of specific

65 CMV-infected fibroblasts activated via the classical complement pathway independent of specific ant

66 time of human platelet-poor plasma or in the classical complement pathway, indicating that it is a sp

67 In addition, PepO binds the classical complement pathway inhibitor C4BP, thereby reg

68 Several gonococcal strains bind the classical complement pathway inhibitor, C4b-binding prot

69 tly, mice that lack a major component of the classical complement pathway initiation complex (C1q) bu

70 The first step of activation of the classical complement pathway involves the binding of the

71 The classical complement pathway is activated by antibody-an

72 The classical complement pathway is initiated by IgG molecul

73 C1q, a key component of the classical complement pathway, is a major player in the r

74 C1q, the first component of the classical complement pathway, is also a pattern recognit

75 s to the donor endothelium that activate the classical complement pathway, it was hypothesized that p

76 bular head region of C1q and to initiate the classical complement pathway, leading to activation of C

77 q-dependent C4b deposition on live bacteria (classical complement pathway), only those antibodies tha

78 opulation of the alternative rather than the classical complement pathway, previously not appreciated

79 itopes, engage C1q, activate C4, and mediate classical complement pathway SBA.

80 ), a meningococcal vaccine antigen, activate classical complement pathway serum bactericidal activity

81 ed to inhibit IgM-mediated activation of the classical complement pathway, since survival of the tspB

82 nd altered self components, and triggers the classical complement pathway through activation of its a

83 um against N. gonorrhoeae is mediated by the classical complement pathway through an antibody-depende

84 cognize microbial pathogens and activate the classical complement pathway through C1q (refs 3 and 4).

85 lternative complement pathway as well as the classical complement pathway; trigger the formation of c

86 ermatomyositis result from activation of the classical complement pathway triggered by direct binding

87 We found that activation of the classical complement pathway up to C5 was sufficient to

88 Specific inhibition of the classical complement pathway using TNT003 or C1q-deplete

89 ese data indicate that ethanol activates the classical complement pathway via C1q binding to apoptoti

90 r, these data suggest that initiation of the classical complement pathway via C1q is detrimental to r

91 le levels, suggesting that activation of the classical complement pathway was not required for innate

92 Since IgM is a potent activator of the classical complement pathway, we examined IgM binding to

93 binding site of SpA and 2) proceeded via the classical complement pathway, we tested a panel of monoc

94 Activation of the classical complement pathway with deposition of C3 is pa